ISOBUTYRIC ACID

ISOBUTYRIC ACID is a lipid of Fatty Acyls (FA) class. Isobutyric acid is associated with abnormalities such as Atrophy, Muscular, Spinobulbar. The involved functions are known as Signal Transduction, Oxidation, Vmax, Metabolic Inhibition and Regulation. Isobutyric acid often locates in Cytoplasm, Plasma membrane, peroxisome, Mouse Embryonic Fibroblast and Protoplasm. The associated genes with ISOBUTYRIC ACID are Candidate Disease Gene, CDKN1A gene, MYC gene, E2F1 gene and HBP1 gene. The related lipids are butyrate, Butyrates, lipid structure, Fatty Acids and Propionate. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of ISOBUTYRIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOBUTYRIC ACID?

ISOBUTYRIC ACID is suspected in Atrophy, Muscular, Spinobulbar and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOBUTYRIC ACID

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Werner Syndrome D014898 4 associated lipids
Myoclonic Epilepsies, Progressive D020191 3 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with ISOBUTYRIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with ISOBUTYRIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with ISOBUTYRIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOBUTYRIC ACID?

Knock-out

Knock-out are used in the study 'G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.' (Abramova MV et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with ISOBUTYRIC ACID

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Authors Title Published Journal PubMed Link
Queenan KM et al. Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial. 2007 Nutr J pmid:17386092
Bordonaro M et al. Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells. 2004 Nucleic Acids Res. pmid:15141037
Jacobs DM et al. (1)H NMR metabolite profiling of feces as a tool to assess the impact of nutrition on the human microbiome. 2008 NMR Biomed pmid:18085514
Agarwal P et al. Gabapentin enacarbil - clinical efficacy in restless legs syndrome. 2010 Neuropsychiatr Dis Treat pmid:20505847
Westermann CM et al. Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy. 2008 Neuromuscul. Disord. pmid:18406615
Hilgier W et al. Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis. 2009 Neurobiol. Dis. pmid:19379813
Yu AN et al. Top note compounds of Chinese traditional bacteria-fermented soybean. 2008 Nat. Prod. Res. pmid:19023819
Mastelić J et al. Contribution to the analysis of the essential oil of Helichrysum italicum (Roth) G. Don. Determination of ester bonded acids and phenols. 2008 Molecules pmid:18463581
Biermann J et al. Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells. 2011 Mol. Vis. pmid:21311741
Martin FP et al. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. 2008 Mol. Syst. Biol. pmid:18197175