12-hydroxy-5,8,10-heptadecatrienoic acid

12-hydroxy-5,8,10-heptadecatrienoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 466 references associated with 12-hydroxy-5,8,10-heptadecatrienoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 12-hydroxy-5,8,10-heptadecatrienoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 12-hydroxy-5,8,10-heptadecatrienoic acid

MeSH term MeSH ID Detail
Uremia D014511 33 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Pleurisy D010998 20 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Seizures D012640 87 associated lipids
Weight Loss D015431 56 associated lipids
Total 6

NCBI Entrez Crosslinks

All references with 12-hydroxy-5,8,10-heptadecatrienoic acid

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Authors Title Published Journal PubMed Link
pmid:27786324
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Kis B et al. The effect of substance P on the arachidonate cascade of rat platelets. 1997-1998 Acta Physiol Hung pmid:9706302
Kinoshita K et al. Bioconversion of arachidonic acid in human amnion during pregnancy and labor. 1980 Adv Prostaglandin Thromboxane Res pmid:7376992
Best LC et al. Thromboxane B2 production and lipid peroxidation in human blood platelets. 1980 Adv Prostaglandin Thromboxane Res pmid:7386271
Vincent JE et al. Effect of an inhibitor of TXA2 synthesis and of PGE2 on the formation of 12-L-hydroxy-5,8,10-heptadecatrienoic acid in human platelets. 1980 Adv Prostaglandin Thromboxane Res pmid:7386279
Margalit A et al. Regulation of in vivo prostaglandin biosynthesis by glutathione. 1999 Adv. Exp. Med. Biol. pmid:10667326
Pruimboom WM et al. Eicosanoid production by density-defined human peritoneal macrophages during inflammation. 1992 Agents Actions pmid:1332454
Zijlstra FJ et al. Species differences in the pattern of eicosanoids produced by inflamed and non-inflamed tissue. 1992 Agents Actions pmid:1442338
Gecse A and Telegdy G Captopril as a modifier of the arachidonate cascade of rat platelets. 1992 Agents Actions Suppl. pmid:1462859
Hamsten A et al. Shortened megakaryocyte-platelet regeneration time in young survivors of myocardial infarction. 1985 Am. Heart J. pmid:2866703
Linssen MC et al. Production of arachidonic acid metabolites in adult rat cardiac myocytes, endothelial cells, and fibroblast-like cells. 1993 Am. J. Physiol. pmid:8456996
Margalit A et al. Regulation of prostaglandin biosynthesis in vivo by glutathione. 1998 Am. J. Physiol. pmid:9486284
Kouzan S et al. Stimulation of arachidonic acid metabolism by adherence of alveolar macrophages to a plastic substrate. Modulation by fetal bovine serum. 1988 Am. Rev. Respir. Dis. pmid:2827547
Hofmann U et al. Measurement of 12(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid and its metabolite 12-oxo-5Z,8E,10E-heptadecatrienoic acid in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. 1990 Anal. Biochem. pmid:2281869
Leis HJ et al. Quantitative measurement of 5-, 12-, and 15-hydroxyeicosatetraenoic acid together with 12-hydroxyheptadecatrienoic acid by stable isotope dilution gas chromatography-negative ion chemical ionization-mass spectrometry. 1987 Anal. Biochem. pmid:3300415
Zulak IM et al. A fast, nondestructive purification scheme for prostaglandin H2 using a nonaqueous, bonded-phase high-performance liquid chromatography system. 1986 Anal. Biochem. pmid:3085539
Li X et al. Activation of extracellular signal-regulated kinase by 12-hydroxyheptadecatrienoic acid in prostate cancer PC3 cells. 2007 Arch. Biochem. Biophys. pmid:17880908
Frömel T et al. Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques. 2013 Basic Res. Cardiol. pmid:23224081
Liu Y et al. 12-L-hydroxy-5,8,10-heptadecatrienoic acid (HHT) is an excellent substrate for NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. 1985 Biochem. Biophys. Res. Commun. pmid:4004878
Fujimoto Y et al. Monochloramine potently inhibits arachidonic acid metabolism in rat platelets. 2006 Biochem. Biophys. Res. Commun. pmid:16615995
Miller JL et al. Arachidonic acid metabolism in guinea pig megakaryocytes. 1982 Biochem. Biophys. Res. Commun. pmid:6812584
Chabannes B et al. Decreased arachidonic acid metabolism in human platelets by autologous neutrophils: possible role of cell adhesion. 1994 Biochem. J. pmid:7516654
Calzada C et al. Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. 1997 Biochem. J. pmid:9230133
Satoh K et al. Effects of sulfonylurea agents on platelet arachidonic acid metabolism; study on platelet homogenates. 1994 Biochem. Pharmacol. pmid:8093094
Bauer J et al. Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. 2011 Biochem. Pharmacol. pmid:20933508
Forsell PK et al. Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A2-alpha. 2005 Biochem. Pharmacol. pmid:16290172
Rosolowsky M et al. Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites. 1996 Biochim. Biophys. Acta pmid:8652640
Hall ER and Tai HH Purification of thromboxane synthetase and evidence of two distinct mechanisms for the formation of 12-L-hydroxy-5,8,10-heptadecatrienoic acid by porcine lung microsomes. 1981 Biochim. Biophys. Acta pmid:7197552
Tsunomori M et al. 15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. 1996 Biochim. Biophys. Acta pmid:8679681
Ozaki Y et al. Correlation of intracellular and extracellular calcium ion concentrations with synergy between 1,2-dioctanoyl-sn-glycerol and ionomycin in platelet arachidonic acid mobilization. 1989 Biochim. Biophys. Acta pmid:2499357
Kimura Y et al. Effects of stilbene derivatives on arachidonate metabolism in leukocytes. 1985 Biochim. Biophys. Acta pmid:3931689
Stenke L et al. Deficient lipoxin synthesis: a novel platelet dysfunction in myeloproliferative disorders with special reference to blastic crisis of chronic myelogenous leukemia. 1991 Blood pmid:1659470
Duncan EM and Lloyd JV Interference caused by acid extraction in the study of diacylglycerol in platelets. 1991 Blood Coagul. Fibrinolysis pmid:1893058
Beving H et al. Abnormally high platelet activity after discontinuation of acetylsalicylic acid treatment. 1996 Blood Coagul. Fibrinolysis pmid:8845467
Defreyn G et al. Familial bleeding tendency with partial platelet thromboxane synthetase deficiency: reorientation of cyclic endoperoxide metabolism. 1981 Br. J. Haematol. pmid:6268139
Ruf A et al. Characterization of the thromboxane synthase pathway product 12-oxoheptadeca-5(Z)-8(E)-10(E)-trienoic acid as a thromboxane A2 receptor antagonist with minimal intrinsic activity. 1998 Br. J. Haematol. pmid:9576182
Koeberle A et al. Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1. 2009 Br. J. Pharmacol. pmid:19298395
John H and Schlegel W Determination of the pK(a) of 12-S-hydroxyheptadecatrienoic acid by studies of its vial surface adsorption using high-performance liquid chromatography and liquid scintillation technique. 1999 Chem. Phys. Lipids pmid:11458961
John H and Schlegel W Thermodynamic and structural characterization of cis-trans isomerization of 12-(S)-hydroxy-(5Z, 8E, 10E)-heptadecatrienoic acid by high-performance liquid chromatography and gaschromatography-mass spectrometry. 1998 Chem. Phys. Lipids pmid:11458962
Shyue SK et al. Selective augmentation of prostacyclin production by combined prostacyclin synthase and cyclooxygenase-1 gene transfer. 2001 Circulation pmid:11319200
Guichardant M et al. Metabolism of endogenous arachidonic acid in weakly activated platelets. Absence of leukocyte cooperative products in whole blood. 1989 Eicosanoids pmid:2516743
Hecker M and Ullrich V 12(S)-Hydroxy-5,8,10 (Z,E,E)-heptadecatrienoic acid (HHT) is preferentially metabolized to its 12-keto derivative by human erythrocytes in vitro. 1988 Eicosanoids pmid:3272822
Beck-Speier I et al. Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages. 2001 Environ. Health Perspect. pmid:11544173
Höhl W et al. Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z, 8E, 10E, 12S)-12-hydroxy-5,8,10-heptadecatrienoic acid as substrate. 1993 Eur. J. Biochem. pmid:8508808
Tawata M et al. Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice. 1992 Eur. J. Pharmacol. pmid:1555643
Mezei Z et al. Platelet eicosanoids and the effect of captopril in blood pressure regulation. 1997 Eur. J. Pharmacol. pmid:9527508
Tornhamre S et al. Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products. 1989 Eur. J. Pharmacol. pmid:2572437
Fujimoto Y et al. Sphingomyelin inhibits platelet 12-lipoxygenase activity. 1999 Eur. J. Pharmacol. pmid:10478636