ISOBUTYRIC ACID

ISOBUTYRIC ACID is a lipid of Fatty Acyls (FA) class. Isobutyric acid is associated with abnormalities such as Atrophy, Muscular, Spinobulbar. The involved functions are known as Signal Transduction, Oxidation, Vmax, Metabolic Inhibition and Regulation. Isobutyric acid often locates in Cytoplasm, Plasma membrane, peroxisome, Mouse Embryonic Fibroblast and Protoplasm. The associated genes with ISOBUTYRIC ACID are Candidate Disease Gene, CDKN1A gene, MYC gene, E2F1 gene and HBP1 gene. The related lipids are butyrate, Butyrates, lipid structure, Fatty Acids and Propionate. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of ISOBUTYRIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOBUTYRIC ACID?

ISOBUTYRIC ACID is suspected in Atrophy, Muscular, Spinobulbar and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOBUTYRIC ACID

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Werner Syndrome D014898 4 associated lipids
Myoclonic Epilepsies, Progressive D020191 3 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with ISOBUTYRIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with ISOBUTYRIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOBUTYRIC ACID?

Knock-out

Knock-out are used in the study 'G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.' (Abramova MV et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with ISOBUTYRIC ACID

Download all related citations
Per page 10 20 50 100 | Total 515
Authors Title Published Journal PubMed Link
Himanen M et al. A method for measuring low-weight carboxylic acids from biosolid compost. J. Environ. Qual. pmid:16455852
pmid:
WEGNER GH and FOSTER EM Incorporation of isobutyrate and valerate into cellular plasmalogen by Bacteroides succinogenes. 1963 J. Bacteriol. pmid:13999496
SOCRANSKY SS et al. DEPENDENCY OF TREPONEMA MICRODENTIUM ON OTHER ORAL ORGANISMS FOR ISOBUTYRATE, POLYAMINES, AND A CONTROLLED OXIDATION-REDUCTION POTENTIAL. 1964 J. Bacteriol. pmid:14197888
Allison MJ and Peel JL The biosynthesis of valine from isobutyrate by peptostreptococcus elsdenii and Bacteroides ruminicola. 1971 Biochem. J. pmid:5119780
Goodhue CT and Schaeffer JR Preparation of L (+) beta-hydroxyisobutyric acid by bacterial oxidation of isobutyric acid. 1971 Biotechnol. Bioeng. pmid:5580680
Frenkel C and Haard NF Initiation of Ripening in Bartlett Pear with an Antiauxin alpha(p-Chlorophenoxy)isobutyric Acid. 1973 Plant Physiol. pmid:16658566
Cittadini E and Catalano G [Use of a new combination: dihydroxyprogesterone acetophenide and estradiol-3-benzoate-17 isobutyrate in gynecology]. 1973-1974 Riv Ostet Ginecol Prat Med Perinat pmid:4620236
Herbeck JL and Bryant MP Nutritional features of the intestinal anaerobe Ruminococcus bromii. 1974 Appl Microbiol pmid:4451362
Chawla RK and Rudman D Utilization of alpha-keto and alpha-hydroxy analogues of valine by the growing rat. 1974 J. Clin. Invest. pmid:4367888
Forsee WT and Elbein AD Glycoprotein biosynthesis in plants. Demonstration of lipid-linked oligosaccharides of mannose and N-acetylglucosamine. 1975 J. Biol. Chem. pmid:1194283
Andreani F et al. New alpha-substituted arylthioacetic derivatives forming analogues of clofibrate. 1975 Farmaco Sci pmid:1236653
Drezner MK et al. Stimulation of cartilage amino acid uptake by growth hormone-dependent factors in serum. Mediation by adenosine 3':5'-monophosphate. 1975 Biochim. Biophys. Acta pmid:163105
Lyons AJ et al. Actinomycetales from corn. 1975 Appl Microbiol pmid:803819
Otterby DE et al. Corn grain preserved with ammonium isobutyrate for lactating dairy cattle. 1976 J. Dairy Sci. pmid:956485
Bohmer K and Raper C Studies using KWD 2058, a derivative of terbutaline in isolated atrial and tracheal preparations from the guinea-pig. 1976 Arch Int Pharmacodyn Ther pmid:962428
Goldstein S et al. Decreased proteolysis and increased amino acid efflux in aging human fibroblasts. 1976 May-Jun Mech. Ageing Dev. pmid:940362
Baumwart AL et al. Effect of potassium isobutyrate on absorption of immunoglobulins from colostrum by calves. 1977 J. Dairy Sci. pmid:68043
Freychet P and Le Cam A Amino acid transport in isolated hepatocytes: effect of glucagon. 1977 Ciba Found. Symp. pmid:207495
Keith CL et al. The anaerobic decomposition of benzoic acid during methane fermentation. IV. Dearomatization of the ring and volatile fatty acids formed on ring rupture. 1978 Arch. Microbiol. pmid:697507
Cain WS and Johnson F Lability of odor pleasantness: influence of mere exposure. 1978 Perception pmid:704276
Faed EM and McQueen EG Separation of two conjugates of clofibric acid (CPIB) found in the urine of subjects taking clofibrate. 1978 Mar-Apr Clin. Exp. Pharmacol. Physiol. pmid:648038
Kølvraa S Inhibition of the glycine cleavage system by branched-chain amino acid metabolites. 1979 Pediatr. Res. pmid:481963
Amster J and Tanaka K Isolation and identification of S(+)-3-hydroxyisobutyric acid in the urine of rats loaded with isobutyric acid. 1979 Biochim. Biophys. Acta pmid:465545
Sato M and Takano T Fatty acid composition of cholesteryl esters in cholesterol-fed rabbits treated with lipid-lowering agent (ethyl 2-(p-chlorophenoxy) isobutyrate). 1979 Jpn. J. Pharmacol. pmid:537249
Schofield CJ Demonstration of isobutyric acid in some triatomine bugs. 1979 Acta Trop. pmid:35929
Trube G Anion dependence of the contractions of skinned cardiac cells. 1979 Pflugers Arch. pmid:219417
Papilian-Stoichiţă M et al. Comparative clinical study of the effects of Na isobutyrate and clofibrate on the clotting factors in patients with atherosclerosis. 1979 Apr-Jun Med Interne pmid:472639
Larski Z and Sphohr de Faúndez I [Inhibitory effect of ethyl ester of 2-(4-(chlorophenoxy) isobutyric acid "clofibrate" on Aujeszky's disease virus synthesis in cell cultures]. 1980 Med Dosw Mikrobiol pmid:6273669
Hubert HB et al. Olfactory sensitivity in humans: genetic versus environmental control. 1980 Science pmid:7189296
Tanaka K et al. Metabolism of valine chirally labeled with carbon 13 and deuterium in vitamin B12-folate-deficient rats in vivo. Studies on the physiological role of keto-enol tautomerization. 1980 J. Biol. Chem. pmid:7400144
Amster J and Tanaka K Metabolism in rats in vivo of (2S)[3,3,3-2H3]isobutyrate. Identification of (2-pro-S)methyl group as the source of a proton in dehydrogenation. 1980 J. Biol. Chem. pmid:7350143
Curriden S and Englesberg E Inhibition of growth of proline-requiring Chinese hamster ovary cells (CHO-k1) resulting from antagonism by a system amino acids. 1981 J. Cell. Physiol. pmid:7194346
Dankert J et al. Volatile fatty acids in human peripheral and portal blood: quantitative determination vacuum distillation and gas chromatography. 1981 Clin. Chim. Acta pmid:7226534
Rindler MJ and Saier MH Evidence for Na+/H+ antiport in cultured dog kidney cells (MDCK). 1981 J. Biol. Chem. pmid:7287736
Ehrhardt V Changes of 2-(methylamino) isobutyric acid transport and intracellular pH upon preincubation of rat hepatocyte primary cultures. 1982 Arch. Int. Physiol. Biochim. pmid:6182848
Tsurute S et al. Tocofibrate (tocopheryl 2-(p-chlorophenoxy) isobutyrate); a new peroxisomotropic compound, and its hypocholesterolemic activity in cholesterol-fed rats. 1982 Gen. Pharmacol. pmid:7129071
Reddy MK et al. Induction of hamster hepatic peroxisomal beta-oxidation and peroxisome proliferation-associated 80000 mol. wt. polypeptide by hypolipidemic drugs. 1982 Hum Toxicol pmid:7173894
Legakis NJ et al. Direct quantitative determination of acidic end products in clinical specimens for presumptive diagnosis of anaerobic infections. 1982 Sep-Oct Ann. Microbiol. (Paris) pmid:7149527
Giełdanowski J et al. The influence of methylpropionic acid and pyridazinone-3 derivatives on some immunologic and hemopoietic functions. 1983 Arch. Immunol. Ther. Exp. (Warsz.) pmid:6360076
Watkins JB and Klaassen CD Choleretic effect of structural analogs of valproic acid in the rat. 1983 Res. Commun. Chem. Pathol. Pharmacol. pmid:6407071
Ono M et al. Milbemycins, a new family of macrolide antibiotics. Studies on the biosynthesis of milbemycins alpha 2, alpha 4 and D using 13C labeled precursors. 1983 J. Antibiot. pmid:6630070
Zaccara G et al. Treatment of epileptic patients with valproic acid does not modify plasma and urine short-chain-fatty acids. 1983 Acta Neurol. Scand. pmid:6419536
Panopoulos P et al. Effects of ammonia and organic acids on the intradental sensory nerve activity. 1983 Acta Odontol. Scand. pmid:6578663
Pospísil S et al. Biosynthesis of monensins A and B. 1983 J. Antibiot. pmid:6874581
Iino Y et al. Organic acids and anaerobic microorganisms in the contents of the cholesteatoma sac. 1983 Jan-Feb Ann. Otol. Rhinol. Laryngol. pmid:6337545
Morris GP et al. A functional model for extracellular gastric mucus in the rat. 1984 Virchows Arch., B, Cell Pathol. pmid:6148803
Papas AM et al. Production responses of dairy cows fed diets supplemented with ammonium salts of iso C-4 and C-5 acids. 1984 J. Dairy Sci. pmid:6715625
Morris GP et al. Correlations between changes in indicators of gastric mucosal barrier integrity at time of exposure to "barrier breakers" and extent of hemorrhagic erosions one hour later. 1984 Dig. Dis. Sci. pmid:6420129
Marshall VP et al. Precursor directed biosynthesis of paulomycins A and B. The effects of valine, isoleucine, isobutyric acid and 2-methylbutyric acid. 1984 J. Antibiot. pmid:6480507