12-hydroxy-5,8,10-heptadecatrienoic acid

12-hydroxy-5,8,10-heptadecatrienoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 466 references associated with 12-hydroxy-5,8,10-heptadecatrienoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for 12-hydroxy-5,8,10-heptadecatrienoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 12-hydroxy-5,8,10-heptadecatrienoic acid

MeSH term MeSH ID Detail
Uremia D014511 33 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Pleurisy D010998 20 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Seizures D012640 87 associated lipids
Weight Loss D015431 56 associated lipids
Total 6

NCBI Entrez Crosslinks

All references with 12-hydroxy-5,8,10-heptadecatrienoic acid

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Authors Title Published Journal PubMed Link
Fan SY et al. The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo. 2012 J Ethnopharmacol pmid:21619922
Lee JW et al. 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. 2012 Exp. Mol. Med. pmid:22391335
Hofmann U et al. Measurement of 12(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid and its metabolite 12-oxo-5Z,8E,10E-heptadecatrienoic acid in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. 1990 Anal. Biochem. pmid:2281869
Frömel T et al. Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques. 2013 Basic Res. Cardiol. pmid:23224081
Engels F et al. Modulation of the release of 9-hydroxy-octadecadienoic acid and other fatty acid derived mediators from guinea-pig pulmonary macrophages. 1990 Int. J. Immunopharmacol. pmid:2329013
Matsunaga Y et al. Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. 2013 FASEB J. pmid:23603839
Matsunobu T et al. Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand. 2013 J. Lipid Res. pmid:24009185
Liu M et al. 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. 2014 J. Exp. Med. pmid:24821912
Gus-Brautbar Y and Panigrahy D Time heals all wounds--but 12-HHT is faster. 2014 J. Exp. Med. pmid:24890114
Ozaki Y et al. Correlation of intracellular and extracellular calcium ion concentrations with synergy between 1,2-dioctanoyl-sn-glycerol and ionomycin in platelet arachidonic acid mobilization. 1989 Biochim. Biophys. Acta pmid:2499357
Guichardant M et al. Metabolism of endogenous arachidonic acid in weakly activated platelets. Absence of leukocyte cooperative products in whole blood. 1989 Eicosanoids pmid:2516743
Engels W et al. Influence of a cytomegalovirus infection on functions and arachidonic acid metabolism of rat peritoneal macrophages. 1989 J. Leukoc. Biol. pmid:2540258
Panosian AG et al. [Action of adaptogens: cucurbitacin R diglucoside as a stimulator of arachidonic acid metabolism in the rat adrenal gland]. 1989 Mar-Apr Probl Endokrinol (Mosk) pmid:2544873
Yue TL and Tong L [Effects of dauricine on the metabolism of arachidonic acid in rat pleural neutrophils]. 1989 Zhongguo Yao Li Xue Bao pmid:2558500
Li NY [Selective inhibitory effects of flufenamic acid on metabolic pathways of arachidonate 5-lipoxygenase and cyclooxygenase]. 1989 Sheng Li Ke Xue Jin Zhan pmid:2561227
Tornhamre S et al. Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products. 1989 Eur. J. Pharmacol. pmid:2572437
Hamasaki Y and Miyazaki S [Characterization of 12-L-hydroxy 5, 8, 10-heptadecatrienoic acid produced by rat basophilic leukemia-2H3 cells]. 1989 Nippon Ketsueki Gakkai Zasshi pmid:2618543
Yue TL et al. [Effects of anisodamine on the metabolism of arachidonic acid by washed rat platelets]. 1989 Yao Xue Xue Bao pmid:2618712
Ishii Y et al. Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins. 2016 FASEB J. pmid:26527063
pmid:26896822