(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Congenital Hyperinsulinism D044903 1 associated lipids
Spinal Muscular Atrophies of Childhood D014897 1 associated lipids
Status Epilepticus D013226 1 associated lipids
Pancreatitis, Chronic D050500 1 associated lipids
Aortopulmonary Septal Defect D001028 1 associated lipids
Septo-Optic Dysplasia D025962 1 associated lipids
Lipoma D008067 1 associated lipids
Azotemia D053099 1 associated lipids
Fructose-1,6-Diphosphatase Deficiency D015319 1 associated lipids
Lethargy D053609 1 associated lipids
Forearm Injuries D005543 1 associated lipids
Median Neuropathy D020423 1 associated lipids
Heredodegenerative Disorders, Nervous System D020271 1 associated lipids
Ulnar Neuropathies D020424 1 associated lipids
Adenocarcinoma, Clear Cell D018262 1 associated lipids
Lacrimal Apparatus Diseases D007766 1 associated lipids
Pallor D010167 1 associated lipids
Basal Ganglia Cerebrovascular Disease D020144 1 associated lipids
Wrist Injuries D014954 1 associated lipids
Heart Septal Defects D006343 2 associated lipids
Sandhoff Disease D012497 2 associated lipids
Epilepsy, Generalized D004829 2 associated lipids
Kearns-Sayre Syndrome D007625 2 associated lipids
Intracranial Hemorrhages D020300 2 associated lipids
Cardiac Output, Low D002303 2 associated lipids
Cysticercosis D003551 2 associated lipids
Glycogen Storage Disease Type III D006010 2 associated lipids
Multiple Endocrine Neoplasia Type 1 D018761 2 associated lipids
Insulin Coma D007331 2 associated lipids
Encephalopathy, Bovine Spongiform D016643 2 associated lipids
Short Bowel Syndrome D012778 3 associated lipids
Mastitis D008413 3 associated lipids
Exostoses, Multiple Hereditary D005097 3 associated lipids
Placenta, Retained D018457 3 associated lipids
Dystocia D004420 3 associated lipids
Thyrotoxicosis D013971 3 associated lipids
Dwarfism, Pituitary D004393 3 associated lipids
Alkalosis D000471 3 associated lipids
Lipid Metabolism Disorders D052439 3 associated lipids
Fetal Macrosomia D005320 3 associated lipids
Acid-Base Imbalance D000137 3 associated lipids
HIV Wasting Syndrome D019247 3 associated lipids
Pyruvate Dehydrogenase Complex Deficiency Disease D015325 3 associated lipids
Hepatitis, Chronic D006521 3 associated lipids
Bulimia D002032 3 associated lipids
Spasms, Infantile D013036 3 associated lipids
Fascioliasis D005211 3 associated lipids
Pyruvate Metabolism, Inborn Errors D015323 3 associated lipids
Hepatitis, Viral, Human D006525 3 associated lipids
Alkalosis, Respiratory D000472 4 associated lipids
Jaundice D007565 4 associated lipids
Glycogen Storage Disease Type I D005953 4 associated lipids
Gastroenteritis D005759 4 associated lipids
Syndrome D013577 4 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Hyperglycemic Hyperosmolar Nonketotic Coma D006944 4 associated lipids
Muscle Rigidity D009127 4 associated lipids
Puerperal Disorders D011644 4 associated lipids
Glycogen Storage Disease D006008 4 associated lipids
Neural Tube Defects D009436 5 associated lipids
Abortion, Veterinary D000034 5 associated lipids
Asphyxia D001237 5 associated lipids
Hyperandrogenism D017588 5 associated lipids
Hyponatremia D007010 5 associated lipids
Vibrio Infections D014735 5 associated lipids
Trypanosomiasis, African D014353 5 associated lipids
Epilepsy, Reflex D020195 5 associated lipids
Liver Failure D017093 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Plant Poisoning D010939 5 associated lipids
Sleep Deprivation D012892 5 associated lipids
Malnutrition D044342 6 associated lipids
Intestinal Diseases D007410 6 associated lipids
Uterine Diseases D014591 6 associated lipids
Endometritis D004716 6 associated lipids
Placental Insufficiency D010927 6 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Acromegaly D000172 6 associated lipids
Lipidoses D008064 7 associated lipids
Trichostrongyloidiasis D014252 7 associated lipids
Hypopituitarism D007018 7 associated lipids
Stomach Diseases D013272 7 associated lipids
Genomic Instability D042822 7 associated lipids
Trematode Infections D014201 8 associated lipids
Anorexia D000855 8 associated lipids
Irritable Bowel Syndrome D043183 8 associated lipids
Mastitis, Bovine D008414 8 associated lipids
Obesity, Morbid D009767 8 associated lipids
Diabetes, Gestational D016640 8 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Sheep Diseases D012757 10 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Fatigue D005221 10 associated lipids
Glycosuria D006029 10 associated lipids
Lung Diseases, Obstructive D008173 10 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Dehydration D003681 11 associated lipids
Thinness D013851 11 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

Download all related citations
Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Yokoo H et al. Distinct effects of ketone bodies on down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation in adrenal chromaffin cells. 2003 J. Pharmacol. Exp. Ther. pmid:12604674
Vanelli M et al. Cost effectiveness of the direct measurement of 3-beta-hydroxybutyrate in the management of diabetic ketoacidosis in children. 2003 Diabetes Care pmid:12610078
Bélanger P et al. Effects of inducing physiological hyperglucagonemia on metabolic responses to exercise. 2003 Eur. J. Appl. Physiol. pmid:12627299
Sukdeo N and Charles TC Application of crossover-PCR-mediated deletion-insertion mutagenesis to analysis of the bdhA-xdhA2-xdhB2 mixed-function operon of Sinorhizobium meliloti. 2003 Arch. Microbiol. pmid:12632261
Cremin JD et al. Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12637251
Yager JY et al. Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release. 2002 Dev. Neurosci. pmid:12640175
Brown NW et al. Evidence for metabolic and endocrine abnormalities in subjects recovered from anorexia nervosa. 2003 Metab. Clin. Exp. pmid:12647266
Tedeschi L et al. Endogenous gamma-hydroxybutyric acid is in the rat, mouse and human gastrointestinal tract. 2003 Life Sci. pmid:12650856
Krähenbühl L et al. Reduced hepatic glycogen stores in patients with liver cirrhosis. 2003 Liver Int. pmid:12654132
Fraser DD et al. Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet. 2003 Neurology pmid:12654976
Guerci B et al. Accuracy of an electrochemical sensor for measuring capillary blood ketones by fingerstick samples during metabolic deterioration after continuous subcutaneous insulin infusion interruption in type 1 diabetic patients. 2003 Diabetes Care pmid:12663586
Nielsen NI et al. Diurnal variation and the effect of feed restriction on plasma and milk metabolites in TMR-fed dairy cows. 2003 J Vet Med A Physiol Pathol Clin Med pmid:12667199
Bazaes RA et al. Glucose and lipid metabolism in small for gestational age infants at 48 hours of age. 2003 Pediatrics pmid:12671116
Lu X et al. Enhanced production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) via manipulating the fatty acid beta-oxidation pathway in E. coli. 2003 FEMS Microbiol. Lett. pmid:12694916
Pires CK et al. An automatic flow procedure for the determination of 3-hydroxybutyrate in animal serum and plasma. 2003 J. Agric. Food Chem. pmid:12696920
Holtenius K et al. Effects of feeding intensity during the dry period. 2. Metabolic and hormonal responses. 2003 J. Dairy Sci. pmid:12703625
Hussain K et al. Exogenous administered DL- sodium beta-hydroxybutyrate (beta-OHB) can cross the blood brain barrier. 2003 Pediatr. Res. pmid:12715792
Kamphuis MM et al. Diacylglycerols affect substrate oxidation and appetite in humans. 2003 Am. J. Clin. Nutr. pmid:12716663
Van Hove JL et al. D,L-3-hydroxybutyrate treatment of multiple acyl-CoA dehydrogenase deficiency (MADD). 2003 Lancet pmid:12727399
Duffield TF et al. Effect of a monensin controlled release capsule on metabolic parameters in transition dairy cows. 2003 J. Dairy Sci. pmid:12741541
Reynolds CK et al. Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation. 2003 J. Dairy Sci. pmid:12741545
Van Winden SC et al. Feed intake, milk yield, and metabolic parameters prior to left displaced abomasum in dairy cows. 2003 J. Dairy Sci. pmid:12741571
Eagles DA et al. Calorie restriction of a high-carbohydrate diet elevates the threshold of PTZ-induced seizures to values equal to those seen with a ketogenic diet. 2003 Epilepsy Res. pmid:12742595
Hallebeek JM and Beynen AC Influence of dietary beetpulp on the plasma level of triacylglycerols in horses. 2003 J Anim Physiol Anim Nutr (Berl) pmid:12752823
Raja G et al. Repeated bouts of high-intensity exercise and muscle glycogen sparing in the rat. 2003 J. Exp. Biol. pmid:12771165
Wang X et al. Nutritional regulation of white adipocyte vascular endothelial growth factor (VEGF). 2003 Horm. Metab. Res. pmid:12778363
Reist M et al. Concentrate feeding strategy in lactating dairy cows: metabolic and endocrine changes with emphasis on leptin. 2003 J. Dairy Sci. pmid:12778580
Cahill GF and Veech RL Ketoacids? Good medicine? 2003 Trans. Am. Clin. Climatol. Assoc. pmid:12813917
Tugnoli V et al. Magnetic resonance spectroscopy and high performance liquid chromatography of neoplastic human renal tissues. 2003 Mar-Apr Anticancer Res. pmid:12820421
Pettinari JM et al. Insertion sequence-like elements associated with putative polyhydroxybutyrate regulatory genes in Azotobacter sp. FA8. 2003 Plasmid pmid:12826056
Schlumbohm C and Harmeyer J Hypocalcemia reduces endogenous glucose production in hyperketonemic sheep. 2003 J. Dairy Sci. pmid:12836930
Bobe G et al. Metabolic responses of lactating dairy cows to single and multiple subcutaneous injections of glucagon. 2003 J. Dairy Sci. pmid:12836943
Majee DN et al. Lactation performance by dairy cows fed supplemental biotin and a B-vitamin blend. 2003 J. Dairy Sci. pmid:12836947
Pickett MM et al. Effects of propylene glycol or fat drench on plasma metabolites, liver composition, and production of dairy cows during the periparturient period. 2003 J. Dairy Sci. pmid:12836948
Tsai YC et al. Identification of L-3-hydroxybutyrate as an original ketone body in rat serum by column-switching high-performance liquid chromatography and fluorescence derivatization. 2003 Anal. Biochem. pmid:12842104
Richards JG et al. Exercise and recovery metabolism in the Pacific spiny dogfish (Squalus acanthias). 2003 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:12851779
Deng Y et al. Poly(hydroxybutyrate-co-hydroxyhexanoate) promoted production of extracellular matrix of articular cartilage chondrocytes in vitro. 2003 Biomaterials pmid:12853259
Alimova A et al. Native fluorescence and excitation spectroscopic changes in Bacillus subtilis and Staphylococcus aureus bacteria subjected to conditions of starvation. 2003 Appl Opt pmid:12868850
Athanassakis I et al. Early events of the exogenously provided L-Carnitine in murine macrophages, T- and B-lymphocytes: modulation of prostaglandin E1 and E2 production in response to arachidonic acid. 2003 J. Nutr. Biochem. pmid:12873717
Carragher FM et al. Pitfalls in the measurement of some intermediary metabolites. 2003 Ann. Clin. Biochem. pmid:12880533
Wright GL et al. Effect of fasting on vascular contractility in lean and obese Zucker rats. 2003 Clin Nutr pmid:12880602
Courtney CH et al. Comparison of the priming effects of pulsatile and continuous insulin delivery on insulin action in man. 2003 Metab. Clin. Exp. pmid:12898472
Linke A et al. Shift in metabolic substrate uptake by the heart during development of alloxan-induced diabetes. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12915387
Halkes CJ et al. Gender differences in postprandial ketone bodies in normolipidemic subjects and in untreated patients with familial combined hyperlipidemia. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12933534
Bordin D et al. Effect of middle-intensity exercise on carnitine and beta-hydroxybutyrate plasmatic concentration in men and women. 1992 J Sports Med Phys Fitness pmid:1293423
Nybo L et al. Association between fatigue and failure to preserve cerebral energy turnover during prolonged exercise. 2003 Acta Physiol. Scand. pmid:12940940
Yokoyama H et al. Transient extreme insulin resistance in shock during diabetic ketoacidosis. 1992 Endocrinol. Jpn. pmid:1294375
Zaidi SS and Bhatnagar VK Spectral evidence for the oxidation of beta-hydroxybutyrate to acetoacetate: diminution of spectra by glucose and chloride. 1992 Indian J. Biochem. Biophys. pmid:1294466
Kiba N et al. Simultaneous determination of D-glucose and 3-hydroxybutyrate by chemiluminescence detection with immobilized enzymes in a flow injection system. 2003 Anal Sci pmid:12945679
Koustova E et al. Ketone and pyruvate Ringer's solutions decrease pulmonary apoptosis in a rat model of severe hemorrhagic shock and resuscitation. 2003 Surgery pmid:12947328
Nishina H et al. Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep. 2003 J. Physiol. (Lond.) pmid:12949230
Puchowicz MA et al. Single-pass dual-label indicator method. Blood-to-brain transport of glucose and short-chain monocarboxylic acids. 2003 Methods Mol. Med. pmid:12958426
Weksler-Zangen S et al. Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions. 2003 Birth Defects Res. Part A Clin. Mol. Teratol. pmid:12962287
Windisch W and Kirchgessner M [Concentrations of metabolites and hormones in the blood plasma of lactating dairy cows during treatment with recombinant bovine somatotropin (BST)]. 1992 Arch Tierernahr pmid:1296558
Stanley WC et al. beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12969881
Tieu K et al. D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. 2003 J. Clin. Invest. pmid:12975474
Yang N and Jiang Z [The kinetic observation of serum ketone body levels in surgical patients receiving MCT or LCT emulsions]. 1992 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:1303814
Ikeda T et al. Adrenergic mechanism in hyperketonemia in thyrotoxic and starved rats. 1992 Exp. Clin. Endocrinol. pmid:1305070
Johnson AB et al. Effect of increased free fatty acid supply on glucose metabolism and skeletal muscle glycogen synthase activity in normal man. 1992 Clin. Sci. pmid:1311661
Santini FJ et al. Dietary fiber and milk yield, mastication, digestion, and the rate of passage in goats fed alfalfa hay. 1992 J. Dairy Sci. pmid:1311727
Beaufrère B et al. Effects of D-beta-hydroxybutyrate and long- and medium-chain triglycerides on leucine metabolism in humans. 1992 Am. J. Physiol. pmid:1312786
Erickson PS et al. Supplementation of dairy cow diets with calcium salts of long-chain fatty acids and nicotinic acid in early lactation. 1992 J. Dairy Sci. pmid:1315811
Kennedy CH et al. tert-Butyl hydroperoxide-induced radical production in rat liver mitochondria. 1992 Free Radic. Biol. Med. pmid:1317326
Fulcher GR et al. Acute metabolic and hormonal responses to the inhibition of lipolysis in non-obese patients with non-insulin-dependent (type 2) diabetes mellitus: effects of acipimox. 1992 Clin. Sci. pmid:1317767
Sato N et al. Mechanism of inhibitory action of ketone bodies on the production of reactive oxygen intermediates (ROIS) by polymorphonuclear leukocytes. 1992 Life Sci. pmid:1319534
Turcotte LP et al. Increased plasma FFA uptake and oxidation during prolonged exercise in trained vs. untrained humans. 1992 Am. J. Physiol. pmid:1319676
deRoos R and deRoos CC Effects of mammalian ACTH on potential fuels and gluconeogenic substrates in the plasma of the spiny dogfish shark (Squalus acanthias). 1992 Gen. Comp. Endocrinol. pmid:1320581
Zimmerman CA et al. Influence of dietary protein and supplemental niacin on lactational performance of cows fed normal and low fiber diets. 1992 J. Dairy Sci. pmid:1323586
Chung Y and Jue T 1H NMR observation of redox potential in liver. 1992 Biochemistry pmid:1332750
Kruszynska YT et al. Twenty-four hour C-peptide and insulin secretion rates and diurnal profiles of glucose, lipids and intermediary metabolites in cirrhosis. 1992 Clin. Sci. pmid:1335398
Ferré P et al. Hypoglycemic effects of a beta-agonist, Ro 16-8714, in streptozotocin-diabetic rats: decreased hepatic glucose production and increased glucose utilization in oxidative muscles. 1992 Metab. Clin. Exp. pmid:1346545
Heindorff H et al. Hormonal and neural blockade prevents the postoperative increase in amino acid clearance and urea synthesis. 1992 Surgery pmid:1350868
Takada Y et al. Decrease in arterial ketone body ratio indicating graft dysfunction after liver transplantation. 1992 Eur J Surg pmid:1354500
Luzi L et al. Lack of feedback inhibition of insulin secretion in denervated human pancreas. 1992 Diabetes pmid:1359986
Fujii Y et al. 1H-NMR spectroscopy of serum in SHN mice with and without spontaneous mammary tumours. 1992 May-Jun In Vivo pmid:1391696
Hamanoue M et al. A correlation between arterial ketone body ratio and concentration of beta-hydroxybutyrate as an indicator of hepatic functional reserve. 1992 Surg. Today pmid:1392328
Memon RA et al. In vivo effects of interferon-alpha and interferon-gamma on lipolysis and ketogenesis. 1992 Endocrinology pmid:1396316
Fulcher GR et al. Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects. 1992 Diabetes pmid:1397716
McCarthy JP et al. Changes in the plasma concentration of gastric inhibitory polypeptide and other metabolites in response to feeding in sheep. 1992 J. Endocrinol. pmid:1402533
Alonso de la Torre SR et al. Carrier-mediated beta-D-hydroxybutyrate transport in brush-border membrane vesicles from rat placenta. 1992 Pediatr. Res. pmid:1408469
Knights KM and Drew R The effects of ibuprofen enantiomers on hepatocyte intermediary metabolism and mitochondrial respiration. 1992 Biochem. Pharmacol. pmid:1417953
Chan SP et al. Abnormalities of intermediary metabolism following a gestational diabetic pregnancy. 1992 Clin. Endocrinol. (Oxf) pmid:1424175
Briffeuil P et al. Reappraisal of the role of insulin on sodium handling by the kidney: f1fect of intrarenal insulin infusion in the dog. 1992 Eur. J. Clin. Invest. pmid:1425858
Pries A et al. Identification of a lipoamide dehydrogenase gene as second locus affected in poly(3-hydroxybutyric acid)-leaky mutants of Alcaligenes eutrophus. 1992 FEMS Microbiol. Lett. pmid:1427012
McGarry JD What if Minkowski had been ageusic? An alternative angle on diabetes. 1992 Science pmid:1439783
Bijlsma JG and Counotte GH [The effect of feeding mangel-wurzels on blood beta-hydroxybutyrate level of milk-producing cows]. 1992 Tijdschr Diergeneeskd pmid:1440545
Leonard F et al. Possible effect of pH on the survival of leptospires in cattle urine. 1992 Vet. Rec. pmid:1441163
Montelongo A et al. Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women. 1992 Diabetes pmid:1446807
Donevan SD et al. Voltage-dependent block of N-methyl-D-aspartate receptors by the novel anticonvulsant dibenzylamine, a bioactive constituent of L-(+)-beta-hydroxybutyrate. 2003 Epilepsia pmid:14510820
Jánosi S et al. Energy imbalance related predisposition to mastitis in group-fed high-producing postpartum dairy cows. 2003 Acta Vet. Hung. pmid:14516167
Seyfried TN et al. Role of glucose and ketone bodies in the metabolic control of experimental brain cancer. 2003 Br. J. Cancer pmid:14520474
Oshida Y et al. Effect of muscle constriction on 3-hydroxybutyrate uptake using the microdialysis technique. 1992 Horm. Metab. Res. pmid:1452121
Vannucci SJ and Simpson IA Developmental switch in brain nutrient transporter expression in the rat. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:14534079
Adamus G et al. Electrospray ion-trap multistage mass spectrometry for characterisation of co-monomer compositional distribution of bacterial poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) at the molecular level. 2003 Rapid Commun. Mass Spectrom. pmid:14558123
Lust WD et al. Changing metabolic and energy profiles in fetal, neonatal, and adult rat brain. 2003 Metab Brain Dis pmid:14567470
Olson DE et al. Glucose-responsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats. 2003 Hum. Gene Ther. pmid:14577921
Nakamura S et al. Protective effect of D-beta-hydroxybutyrate on corneal epithelia in dry eye conditions through suppression of apoptosis. 2003 Invest. Ophthalmol. Vis. Sci. pmid:14578386
De Feo P et al. Differential effects of insulin-induced hypoglycaemia on the plasma branched-chain and non-branched-chain amino acid concentrations in humans. 1992 Jul-Aug Diabete Metab pmid:1459315
Bernal-Santos G et al. Production responses of dairy cows to dietary supplementation with conjugated linoleic acid (CLA) during the transition period and early lactation. 2003 J. Dairy Sci. pmid:14594242
Wang YW et al. Attachment, proliferation and differentiation of osteoblasts on random biopolyester poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds. 2004 Biomaterials pmid:14607505