ISOBUTYRIC ACID

ISOBUTYRIC ACID is a lipid of Fatty Acyls (FA) class. Isobutyric acid is associated with abnormalities such as Atrophy, Muscular, Spinobulbar. The involved functions are known as Signal Transduction, Oxidation, Vmax, Metabolic Inhibition and Regulation. Isobutyric acid often locates in Cytoplasm, Plasma membrane, peroxisome, Mouse Embryonic Fibroblast and Protoplasm. The associated genes with ISOBUTYRIC ACID are Candidate Disease Gene, CDKN1A gene, MYC gene, E2F1 gene and HBP1 gene. The related lipids are butyrate, Butyrates, lipid structure, Fatty Acids and Propionate. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of ISOBUTYRIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOBUTYRIC ACID?

ISOBUTYRIC ACID is suspected in Atrophy, Muscular, Spinobulbar and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOBUTYRIC ACID

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Werner Syndrome D014898 4 associated lipids
Myoclonic Epilepsies, Progressive D020191 3 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with ISOBUTYRIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with ISOBUTYRIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOBUTYRIC ACID?

Knock-out

Knock-out are used in the study 'G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.' (Abramova MV et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with ISOBUTYRIC ACID

Download all related citations
Per page 10 20 50 100 | Total 515
Authors Title Published Journal PubMed Link
Hazeldine ST et al. Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4. 2005 Bioorg. Med. Chem. pmid:15911307
Kristensen NB and Harmon DL Effects of adding valerate, caproate, and heptanoate to ruminal buffers on splanchnic metabolism in steers under washed-rumen conditions. 2005 J. Anim. Sci. pmid:16024710
Hanbali FE et al. Chemical composition and antibacterial activity of essential oil of Pulicaria odora L. 2005 J Ethnopharmacol pmid:15896934
Kim YW and Baird JK Chemical equilibrium and critical phenomena: the solubilities of manganese dioxide and aluminum oxide in isobutyric acid + water near its consolute point. 2005 J Phys Chem B pmid:16853203
Kim YW and Baird JK Reaction kinetics and critical phenomena: rates of some first order gas evolution reactions in binary solvents with a consolute point. 2005 J Phys Chem A pmid:16833817
Díaz-Maroto MC et al. Formation pathways of ethyl esters of branched short-chain fatty acids during wine aging. 2005 J. Agric. Food Chem. pmid:15853394
Zhu K et al. Precursor and temperature modulation of fatty acid composition and growth of Listeria monocytogenes cold-sensitive mutants with transposon-interrupted branched-chain alpha-keto acid dehydrogenase. 2005 Microbiology (Reading, Engl.) pmid:15699210
Lung FD et al. Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface plasmon resonance technology. 2005 Biopolymers pmid:15660381
Trotta M et al. Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique. 2005 Int J Pharm pmid:15620868
Looby E et al. Bile acid deoxycholate induces differential subcellular localisation of the PKC isoenzymes beta 1, epsilon and delta in colonic epithelial cells in a sodium butyrate insensitive manner. 2005 Int. J. Cancer pmid:15645414
Hiesberger T et al. Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis. 2005 J. Biol. Chem. pmid:15647252
Sercu B et al. Degradation of isobutanal at high loading rates in a compost biofilter. 2005 J Air Waste Manag Assoc pmid:16187591
Sakurazawa T and Ohkusa T Cytotoxicity of organic acids produced by anaerobic intestinal bacteria on cultured epithelial cells. 2005 J. Gastroenterol. pmid:16007394
Stokrová J et al. Response of HT115, a highly invasive human colorectal adenocarcinoma cell line, to sodium butyrate treatment and glucose deprivation. 2005 Int. J. Oncol. pmid:15703838
El Hamidi A et al. Microextraction of bacterial lipid A: easy and rapid method for mass spectrometric characterization. 2005 J. Lipid Res. pmid:15930524
Izawa H et al. Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells. 2005 Int. J. Oncol. pmid:15942645
Talasz H et al. Histone H4-lysine 20 monomethylation is increased in promoter and coding regions of active genes and correlates with hyperacetylation. 2005 J. Biol. Chem. pmid:16166085
Waligora-Dupriet AJ et al. Evidence for clostridial implication in necrotizing enterocolitis through bacterial fermentation in a gnotobiotic quail model. 2005 Pediatr. Res. pmid:16189185
Bachetti T et al. An in vitro approach to test the possible role of candidate factors in the transcriptional regulation of the RET proto-oncogene. 2005 Gene Expr. pmid:16127999
Miller SJ et al. Short-chain fatty acids modulate gene expression for vascular endothelial cell adhesion molecules. 2005 Nutrition pmid:15925300
Wu S et al. Characteristic volatiles from young and aged fruiting bodies of wild Polyporus sulfureus (Bull.:Fr.) Fr. 2005 J. Agric. Food Chem. pmid:15913320
Sullivan HM et al. Ruminal fermentation and amino acid flow in Holstein steers fed whole cottonseed with elevated concentrations of free fatty acids in the oil. 2005 J. Dairy Sci. pmid:15653536
Vidyasagar S et al. Role of short-chain fatty acids in colonic HCO(3) secretion. 2005 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15677553
Koizumi Y et al. Potential sulfur metabolisms and associated bacteria within anoxic surface sediment from saline meromictic Lake Kaiike (Japan). 2005 FEMS Microbiol. Ecol. pmid:16329915
Beck HC Branched-chain fatty acid biosynthesis in a branched-chain amino acid aminotransferase mutant of Staphylococcus carnosus. 2005 FEMS Microbiol. Lett. pmid:15667998
Hristov AN et al. Effect of carbohydrate source on ammonia utilization in lactating dairy cows. 2005 J. Anim. Sci. pmid:15644514
Tang Y et al. Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. 2004 PLoS Biol. pmid:14966533
Bräsen C and Schönheit P Unusual ADP-forming acetyl-coenzyme A synthetases from the mesophilic halophilic euryarchaeon Haloarcula marismortui and from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum. 2004 Arch. Microbiol. pmid:15340786
Yu HQ et al. Thermodynamic analysis of product formation in mesophilic acidogenesis of lactose. 2004 Biotechnol. Bioeng. pmid:15334408
Zduńczyk Z et al. Performance and caecal adaptation of turkeys to diets without or with antibiotic and with different levels of mannan-oligosaccharide. 2004 Arch Anim Nutr pmid:15595620
Hirano J et al. Novel stable fluorophore, 6-methoxy-4-quinolone, with strong fluorescence in wide pH range of aqueous media, and its application as a fluorescent labeling reagent. 2004 J Chromatogr A pmid:15628146
Haba Y et al. Rendering poly(amidoamine) or poly(propylenimine) dendrimers temperature sensitive. 2004 J. Am. Chem. Soc. pmid:15469255
Posner GH et al. Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents. 2004 J. Med. Chem. pmid:14971910
Glissman K et al. Methanogenic pathway and archaeal community structure in the sediment of eutrophic Lake Dagow: effect of temperature. 2004 Microb. Ecol. pmid:15692859
Api AM Evaluation of the dermal subchronic toxicity of phenoxyethyl isobutyrate in the rat. 2004 Food Chem. Toxicol. pmid:14667475
Zeyner A et al. Effects of hay intake and feeding sequence on variables in faeces and faecal water (dry matter, pH value, organic acids, ammonia, buffering capacity) of horses. 2004 J Anim Physiol Anim Nutr (Berl) pmid:19774758
Qiu X et al. Effects of substrate, passage rate, and pH in continuous culture on flows of conjugated linoleic acid and trans C18:1. 2004 J. Dairy Sci. pmid:15377625
Vidyasagar S et al. Three distinct mechanisms of HCO3- secretion in rat distal colon. 2004 Am. J. Physiol., Cell Physiol. pmid:15308466
Bordonaro M et al. Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells. 2004 Nucleic Acids Res. pmid:15141037
Mix KS et al. Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling. 2004 Mol. Pharmacol. pmid:14742672
Wrigley DM Inhibition of Clostridium perfringens sporulation by Bacteroides fragilis and short-chain fatty acids. 2004 Anaerobe pmid:16701530
Bordin M et al. Histone deacetylase inhibitors up-regulate the expression of tight junction proteins. 2004 Mol. Cancer Res. pmid:15634758
Raut NM et al. Separation and determination of lanthanides, thorium and uranium using a dual gradient in reversed-phase liquid chromatography. 2004 J Chromatogr A pmid:15527129
Xiong Y et al. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:14722361
Kim JD and Kang KH Isolation of Lactobacillus sakei strain KJ-2008 and its removal of characteristic malodorous gases under anaerobic culture conditions. 2004 Biosci. Biotechnol. Biochem. pmid:15618611
Kristensen NB and Harmon DL Effect of increasing ruminal butyrate absorption on splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers. 2004 J. Anim. Sci. pmid:15537776
Kristensen NB and Harmon DL Splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers. 2004 J. Anim. Sci. pmid:15309950
Abreu A et al. Effects of Sapindus saponaria fruits on ruminal fermentation and duodenal nitrogen flow of sheep fed a tropical grass diet with and without legume. 2004 J. Anim. Sci. pmid:15144079
Stoeck M et al. In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide. 2004 J. Pharmacol. Exp. Ther. pmid:14718604
Bernard JK et al. Ruminal fermentation and bacterial protein synthesis of whole cottonseed coated with combinations of gelatinized corn starch and urea. 2003 J. Dairy Sci. pmid:14672196
Yu HQ and Fang HH Acidogenesis of gelatin-rich wastewater in an upflow anaerobic reactor: influence of pH and temperature. 2003 Water Res. pmid:12465788
Shigematsu T et al. Delftia tsuruhatensis sp. nov., a terephthalate-assimilating bacterium isolated from activated sludge. 2003 Int. J. Syst. Evol. Microbiol. pmid:13130036
Gallert C et al. Scale-up of anaerobic digestion of the biowaste fraction from domestic wastes. 2003 Water Res. pmid:12598207
Zhang WF et al. Effects of isomalto-oligosaccharides on broiler performance and intestinal microflora. 2003 Poult. Sci. pmid:12710488
Noftsger SM et al. Effects of 2-hydroxy-4-(methylthio) butanoic acid (HMB) on microbial growth in continuous culture. 2003 J. Dairy Sci. pmid:12939087
Batstone DJ et al. Kinetics of thermophilic, anaerobic oxidation of straight and branched chain butyrate and valerate. 2003 Biotechnol. Bioeng. pmid:12966576
Wang YH et al. Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305. 2003 J. Biol. Chem. pmid:12724314
Pind PF et al. Dynamics of the anaerobic process: effects of volatile fatty acids. 2003 Biotechnol. Bioeng. pmid:12701145
Huys G et al. Aeromonas hydrophila subsp. ranae subsp. nov., isolated from septicaemic farmed frogs in Thailand. 2003 Int. J. Syst. Evol. Microbiol. pmid:12807217
Sanceda NG et al. Branched chain amino acids as source of specific branched chain volatile fatty acids during the fermentation process of fish sauce. 2003 Amino Acids pmid:12624738
David RM et al. Lack of sensitization for trimellitate, phthalate, terephthalate and isobutyrate plasticizers in a human repeated insult patch test. 2003 Food Chem. Toxicol. pmid:12615132
Cao X et al. Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line. 2003 Endocrinology pmid:12697711
Lemoff AS et al. Binding energies of water to sodiated valine and structural isomers in the gas phase: the effect of proton affinity on zwitterion stability. 2003 J. Am. Chem. Soc. pmid:14583055
Matich AJ et al. Actinidia arguta: volatile compounds in fruit and flowers. 2003 Phytochemistry pmid:12737978
Diao J et al. Crystallization of butyrate kinase 2 from Thermotoga maritima mediated by vapor diffusion of acetic acid. 2003 Acta Crystallogr. D Biol. Crystallogr. pmid:12777787
Gabler MT and Heinrichs AJ Altering soluble and potentially rumen degradable protein for prepubertal Holstein heifers. 2003 J. Dairy Sci. pmid:12836949
Schauber J et al. Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. 2003 Gut pmid:12692061
Le Poul E et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. 2003 J. Biol. Chem. pmid:12711604
Brown AJ et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. 2003 J. Biol. Chem. pmid:12496283
Suzuki-Mizushima Y et al. Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells. 2002 Brain Res. pmid:12270499
Fang HH and Yu H Mesophilic acidification of gelatinaceous wastewater. 2002 J. Biotechnol. pmid:11738717
Kim NS and Lee GM Inhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3. 2002 Biotechnol. Bioeng. pmid:11870612
Kukushkin AN et al. Downregulation of c-fos gene transcription in cells transformed by E1A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-fos promoter. 2002 Oncogene pmid:11850800
Fushinobu S et al. Crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with cleavage products. 2002 Protein Sci. pmid:12192074
Rojas JC et al. A reinvestigation of brindley's gland exocrine compounds of Rhodnius prolixus (Hemiptera: Reduviidae). 2002 J. Med. Entomol. pmid:11931024
Yang CM Response of forage fiber degradation by ruminal microorganisms to branched-chain volatile fatty acids, amino acids, and dipeptides. 2002 J. Dairy Sci. pmid:12086054
Kumazawa S et al. Studies of the constituents of Uruguayan propolis. 2002 J. Agric. Food Chem. pmid:12166959
Mata R et al. Sesquiterpene lactones and phenylpropanoids from Cosmos pringlei. 2002 J. Nat. Prod. pmid:12141867
Cibis E et al. Biodegradation of potato slops from a rural distillery by thermophilic aerobic bacteria. 2002 Bioresour. Technol. pmid:12146644
Hernandez-Eugenio G et al. Sporanaerobacter acetigenes gen. nov., sp. nov., a novel acetogenic, facultatively sulfur-reducing bacterium. 2002 Int. J. Syst. Evol. Microbiol. pmid:12148631
Akay V et al. NutriDense and waxy corn hybrids: effects on site and extent of disappearance of nutrients in sheep. 2002 J. Anim. Sci. pmid:12019623
Hernández-Orte P et al. Relationship between varietal amino acid profile of grapes and wine aromatic composition. Experiments with model solutions and chemometric study. 2002 J. Agric. Food Chem. pmid:11982416
Bourne PC et al. Ecdysteroid 7,9(11)-dien-6-ones as potential photoaffinity labels for ecdysteroid binding proteins. 2002 J. Insect Sci. pmid:15455045
Hernández-Eugenio G et al. Clostridium thiosulfatireducens sp. nov., a proteolytic, thiosulfate- and sulfur-reducing bacterium isolated from an upflow anaerobic sludge blanket (UASB) reactor. 2002 Int. J. Syst. Evol. Microbiol. pmid:12361247
Ith M et al. Observation and identification of metabolites emerging during postmortem decomposition of brain tissue by means of in situ 1H-magnetic resonance spectroscopy. 2002 Magn Reson Med pmid:12418008
Hansen JL et al. The structures of four macrolide antibiotics bound to the large ribosomal subunit. 2002 Mol. Cell pmid:12150912
McGuinness MC et al. Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy. 2001 Sep-Oct Mol. Genet. Metab. pmid:11592822
Guerenstein PG and Guerin PM Olfactory and behavioural responses of the blood-sucking bug Triatoma infestans to odours of vertebrate hosts. 2001 J. Exp. Biol. pmid:11171309
Yu HQ and Fang HH Acidification of mid- and high-strength dairy wastewaters. 2001 Water Res. pmid:11561632
Etchebehere C et al. Comamonas nitrativorans sp. nov., a novel denitrifier isolated from a denitrifying reactor treating landfill leachate. 2001 Int. J. Syst. Evol. Microbiol. pmid:11411724
Osborne A et al. Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. 2001 Mol. Cell. Biol. pmid:11533238
Paulukat J et al. Expression and release of IL-18 binding protein in response to IFN-gamma. 2001 J. Immunol. pmid:11739524
Walczak RJ et al. Nonactin biosynthesis: disruption of the polyketide synthase genes, nonKJ, in Streptomyces griseus leads to an overall 96 decrease in macrotetrolide production, yet a net increase in nonactin analogues which incorporate isobutyrate. 2001 J. Am. Chem. Soc. pmid:11604004
Hung MW et al. Differential regulation of placental and germ cell alkaline phosphatases by glucocorticoid and sodium butyrate in human gastric carcinoma cell line TMK-1. 2001 Arch. Biochem. Biophys. pmid:11361139
Suresh CH et al. Revisiting Markovnikov addition to alkenes via molecular electrostatic potential. 2001 J. Org. Chem. pmid:11597205
Fujino T et al. Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. 2001 J. Biol. Chem. pmid:11470804
Takahashi N and Sato T Preferential utilization of dipeptides by Porphyromonas gingivalis. 2001 J. Dent. Res. pmid:11437213
Bandyk CA et al. Effect of ruminal vs postruminal administration of degradable protein on utilization of low-quality forage by beef steers. 2001 J. Anim. Sci. pmid:11204704
Smirnova N and Reynolds KA Branched-chain fatty acid biosynthesis in Escherichia coli. 2001 J. Ind. Microbiol. Biotechnol. pmid:11687938
Besong S et al. Influence of supplemental chromium on concentrations of liver triglyceride, blood metabolites and rumen VFA profile in steers fed a moderately high fat diet. 2001 J. Dairy Sci. pmid:11467818