(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Congenital Abnormalities D000013 11 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Abortion, Veterinary D000034 5 associated lipids
Acid-Base Imbalance D000137 3 associated lipids
Acidosis D000138 13 associated lipids
Acromegaly D000172 6 associated lipids
Adenocarcinoma D000230 166 associated lipids
Albuminuria D000419 18 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Alkalosis D000471 3 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

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Authors Title Published Journal PubMed Link
Sarna GS et al. The turnover of plasma glucose and free fatty acids in vivo after portacaval anastomosis and chronic underfeeding in the rat. 1981 Clin. Sci. pmid:7237928
Lund J et al. The exchange of blood-borne amino acids in the leg during abdominal surgical trauma: effects of glucose infusion. 1986 Clin. Sci. pmid:3769399
Szabó Z et al. Effects of high-dose glucose-insulin-potassium on myocardial metabolism after coronary surgery in patients with Type II diabetes. 2001 Clin. Sci. pmid:11410112
Metcalfe HK et al. Carrier-mediated efflux of ketone bodies in isolated rat hepatocytes. 1986 Clin. Sci. pmid:3791876
Kruszynska YT et al. Twenty-four hour C-peptide and insulin secretion rates and diurnal profiles of glucose, lipids and intermediary metabolites in cirrhosis. 1992 Clin. Sci. pmid:1335398
Webber J et al. Metabolic effects of acute hyperketonaemia in man before and during an hyperinsulinaemic euglycaemic clamp. 1994 Clin. Sci. pmid:8062504
Forse RA et al. Effects of glucose on nitrogen balance during high nitrogen intake in malnourished patients. 1990 Clin. Sci. pmid:2156647
Umpleby AM et al. The effect of ketone bodies on leucine and alanine metabolism in dogs. 1988 Clin. Sci. pmid:2827938
Elia M et al. Ketone body metabolism in lean male adults during short-term starvation, with particular reference to forearm muscle metabolism. 1990 Clin. Sci. pmid:2165890
Riley M et al. Substrate utilization during exercise in chronic cardiac failure. 1990 Clin. Sci. pmid:2167796
Moller L et al. Fasting in healthy subjects is associated with intrahepatic accumulation of lipids as assessed by 1H-magnetic resonance spectroscopy. 2008 Clin. Sci. pmid:17990983
Swaminathan R et al. Effect of fasting on the disappearance of injected alanine and 3-hydroxybutyrate in obese subjects. 1982 Clin. Sci. pmid:7056033
Smith SL et al. KTX 0101: a potential metabolic approach to cytoprotection in major surgery and neurological disorders. 2005 CNS Drug Rev pmid:16007235
Kimura R et al. Acute exposure to the mitochondrial complex I toxin rotenone impairs synaptic long-term potentiation in rat hippocampal slices. 2012 CNS Neurosci Ther pmid:22613619
Shen F et al. Surface bio-modification of poly(hydroxybutyrate-co-hydroxyhexanoate) and its aging effect. 2009 Colloids Surf B Biointerfaces pmid:19559576
Tokuyama K et al. Seasonal glucose uptake in marmots (Marmota flaviventris): the role of pancreatic hormones. 1991 Comp Biochem Physiol A Comp Physiol pmid:1685387
Herberg L and Buchanan KD Effect of high glucagon infusions on blood glucose, plasma insulin and beta-OH-butyrate concentrations in streptozotocin-diabetic and normal Osborne Mendel rats. 1982 Comp Biochem Physiol A Comp Physiol pmid:6125314
Pontes Rde C et al. Concentrations of ketone bodies in the blood of the green lizard Ameiva ameiva (Teiidae) in different physiological situations. 1988 Comp Biochem Physiol A Comp Physiol pmid:2896561
Legge M et al. Energy substrate utilization in the common brushtailed possum (Trichosurus vulpecula) using intravenous tolerance tests. 2011 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:20977945
Weltzien FA et al. beta-Hydroxybutyrate in developing nauplii of brine shrimp (Artemia franciscana K.) under feeding and non-feeding conditions. 2000 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:10840642
Sweazea KL et al. Inhibition of lipolysis does not affect insulin sensitivity to glucose uptake in the mourning dove. 2006 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:16753324
Chida Y et al. Carbohydrate metabolism in temporal and persistent hypoglycemic chickens induced by insulin infusion. 2000 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:11050690
Doelman J et al. Transcript profiling of the ruminant liver indicates a unique program of transcriptional regulation of ketogenic enzymes during food restriction. 2012 Comp. Biochem. Physiol. Part D Genomics Proteomics pmid:22748507
Linares A et al. Changes in ketone body utilization by chick liver, duodenal mucosa and kidney during embryonic and postnatal development. 1993 Comp. Biochem. Physiol., B pmid:8359015
D'Alecy LG et al. Beta-hydroxybutyrate and response to hypoxia in the ground squirrel, Spermophilus tridecimlineatus. 1990 Comp. Biochem. Physiol., B pmid:2364670
Nehlig A et al. Utilization of 3-hydroxybutyrate by chick cerebral hemispheres during postnatal maturation. 1978 Comp. Biochem. Physiol., B pmid:318363
Latruffe N Transport of D-beta-hydroxybutyrate across rat liver mitochondrial membranes. 1987 Comp. Biochem. Physiol., B pmid:3427918
Goubern M and Cadot M Ketone bodies in cold-acclimated rats. 1983 Comp. Biochem. Physiol., B pmid:6661898
Frick NT et al. Lipid, ketone body and oxidative metabolism in the African lungfish, Protopterus dolloi following 60 days of fasting and aestivation. 2008 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:18598776
Arnould JP et al. Fasting metabolism in Antarctic fur seal (Arctocephalus gazella) pups. 2001 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:11440869
Wood CM et al. The influence of feeding and fasting on plasma metabolites in the dogfish shark (Squalus acanthias). 2010 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:19782147
Guinet C et al. Change in plasma cortisol and metabolites during the attendance period ashore in fasting lactating subantarctic fur seals. 2004 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:15123189
Crocker DE et al. Hormone and metabolite changes associated with extended breeding fasts in male northern elephant seals (Mirounga angustirostris). 2012 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:22227222
Ohtsu H et al. High beta-hydroxybutyrate concentration in liver and skeletal muscle of newly hatched chicks. 2003 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:12600671
Sato M et al. Heat production and lipid metabolism in broiler and layer chickens during embryonic development. 2006 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:16460976
Albano N et al. Plasma metabolite levels predict bird growth rates: A field test of model predictive ability. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21575739
Artacho P et al. Blood biochemistry reveals malnutrition in black-necked swans (Cygnus melanocoryphus) living in a conservation priority area. 2007 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:17158079
Fuglei E et al. Hormones and metabolites of arctic foxes (Alopex lagopus) in response to season, starvation and re-feeding. 2000 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:10936768
Kabara E et al. Adiponectin links adipose tissue function and monocyte inflammatory responses during bovine metabolic stress. 2014 Comp. Immunol. Microbiol. Infect. Dis. pmid:24296305
Tetrick MA et al. Blood D-(-)-3-hydroxybutyrate concentrations after oral administration of trioctanoin, trinonanoin, or tridecanoin to newborn rhesus monkeys (Macaca mulatta). 2010 Comp. Med. pmid:21262136
Tatewaki R et al. Chromosome analysis of blastocysts cultured under the diabetic condition. 2002 Congenit Anom (Kyoto) pmid:12094076
Singh BM et al. Metabolic effects of combined oral contraceptive preparations. 1987 Contraception pmid:3128428
Goldstein L and Perlman DF Renal oxidative metabolism and ammoniagenesis. 1985 Contrib Nephrol pmid:4064690
Halperin ML et al. Ensuring a minimum urine flow rate during water deprivation in chronic fasting. 1997 Contrib Nephrol pmid:9336697
Davies AO and Samuelson WM Nonequilibrium of two redox couplets in human plasma: lactate-pyruvate and beta-hydroxybutyrate-acetoacetate. 1986 Crit. Care Med. pmid:3769505
Davies AO and Samuelson WM Assessing redox status in human plasma: experience in critically ill patients. 1986 Crit. Care Med. pmid:3769506
Beylot M et al. Metabolic effects of a D-beta-hydroxybutyrate infusion in septic patients: inhibition of lipolysis and glucose production but not leucine oxidation. 1994 Crit. Care Med. pmid:8026196
Wang W et al. Pentoxifylline increases gut ketogenesis following trauma and hemorrhagic shock. 1998 Crit. Care Med. pmid:9428550
Yang Q et al. The properties of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) and its applications in tissue engineering. 2014 Curr Stem Cell Res Ther pmid:24524792
Souba WW et al. Gut consumption of intravenously administered fuels. 1984 Nov-Dec Curr Surg pmid:6440741
Sugiyama A et al. Roles of poly(3-hydroxybutyrate) depolymerase and 3HB-oligomer hydrolase in bacterial PHB metabolism. 2004 Curr. Microbiol. pmid:15170237
Mountassif D et al. Structural and catalytic properties of the D-3-hydroxybutyrate dehydrogenase from Pseudomonas aeruginosa. 2010 Curr. Microbiol. pmid:20052585
Manna A et al. Accumulation of poly (3-hydroxybutyric acid) by some soil Streptomyces. 1999 Curr. Microbiol. pmid:10441729
Guyton JR Niacin in cardiovascular prevention: mechanisms, efficacy, and safety. 2007 Curr. Opin. Lipidol. pmid:17620858
Serlenga E et al. Polymorphonuclear cell-mediated phagocytosis and superoxide anion release in insulin-dependent diabetes mellitus. 1993 Cytobios pmid:8404029
Szutowicz A et al. Putative significance of shifts in acetyl-CoA compartmentalization in nerve terminals for disturbances of cholinergic transmission in brain. 1998 Dev. Neurosci. pmid:9778588
McKenna MC et al. Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: differences revealed using aminooxyacetate. 1993 Dev. Neurosci. pmid:7805585
Yager JY et al. Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release. 2002 Dev. Neurosci. pmid:12640175
Bough KJ et al. Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat. 1999 Dev. Neurosci. pmid:10575264
Nehlig A Respective roles of glucose and ketone bodies as substrates for cerebral energy metabolism in the suckling rat. 1996 Dev. Neurosci. pmid:8940615
McBride MO et al. Bedside blood ketone body monitoring. 1991 Aug-Sep Diabet. Med. pmid:1833124
Berrish TS et al. The role of plasma non-esterified fatty acids during exercise in type 2 diabetes mellitus. 1993 Diabet. Med. pmid:8458192
Nord E et al. Assessment of therapy in gestational diabetes by substrate and hormone responses to a standardized test meal. 1997 Diabet. Med. pmid:9371476
Harris S et al. Near patient blood ketone measurements and their utility in predicting diabetic ketoacidosis. 2005 Diabet. Med. pmid:15660743
Bracken RM et al. Impact of pre-exercise rapid-acting insulin reductions on ketogenesis following running in Type 1 diabetes. 2011 Diabet. Med. pmid:21219433
Scott AR et al. Effect of phase of menstrual cycle on insulin sensitivity, peripheral blood flow and cardiovascular responses to hyperinsulinaemia in young women with type 1 diabetes. 1990 Diabet. Med. pmid:2137065
Watts GF and Pillay D Effect of ketones and glucose on the estimation of urinary creatinine: implications for microalbuminuria screening. 1990 Mar-Apr Diabet. Med. pmid:2139401
Laffel LM et al. Sick day management using blood 3-hydroxybutyrate (3-OHB) compared with urine ketone monitoring reduces hospital visits in young people with T1DM: a randomized clinical trial. 2006 Diabet. Med. pmid:16492211
Quin JD et al. The effect of recombinant insulin-like growth factor I on ketone body, lipid and apolipoprotein concentrations and its use to treat ketoacidosis in severe insulin resistance. 1994 Diabet. Med. pmid:7955979
Klocker AA et al. Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. 2013 Diabet. Med. pmid:23330615
Dejgaard A et al. Cardiovascular, metabolic, and hormonal responses to noradrenaline in diabetic patients with autonomic neuropathy. 1996 Diabet. Med. pmid:8946158
Binimelis J et al. Plasma immunoreactive somatostatin is elevated in diabetic ketoacidosis and correlates with plasma non-esterified fatty acid concentration. 1987 May-Jun Diabet. Med. pmid:2886248
Gray RS et al. Reversal of insulin resistance in type 1 diabetes following initiation of insulin treatment. 1986 Diabet. Med. pmid:2951129
Seefeldt T et al. Lack of effects of angiotensin-converting enzyme (ACE)-inhibitors on glucose metabolism in type 1 diabetes. 1990 Sep-Oct Diabet. Med. pmid:2147631
Smith CP et al. A comparison of morning and bed-time ultralente administration when using multiple injections in adolescence. 1988 May-Jun Diabet. Med. pmid:2968885
Shelgikar KM et al. Circulating lipids and cardiovascular risk in newly diagnosed non-insulin-dependent diabetic subjects in India. 1997 Diabet. Med. pmid:9300225
Wallace TM et al. The hospital and home use of a 30-second hand-held blood ketone meter: guidelines for clinical practice. 2001 Diabet. Med. pmid:11553201
Lilet H et al. [Lack of benefit from the intermittent administration of insulin in treatment using subcutaneous perfusion pump in type 1 diabetes]. 1991 May-Jun Diabete Metab pmid:1884881
Kruszynska YT and Home PD Night-time metabolic changes in normal subjects in the absence of the dawn phenomenon. 1988 Jul-Aug Diabete Metab pmid:3066651
Paolisso G et al. Pulsatile rather than continuous glucagon infusion leads to greater metabolic derangements in insulin-dependent diabetic subjects. 1990 Jan-Feb Diabete Metab pmid:2332096
De Feo P et al. Differential effects of insulin-induced hypoglycaemia on the plasma branched-chain and non-branched-chain amino acid concentrations in humans. 1992 Jul-Aug Diabete Metab pmid:1459315
Pernet A et al. Metabolic effects of adrenaline and noradrenaline in man: studies with somatostatin. 1984 Diabete Metab pmid:6146542
Dahlkvist HH et al. Influence of diabetes on oxidation of exogenous substrates in rat aorta. 1981 Diabete Metab pmid:7037491
Pernet A et al. Transient triiodothyronine deficiency. Absence of effect on basal or adrenaline-stimulated carbohydrate and lipid metabolism in man. 1982 Diabete Metab pmid:7047251
Bell PM et al. The effect of starvation on the gastro-entero-pancreatic hormonal and metabolic responses to exercise. (GEP hormones in starvation and exercise). 1984 Diabete Metab pmid:6386559
Krarup T et al. The effect of insulin deprivation on fasting levels of 5000 dalton gastric inhibitory polypeptide in type 1 (insulin-dependent) diabetics. 1985 Diabete Metab pmid:3910488
Schmitz O et al. Angiotensin-converting enzyme in diabetes mellitus dependence on metabolic aberration. 1983 Diabete Metab pmid:6317477
Flatt PR et al. Effects of diet-induced ketosis in rats with hypoglycaemia due to a serially transplantable insulinoma. 1987 Sep-Oct Diabete Metab pmid:2828127
Pontiroli AE et al. Combined therapy with glibenclamide and ultralente insulin in lean patients with NIDDM with secondary failure of sulfonylureas. Follow up at two years. 1990 Jul-Aug Diabete Metab pmid:2125014
Jensen CB et al. Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight. 2002 Diabetes pmid:11916955
Jain SK et al. Hyperketonemia increases tumor necrosis factor-alpha secretion in cultured U937 monocytes and Type 1 diabetic patients and is apparently mediated by oxidative stress and cAMP deficiency. 2002 Diabetes pmid:12086962
Rodriguez NR et al. Effects of acute metabolic acidosis and alkalosis on leucine metabolism in conscious dogs. 1989 Diabetes pmid:2544471
Ostman J et al. Effects of pancreas transplantation on metabolic and hormonal profiles in IDDM patients. 1989 Diabetes pmid:2642863
Jain SK and McVie R Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients. 1999 Diabetes pmid:10480618
Miles JM et al. Failure of infused beta-hydroxybutyrate to decrease proteolysis in man. 1983 Diabetes pmid:6298041
Page KA et al. Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia. 2009 Diabetes pmid:19223595
Maresh M et al. The effect of diet and insulin on metabolic profiles of women with gestational diabetes mellitus. 1985 Diabetes pmid:3888747
Kalkhoff RK Therapeutic results of insulin therapy in gestational diabetes mellitus. 1985 Diabetes pmid:3888749
Bourbon JR et al. Maturation of fetal rat lung in diabetic pregnancies of graduated severity. 1985 Diabetes pmid:3894117
Bottini P et al. Contribution of autonomic neuropathy to reduced plasma adrenaline responses to hypoglycemia in IDDM: evidence for a nonselective defect. 1997 Diabetes pmid:9133549