ISOBUTYRIC ACID

ISOBUTYRIC ACID is a lipid of Fatty Acyls (FA) class. Isobutyric acid is associated with abnormalities such as Atrophy, Muscular, Spinobulbar. The involved functions are known as Signal Transduction, Oxidation, Vmax, Metabolic Inhibition and Regulation. Isobutyric acid often locates in Cytoplasm, Plasma membrane, peroxisome, Mouse Embryonic Fibroblast and Protoplasm. The associated genes with ISOBUTYRIC ACID are Candidate Disease Gene, CDKN1A gene, MYC gene, E2F1 gene and HBP1 gene. The related lipids are butyrate, Butyrates, lipid structure, Fatty Acids and Propionate. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of ISOBUTYRIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOBUTYRIC ACID?

ISOBUTYRIC ACID is suspected in Atrophy, Muscular, Spinobulbar and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOBUTYRIC ACID

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Werner Syndrome D014898 4 associated lipids
Myoclonic Epilepsies, Progressive D020191 3 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with ISOBUTYRIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with ISOBUTYRIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOBUTYRIC ACID?

Knock-out

Knock-out are used in the study 'G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.' (Abramova MV et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with ISOBUTYRIC ACID

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Authors Title Published Journal PubMed Link
Cruz Lopez L et al. Brindley's gland exocrine products of Triatoma infestans. 1995 Med. Vet. Entomol. pmid:8541592
Lounès A et al. Regulation of valine catabolism by ammonium in Streptomyces ambofaciens, producer of spiramycin. 1995 Can. J. Microbiol. pmid:7585357
Bungay PM et al. Cross-flow membrane plasmapheresis technique for continuous ex vivo plasma sampling. 1994 J Pharmacol Toxicol Methods pmid:7858312
Tang L et al. Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae. 1994 J. Bacteriol. pmid:7928973
Laakel M et al. Relationship between valine, fatty acids, and spiramycin biosynthesis in Streptomyces ambofaciens. 1994 Can. J. Microbiol. pmid:7922889
Huhtanen P et al. Effect of increasing ruminal butyrate on milk yield and blood constituents in dairy cows fed a grass silage-based diet. 1993 J. Dairy Sci. pmid:8486840
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Rezanka T et al. Isobutyrate as a precursor of n-butyrate in the biosynthesis of tylosine and fatty acids. 1991 FEMS Microbiol. Lett. pmid:1769552
Tonetti M et al. Intracellular pH regulates the production of different oxygen metabolites in neutrophils: effects of organic acids produced by anaerobic bacteria. 1991 J. Leukoc. Biol. pmid:1846905
Pospísil S Resistance of Streptomyces cinnamonensis to butyrate and isobutyrate: production and properties of a new anti-isobutyrate (AIB) factor. 1991 J. Gen. Microbiol. pmid:1748869
Eilam Y et al. Transient increase in Ca2+ influx in Saccharomyces cerevisiae in response to glucose: effects of intracellular acidification and cAMP levels. 1990 J. Gen. Microbiol. pmid:1964173
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Chen HM and Lifschitz CH Preparation of fecal samples for assay of volatile fatty acids by gas-liquid chromatography and high-performance liquid chromatography. 1989 Clin. Chem. pmid:2910583
Kone P et al. Effect of the combination of monensin and isoacids on rumen fermentation in vitro. 1989 J. Dairy Sci. pmid:2600235
Matsuzaki K et al. Reduction in sensitivity to Cl- channel blockers by HCO3- -CO2 in rabbit cortical collecting duct. 1989 Am. J. Physiol. pmid:2473650
Castro-Pichel J et al. Synthesis and antiviral activity of 5'-O-(substituted) sulfamoyl pyrimidine nucleosides. 1989 Arch. Pharm. (Weinheim) pmid:2730285
Pine L et al. Physiological studies on the growth and utilization of sugars by Listeria species. 1989 Can. J. Microbiol. pmid:2501014
Matsuzaki K et al. Inhibition of cortical collecting tubule chloride transport by organic acids. 1988 J. Clin. Invest. pmid:3392216
Apps PJ et al. Aggregation pheromones of the bont tick Amblyomma hebraeum: identification of candidates for bioassay. 1988 Onderstepoort J. Vet. Res. pmid:3194113