(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Uremia D014511 33 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Sheep Diseases D012757 10 associated lipids
Stomach Diseases D013272 7 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hyperglycemia D006943 21 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Reperfusion Injury D015427 65 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Ketosis D007662 13 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Intestinal Diseases D007410 6 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Coronary Disease D003327 70 associated lipids
Liver Diseases D008107 31 associated lipids
Corneal Diseases D003316 13 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Brain Neoplasms D001932 15 associated lipids
Hypothyroidism D007037 32 associated lipids
Uterine Diseases D014591 6 associated lipids
Weight Gain D015430 101 associated lipids
Acidosis D000138 13 associated lipids
Glioma D005910 112 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Obesity D009765 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Cholestasis D002779 23 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Hypoglycemia D007003 13 associated lipids
Metabolic Diseases D008659 12 associated lipids
Starvation D013217 47 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Hypocalcemia D006996 12 associated lipids
Brain Ischemia D002545 89 associated lipids
Dwarfism, Pituitary D004393 3 associated lipids
Glycosuria D006029 10 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Birth Weight D001724 23 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Alkalosis D000471 3 associated lipids
Vomiting D014839 21 associated lipids
Shock D012769 11 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Hepatitis, Chronic D006521 3 associated lipids
Hyperlipidemias D006949 73 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Death, Sudden D003645 12 associated lipids
Acid-Base Imbalance D000137 3 associated lipids
Lung Diseases, Obstructive D008173 10 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Cachexia D002100 21 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Jaundice D007565 4 associated lipids
Reye Syndrome D012202 14 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Albuminuria D000419 18 associated lipids
Hyperinsulinism D006946 27 associated lipids
Plant Poisoning D010939 5 associated lipids
Acromegaly D000172 6 associated lipids
Trematode Infections D014201 8 associated lipids
Trichostrongyloidiasis D014252 7 associated lipids
Parkinson Disease D010300 53 associated lipids
Mastitis, Bovine D008414 8 associated lipids
Congenital Abnormalities D000013 11 associated lipids
Placental Insufficiency D010927 6 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Neural Tube Defects D009436 5 associated lipids
Asphyxia D001237 5 associated lipids
Lipidoses D008064 7 associated lipids
Hypopituitarism D007018 7 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Amyotrophic Lateral Sclerosis D000690 11 associated lipids
Diabetes, Gestational D016640 8 associated lipids
Malnutrition D044342 6 associated lipids
Insulin Resistance D007333 99 associated lipids
Dehydration D003681 11 associated lipids
Fatigue D005221 10 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

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Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Porter WH et al. Laboratory and clinical evaluation of assays for beta-hydroxybutyrate. 1997 Am. J. Clin. Pathol. pmid:9052387
Custer EM et al. The storage stability of 3-hydroxybutyrate in serum, plasma, and whole blood. 1983 Am. J. Clin. Pathol. pmid:6410906
Eckfeldt JH et al. Error in calibration. 1984 Am. J. Clin. Pathol. pmid:6695863
Wolfsdorf JI et al. Ketonuria does not exclude hyperinsulinemic hypoglycemia. 1984 Am. J. Dis. Child. pmid:6364785
Fulop M et al. Plasma lactate and 3-hydroxybutyrate levels in patients with acute ethanol intoxication. 1986 Am. J. Med. pmid:3080879
Umpierrez GE et al. Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis. 2004 Am. J. Med. pmid:15336577
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Watts NB and DiGirolamo M Carbohydrate tolerance improves with fasting in obese subjects with noninsulin-dependent (type II) diabetes. 1990 Am. J. Med. Sci. pmid:2181873
Davies AO Effects of endogenous redox-active compounds on coupling of human beta 2-adrenergic receptors. 1986 Am. J. Med. Sci. pmid:3022589
Oster JR and Epstein M Acid-base aspects of ketoacidosis. 1984 Am. J. Nephrol. pmid:6430087
Miodovnik M et al. Cardiovascular and biochemical effects of infusion of beta hydroxybutyrate into the fetal lamb. 1982 Am. J. Obstet. Gynecol. pmid:7137244
Seeds AE et al. Comparison of human and sheep chorion laeve permeability to glucose, beta-hydroxybutyrate, and glycerol. 1980 Am. J. Obstet. Gynecol. pmid:7435525
Hertz RH et al. Management of third-trimester diabetic pregnancies with the use of continuous subcutaneous insulin infusion therapy: a pilot study. 1984 Am. J. Obstet. Gynecol. pmid:6731504
Miodovnik M et al. Effect of maternal ketoacidemia on the pregnant ewe and the fetus. 1982 Am. J. Obstet. Gynecol. pmid:6814255
Harding JE et al. Effects of beta-hydroxybutyrate infusion on hind limb metabolism in fetal sheep. 1992 Am. J. Obstet. Gynecol. pmid:1536251
Sacks DA et al. When is fasting really fasting? The influence of time of day, interval after a meal, and maternal body mass on maternal glycemia in gestational diabetes. 1999 Am. J. Obstet. Gynecol. pmid:10521751
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Goldstein RE et al. Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism. 1993 Am. J. Physiol. pmid:8430780
Robin JP et al. Behavioral changes in fasting emperor penguins: evidence for a "refeeding signal" linked to a metabolic shift. 1998 Am. J. Physiol. pmid:9530242
Pere MC et al. Hepatic metabolism during fasting-refeeding transition in conscious pregnant rabbits. 1992 Am. J. Physiol. pmid:1616023
Shambaugh GE and Koehler RA Fetal fuels. IV. Regulation of branched-chain amino and keto acid metabolism in fetal brain. 1981 Am. J. Physiol. pmid:7282922
Vanoverschelde JL et al. Competition between palmitate and ketone bodies as fuels for the heart: study with positron emission tomography. 1993 Am. J. Physiol. pmid:8456973
Shi ZQ et al. Effects of subbasal insulin infusion on resting and exercise-induced glucose turnover in depancreatized dogs. 1993 Am. J. Physiol. pmid:8460681
Ferrier B et al. Transport of beta-hydroxybutyrate and acetoacetate along rat nephrons: a micropuncture study. 1992 Am. J. Physiol. pmid:1590421
Bougneres PF and Ferre P Study of ketone body kinetics in children by a combined perfusion of 13C and 2H3 tracers. 1987 Am. J. Physiol. pmid:3688221
Cobelli C et al. Models to interpret kinetic data in stable isotope tracer studies. 1987 Am. J. Physiol. pmid:3688225
Ferrannini E et al. Metabolic and hemodynamic effects of insulin on human hearts. 1993 Am. J. Physiol. pmid:8447398
Marker JC et al. Catecholamines in prevention of hypoglycemia during exercise in humans. 1991 Am. J. Physiol. pmid:1674642
Cherel Y and Le Maho Y Five months of fasting in king penguin chicks: body mass loss and fuel metabolism. 1985 Am. J. Physiol. pmid:4051024
Sindelar DK et al. Interaction of equal increments in arterial and portal vein insulin on hepatic glucose production in the dog. 1997 Am. J. Physiol. pmid:9374684
Swithers SE Development of independent ingestive responding to blockade of fatty acid oxidation in rats. 1997 Am. J. Physiol. pmid:9374805
Blomqvist G et al. Use of R-beta-[1-11C]hydroxybutyrate in PET studies of regional cerebral uptake of ketone bodies in humans. 1995 Am. J. Physiol. pmid:7491948
Fery F et al. Mechanisms of starvation diabetes: a study with double tracer and indirect calorimetry. 1990 Am. J. Physiol. pmid:2260646
Stallknecht B et al. Effect of training on epinephrine-stimulated lipolysis determined by microdialysis in human adipose tissue. 1995 Am. J. Physiol. pmid:8572197
Rössle C et al. Medium-chain triglycerides induce alterations in carnitine metabolism. 1990 Am. J. Physiol. pmid:2360627
Hildebrandt LA et al. Utilization and preferred metabolic pathway of ketone bodies for lipid synthesis by isolated rat hepatoma cells. 1995 Am. J. Physiol. pmid:7631749
Ciraolo ST et al. Model of extreme hypoglycemia in dogs made ketotic with (R,S)-1,3-butanediol acetoacetate esters. 1995 Am. J. Physiol. pmid:7631780
Scharrer E and Langhans W Control of food intake by fatty acid oxidation. 1986 Am. J. Physiol. pmid:3717372
Goodwin GW and Taegtmeyer H Metabolic recovery of isolated working rat heart after brief global ischemia. 1994 Am. J. Physiol. pmid:8067397
Beaufrère B et al. Effects of D-beta-hydroxybutyrate and long- and medium-chain triglycerides on leucine metabolism in humans. 1992 Am. J. Physiol. pmid:1312786
Fafournoux P et al. Mechanisms involved in ketone body release by rat liver cells: influence of pH and bicarbonate. 1987 Am. J. Physiol. pmid:3826348
Turcotte LP et al. Increased plasma FFA uptake and oxidation during prolonged exercise in trained vs. untrained humans. 1992 Am. J. Physiol. pmid:1319676
Tildon JT and Roeder LM Transport of 3-hydroxy[3-14C]butyrate by dissociated cells from rat brain. 1988 Am. J. Physiol. pmid:3407758
Avogaro A et al. Epinephrine's ketogenic effect in humans is mediated principally by lipolysis. 1992 Am. J. Physiol. pmid:1514604
De Feo P et al. Contribution of cortisol to glucose counterregulation in humans. 1989 Am. J. Physiol. pmid:2665516
Mikines KJ et al. Effect of 7 days of bed rest on dose-response relation between plasma glucose and insulin secretion. 1989 Am. J. Physiol. pmid:2665517
Bonadonna RC et al. Time dependence of the interaction between lipid and glucose in humans. 1989 Am. J. Physiol. pmid:2665518
Leturque A et al. Fetal glucose utilization in response to maternal starvation and acute hyperketonemia. 1989 Am. J. Physiol. pmid:2660583
Benavides A et al. Circadian rhythms of lipoprotein lipase and hepatic lipase activities in intermediate metabolism of adult rat. 1998 Am. J. Physiol. pmid:9728079
Møller N et al. Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. 1990 Am. J. Physiol. pmid:2405702
Mansell PI et al. Enhanced thermogenic response to epinephrine after 48-h starvation in humans. 1990 Am. J. Physiol. pmid:2405717
Cersosimo E et al. Glutamine blocks lipolysis and ketogenesis of fasting. 1986 Am. J. Physiol. pmid:3513612
Féry F and Balasse EO Response of ketone body metabolism to exercise during transition from postabsorptive to fasted state. 1986 Am. J. Physiol. pmid:3518484
Laughlin MR et al. Nonglucose substrates increase glycogen synthesis in vivo in dog heart. 1994 Am. J. Physiol. pmid:8048587
De Feo P et al. Evidence against important catecholamine compensation for absent glucagon counterregulation. 1991 Am. J. Physiol. pmid:1996624
Shambaugh GE et al. Fetal fuels. VII. Ketone bodies inhibit synthesis of purines in fetal rat brain. 1984 Am. J. Physiol. pmid:6742185
Miles JM et al. A dual-isotope technique for determination of in vivo ketone body kinetics. 1986 Am. J. Physiol. pmid:3526920
Hirsch IB et al. Insulin and glucagon in prevention of hypoglycemia during exercise in humans. 1991 Am. J. Physiol. pmid:2035626
Davis TA et al. Response of muscle protein synthesis to fasting in suckling and weaned rats. 1991 Am. J. Physiol. pmid:1721504
Butler P et al. Mechanism of growth hormone-induced postprandial carbohydrate intolerance in humans. 1991 Am. J. Physiol. pmid:2018116
Beattie MA and Winder WW Mechanism of training-induced attenuation of postexercise ketosis. 1984 Am. J. Physiol. pmid:6093602
Bougnères PF et al. Medium-chain fatty acids increase glucose production in normal and low birth weight newborns. 1989 Am. J. Physiol. pmid:2719106
Stevenson RW et al. Metabolic responses to intraduodenal glucose loading in insulin-infused diabetic dogs. 1983 Am. J. Physiol. pmid:6349384
Castellini MA and Costa DP Relationships between plasma ketones and fasting duration in neonatal elephant seals. 1990 Am. J. Physiol. pmid:2240269
Deems RO et al. Hypoglycemic effects of a novel fatty acid oxidation inhibitor in rats and monkeys. 1998 Am. J. Physiol. pmid:9486313
Lundgren F et al. Substrate exchange in human limb muscle during exercise at reduced blood flow. 1988 Am. J. Physiol. pmid:3142276
Winder WW et al. Endurance training attenuates stress hormone responses to exercise in fasted rats. 1982 Am. J. Physiol. pmid:6283921
Tuttle KR et al. Glucagon, not insulin, may play a secondary role in defense against hypoglycemia during exercise. 1988 Am. J. Physiol. pmid:3287952
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Sussman I et al. Differential effect of metabolic fuels on the energy state and Na(+)-K(+)-ATPase in isolated cerebral microvessels. 1993 Am. J. Physiol. pmid:7902010
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Féry F et al. Role of fat-derived substrates in the regulation of gluconeogenesis during fasting. 1996 Am. J. Physiol. pmid:8967471
Heller SR and Cryer PE Hypoinsulinemia is not critical to glucose recovery from hypoglycemia in humans. 1991 Am. J. Physiol. pmid:1858873
Hoffer LJ and Forse RA Protein metabolic effects of a prolonged fast and hypocaloric refeeding. 1990 Am. J. Physiol. pmid:2185664
Féry F and Balasse EO Ketone body turnover during and after exercise in overnight-fasted and starved humans. 1983 Am. J. Physiol. pmid:6353933
Bailey JW et al. Validation of two-pool model for in vivo ketone body kinetics. 1990 Am. J. Physiol. pmid:2185666
De Feo P et al. The pancreatic-adrenocortical-pituitary clamp technique for study of counterregulation in humans. 1987 Am. J. Physiol. pmid:2882686
Stunff CL and Bougnères PF Alterations of plasma lactate and glucose metabolism in obese children. 1996 Am. J. Physiol. pmid:8944666
Uchida S and Endou H Substrate specificity to maintain cellular ATP along the mouse nephron. 1988 Am. J. Physiol. pmid:2847554
Malaisse WJ et al. Ketone bodies and islet function: 45Ca handling, insulin synthesis, and release. 1990 Am. J. Physiol. pmid:2196820
Tullson PC and Aprille JR Regulation of mitochondrial adenine nucleotide content in newborn rabbit liver. 1987 Am. J. Physiol. pmid:2891302
Malaisse WJ et al. Ketone bodies and islet function: 86Rb handling and metabolic data. 1990 Am. J. Physiol. pmid:2196821
Zhang C and Paul RJ Excitation-contraction coupling and relaxation in porcine carotid arteries are specifically dependent on glucose. 1994 Am. J. Physiol. pmid:7977831
Hawkins RA et al. Regional ketone body utilization by rat brain in starvation and diabetes. 1986 Am. J. Physiol. pmid:2937307
Taguchi Y et al. Mechanism of the acceleration of CO2 production from pyruvate in liver mitochondria by HCO3-. 1997 Am. J. Physiol. pmid:9252446
Nosadini R et al. Acetoacetate and 3-hydroxybutyrate kinetics in obese and insulin-dependent diabetic humans. 1985 Am. J. Physiol. pmid:3922234
McCall AL et al. Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels. 1988 Am. J. Physiol. pmid:2964787
Divertie GD et al. Lipolytic responsiveness to epinephrine in nondiabetic and diabetic humans. 1997 Am. J. Physiol. pmid:9227461
Geary N et al. Blood metabolites and feeding during postinsulin hypophagia. 1982 Am. J. Physiol. pmid:7051864
Cobelli C et al. Model of the kinetics of ketone bodies in humans. 1982 Am. J. Physiol. pmid:7091397
Goldstein L et al. Ketone body effects on glutamine metabolism in isolated kidneys and mitochondria. 1982 Am. J. Physiol. pmid:7114217
Vissing J et al. Role of metabolic feedback regulation in glucose production of running rats. 1988 Am. J. Physiol. pmid:3046377
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