ISOBUTYRIC ACID

ISOBUTYRIC ACID is a lipid of Fatty Acyls (FA) class. Isobutyric acid is associated with abnormalities such as Atrophy, Muscular, Spinobulbar. The involved functions are known as Signal Transduction, Oxidation, Vmax, Metabolic Inhibition and Regulation. Isobutyric acid often locates in Cytoplasm, Plasma membrane, peroxisome, Mouse Embryonic Fibroblast and Protoplasm. The associated genes with ISOBUTYRIC ACID are Candidate Disease Gene, CDKN1A gene, MYC gene, E2F1 gene and HBP1 gene. The related lipids are butyrate, Butyrates, lipid structure, Fatty Acids and Propionate. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of ISOBUTYRIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOBUTYRIC ACID?

ISOBUTYRIC ACID is suspected in Atrophy, Muscular, Spinobulbar and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOBUTYRIC ACID

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Stomach Ulcer D013276 75 associated lipids
Werner Syndrome D014898 4 associated lipids
Myoclonic Epilepsies, Progressive D020191 3 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with ISOBUTYRIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with ISOBUTYRIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOBUTYRIC ACID?

Knock-out

Knock-out are used in the study 'G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.' (Abramova MV et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with ISOBUTYRIC ACID

Download all related citations
Per page 10 20 50 100 | Total 515
Authors Title Published Journal PubMed Link
Kuroda J et al. Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells. 2005 Int. J. Oncol. pmid:15645120
Stokrová J et al. Response of HT115, a highly invasive human colorectal adenocarcinoma cell line, to sodium butyrate treatment and glucose deprivation. 2005 Int. J. Oncol. pmid:15703838
Izawa H et al. Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells. 2005 Int. J. Oncol. pmid:15942645
Looby E et al. Bile acid deoxycholate induces differential subcellular localisation of the PKC isoenzymes beta 1, epsilon and delta in colonic epithelial cells in a sodium butyrate insensitive manner. 2005 Int. J. Cancer pmid:15645414
Trotta M et al. Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique. 2005 Int J Pharm pmid:15620868
SestraÅŸ RE et al. Poisson parameters of antimicrobial activity: a quantitative structure-activity approach. 2012 Int J Mol Sci pmid:22606039
Kong XF et al. Fermentation characterization of chinese yam polysaccharide and its effects on the gut microbiota of rats. 2009 Int J Microbiol pmid:19936111
Houston MA et al. Stable differences in intrinsic mitochondrial membrane potential of tumor cell subpopulations reflect phenotypic heterogeneity. 2011 Int J Cell Biol pmid:21760799
Zea L et al. Chromatography-olfactometry study of the aroma of fino sherry wines. 2010 Int J Anal Chem pmid:20689702
Sankar R and Archunan G Gas chromatographic/mass spectrometric analysis of volatile metabolites in bovine vaginal fluid and assessment of their bioactivity. 2011 Int J Anal Chem pmid:22114602
Grenier D Nutritional interactions between two suspected periodontopathogens, Treponema denticola and Porphyromonas gingivalis. 1992 Infect. Immun. pmid:1333450
Madan M et al. In situ forming polymeric drug delivery systems. 2009 Indian J Pharm Sci pmid:20490289
Reddy MK et al. Induction of hamster hepatic peroxisomal beta-oxidation and peroxisome proliferation-associated 80000 mol. wt. polypeptide by hypolipidemic drugs. 1982 Hum Toxicol pmid:7173894
Qi S et al. Comparison of the metabolic profiling of hepatitis B virus-infected cirrhosis and alcoholic cirrhosis patients by using (1) H NMR-based metabonomics. 2012 Hepatol. Res. pmid:22404306
Schauber J et al. Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. 2003 Gut pmid:12692061
Wright KE et al. Inducing mineral precipitation in groundwater by addition of phosphate. 2011 Geochem. Trans. pmid:22029908
Bachetti T et al. An in vitro approach to test the possible role of candidate factors in the transcriptional regulation of the RET proto-oncogene. 2005 Gene Expr. pmid:16127999
Tsurute S et al. Tocofibrate (tocopheryl 2-(p-chlorophenoxy) isobutyrate); a new peroxisomotropic compound, and its hypocholesterolemic activity in cholesterol-fed rats. 1982 Gen. Pharmacol. pmid:7129071
HÃ¥kansson A et al. Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments. 2011 Gastroenterol Res Pract pmid:22007198
Corcuff R et al. Effect of water activity on the production of volatile organic compounds by Muscodor albus and their effect on three pathogens in stored potato. 2011 Fungal Biol pmid:21354528
Lever MA Acetogenesis in the energy-starved deep biosphere - a paradox? 2011 Front Microbiol pmid:22347874
Haaijer SC et al. Anoxic iron cycling bacteria from an iron sulfide- and nitrate-rich freshwater environment. 2012 Front Microbiol pmid:22347219
Picard A and Ferdelman TG Linking microbial heterotrophic activity and sediment lithology in oxic, oligotrophic sub-seafloor sediments of the north atlantic ocean. 2011 Front Microbiol pmid:22207869
Bhumbra GS et al. Co-Release of GABA Does Not Occur at Glycinergic Synapses onto Lumbar Motoneurons in Juvenile Mice. 2012 Front Cell Neurosci pmid:22461768
Boumba VA et al. Biochemical pathways generating post-mortem volatile compounds co-detected during forensic ethanol analyses. 2008 Forensic Sci. Int. pmid:17452087
Haskå L et al. A water-soluble fraction from a by-product of wheat increases the formation of propionic acid in rats compared with diets based on other by-product fractions and oligofructose. 2011 Food Nutr Res pmid:22022302
Gutsche KA et al. Production of volatile compounds by Lactobacillus sakei from branched chain α-keto acids. 2012 Food Microbiol. pmid:22202876
Panagou EZ and Tassou CC Changes in volatile compounds and related biochemical profile during controlled fermentation of cv. Conservolea green olives. 2006 Food Microbiol. pmid:16943076
McGinty D et al. Fragrance material review on 1,1-dimethyl-2-phenylethyl acetate. 2012 Food Chem. Toxicol. pmid:22445843
McGinty D et al. Fragrance material review on benzyl formate. 2012 Food Chem. Toxicol. pmid:22406578
McGinty D et al. Fragrance material review on piperonyl acetate. 2012 Food Chem. Toxicol. pmid:22445840
McGinty D et al. Fragrance material review on anisyl propionate. 2012 Food Chem. Toxicol. pmid:22406577
McGinty D et al. Fragrance material review on α-methylbenzyl acetate. 2012 Food Chem. Toxicol. pmid:22406576
McGinty D et al. Fragrance material review on 1,2-ethanediol, 1-phenyl-, 1,2-diacetate. 2012 Food Chem. Toxicol. pmid:22406575
McGinty D et al. Fragrance material review on 1-phenyl-3-methyl-3-pentyl acetate. 2012 Food Chem. Toxicol. pmid:22406574
McGinty D et al. Fragrance material review on 1,1-dimethyl-2-phenylethyl formate. 2012 Food Chem. Toxicol. pmid:22406573
McGinty D et al. Fragrance material review on α-methylbenzyl propionate. 2012 Food Chem. Toxicol. pmid:22406572
McGinty D et al. Fragrance material review on phenethyl butyrate. 2012 Food Chem. Toxicol. pmid:22406571
McGinty D et al. Fragrance material review on α-methylbenzyl isobutyrate. 2012 Food Chem. Toxicol. pmid:22406570
McGinty D et al. Fragrance material review on phenethyl formate. 2012 Food Chem. Toxicol. pmid:22406569
McGinty D et al. Fragrance material review on 1,3-benzodioxole-5-propanol, α-methyl-, 5-acetate. 2012 Food Chem. Toxicol. pmid:22406568
McGinty D et al. Fragrance material review on benzyl butyrate. 2012 Food Chem. Toxicol. pmid:22406567
McGinty D et al. Fragrance material review on 1,1-dimethyl-2-phenylethyl isobutyrate. 2012 Food Chem. Toxicol. pmid:22406566
McGinty D et al. Fragrance material review on phenethyl propionate. 2012 Food Chem. Toxicol. pmid:22406565
McGinty D et al. Fragrance material review on (4-methoxyphenyl)methyl isobutyrate. 2012 Food Chem. Toxicol. pmid:22406564
McGinty D et al. Fragrance material review on phenethyl isobutyrate. 2012 Food Chem. Toxicol. pmid:22406563
McGinty D et al. Fragrance material review on 1,3-dimethyl-3-phenylbutyl acetate. 2012 Food Chem. Toxicol. pmid:22406562
McGinty D et al. Fragrance material review on benzyl 2-hydroxypropionate. 2012 Food Chem. Toxicol. pmid:22406561
McGinty D et al. Fragrance material review on p-isopropylbenzyl acetate. 2012 Food Chem. Toxicol. pmid:22406560
McGinty D et al. Fragrance material review on 1,1-dimethyl-2-phenylethyl propionate. 2012 Food Chem. Toxicol. pmid:22406559
McGinty D et al. Fragrance material review on benzyl isobutyrate. 2012 Food Chem. Toxicol. pmid:22406205
McGinty D et al. Fragrance material review on 2-methyl-4-phenyl-2-butyl acetate. 2012 Food Chem. Toxicol. pmid:22402310
McGinty D et al. Fragrance material review on 3-phenyl-3-buten-1-yl acetate. 2012 Food Chem. Toxicol. pmid:22402309
Api AM Evaluation of the dermal subchronic toxicity of phenoxyethyl isobutyrate in the rat. 2004 Food Chem. Toxicol. pmid:14667475
David RM et al. Lack of sensitization for trimellitate, phthalate, terephthalate and isobutyrate plasticizers in a human repeated insult patch test. 2003 Food Chem. Toxicol. pmid:12615132
McGinty D et al. Fragrance material review on ethyl phenyl carbinyl acetate. 2012 Food Chem. Toxicol. pmid:22433983
McGinty D et al. Fragrance material review on benzyl acetate. 2012 Food Chem. Toxicol. pmid:22387848
McGinty D et al. Fragrance material review on 2-phenylpropyl acetate. 2012 Food Chem. Toxicol. pmid:22421639
McGinty D et al. Fragrance material review on p-anisyl acetate. 2012 Food Chem. Toxicol. pmid:22417777
McGinty D et al. Fragrance material review on 2-hydroxy-2-phenylethyl acetate. 2012 Food Chem. Toxicol. pmid:22414656
McGinty D et al. Fragrance material review on anisyl acetate. 2012 Food Chem. Toxicol. pmid:22414654
McGinty D et al. Fragrance material review on 2-phenoxyethyl propionate. 2012 Food Chem. Toxicol. pmid:22414653
McGinty D et al. Fragrance material review on 2-(p-tolyloxy)ethyl acetate. 2012 Food Chem. Toxicol. pmid:22414652
McGinty D et al. Fragrance material review on 3-phenylpropyl acetate. 2012 Food Chem. Toxicol. pmid:22414651
McGinty D et al. Fragrance material review on anisyl formate. 2012 Food Chem. Toxicol. pmid:22414650
McGinty D et al. Fragrance material review on 2-phenoxyethyl isobutyrate. 2012 Food Chem. Toxicol. pmid:22414648
McGinty D et al. Fragrance material review on carbonic acid, methyl phenylmethyl ester. 2012 Food Chem. Toxicol. pmid:22414647
McGinty D et al. Fragrance material review on 1,1-dimethyl-2-phenylethyl butyrate. 2012 Food Chem. Toxicol. pmid:22414645
McGinty D et al. Fragrance material review on phenethyl acetate. 2012 Food Chem. Toxicol. pmid:22414644
McGinty D et al. Fragrance material review on 4-methylbenzyl acetate. 2012 Food Chem. Toxicol. pmid:22414643
McGinty D et al. Fragrance material review on benzyl propionate. 2012 Food Chem. Toxicol. pmid:22414642
McGinty D et al. Fragrance material review on 2,4-dimethylbenzyl acetate. 2012 Food Chem. Toxicol. pmid:22414641
Stojakowska A et al. Antimicrobial activity of 10-isobutyryloxy-8,9-epoxythymol isobutyrate. 2005 Fitoterapia pmid:16242268
Wu X et al. Comparative genomics and functional analysis of niche-specific adaptation in Pseudomonas putida. 2011 FEMS Microbiol. Rev. pmid:20796030
Rezanka T et al. Isobutyrate as a precursor of n-butyrate in the biosynthesis of tylosine and fatty acids. 1991 FEMS Microbiol. Lett. pmid:1769552
Wyss C Fatty acids synthesized by oral treponemes in chemically defined media. 2007 FEMS Microbiol. Lett. pmid:17229060
Kendall MM et al. Butyrate- and propionate-degrading syntrophs from permanently cold marine sediments in Skan Bay, Alaska, and description of Algorimarina butyrica gen. nov., sp. nov. 2006 FEMS Microbiol. Lett. pmid:16907746
Sorokin DY et al. Utilization of aliphatic nitriles under haloalkaline conditions by Bacillus alkalinitrilicus sp. nov. isolated from soda solonchak soil. 2008 FEMS Microbiol. Lett. pmid:18801047
Strobel GA et al. Synergism among volatile organic compounds resulting in increased antibiosis in Oidium sp. 2008 FEMS Microbiol. Lett. pmid:18422630
Beck HC Branched-chain fatty acid biosynthesis in a branched-chain amino acid aminotransferase mutant of Staphylococcus carnosus. 2005 FEMS Microbiol. Lett. pmid:15667998
Finke N et al. Acetate, lactate, propionate, and isobutyrate as electron donors for iron and sulfate reduction in Arctic marine sediments, Svalbard. 2007 FEMS Microbiol. Ecol. pmid:17069623
Koizumi Y et al. Potential sulfur metabolisms and associated bacteria within anoxic surface sediment from saline meromictic Lake Kaiike (Japan). 2005 FEMS Microbiol. Ecol. pmid:16329915
Kikugawa M et al. Bisfunction of propionic acid on purified rat liver beta-ureidopropionase. 1988 FEBS Lett. pmid:3345846
Plaga W et al. Modification of Cys-418 of pyruvate formate-lyase by methacrylic acid, based on its radical mechanism. 2000 FEBS Lett. pmid:10648809
Andreani F et al. New alpha-substituted arylthioacetic derivatives forming analogues of clofibrate. 1975 Farmaco Sci pmid:1236653
Sorokin DY et al. Propionate and butyrate dependent bacterial sulfate reduction at extremely haloalkaline conditions and description of Desulfobotulus alkaliphilus sp. nov. 2010 Extremophiles pmid:19888546
Reyes-Moreno M et al. Synthesis and anabolic/androgenic evaluation of novel 9alpha-fluorosteroids. 2009 Eur J Med Chem pmid:19615789
Nilsson U et al. Dietary supplementation with beta-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects. 2008 Eur J Clin Nutr pmid:17522598
Kokushi E et al. ¹H NMR-based metabolomics approach to assess toxicity of bunker a heavy oil to freshwater carp, Cyprinus carpio. 2012 Environ. Toxicol. pmid:20882592
Schellenberger S et al. Metabolic responses of novel cellulolytic and saccharolytic agricultural soil Bacteria to oxygen. 2010 Environ. Microbiol. pmid:20050868
Huang W and Kim Y Electrochemical techniques for evaluating short-chain fatty acid utilization by bioanodes. 2017 Environ Sci Pollut Res Int pmid:27826830
Cao X et al. Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line. 2003 Endocrinology pmid:12697711
Ortiz-Caro J et al. Short chain fatty acids modulate nuclear receptor and extranuclear L-triiodothyronine levels in glial C6 cells by different mechanisms. 1988 Endocrinology pmid:2836168
Kanazu T and Yamaguchi T Comparison of in vitro carnitine and glycine conjugation with branched-side chain and cyclic side chain carboxylic acids in rats. 1997 Drug Metab. Dispos. pmid:9029044
Edwards A et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. 2011 Dis Model Mech pmid:21504911
Morris GP et al. Correlations between changes in indicators of gastric mucosal barrier integrity at time of exposure to "barrier breakers" and extent of hemorrhagic erosions one hour later. 1984 Dig. Dis. Sci. pmid:6420129
Kurata S et al. Cytotoxic effects of acrylic acid, methacrylic acid, their corresponding saturated carboxylic acids, HEMA, and hydroquinone on fibroblasts derived from human pulp. 2012 Dent Mater J pmid:22447055
Duray SJ et al. Comparison of chemical analysis of residual monomer in a chemical-cured dental acrylic material to an FTIR method. 1997 Dent Mater pmid:11696903
Ballivet-Tkatchenko D et al. Insertion reaction of carbon dioxide into Sn-OR bond. Synthesis, structure and DFT calculations of di- and tetranuclear isopropylcarbonato tin(IV) complexes. 2006 Dalton Trans pmid:17077890
Durand T et al. Role of intracellular buffering power on the mitochondria-cytosol pH gradient in the rat liver perfused at 4 degrees C. 1999 Cryobiology pmid:10079131