(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Uremia D014511 33 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Sheep Diseases D012757 10 associated lipids
Stomach Diseases D013272 7 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

Download all related citations
Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Bartelds B et al. Role of ketone bodies in perinatal myocardial energy metabolism. 2001 Biochem. Soc. Trans. pmid:11356176
Jiffri E et al. Altered renal intermediary metabolism and the onset of renal dysfunction in the streptozotocin diabetic rat. 1996 Biochem. Soc. Trans. pmid:8736922
Chung Y and Jue T 1H NMR observation of redox potential in liver. 1992 Biochemistry pmid:1332750
Green D et al. Wild type and mutant human heart (R)-3-hydroxybutyrate dehydrogenase expressed in insect cells. 1996 Biochemistry pmid:8679568
Bahnson BJ and Anderson VE Crotonase-catalyzed beta-elimination is concerted: a double isotope effect study. 1991 Biochemistry pmid:2043630
Tian J et al. Class III polyhydroxybutyrate synthase: involvement in chain termination and reinitiation. 2005 Biochemistry pmid:15938626
Macdonald MJ et al. Studies with leucine, beta-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion. 2008 Jul-Aug Biochim. Biophys. Acta pmid:18439432
Tanaka A et al. Delayed oxidation of intramitochondrial pyridine nucleotide oxidoreduction state as compared with tissue oxygenation in human liver transplantation. 1993 Biochim. Biophys. Acta pmid:8399359
Zhang J et al. NMR-based metabolomics study of canine bladder cancer. 2012 Biochim. Biophys. Acta pmid:22967815
Jocelyn PC and Dickson J Glutathione and the mitochondrial reduction of hydroperoxides. 1980 Biochim. Biophys. Acta pmid:7356992
Ozawa K et al. Linear correlation between acetoacetate/beta-hydroxybutyrate in arterial blood and oxidized flavoprotein/reduced pyridine nucleotide in freeze-trapped human liver tissue. 1992 Biochim. Biophys. Acta pmid:1562619
Boschmann M et al. Interrelation between mitochondrial respiration, substrate supply and redox ratio in perifused permeabilized rat hepatocytes. 1996 Biochim. Biophys. Acta pmid:8616160
Pagani R et al. Identification of a mitochondrial inhibitor of rat liver L-threonine dehydrogenase. 1995 Biochim. Biophys. Acta pmid:7766668
Davies NT et al. Studies on the effects of copper deficiency on rat liver mitochondria. II. Effects on oxidative phosphorylation. 1985 Biochim. Biophys. Acta pmid:2864080
Agius L and Williamson DH The utilization of ketone bodies by the interscapular brown adipose tissue of the rat. 1981 Biochim. Biophys. Acta pmid:6117324
López-Luna P et al. Effect of starvation on lipoprotein lipase activity in different tissues during gestation in the rat. 1994 Biochim. Biophys. Acta pmid:7811711
Hernández-Muñoz R et al. Possible role of cell redox state on collagen metabolism in carbon tetrachloride-induced cirrhosis as evidenced by adenosine administration to rats. 1994 Biochim. Biophys. Acta pmid:8031847
Zhang Z et al. Evaluation of the change of serum copper and zinc concentrations of dairy cows with subclinical ketosis. 2010 Biol Trace Elem Res pmid:20101474
Zhang Z et al. Concentrations of sodium, potassium, magnesium, and iron in the serum of dairy cows with subclinical ketosis. 2011 Biol Trace Elem Res pmid:21739162
Wagner S et al. Carnitine metabolism in isolated rat kidney cortex tubules. 1986 Biol. Chem. Hoppe-Seyler pmid:3954891
Filippi L et al. Redox status in very-low birth-weight newborns. 2004 Biol. Neonate pmid:14707434
Eriksson UJ et al. Mechanisms of congenital malformations in diabetic pregnancy. 1987 Biol. Neonate pmid:3552057
Metzger BE and Freinkel N Accelerated starvation in pregnancy: implications for dietary treatment of obesity and gestational diabetes mellitus. 1987 Biol. Neonate pmid:3552061
Sann L et al. Ketogenesis in hypoglycemic neonates. Carnitine and dicarboxylic acids in neonatal hypoglycemia. 1987 Biol. Neonate pmid:3651517
Crane SC and Morgan BL Brain beta-hydroxybutyrate utilization in neonatal hypothyroidism in rats. 1983 Biol. Neonate pmid:6409170
Murphy P et al. The antidepressant properties of the ketogenic diet. 2004 Biol. Psychiatry pmid:15601609
Laessle RG et al. Cognitive performance in patients with bulimia nervosa: relationship to intermittent starvation. 1990 Biol. Psychiatry pmid:2310808
Laessle RG et al. Depression as a correlate of starvation in patients with eating disorders. 1988 Biol. Psychiatry pmid:3370268
Krieg JC et al. Endocrine, metabolic, and cranial computed tomographic findings in anorexia nervosa. 1988 Biol. Psychiatry pmid:3342267
Kubow S and Koski KG Maternal dietary glucose-lipid interactions modulate embryological development in vivo and in embryo culture. 1995 Biol. Reprod. pmid:7711173
McLean MP et al. Altered ovarian sterol carrier protein expression in the pregnant streptozotocin-treated diabetic rat. 1996 Biol. Reprod. pmid:8793056
Zadworny D et al. Effect of feed and water deprivation or force-feeding on plasma prolactin concentration in turkey hens. 1985 Biol. Reprod. pmid:3986264
Tanadchangsaeng N et al. Identification, biosynthesis, and characterization of polyhydroxyalkanoate copolymer consisting of 3-hydroxybutyrate and 3-hydroxy-4-methylvalerate. 2009 Biomacromolecules pmid:19681605
Wang YW et al. Gelatin blending improves the performance of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) films for biomedical application. 2005 Mar-Apr Biomacromolecules pmid:15762614
Cheng S et al. Influence of DL-beta-hydroxybutyric acid on cell proliferation and calcium influx. 2005 Mar-Apr Biomacromolecules pmid:15762618
Lenz RW and Marchessault RH Bacterial polyesters: biosynthesis, biodegradable plastics and biotechnology. 2005 Jan-Feb Biomacromolecules pmid:15638495
Fukui T et al. Engineering of Ralstonia eutropha for production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from fructose and solid-state properties of the copolymer. 2002 May-Jun Biomacromolecules pmid:12005535
Asrar J et al. Biosynthesis and properties of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) polymers. 2002 Sep-Oct Biomacromolecules pmid:12217047
Feng L et al. Studies on comonomer compositional distribution of bacterial poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)s and thermal characteristics of their factions. 2002 Sep-Oct Biomacromolecules pmid:12217055
Loh XJ et al. New biodegradable thermogelling copolymers having very low gelation concentrations. 2007 Biomacromolecules pmid:17291082
Zhang X et al. Application of (R)-3-hydroxyalkanoate methyl esters derived from microbial polyhydroxyalkanoates as novel biofuels. 2009 Biomacromolecules pmid:19249855
Yamada M et al. Microbial production of lactate-enriched poly[(R)-lactate-co-(R)-3-hydroxybutyrate] with novel thermal properties. 2009 Biomacromolecules pmid:19249863
Matsumoto K et al. Production of short-chain-length/medium-chain-length polyhydroxyalkanoate (PHA) copolymer in the plastid of Arabidopsis thaliana using an engineered 3-ketoacyl-acyl carrier protein synthase III. 2009 Biomacromolecules pmid:19265441
Pietrini M et al. Comparative life cycle studies on poly(3-hydroxybutyrate)-based composites as potential replacement for conventional petrochemical plastics. 2007 Biomacromolecules pmid:17583946
Matsusaki H et al. Biosynthesis and properties of poly(3-hydroxybutyrate-co-3-hydroxyalkanoates) by recombinant strains of Pseudomonas sp. 61-3. 2000 Biomacromolecules pmid:11709837
Hiraishi T et al. Function of the catalytic domain of poly(3-hydroxybutyrate) depolymerase from Pseudomonas stutzeri. 2000 Biomacromolecules pmid:11710119
Scherer TM et al. Enzymatic hydrolysis of oligomeric models of poly-3-hydroxybutyrate. 2000 Biomacromolecules pmid:11710184
Impallomeni G et al. Sequencing microbial copolymers of 3-hydroxybutyric and 3-mercaptoalkanoic acids by NMR, electrospray ionization mass spectrometry, and size exclusion chromatography NMR. 2007 Biomacromolecules pmid:17261066
Lütke-Eversloh T et al. Characterization of microbial polythioesters: physical properties of novel copolymers synthesized by Ralstonia eutropha. 2002 Jan-Feb Biomacromolecules pmid:11866569
Green PR et al. Formation of short chain length/medium chain length polyhydroxyalkanoate copolymers by fatty acid beta-oxidation inhibited Ralstonia eutropha. 2002 Jan-Feb Biomacromolecules pmid:11866575
Ye C et al. PHB/PHBHHx scaffolds and human adipose-derived stem cells for cartilage tissue engineering. 2009 Biomaterials pmid:19481254
Wang Y et al. Evaluation of three-dimensional scaffolds prepared from poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) for growth of allogeneic chondrocytes for cartilage repair in rabbits. 2008 Biomaterials pmid:18406457
Yang M et al. Studies on bone marrow stromal cells affinity of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate). 2004 Mar-Apr Biomaterials pmid:14643611
Zheng Z et al. Effects of crystallization of polyhydroxyalkanoate blend on surface physicochemical properties and interactions with rabbit articular cartilage chondrocytes. 2005 Biomaterials pmid:15621244
Wang YW et al. Effect of composition of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) on growth of fibroblast and osteoblast. 2005 Biomaterials pmid:15350780
Wang YW et al. Evaluation of three-dimensional scaffolds made of blends of hydroxyapatite and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) for bone reconstruction. 2005 Biomaterials pmid:15353201
Wang Z et al. Fabrication of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) microstructures using soft lithography for scaffold applications. 2006 Biomaterials pmid:16364433
Shangguan YY et al. The mechanical properties and in vitro biodegradation and biocompatibility of UV-treated poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). 2006 Biomaterials pmid:16325905
Wang Y et al. The differential effects of aligned electrospun PHBHHx fibers on adipogenic and osteogenic potential of MSCs through the regulation of PPARγ signaling. 2012 Biomaterials pmid:22014456
Piddubnyak V et al. Oligo-3-hydroxybutyrates as potential carriers for drug delivery. 2004 Biomaterials pmid:15110478
Zhou J et al. The use of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tarsal repair in eyelid reconstruction in the rat. 2010 Biomaterials pmid:20663550
Wang YW et al. Attachment, proliferation and differentiation of osteoblasts on random biopolyester poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds. 2004 Biomaterials pmid:14607505
Kunze C et al. In vitro and in vivo studies on blends of isotactic and atactic poly (3-hydroxybutyrate) for development of a dura substitute material. 2006 Biomaterials pmid:16046233
Peng Q et al. A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles. 2012 Biomaterials pmid:22112760
Zhao K et al. Polyhydroxyalkanoate (PHA) scaffolds with good mechanical properties and biocompatibility. 2003 Biomaterials pmid:12504526
Qu XH et al. Enhanced vascular-related cellular affinity on surface modified copolyesters of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx). 2005 Biomaterials pmid:15998539
Deng Y et al. Poly(hydroxybutyrate-co-hydroxyhexanoate) promoted production of extracellular matrix of articular cartilage chondrocytes in vitro. 2003 Biomaterials pmid:12853259
Wang Y et al. MicroRNAs in the regulation of interfacial behaviors of MSCs cultured on microgrooved surface pattern. 2011 Biomaterials pmid:21890196
Zhang J et al. 3-Hydroxybutyrate methyl ester as a potential drug against Alzheimer's disease via mitochondria protection mechanism. 2013 Biomaterials pmid:23849878
Chen Z et al. Block poly(ester-urethane)s based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(3-hydroxyhexanoate-co-3-hydroxyoctanoate). 2009 Biomaterials pmid:19167751
Dai ZW et al. Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as an injectable implant system for prevention of post-surgical tissue adhesion. 2009 Biomaterials pmid:19269028
Sun J et al. In vitro effect of oligo-hydroxyalkanoates on the growth of mouse fibroblast cell line L929. 2007 Biomaterials pmid:17574664
Bian YZ et al. Evaluation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) conduits for peripheral nerve regeneration. 2009 Biomaterials pmid:18849069
Xiao XQ et al. The effect of 3-hydroxybutyrate and its derivatives on the growth of glial cells. 2007 Biomaterials pmid:17532039
Qu XH et al. In vivo studies of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) based polymers: biodegradation and tissue reactions. 2006 Biomaterials pmid:16542719
Cheng S et al. The effect of D,L-beta-hydroxybutyric acid on cell death and proliferation in L929 cells. 2006 Biomaterials pmid:16549197
Webb WR et al. The application of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tendon repair in the rat model. 2013 Biomaterials pmid:23768899
Fan MR et al. Tissue engineered esophagus scaffold constructed with porcine small intestinal submucosa and synthetic polymers. 2014 Biomed Mater pmid:24457267
García-García JM et al. Novel poly(hydroxyalkanoates)-based composites containing Bioglass® and calcium sulfate for bone tissue engineering. 2012 Biomed Mater pmid:22972204
Etzrodt D et al. [Effect of molecular weight and protein coating of surface properties of poly(beta-hydroxybutyric acid) and the effect on polymer-cell interaction]. 1997 Biomed Tech (Berl) pmid:9517229
Pohl K et al. Lactate and ornithine improve substrate hydrogen supply in isolated hepatocytes. 1990 Biomed. Biochim. Acta pmid:2360907
Schönfeld P et al. Influence of the beta-hydroxybutyrate/acetoacetate ratio on the redox states of mitochondrial NAD(P) and cytochrome c systems, extramitochondrial ATP/ADP ratio and the respiration of isolated liver mitochondria in the resting state. 1983 Biomed. Biochim. Acta pmid:6309158
Krinelke L and Kunz WS [Characterization of surface fluorescence signals of isolated perfused rat kidney]. 1990 Biomed. Biochim. Acta pmid:2094217
Fukushima T et al. Simultaneous determination of D-lactic acid and 3-hydroxybutyric acid in rat plasma using a column-switching HPLC with fluorescent derivatization with 4-nitro-7-piperazino-2,1,3-benzoxadiazole (NBD-PZ). 2001 Biomed. Chromatogr. pmid:11391675
Chen CM et al. Construction of a light-emitting diode fluorescence detector for high-performance liquid chromatography and its application to fluorometric determination of L-3-hydroxybutyrate. 2012 Biomed. Chromatogr. pmid:21594881
Mamer OA Measurement of urinary lactic, 3-hydroxybutyric, pyruvic and acetoacetic acids in a single analysis using selected ion monitoring and stable isotope labelling techniques. 1988 Biomed. Environ. Mass Spectrom. pmid:3349207
Lau DT et al. The effect of the fat content of food on the pharmacokinetics and pharmacodynamics of SDZ FOX 988, an antidiabetic agent, in the dog. 1995 Biopharm Drug Dispos pmid:7780047
Volova TG et al. Cell growth and accumulation of polyhydroxyalkanoates from CO2 and H2 of a hydrogen-oxidizing bacterium, Cupriavidus eutrophus B-10646. 2013 Bioresour. Technol. pmid:23934338
Koller M et al. Polyhydroxyalkanoate production from whey by Pseudomonas hydrogenovora. 2008 Bioresour. Technol. pmid:18053709
Nath A et al. Enhanced PHB production and scale up studies using cheese whey in fed batch culture of Methylobacterium sp. ZP24. 2008 Bioresour. Technol. pmid:18032031
Pradella JG et al. High-cell-density poly (3-hydroxybutyrate) production from sucrose using Burkholderia sacchari culture in airlift bioreactor. 2010 Bioresour. Technol. pmid:20580221
Gözke G et al. Electrofiltration as a purification strategy for microbial poly-(3-hydroxybutyrate). 2012 Bioresour. Technol. pmid:22940329
Liu F et al. Metabolic engineering of Aeromonas hydrophila 4AK4 for production of copolymers of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoate. 2011 Bioresour. Technol. pmid:21680176
Ugwu CU et al. Production of (R)-3-hydroxybutyric acid by fermentation and bioconversion processes with Azohydromonas lata. 2011 Bioresour. Technol. pmid:21507620
Kawata Y et al. Efficient secretion of (R)-3-hydroxybutyric acid from Halomonas sp. KM-1 cultured with saccharified Japanese cedar under microaerobic conditions. 2013 Bioresour. Technol. pmid:23719194
Sun J et al. Production of P(3-hydroxybutyrate-co-3-hydroxyhexanoate-co-3-hydroxyoctanoate) terpolymers using a chimeric PHA synthase in recombinant Ralstonia eutropha and Pseudomonas putida. 2010 Biosci. Biotechnol. Biochem. pmid:20699558
Shozui F et al. A new beneficial mutation in pseudomonas sp. 61-3 polyhydroxyalkanoate (PHA) synthase for enhanced cellular content of 3-hydroxybutyrate-based PHA explored using its enzyme homolog as a mutation template. 2010 Biosci. Biotechnol. Biochem. pmid:20699564
Ide T Enzymatic-HPLC method to analyze D-3-hydroxybutyric acid in rat serum. 2010 Biosci. Biotechnol. Biochem. pmid:20699574
Vilaró S et al. Chronic and acute ethanol impair the in vivo glucose uptake by lactating rat mammary gland. 1987 Biosci. Rep. pmid:3447639
Kümmel L Possible interrelationship between gluconeogenesis and ketogenesis in the liver. 1983 Biosci. Rep. pmid:6626706