ISOBUTYRIC ACID

ISOBUTYRIC ACID is a lipid of Fatty Acyls (FA) class. Isobutyric acid is associated with abnormalities such as Atrophy, Muscular, Spinobulbar. The involved functions are known as Signal Transduction, Oxidation, Vmax, Metabolic Inhibition and Regulation. Isobutyric acid often locates in Cytoplasm, Plasma membrane, peroxisome, Mouse Embryonic Fibroblast and Protoplasm. The associated genes with ISOBUTYRIC ACID are Candidate Disease Gene, CDKN1A gene, MYC gene, E2F1 gene and HBP1 gene. The related lipids are butyrate, Butyrates, lipid structure, Fatty Acids and Propionate. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of ISOBUTYRIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOBUTYRIC ACID?

ISOBUTYRIC ACID is suspected in Atrophy, Muscular, Spinobulbar and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOBUTYRIC ACID

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Werner Syndrome D014898 4 associated lipids
Myoclonic Epilepsies, Progressive D020191 3 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with ISOBUTYRIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with ISOBUTYRIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOBUTYRIC ACID?

Knock-out

Knock-out are used in the study 'G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.' (Abramova MV et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with ISOBUTYRIC ACID

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Authors Title Published Journal PubMed Link
Dickschat JS et al. Biosynthesis of iso-fatty acids in myxobacteria. 2005 Org. Biomol. Chem. pmid:16032360
Okawa K et al. Degradation of chemical substances using wet peroxide oxidation under mild conditions. 2005 J. Hazard. Mater. pmid:16081206
Hazeldine ST et al. Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4. 2005 Bioorg. Med. Chem. pmid:15911307
Kristensen NB and Harmon DL Effects of adding valerate, caproate, and heptanoate to ruminal buffers on splanchnic metabolism in steers under washed-rumen conditions. 2005 J. Anim. Sci. pmid:16024710
Hanbali FE et al. Chemical composition and antibacterial activity of essential oil of Pulicaria odora L. 2005 J Ethnopharmacol pmid:15896934
Vyalikh A et al. Evidence of microphase separation in controlled pore glasses. 2005 Solid State Nucl Magn Reson pmid:16061359
Schemmel S et al. Local structure of a phase-separating binary mixture in a mesoporous glass matrix studied by small-angle neutron scattering. 2005 J Chem Phys pmid:16035804
Díaz-Maroto MC et al. Formation pathways of ethyl esters of branched short-chain fatty acids during wine aging. 2005 J. Agric. Food Chem. pmid:15853394
Zhu K et al. Precursor and temperature modulation of fatty acid composition and growth of Listeria monocytogenes cold-sensitive mutants with transposon-interrupted branched-chain alpha-keto acid dehydrogenase. 2005 Microbiology (Reading, Engl.) pmid:15699210
Lung FD et al. Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface plasmon resonance technology. 2005 Biopolymers pmid:15660381
Trotta M et al. Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique. 2005 Int J Pharm pmid:15620868
Wakabayashi K et al. Gene expression associated with the decrease in malignant phenotype of human liver cancer cells following stimulation with a histone deacetylase inhibitor. 2005 Int. J. Oncol. pmid:15586245
Kuroda J et al. Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells. 2005 Int. J. Oncol. pmid:15645120
Looby E et al. Bile acid deoxycholate induces differential subcellular localisation of the PKC isoenzymes beta 1, epsilon and delta in colonic epithelial cells in a sodium butyrate insensitive manner. 2005 Int. J. Cancer pmid:15645414
Hiesberger T et al. Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis. 2005 J. Biol. Chem. pmid:15647252
Sakurazawa T and Ohkusa T Cytotoxicity of organic acids produced by anaerobic intestinal bacteria on cultured epithelial cells. 2005 J. Gastroenterol. pmid:16007394
Miller SJ et al. Short-chain fatty acids modulate gene expression for vascular endothelial cell adhesion molecules. 2005 Nutrition pmid:15925300
Wu S et al. Characteristic volatiles from young and aged fruiting bodies of wild Polyporus sulfureus (Bull.:Fr.) Fr. 2005 J. Agric. Food Chem. pmid:15913320
Sullivan HM et al. Ruminal fermentation and amino acid flow in Holstein steers fed whole cottonseed with elevated concentrations of free fatty acids in the oil. 2005 J. Dairy Sci. pmid:15653536
Vidyasagar S et al. Role of short-chain fatty acids in colonic HCO(3) secretion. 2005 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15677553
Koizumi Y et al. Potential sulfur metabolisms and associated bacteria within anoxic surface sediment from saline meromictic Lake Kaiike (Japan). 2005 FEMS Microbiol. Ecol. pmid:16329915
Beck HC Branched-chain fatty acid biosynthesis in a branched-chain amino acid aminotransferase mutant of Staphylococcus carnosus. 2005 FEMS Microbiol. Lett. pmid:15667998
Hristov AN et al. Effect of carbohydrate source on ammonia utilization in lactating dairy cows. 2005 J. Anim. Sci. pmid:15644514
Zhilina TN et al. ["Candidatus contubernalis alkalaceticum," an obligately syntrophic alkaliphilic bacterium capable of anaerobic acetate oxidation in a coculture with Desulfonatronum cooperativum]. 2005 Nov-Dec Mikrobiologiia pmid:16400991
Zhao G et al. Rapid determination of short-chain fatty acids in colonic contents and faeces of humans and rats by acidified water-extraction and direct-injection gas chromatography. 2006 Biomed. Chromatogr. pmid:16206138
Clifford S et al. Monte carlo simulation of carboxylic acid phase equilibria. 2006 J Phys Chem B pmid:17064162
Hu ZH and Yu HQ Anaerobic digestion of cattail by rumen cultures. 2006 Waste Manag pmid:16198552
Hu ZH et al. Application of response surface methodology for optimization of acidogenesis of cattail by rumen cultures. 2006 Bioresour. Technol. pmid:16289873
Fahrbach M et al. Denitratisoma oestradiolicum gen. nov., sp. nov., a 17beta-oestradiol-degrading, denitrifying betaproteobacterium. 2006 Int. J. Syst. Evol. Microbiol. pmid:16825628
Guo J et al. An efficient synthesis of a potent PPARpan agonist. 2006 J. Org. Chem. pmid:17025332
Charrier C et al. A novel class of CoA-transferase involved in short-chain fatty acid metabolism in butyrate-producing human colonic bacteria. 2006 Microbiology (Reading, Engl.) pmid:16385128
Castellanos P et al. Conformational change of poly(ethylene glycol) near the critical point of isobutyric acid + water. 2006 J Phys Chem B pmid:17078654
Ballivet-Tkatchenko D et al. Insertion reaction of carbon dioxide into Sn-OR bond. Synthesis, structure and DFT calculations of di- and tetranuclear isopropylcarbonato tin(IV) complexes. 2006 Dalton Trans pmid:17077890
Panagou EZ and Tassou CC Changes in volatile compounds and related biochemical profile during controlled fermentation of cv. Conservolea green olives. 2006 Food Microbiol. pmid:16943076
Venkatesu P Polymer modifies the critical region of the coexisting liquid phases. 2006 J Phys Chem B pmid:16942068
Manrique G et al. Chemical communication in Chagas disease vectors. Source, identity, and potential function of volatiles released by the metasternal and Brindley's glands of Triatoma infestans adults. 2006 J. Chem. Ecol. pmid:16902820
Li L et al. Nucleophilic group transfer reactivity for fibric acid derived drug molecules. 2006 J Pharm Sci pmid:16865691
de Souza MD et al. Characterization of cachaça and rum aroma. 2006 J. Agric. Food Chem. pmid:16417309
Wang Y et al. Exploration of the direct metabolic effects of mercury II chloride on the kidney of Sprague-Dawley rats using high-resolution magic angle spinning 1H NMR spectroscopy of intact tissue and pattern recognition. 2006 J Pharm Biomed Anal pmid:16146678
Seeling K et al. On the effects of Fusarium toxin contaminated wheat and wheat chaff on nutrient utilisation and turnover of deoxynivalenol and zearalenone in vitro (Rusitec). 2006 Toxicol In Vitro pmid:16321500
Mu Y et al. The role of pH in the fermentative H2 production from an acidogenic granule-based reactor. 2006 Chemosphere pmid:16466779
Ying M et al. Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. 2006 J. Biol. Chem. pmid:16407196
Pojman JA et al. Evidence for the existence of an effective interfacial tension between miscible fluids: isobutyric acid-water and 1-butanol-water in a spinning-drop tensiometer. 2006 Langmuir pmid:16519456
Masaki Y et al. Recyclable polymeric pi-acid catalyst effective on Mannich-type reaction in water. 2006 Chem. Pharm. Bull. pmid:16595974
Abramova MV et al. G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin. 2006 J. Biol. Chem. pmid:16717102
Jaison PG et al. Direct determination of lanthanides in simulated irradiated thoria fuels using reversed-phase high-performance liquid chromatography. 2006 J Chromatogr A pmid:16687151
Kendall MM et al. Butyrate- and propionate-degrading syntrophs from permanently cold marine sediments in Skan Bay, Alaska, and description of Algorimarina butyrica gen. nov., sp. nov. 2006 FEMS Microbiol. Lett. pmid:16907746
Reed JJ et al. Effects of season and inclusion of corn distillers dried grains with solubles in creep feed on intake, microbial protein synthesis and efficiency, ruminal fermentation, digestion, and performance of nursing calves grazing native range in southeastern North Dakota. 2006 J. Anim. Sci. pmid:16864882
Dresler K et al. Production of a recombinant polyester-cleaving hydrolase from Thermobifida fusca in Escherichia coli. 2006 Bioprocess Biosyst Eng pmid:16770590
Bertin L et al. Performances and microbial features of an aerobic packed-bed biofilm reactor developed to post-treat an olive mill effluent from an anaerobic GAC reactor. 2006 Microb. Cell Fact. pmid:16595023
Zhao G et al. Determination of short-chain fatty acids in serum by hollow fiber supported liquid membrane extraction coupled with gas chromatography. 2007 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:17070116
Cooke KM et al. Performance and ruminal fermentation of dairy cows fed whole cottonseed with elevated concentrations of free fatty acids in the oil. 2007 J. Dairy Sci. pmid:17430935
Barmeyer C et al. Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells. 2007 Pflugers Arch. pmid:17492310
Lynch MB et al. Effects of increasing the intake of dietary β-glucans by exchanging wheat for barley on nutrient digestibility, nitrogen excretion, intestinal microflora, volatile fatty acid concentration and manure ammonia emissions in finishing pigs. 2007 Animal pmid:22444744
Tjellström B et al. Gut microflora associated characteristics in first-degree relatives of children with celiac disease. 2007 Scand. J. Gastroenterol. pmid:17852880
Jiang S et al. Biological short-chain fatty acids (SCFAs) production from waste-activated sludge affected by surfactant. 2007 Water Res. pmid:17499838
Basri M et al. Comparison of estimation capabilities of response surface methodology (RSM) with artificial neural network (ANN) in lipase-catalyzed synthesis of palm-based wax ester. 2007 BMC Biotechnol. pmid:17760990
Siporska A et al. (18)O/(16)O isotope effect on miscibility of isobutyric acid with water. 2007 J Phys Chem B pmid:17877388
Mercier J and Jiménez JI Potential of the volatile-producing fungus Muscodor albus for control of building molds. 2007 Can. J. Microbiol. pmid:17538650
Brito AF and Broderick GA Effects of different protein supplements on milk production and nutrient utilization in lactating dairy cows. 2007 J. Dairy Sci. pmid:17369223
Dhale MA et al. Isolation and characterization of dihydromonacolin-MV from Monascus purpureus for antioxidant properties. 2007 Appl. Microbiol. Biotechnol. pmid:17043831
Pluske JR et al. Feeding different types of cooked white rice to piglets after weaning influences starch digestion, digesta and fermentation characteristics and the faecal shedding of beta-haemolytic Escherichia coli. 2007 Br. J. Nutr. pmid:17298698
Strobel GA et al. Muscodor albus E-6, an endophyte of Guazuma ulmifolia making volatile antibiotics: isolation, characterization and experimental establishment in the host plant. 2007 Microbiology (Reading, Engl.) pmid:17660425
Biagi G et al. Performance, intestinal microflora, and wall morphology of weanling pigs fed sodium butyrate. 2007 J. Anim. Sci. pmid:17296766
Vyalikh A et al. 2H-solid state NMR and DSC study of isobutyric acid in mesoporous silica materials. 2007 Phys Chem Chem Phys pmid:17487322
Hoven VP et al. Polymer brushes in nanopores surrounded by silicon-supported tris(trimethylsiloxy)silyl monolayers. 2007 J Colloid Interface Sci pmid:17662300
He L et al. Possible mechanism for the regulation of glucose on proliferation, inhibition and apoptosis of colon cancer cells induced by sodium butyrate. 2007 World J. Gastroenterol. pmid:17663521
Beffagna N and Lutzu I Inhibition of catalase activity as an early response of Arabidopsis thaliana cultured cells to the phytotoxin fusicoccin. 2007 J. Exp. Bot. pmid:18039736
Wyss C Fatty acids synthesized by oral treponemes in chemically defined media. 2007 FEMS Microbiol. Lett. pmid:17229060
Queenan KM et al. Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial. 2007 Nutr J pmid:17386092
Lucas KA et al. Peroxisomal metabolism of propionic acid and isobutyric acid in plants. 2007 J. Biol. Chem. pmid:17580301
Kristensen NB et al. Metabolism of silage alcohols in lactating dairy cows. 2007 J. Dairy Sci. pmid:17297111
Htoo JK et al. Effect of dietary protein content on ileal amino acid digestibility, growth performance, and formation of microbial metabolites in ileal and cecal digesta of early-weaned pigs. 2007 J. Anim. Sci. pmid:17785591
Farnworth ER et al. The effect of drinking milk containing conjugated linoleic acid on fecal microbiological profile, enzymatic activity, and fecal characteristics in humans. 2007 Nutr J pmid:17620127
Martin FP et al. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. 2007 Mol. Syst. Biol. pmid:17515922
Piao SJ et al. The organic acid profiles in the feces of pigs at Brachyspira hyodysenteriae- or B. pilosicoli-positive farms. 2007 J. Vet. Med. Sci. pmid:17485934
Dunkley KD et al. Comparison of in vitro fermentation and molecular microbial profiles of high-fiber feed substrates incubated with chicken cecal inocula. 2007 Poult. Sci. pmid:17435012
Finke N et al. Acetate, lactate, propionate, and isobutyrate as electron donors for iron and sulfate reduction in Arctic marine sediments, Svalbard. 2007 FEMS Microbiol. Ecol. pmid:17069623
González LA et al. Increasing sodium bicarbonate level in high-concentrate diets for heifers. I. Effects on intake, water consumption and ruminal fermentation. 2008 Animal pmid:22443595
Dalmasso G et al. Butyrate transcriptionally enhances peptide transporter PepT1 expression and activity. 2008 PLoS ONE pmid:18575574
Martin FP et al. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. 2008 Mol. Syst. Biol. pmid:18197175
Zarzycki PK and Zarzycka MB Application of temperature-controlled micro planar chromatography for separation and quantification of testosterone and its derivatives. 2008 Anal Bioanal Chem pmid:18338160
Kawata J et al. Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon. 2008 J Nat Med pmid:18404332
Nilsson U et al. Dietary supplementation with beta-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects. 2008 Eur J Clin Nutr pmid:17522598
Zhao QB and Yu HQ Fermentative H2 production in an upflow anaerobic sludge blanket reactor at various pH values. 2008 Bioresour. Technol. pmid:17482810
Liu Q et al. Effects of isobutyrate on rumen fermentation, urinary excretion of purine derivatives and digestibility in steers. 2008 Arch Anim Nutr pmid:18942585
Lee M et al. Effect of temperature on performance and microbial diversity in hyperthermophilic digester system fed with kitchen garbage. 2008 Bioresour. Technol. pmid:18328699
Mahran A et al. Mortality of Pratylenchus penetrans by Volatile Fatty Acids from Liquid Hog Manure. 2008 J. Nematol. pmid:19259528
Shiratori H et al. Lutispora thermophila gen. nov., sp. nov., a thermophilic, spore-forming bacterium isolated from a thermophilic methanogenic bioreactor digesting municipal solid wastes. 2008 Int. J. Syst. Evol. Microbiol. pmid:18398203
Mastelić J et al. Contribution to the analysis of the essential oil of Helichrysum italicum (Roth) G. Don. Determination of ester bonded acids and phenols. 2008 Molecules pmid:18463581
Varel VH et al. Odorant production and persistence of Escherichia coli in manure slurries from cattle fed zero, twenty, forty, or sixty percent wet distillers grains with solubles. 2008 J. Anim. Sci. pmid:18676716
Martin FP et al. Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. 2008 Mol. Syst. Biol. pmid:18628745
Westermann CM et al. Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy. 2008 Neuromuscul. Disord. pmid:18406615
Boumba VA et al. Biochemical pathways generating post-mortem volatile compounds co-detected during forensic ethanol analyses. 2008 Forensic Sci. Int. pmid:17452087
Jacobs DM et al. (1)H NMR metabolite profiling of feces as a tool to assess the impact of nutrition on the human microbiome. 2008 NMR Biomed pmid:18085514
Holm-Nielsen JB et al. On-line near infrared monitoring of glycerol-boosted anaerobic digestion processes: evaluation of process analytical technologies. 2008 Biotechnol. Bioeng. pmid:17626304
Pscheidt B and Glieder A Yeast cell factories for fine chemical and API production. 2008 Microb. Cell Fact. pmid:18684335
Strobel GA et al. Synergism among volatile organic compounds resulting in increased antibiosis in Oidium sp. 2008 FEMS Microbiol. Lett. pmid:18422630
Kanistanon D et al. A Francisella mutant in lipid A carbohydrate modification elicits protective immunity. 2008 PLoS Pathog. pmid:18266468
Bell JA et al. Ecological characterization of the colonic microbiota of normal and diarrheic dogs. 2008 Interdiscip Perspect Infect Dis pmid:19282974