ISOBUTYRIC ACID

ISOBUTYRIC ACID is a lipid of Fatty Acyls (FA) class. Isobutyric acid is associated with abnormalities such as Atrophy, Muscular, Spinobulbar. The involved functions are known as Signal Transduction, Oxidation, Vmax, Metabolic Inhibition and Regulation. Isobutyric acid often locates in Cytoplasm, Plasma membrane, peroxisome, Mouse Embryonic Fibroblast and Protoplasm. The associated genes with ISOBUTYRIC ACID are Candidate Disease Gene, CDKN1A gene, MYC gene, E2F1 gene and HBP1 gene. The related lipids are butyrate, Butyrates, lipid structure, Fatty Acids and Propionate. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of ISOBUTYRIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOBUTYRIC ACID?

ISOBUTYRIC ACID is suspected in Atrophy, Muscular, Spinobulbar and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOBUTYRIC ACID

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Werner Syndrome D014898 4 associated lipids
Myoclonic Epilepsies, Progressive D020191 3 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with ISOBUTYRIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with ISOBUTYRIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOBUTYRIC ACID?

Knock-out

Knock-out are used in the study 'G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.' (Abramova MV et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with ISOBUTYRIC ACID

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Authors Title Published Journal PubMed Link
Himanen M et al. A method for measuring low-weight carboxylic acids from biosolid compost. J. Environ. Qual. pmid:16455852
pmid:
WEGNER GH and FOSTER EM Incorporation of isobutyrate and valerate into cellular plasmalogen by Bacteroides succinogenes. 1963 J. Bacteriol. pmid:13999496
SOCRANSKY SS et al. DEPENDENCY OF TREPONEMA MICRODENTIUM ON OTHER ORAL ORGANISMS FOR ISOBUTYRATE, POLYAMINES, AND A CONTROLLED OXIDATION-REDUCTION POTENTIAL. 1964 J. Bacteriol. pmid:14197888
Allison MJ and Peel JL The biosynthesis of valine from isobutyrate by peptostreptococcus elsdenii and Bacteroides ruminicola. 1971 Biochem. J. pmid:5119780
Goodhue CT and Schaeffer JR Preparation of L (+) beta-hydroxyisobutyric acid by bacterial oxidation of isobutyric acid. 1971 Biotechnol. Bioeng. pmid:5580680
Frenkel C and Haard NF Initiation of Ripening in Bartlett Pear with an Antiauxin alpha(p-Chlorophenoxy)isobutyric Acid. 1973 Plant Physiol. pmid:16658566
Cittadini E and Catalano G [Use of a new combination: dihydroxyprogesterone acetophenide and estradiol-3-benzoate-17 isobutyrate in gynecology]. 1973-1974 Riv Ostet Ginecol Prat Med Perinat pmid:4620236
Herbeck JL and Bryant MP Nutritional features of the intestinal anaerobe Ruminococcus bromii. 1974 Appl Microbiol pmid:4451362
Chawla RK and Rudman D Utilization of alpha-keto and alpha-hydroxy analogues of valine by the growing rat. 1974 J. Clin. Invest. pmid:4367888
Forsee WT and Elbein AD Glycoprotein biosynthesis in plants. Demonstration of lipid-linked oligosaccharides of mannose and N-acetylglucosamine. 1975 J. Biol. Chem. pmid:1194283
Andreani F et al. New alpha-substituted arylthioacetic derivatives forming analogues of clofibrate. 1975 Farmaco Sci pmid:1236653
Drezner MK et al. Stimulation of cartilage amino acid uptake by growth hormone-dependent factors in serum. Mediation by adenosine 3':5'-monophosphate. 1975 Biochim. Biophys. Acta pmid:163105
Lyons AJ et al. Actinomycetales from corn. 1975 Appl Microbiol pmid:803819
Otterby DE et al. Corn grain preserved with ammonium isobutyrate for lactating dairy cattle. 1976 J. Dairy Sci. pmid:956485
Bohmer K and Raper C Studies using KWD 2058, a derivative of terbutaline in isolated atrial and tracheal preparations from the guinea-pig. 1976 Arch Int Pharmacodyn Ther pmid:962428
Goldstein S et al. Decreased proteolysis and increased amino acid efflux in aging human fibroblasts. 1976 May-Jun Mech. Ageing Dev. pmid:940362
Baumwart AL et al. Effect of potassium isobutyrate on absorption of immunoglobulins from colostrum by calves. 1977 J. Dairy Sci. pmid:68043
Freychet P and Le Cam A Amino acid transport in isolated hepatocytes: effect of glucagon. 1977 Ciba Found. Symp. pmid:207495
Keith CL et al. The anaerobic decomposition of benzoic acid during methane fermentation. IV. Dearomatization of the ring and volatile fatty acids formed on ring rupture. 1978 Arch. Microbiol. pmid:697507