12-hydroxy-5,8,10-heptadecatrienoic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with 12-hydroxy-5,8,10-heptadecatrienoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Uremia | D014511 | 33 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ishii Y et al. | Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins. | 2016 | FASEB J. | pmid:26527063 |
| Liu M et al. | 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. | 2014 | J. Exp. Med. | pmid:24821912 |
| Gus-Brautbar Y and Panigrahy D | Time heals all wounds--but 12-HHT is faster. | 2014 | J. Exp. Med. | pmid:24890114 |
| Frömel T et al. | Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques. | 2013 | Basic Res. Cardiol. | pmid:23224081 |
| Matsunaga Y et al. | Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. | 2013 | FASEB J. | pmid:23603839 |
| Matsunobu T et al. | Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand. | 2013 | J. Lipid Res. | pmid:24009185 |
| Fan SY et al. | The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo. | 2012 | J Ethnopharmacol | pmid:21619922 |
| Lee JW et al. | 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. | 2012 | Exp. Mol. Med. | pmid:22391335 |
| Bauer J et al. | Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. | 2011 | Biochem. Pharmacol. | pmid:20933508 |
| Sakuma S et al. | Perfluorinated carboxylic acids inhibit cyclooxygenase pathway more potently than 12-lipoxygenase pathway in rat platelets. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20678909 |
| Koeberle A et al. | Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1. | 2009 | Br. J. Pharmacol. | pmid:19298395 |
| Yasuda D et al. | Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum. | 2009 | FASEB J. | pmid:19126593 |
| Csányi G et al. | Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis. | 2008 May-Jun | Pharmacol Rep | pmid:18622059 |
| Okuno T et al. | 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. | 2008 | J. Exp. Med. | pmid:18378794 |
| Csanyi G et al. | Lack of endothelium-derived hyperpolarizing factor (EDHF) up-regulation in endothelial dysfunction in aorta in diabetic rats. | 2007 Jul-Aug | Pharmacol Rep | pmid:17901574 |
| Espada CE et al. | Effect of Chia oil (Salvia Hispanica) rich in omega-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17618100 |
| Li X et al. | Activation of extracellular signal-regulated kinase by 12-hydroxyheptadecatrienoic acid in prostate cancer PC3 cells. | 2007 | Arch. Biochem. Biophys. | pmid:17880908 |
| Fujimoto Y et al. | Monochloramine potently inhibits arachidonic acid metabolism in rat platelets. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16615995 |
| Pataki I et al. | In vivo effects of isatin on rat platelet eicosanoids. | 2005 | Platelets | pmid:15763895 |
| Forsell PK et al. | Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A2-alpha. | 2005 | Biochem. Pharmacol. | pmid:16290172 |
| Trebino CE et al. | Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages. | 2005 | J. Biol. Chem. | pmid:15722356 |
| Fujimoto Y et al. | Effects of endocrine disruptors on arachidonic acid metabolism in rabbit platelets. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12781627 |
| Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
| Vecino AM et al. | Phospholipase A2 activity in platelets of patients with uremia. | 2002 | Platelets | pmid:12487789 |
| Fujimoto Y et al. | Tetrahydrobiopterin attenuates modulation of platelet 12-lipoxygenase and cyclooxygenase activities by nitric oxide. | 2001 | Nitric Oxide | pmid:11178940 |
| Beck-Speier I et al. | Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages. | 2001 | Environ. Health Perspect. | pmid:11544173 |
| Shyue SK et al. | Selective augmentation of prostacyclin production by combined prostacyclin synthase and cyclooxygenase-1 gene transfer. | 2001 | Circulation | pmid:11319200 |
| Plastaras JP et al. | Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. | 2000 | J. Biol. Chem. | pmid:10766802 |
| Camacho M and Vila L | Transcellular formation of thromboxane A(2) in mixed incubations of endothelial cells and aspirin-treated platelets strongly depends on the prostaglandin I-synthase activity. | 2000 | Thromb. Res. | pmid:10946089 |
| Mezei Z et al. | Platelet arachidonate cascade of migraineurs in the interictal phase. | 2000 | Platelets | pmid:10938901 |
| Fujimoto Y et al. | Sphingomyelin inhibits platelet 12-lipoxygenase activity. | 1999 | Eur. J. Pharmacol. | pmid:10478636 |
| John H and Schlegel W | Determination of the pK(a) of 12-S-hydroxyheptadecatrienoic acid by studies of its vial surface adsorption using high-performance liquid chromatography and liquid scintillation technique. | 1999 | Chem. Phys. Lipids | pmid:11458961 |
| Margalit A et al. | Regulation of in vivo prostaglandin biosynthesis by glutathione. | 1999 | Adv. Exp. Med. Biol. | pmid:10667326 |
| Ruf A et al. | Characterization of the thromboxane synthase pathway product 12-oxoheptadeca-5(Z)-8(E)-10(E)-trienoic acid as a thromboxane A2 receptor antagonist with minimal intrinsic activity. | 1998 | Br. J. Haematol. | pmid:9576182 |
| Sakuma S et al. | Effects of daphnodorin A, B and C, new flavans isolated from traditional Chinese medicine, on the 12-lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578153 |
| Fujimoto Y et al. | Comparison of the effects of nitric oxide and peroxynitrite on the 12-lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9774172 |
| John H et al. | Development and review of radioimmunoassay of 12-S-hydroxyheptadecatrienoic acid. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9785378 |
| John H and Schlegel W | Thermodynamic and structural characterization of cis-trans isomerization of 12-(S)-hydroxy-(5Z, 8E, 10E)-heptadecatrienoic acid by high-performance liquid chromatography and gaschromatography-mass spectrometry. | 1998 | Chem. Phys. Lipids | pmid:11458962 |
| Margalit A et al. | Regulation of prostaglandin biosynthesis in vivo by glutathione. | 1998 | Am. J. Physiol. | pmid:9486284 |
| Kis B et al. | The effect of substance P on the arachidonate cascade of rat platelets. | 1997-1998 | Acta Physiol Hung | pmid:9706302 |
| Calzada C et al. | Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. | 1997 | Biochem. J. | pmid:9230133 |
| Mezei Z et al. | Platelet eicosanoids and the effect of captopril in blood pressure regulation. | 1997 | Eur. J. Pharmacol. | pmid:9527508 |
| Berdeaux O et al. | Effects of a trans isomer of arachidonic acid on rat platelet aggregation and eicosanoid production. | 1996 | J. Lipid Res. | pmid:8906600 |
| Rosolowsky M et al. | Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites. | 1996 | Biochim. Biophys. Acta | pmid:8652640 |
| Köller M et al. | Effect of the PAF-receptor antagonist SM-12502 on human platelets. | 1996 | Inflammation | pmid:8926050 |
| Beving H et al. | Abnormally high platelet activity after discontinuation of acetylsalicylic acid treatment. | 1996 | Blood Coagul. Fibrinolysis | pmid:8845467 |
| Tsunomori M et al. | 15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. | 1996 | Biochim. Biophys. Acta | pmid:8679681 |
| Muller M and Sorrell TC | Inhibition of the human platelet cyclooxygenase response by the naturally occurring phenazine derivative, 1-hydroxyphenazine. | 1995 Nov-Dec | Prostaglandins | pmid:8838240 |
| Kimura Y et al. | Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. | 1995 | J Ethnopharmacol | pmid:7776662 |
| Teissier E et al. | Interactions of alpha Ni3S2 with guinea pig alveolar macrophages and liberation of inflammatory mediators. | 1994 May-Jun | J Appl Toxicol | pmid:8083477 |