ISOBUTYRIC ACID

ISOBUTYRIC ACID is a lipid of Fatty Acyls (FA) class. Isobutyric acid is associated with abnormalities such as Atrophy, Muscular, Spinobulbar. The involved functions are known as Signal Transduction, Oxidation, Vmax, Metabolic Inhibition and Regulation. Isobutyric acid often locates in Cytoplasm, Plasma membrane, peroxisome, Mouse Embryonic Fibroblast and Protoplasm. The associated genes with ISOBUTYRIC ACID are Candidate Disease Gene, CDKN1A gene, MYC gene, E2F1 gene and HBP1 gene. The related lipids are butyrate, Butyrates, lipid structure, Fatty Acids and Propionate. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of ISOBUTYRIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOBUTYRIC ACID?

ISOBUTYRIC ACID is suspected in Atrophy, Muscular, Spinobulbar and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOBUTYRIC ACID

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Werner Syndrome D014898 4 associated lipids
Myoclonic Epilepsies, Progressive D020191 3 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with ISOBUTYRIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with ISOBUTYRIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOBUTYRIC ACID?

Knock-out

Knock-out are used in the study 'G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.' (Abramova MV et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with ISOBUTYRIC ACID

Download all related citations
Per page 10 20 50 100 | Total 515
Authors Title Published Journal PubMed Link
pmid:
Durand T et al. Role of intracellular buffering power on the mitochondria-cytosol pH gradient in the rat liver perfused at 4 degrees C. 1999 Cryobiology pmid:10079131
Huang H et al. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. 1999 Cancer Res. pmid:10383164
Sullivan HM and Martin SA Effects of a Saccharomyces cerevisiae culture on in vitro mixed ruminal microorganism fermentation. 1999 J. Dairy Sci. pmid:10509261
Plaga W et al. Modification of Cys-418 of pyruvate formate-lyase by methacrylic acid, based on its radical mechanism. 2000 FEBS Lett. pmid:10648809
Le Maire V et al. System A neutral amino acid transporter regulation by interleukin-1beta in human osteoarthritic synovial cells: evidence for involvement of prostaglandin E(2) as a second messenger. 2000 J. Cell. Physiol. pmid:10699967
Seigler DS and Lampman RL Isobutyric acid from the Brindley's glands of Triatoma lecticularia. 2000 J. Am. Mosq. Control Assoc. pmid:10757489
Sekiguchi Y et al. Syntrophothermus lipocalidus gen. nov., sp. nov., a novel thermophilic, syntrophic, fatty-acid-oxidizing anaerobe which utilizes isobutyrate. 2000 Int. J. Syst. Evol. Microbiol. pmid:10758888
Kristensen NB et al. Net portal appearance of volatile fatty acids in sheep intraruminally infused with mixtures of acetate, propionate, isobutyrate, butyrate, and valerate. 2000 J. Anim. Sci. pmid:10834594
Kambara T and Tomioka K Controlling factors in chiral bisoxazoline-catalyzed asymmetric lithium ester enolate-imine condensation producing a beta-lactam. 2000 Chem. Pharm. Bull. pmid:11045472
Takahashi N and Yamada T Pathways for amino acid metabolism by Prevotella intermedia and Prevotella nigrescens. 2000 Oral Microbiol. Immunol. pmid:11155172
Guerenstein PG and Guerin PM Olfactory and behavioural responses of the blood-sucking bug Triatoma infestans to odours of vertebrate hosts. 2001 J. Exp. Biol. pmid:11171309
Bandyk CA et al. Effect of ruminal vs postruminal administration of degradable protein on utilization of low-quality forage by beef steers. 2001 J. Anim. Sci. pmid:11204704
Zaharia V et al. Effects of short chain fatty acids on colonic Na+ absorption and enzyme activity. 2001 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:11223395
Itoh N et al. Cloning and biochemical characterization of Co(2+)-activated bromoperoxidase-esterase (perhydrolase) from Pseudomonas putida IF-3 strain. 2001 Biochim. Biophys. Acta pmid:11342031
Hung MW et al. Differential regulation of placental and germ cell alkaline phosphatases by glucocorticoid and sodium butyrate in human gastric carcinoma cell line TMK-1. 2001 Arch. Biochem. Biophys. pmid:11361139
Etchebehere C et al. Comamonas nitrativorans sp. nov., a novel denitrifier isolated from a denitrifying reactor treating landfill leachate. 2001 Int. J. Syst. Evol. Microbiol. pmid:11411724
Takahashi N and Sato T Preferential utilization of dipeptides by Porphyromonas gingivalis. 2001 J. Dent. Res. pmid:11437213
Besong S et al. Influence of supplemental chromium on concentrations of liver triglyceride, blood metabolites and rumen VFA profile in steers fed a moderately high fat diet. 2001 J. Dairy Sci. pmid:11467818
Fujino T et al. Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. 2001 J. Biol. Chem. pmid:11470804
Osborne A et al. Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. 2001 Mol. Cell. Biol. pmid:11533238
Yu HQ and Fang HH Acidification of mid- and high-strength dairy wastewaters. 2001 Water Res. pmid:11561632
McGuinness MC et al. Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy. 2001 Sep-Oct Mol. Genet. Metab. pmid:11592822
Suresh CH et al. Revisiting Markovnikov addition to alkenes via molecular electrostatic potential. 2001 J. Org. Chem. pmid:11597205
Walczak RJ et al. Nonactin biosynthesis: disruption of the polyketide synthase genes, nonKJ, in Streptomyces griseus leads to an overall 96 decrease in macrotetrolide production, yet a net increase in nonactin analogues which incorporate isobutyrate. 2001 J. Am. Chem. Soc. pmid:11604004
Yamada M et al. New thiocholine ester substrates for the assay of human serum cholinesterase. 2001 Clin. Chem. pmid:11673363
Smirnova N and Reynolds KA Branched-chain fatty acid biosynthesis in Escherichia coli. 2001 J. Ind. Microbiol. Biotechnol. pmid:11687938
Duray SJ et al. Comparison of chemical analysis of residual monomer in a chemical-cured dental acrylic material to an FTIR method. 1997 Dent Mater pmid:11696903
Fang HH and Yu H Mesophilic acidification of gelatinaceous wastewater. 2002 J. Biotechnol. pmid:11738717
Paulukat J et al. Expression and release of IL-18 binding protein in response to IFN-gamma. 2001 J. Immunol. pmid:11739524
Kukushkin AN et al. Downregulation of c-fos gene transcription in cells transformed by E1A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-fos promoter. 2002 Oncogene pmid:11850800
Kim NS and Lee GM Inhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3. 2002 Biotechnol. Bioeng. pmid:11870612
Rojas JC et al. A reinvestigation of brindley's gland exocrine compounds of Rhodnius prolixus (Hemiptera: Reduviidae). 2002 J. Med. Entomol. pmid:11931024
Forsee WT and Elbein AD Glycoprotein biosynthesis in plants. Demonstration of lipid-linked oligosaccharides of mannose and N-acetylglucosamine. 1975 J. Biol. Chem. pmid:1194283
Hernández-Orte P et al. Relationship between varietal amino acid profile of grapes and wine aromatic composition. Experiments with model solutions and chemometric study. 2002 J. Agric. Food Chem. pmid:11982416
Akay V et al. NutriDense and waxy corn hybrids: effects on site and extent of disappearance of nutrients in sheep. 2002 J. Anim. Sci. pmid:12019623
Yang CM Response of forage fiber degradation by ruminal microorganisms to branched-chain volatile fatty acids, amino acids, and dipeptides. 2002 J. Dairy Sci. pmid:12086054
Mata R et al. Sesquiterpene lactones and phenylpropanoids from Cosmos pringlei. 2002 J. Nat. Prod. pmid:12141867
Cibis E et al. Biodegradation of potato slops from a rural distillery by thermophilic aerobic bacteria. 2002 Bioresour. Technol. pmid:12146644
Hernandez-Eugenio G et al. Sporanaerobacter acetigenes gen. nov., sp. nov., a novel acetogenic, facultatively sulfur-reducing bacterium. 2002 Int. J. Syst. Evol. Microbiol. pmid:12148631
Hansen JL et al. The structures of four macrolide antibiotics bound to the large ribosomal subunit. 2002 Mol. Cell pmid:12150912
Kumazawa S et al. Studies of the constituents of Uruguayan propolis. 2002 J. Agric. Food Chem. pmid:12166959
Fushinobu S et al. Crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with cleavage products. 2002 Protein Sci. pmid:12192074
Suzuki-Mizushima Y et al. Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells. 2002 Brain Res. pmid:12270499
Hernández-Eugenio G et al. Clostridium thiosulfatireducens sp. nov., a proteolytic, thiosulfate- and sulfur-reducing bacterium isolated from an upflow anaerobic sludge blanket (UASB) reactor. 2002 Int. J. Syst. Evol. Microbiol. pmid:12361247
Andreani F et al. New alpha-substituted arylthioacetic derivatives forming analogues of clofibrate. 1975 Farmaco Sci pmid:1236653
Ith M et al. Observation and identification of metabolites emerging during postmortem decomposition of brain tissue by means of in situ 1H-magnetic resonance spectroscopy. 2002 Magn Reson Med pmid:12418008
Yu HQ and Fang HH Acidogenesis of gelatin-rich wastewater in an upflow anaerobic reactor: influence of pH and temperature. 2003 Water Res. pmid:12465788
Brown AJ et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. 2003 J. Biol. Chem. pmid:12496283
Gallert C et al. Scale-up of anaerobic digestion of the biowaste fraction from domestic wastes. 2003 Water Res. pmid:12598207
David RM et al. Lack of sensitization for trimellitate, phthalate, terephthalate and isobutyrate plasticizers in a human repeated insult patch test. 2003 Food Chem. Toxicol. pmid:12615132
Sanceda NG et al. Branched chain amino acids as source of specific branched chain volatile fatty acids during the fermentation process of fish sauce. 2003 Amino Acids pmid:12624738
Schauber J et al. Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. 2003 Gut pmid:12692061
Cao X et al. Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line. 2003 Endocrinology pmid:12697711
Pind PF et al. Dynamics of the anaerobic process: effects of volatile fatty acids. 2003 Biotechnol. Bioeng. pmid:12701145
Zhang WF et al. Effects of isomalto-oligosaccharides on broiler performance and intestinal microflora. 2003 Poult. Sci. pmid:12710488
Le Poul E et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. 2003 J. Biol. Chem. pmid:12711604
Wang YH et al. Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305. 2003 J. Biol. Chem. pmid:12724314
Matich AJ et al. Actinidia arguta: volatile compounds in fruit and flowers. 2003 Phytochemistry pmid:12737978
Diao J et al. Crystallization of butyrate kinase 2 from Thermotoga maritima mediated by vapor diffusion of acetic acid. 2003 Acta Crystallogr. D Biol. Crystallogr. pmid:12777787
Huys G et al. Aeromonas hydrophila subsp. ranae subsp. nov., isolated from septicaemic farmed frogs in Thailand. 2003 Int. J. Syst. Evol. Microbiol. pmid:12807217
Gabler MT and Heinrichs AJ Altering soluble and potentially rumen degradable protein for prepubertal Holstein heifers. 2003 J. Dairy Sci. pmid:12836949
Noftsger SM et al. Effects of 2-hydroxy-4-(methylthio) butanoic acid (HMB) on microbial growth in continuous culture. 2003 J. Dairy Sci. pmid:12939087
Batstone DJ et al. Kinetics of thermophilic, anaerobic oxidation of straight and branched chain butyrate and valerate. 2003 Biotechnol. Bioeng. pmid:12966576
Shigematsu T et al. Delftia tsuruhatensis sp. nov., a terephthalate-assimilating bacterium isolated from activated sludge. 2003 Int. J. Syst. Evol. Microbiol. pmid:13130036
Grenier D Nutritional interactions between two suspected periodontopathogens, Treponema denticola and Porphyromonas gingivalis. 1992 Infect. Immun. pmid:1333450
Wang SS et al. Cleavage and deprotection of peptides on MBHA-resin with hydrogen bromide. 1992 Sep-Oct Int. J. Pept. Protein Res. pmid:1335998
WEGNER GH and FOSTER EM Incorporation of isobutyrate and valerate into cellular plasmalogen by Bacteroides succinogenes. 1963 J. Bacteriol. pmid:13999496
SOCRANSKY SS et al. DEPENDENCY OF TREPONEMA MICRODENTIUM ON OTHER ORAL ORGANISMS FOR ISOBUTYRATE, POLYAMINES, AND A CONTROLLED OXIDATION-REDUCTION POTENTIAL. 1964 J. Bacteriol. pmid:14197888
Lemoff AS et al. Binding energies of water to sodiated valine and structural isomers in the gas phase: the effect of proton affinity on zwitterion stability. 2003 J. Am. Chem. Soc. pmid:14583055
Api AM Evaluation of the dermal subchronic toxicity of phenoxyethyl isobutyrate in the rat. 2004 Food Chem. Toxicol. pmid:14667475
Bernard JK et al. Ruminal fermentation and bacterial protein synthesis of whole cottonseed coated with combinations of gelatinized corn starch and urea. 2003 J. Dairy Sci. pmid:14672196
Stoeck M et al. In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide. 2004 J. Pharmacol. Exp. Ther. pmid:14718604
Xiong Y et al. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:14722361
Mix KS et al. Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling. 2004 Mol. Pharmacol. pmid:14742672
Tang Y et al. Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. 2004 PLoS Biol. pmid:14966533
Posner GH et al. Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents. 2004 J. Med. Chem. pmid:14971910
Bordonaro M et al. Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells. 2004 Nucleic Acids Res. pmid:15141037
Abreu A et al. Effects of Sapindus saponaria fruits on ruminal fermentation and duodenal nitrogen flow of sheep fed a tropical grass diet with and without legume. 2004 J. Anim. Sci. pmid:15144079
Vidyasagar S et al. Three distinct mechanisms of HCO3- secretion in rat distal colon. 2004 Am. J. Physiol., Cell Physiol. pmid:15308466
Kristensen NB and Harmon DL Splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers. 2004 J. Anim. Sci. pmid:15309950
Yu HQ et al. Thermodynamic analysis of product formation in mesophilic acidogenesis of lactose. 2004 Biotechnol. Bioeng. pmid:15334408
Bräsen C and Schönheit P Unusual ADP-forming acetyl-coenzyme A synthetases from the mesophilic halophilic euryarchaeon Haloarcula marismortui and from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum. 2004 Arch. Microbiol. pmid:15340786
Qiu X et al. Effects of substrate, passage rate, and pH in continuous culture on flows of conjugated linoleic acid and trans C18:1. 2004 J. Dairy Sci. pmid:15377625
Bourne PC et al. Ecdysteroid 7,9(11)-dien-6-ones as potential photoaffinity labels for ecdysteroid binding proteins. 2002 J. Insect Sci. pmid:15455045
Haba Y et al. Rendering poly(amidoamine) or poly(propylenimine) dendrimers temperature sensitive. 2004 J. Am. Chem. Soc. pmid:15469255
Raut NM et al. Separation and determination of lanthanides, thorium and uranium using a dual gradient in reversed-phase liquid chromatography. 2004 J Chromatogr A pmid:15527129
Kristensen NB and Harmon DL Effect of increasing ruminal butyrate absorption on splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers. 2004 J. Anim. Sci. pmid:15537776
Wakabayashi K et al. Gene expression associated with the decrease in malignant phenotype of human liver cancer cells following stimulation with a histone deacetylase inhibitor. 2005 Int. J. Oncol. pmid:15586245
Zduńczyk Z et al. Performance and caecal adaptation of turkeys to diets without or with antibiotic and with different levels of mannan-oligosaccharide. 2004 Arch Anim Nutr pmid:15595620
Kim JD and Kang KH Isolation of Lactobacillus sakei strain KJ-2008 and its removal of characteristic malodorous gases under anaerobic culture conditions. 2004 Biosci. Biotechnol. Biochem. pmid:15618611
Trotta M et al. Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique. 2005 Int J Pharm pmid:15620868
Hirano J et al. Novel stable fluorophore, 6-methoxy-4-quinolone, with strong fluorescence in wide pH range of aqueous media, and its application as a fluorescent labeling reagent. 2004 J Chromatogr A pmid:15628146
Bordin M et al. Histone deacetylase inhibitors up-regulate the expression of tight junction proteins. 2004 Mol. Cancer Res. pmid:15634758
Hristov AN et al. Effect of carbohydrate source on ammonia utilization in lactating dairy cows. 2005 J. Anim. Sci. pmid:15644514
Kuroda J et al. Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells. 2005 Int. J. Oncol. pmid:15645120
Looby E et al. Bile acid deoxycholate induces differential subcellular localisation of the PKC isoenzymes beta 1, epsilon and delta in colonic epithelial cells in a sodium butyrate insensitive manner. 2005 Int. J. Cancer pmid:15645414
Hiesberger T et al. Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis. 2005 J. Biol. Chem. pmid:15647252
Sullivan HM et al. Ruminal fermentation and amino acid flow in Holstein steers fed whole cottonseed with elevated concentrations of free fatty acids in the oil. 2005 J. Dairy Sci. pmid:15653536
Lung FD et al. Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface plasmon resonance technology. 2005 Biopolymers pmid:15660381