(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Median Neuropathy D020423 1 associated lipids
Heredodegenerative Disorders, Nervous System D020271 1 associated lipids
Ulnar Neuropathies D020424 1 associated lipids
Adenocarcinoma, Clear Cell D018262 1 associated lipids
Lacrimal Apparatus Diseases D007766 1 associated lipids
Pallor D010167 1 associated lipids
Basal Ganglia Cerebrovascular Disease D020144 1 associated lipids
Wrist Injuries D014954 1 associated lipids
Congenital Hyperinsulinism D044903 1 associated lipids
Spinal Muscular Atrophies of Childhood D014897 1 associated lipids
Status Epilepticus D013226 1 associated lipids
Pancreatitis, Chronic D050500 1 associated lipids
Aortopulmonary Septal Defect D001028 1 associated lipids
Septo-Optic Dysplasia D025962 1 associated lipids
Lipoma D008067 1 associated lipids
Azotemia D053099 1 associated lipids
Fructose-1,6-Diphosphatase Deficiency D015319 1 associated lipids
Lethargy D053609 1 associated lipids
Forearm Injuries D005543 1 associated lipids
Cardiac Output, Low D002303 2 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

Download all related citations
Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Lund TM et al. β-Hydroxybutyrate is the preferred substrate for GABA and glutamate synthesis while glucose is indispensable during depolarization in cultured GABAergic neurons. 2011 Neurochem. Int. pmid:21684314
Caamaño GJ et al. In vivo utilization of D(-)-3-hydroxybutyrate by chick brain and spinal cord. 1990 Neurochem. Res. pmid:2370945
Rotta LN et al. Utilization of energy nutrients by cerebellar slices. 2002 Neurochem. Res. pmid:11958517
Cheng B et al. D-beta-hydroxybutyrate prevents MPP+-induced neurotoxicity in PC12 cells. 2010 Neurochem. Res. pmid:19851865
Eloqayli H et al. [2,4-(13)C]β-hydroxybutyrate metabolism in astrocytes and C6 glioblastoma cells. 2011 Neurochem. Res. pmid:21538079
Lai JC and Sheu KF The effect of 2-oxoglutarate or 3-hydroxybutyrate on pyruvate dehydrogenase complex in isolated cerebrocortical mitochondria. 1987 Neurochem. Res. pmid:3627360
Tildon JT et al. Transport of 3-hydroxybutyrate by cultured rat brain astrocytes. 1994 Neurochem. Res. pmid:7891839
Mejía-Toiber J et al. D-beta-hydroxybutyrate prevents glutamate-mediated lipoperoxidation and neuronal damage elicited during glycolysis inhibition in vivo. 2006 Neurochem. Res. pmid:17115265
McKenna MC Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain. 2012 Neurochem. Res. pmid:23079895
Linares A et al. Utilization of ketone bodies by chick brain and spinal cord during embryonic and postnatal development. 1993 Neurochem. Res. pmid:8255360
Tamaki T et al. Changes of the plasma ketone body level and arterial ketone body ratio at the onset of mild aneurysmal subarachnoid hemorrhage. 2008 Neurol. Res. pmid:18691448
Lu HX et al. Low concentration of serum helps to maintain the characteristics of NSCs/NPCs on alkali-treated PHBHHx film in vitro. 2014 Neurol. Res. pmid:24512014
Pikija S et al. Is on-admission capillary blood beta-hydroxybutyrate concentration associated with the acute stroke severity and short-term functional outcome? 2013 Neurol. Res. pmid:23815820
al-Mudallal AS et al. Effects of unbalanced diets on cerebral glucose metabolism in the adult rat. 1995 Neurology pmid:8848204
Fraser DD et al. Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet. 2003 Neurology pmid:12654976
Vanitallie TB et al. Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study. 2005 Neurology pmid:15728303
Thurston JH et al. Chronic valproate administration produces hepatic dysfunction and may delay brain maturation in infant mice. 1981 Neurology pmid:6791049
Sanjak M et al. Physiologic and metabolic response to progressive and prolonged exercise in amyotrophic lateral sclerosis. 1987 Neurology pmid:3601086
Best TH et al. Cardiac complications in pediatric patients on the ketogenic diet. 2000 Neurology pmid:10881264
Thio LL et al. Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission. 2000 Neurology pmid:10668691
Szutowicz A et al. Acetylcholine synthesis in nerve terminals of diabetic rats. 1994 Neuroreport pmid:7696572
Arakawa T et al. Effect of ketone body (D-3-hydroxybutyrate) on neural activity and energy metabolism in hippocampal slices of the adult guinea pig. 1991 Neurosci. Lett. pmid:1749516
Hoffman WH et al. Acetoacetate increases expression of intercellular adhesion molecule-1 (ICAM-1) in human brain microvascular endothelial cells. 2002 Neurosci. Lett. pmid:12435474
Brandt K et al. Vagal afferents mediate the feeding response to mercaptoacetate but not to the beta (3) adrenergic receptor agonist CL 316,243. 2007 Neurosci. Lett. pmid:17112664
Davidson TL et al. Inter-relationships among diet, obesity and hippocampal-dependent cognitive function. 2013 Neuroscience pmid:23999121
Maalouf M et al. Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. 2007 Neuroscience pmid:17240074
Nehlig A et al. Autoradiographic measurement of local cerebral beta-hydroxybutyrate uptake in the rat during postnatal development. 1991 Neuroscience pmid:2062444
Massieu L et al. Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates. 2001 Neuroscience pmid:11682154
Chmiel-Perzyńska I et al. Novel aspect of ketone action: β-hydroxybutyrate increases brain synthesis of kynurenic acid in vitro. 2011 Neurotox Res pmid:20838951
Menon NK and Lopez RR The effects of mild congenital methylmercury intoxication on the metabolism of 3-hydroxybutyrate and glucose in the brains of suckling rats. 1985 Neurotoxicology pmid:3873037
Hamanoue M et al. [Research on liver function before and after surgery by the relation of artery blood ketone body ratio and beta-hydroxybutyrate: preliminary report]. 1988 Nihon Geka Gakkai Zasshi pmid:3200245
Yamamoto M et al. Acetoacetate/beta-hydroxybutyrate ratio in arterial blood and liver during and after liver ischemia--a clue to detect the viability of ischemic liver. 1983 Nihon Geka Hokan pmid:6660989
Harano Y [Blood level of ketone bodies and its clinical significance]. 2002 Nippon Rinsho pmid:12355785
Ziegler A et al. Non-invasive measurements of myocardial carbon metabolism using in vivo 13C NMR spectroscopy. 2002 NMR Biomed pmid:11968138
Künnecke B et al. Cerebral metabolism of [1,2-13C2]glucose and [U-13C4]3-hydroxybutyrate in rat brain as detected by 13C NMR spectroscopy. 1993 Jul-Aug NMR Biomed pmid:8105858
Tamaki T et al. [Metabolic acidosis and ketone body in severely head-injured patients]. 2000 No Shinkei Geka pmid:10920824
Torres MD et al. Breakfast, plasma glucose and beta-hydroxybutyrate, body mass index and academic performance in children from Extremadura, Spain. 2007 Jul-Aug Nutr Hosp pmid:17650890
Prete ED et al. Effects of mercaptoacetate on feeding, circulating glucose and lipids, and gastric emptying in rats fed a carbohydrate-free high-fat diet. 2001 Nutr Neurosci pmid:11842892
Pifferi F et al. Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats. 2011 Nutr Neurosci pmid:21605500
Seong SH et al. L-carnitine-supplemented parenteral nutrition improves fat metabolism but fails to support compensatory growth in premature Korean infants. 2010 Nutr Res pmid:20534325
Siddiqui SM et al. Dietary intervention with vitamin D, calcium, and whey protein reduced fat mass and increased lean mass in rats. 2008 Nutr Res pmid:19083488
How ketones spare protein in starvation. 1989 Nutr. Rev. pmid:2649806
Metabolic and endocrine responses of infants to breast milk and formulas. 1982 Nutr. Rev. pmid:7048153
Pedersen SM et al. The serum metabolite response to diet intervention with probiotic acidified milk in irritable bowel syndrome patients is indistinguishable from that of non-probiotic acidified milk by 1H NMR-based metabonomic analysis. 2010 Nutrients pmid:22254002
Campillo B et al. Influence of liver failure, ascites, and energy expenditure on the response to oral nutrition in alcoholic liver cirrhosis. 1997 Jul-Aug Nutrition pmid:9263252
Hirsch S et al. Lipid turnover in alcoholics before and after an ethanol load. 1998 Nutrition pmid:9614308
Kawamura T et al. Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults. 2012 Nov-Dec Nutrition pmid:22673596
MacFie J et al. Continuous versus intermittent infusion of fat emulsions during total parenteral nutrition: clinical trial. 1991 Mar-Apr Nutrition pmid:1802203
Kahler A et al. Suppression of hepatic fatty acid oxidation and food intake in men. 1999 Nov-Dec Nutrition pmid:10575655
Courchesne-Loyer A et al. Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism. 2013 Nutrition pmid:23274095
Kohlhardt SR et al. Metabolic response to a high-lipid, high-nitrogen peripheral intravenous nutrition solution after major upper-gastrointestinal surgery. 1994 Jul-Aug Nutrition pmid:8000153
Maki KC et al. Postprandial metabolism with 1,3-diacylglycerol oil versus equivalent intakes of long-chain and medium-chain triacylglycerol oils. 2009 Nutrition pmid:19217260
Aberg W et al. Fat oxidation and plasma removal capacity of an intravenous fat emulsion in elderly and young men. 2006 Jul-Aug Nutrition pmid:16815487
Birkhahn RH et al. Potential of the monoglyceride and triglyceride of DL-3-hydroxybutyrate for parenteral nutrition: synthesis and preliminary biological testing in the rat. 1997 Nutrition pmid:9131681
Kinzig KP et al. Altered hypothalamic signaling and responses to food deprivation in rats fed a low-carbohydrate diet. 2005 Obes. Res. pmid:16286514
Devenny JJ et al. Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats. 2012 Obesity (Silver Spring) pmid:22402735
Hughes TE et al. Ascending dose-controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women. 2013 Obesity (Silver Spring) pmid:23512440
Haviland JA et al. NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T(1)AM treatment. 2013 Obesity (Silver Spring) pmid:23512955
Righi V et al. MRS study of meningeal hemangiopericytoma and edema: a comparison with meningothelial meningioma. 2012 Oncol. Rep. pmid:22824994
Alm A and Törnquist P Lactate transport through the blood-retinal and the blood-brain barrier in rats. 1985 Ophthalmic Res. pmid:4011131
Ghorbani B et al. Effects of niacin on milk production and blood parameters in early lactation of dairy cows. 2008 Pak. J. Biol. Sci. pmid:18819645
Yu HY et al. Clinical utility of Abbott Precision Xceed Pro® ketone meter in diabetic patients. 2011 Pediatr Diabetes pmid:22034832
Ham MR et al. Bedside ketone determination in diabetic children with hyperglycemia and ketosis in the acute care setting. 2004 Pediatr Diabetes pmid:15043689
Prisco F et al. Blood ketone bodies in patients with recent-onset type 1 diabetes (a multicenter study). 2006 Pediatr Diabetes pmid:16911010
Noyes KJ et al. Hydroxybutyrate near-patient testing to evaluate a new end-point for intravenous insulin therapy in the treatment of diabetic ketoacidosis in children. 2007 Pediatr Diabetes pmid:17550425
Hanas R and Ludvigsson J Hypoglycemia and ketoacidosis with insulin pump therapy in children and adolescents. 2006 Pediatr Diabetes pmid:16774616
Zusman I and Ornoy A Effects of hyperglycemia and ketone bodies on the in vitro development of early somite rate embryos. 1987 Pediatr Pathol pmid:3449815
Bennett MJ et al. Fatal hepatic short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase deficiency: clinical, biochemical, and pathological studies on three subjects with this recently identified disorder of mitochondrial beta-oxidation. 1999 Jul-Aug Pediatr. Dev. Pathol. pmid:10347277
Dalinghaus M et al. Left ventricular oxygen and substrate uptake in chronically hypoxemic lambs. 1993 Pediatr. Res. pmid:8255680
Bolaños JP and Medina JM Lipogenesis from lactate in fetal rat brain during late gestation. 1993 Pediatr. Res. pmid:8433864
Sparks JW et al. Substrate concentration changes during pregnancy in the guinea pig studied under unstressed steady state conditions. 1981 Pediatr. Res. pmid:7301456
Gratama JW et al. Myocardial carbohydrate, ketone, and fatty acid uptake in conscious lambs with aortopulmonary shunts. 1992 Pediatr. Res. pmid:1635842
Wu PY et al. Medium-chain triglycerides in infant formulas and their relation to plasma ketone body concentrations. 1986 Pediatr. Res. pmid:3703623
Plecko B et al. Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy. 2002 Pediatr. Res. pmid:12149510
Ogata ES et al. Altered growth, hypoglycemia, hypoalaninemia, and ketonemia in the young rat: postnatal consequences of intrauterine growth retardation. 1985 Pediatr. Res. pmid:3881726
Fox RE et al. The role of glutamine and other alternate substrates as energy sources in the fetal rat lung type II cell. 1996 Pediatr. Res. pmid:8798259
Van Cappellen Van Walsum AM et al. 1H-NMR spectroscopy of cerebrospinal fluid of fetal sheep during hypoxia-induced acidemia and recovery. 2002 Pediatr. Res. pmid:12084848
Vicario C et al. Regulation of lactate metabolism by albumin in rat neurons and astrocytes from primary culture. 1993 Pediatr. Res. pmid:8108180
Kimura RE et al. The effect of ketone bodies and fatty acid on intestinal glucose metabolism during development. 1984 Pediatr. Res. pmid:6472928
Alonso de la Torre SR et al. Carrier-mediated beta-D-hydroxybutyrate transport in brush-border membrane vesicles from rat placenta. 1992 Pediatr. Res. pmid:1408469
Birk RZ and Brannon PM Regulation of pancreatic lipase by dietary medium chain triglycerides in the weanling rat. 2004 Pediatr. Res. pmid:15071157
Bossi E et al. Utilization of D-beta-hydroxybutyrate and oleate as alternate energy fuels in brain cell cultures of newborn mice after hypoxia at different glucose concentrations. 1989 Pediatr. Res. pmid:2510120
Kimura RE Glutamine oxidation by developing rat small intestine. 1987 Pediatr. Res. pmid:3103088
Hussain K et al. Exogenous administered DL- sodium beta-hydroxybutyrate (beta-OHB) can cross the blood brain barrier. 2003 Pediatr. Res. pmid:12715792
Valayannopoulos V et al. Successful treatment of severe cardiomyopathy in glycogen storage disease type III With D,L-3-hydroxybutyrate, ketogenic and high-protein diet. 2011 Pediatr. Res. pmid:21857385
Roth KS et al. Transport of beta-hydroxy-beta-methyl-glutarate and beta-hydroxbutyrate by renal brushborder membrane vesicles. 1982 Pediatr. Res. pmid:6180372
Paton JB et al. Placental transfer and fetal effects of maternal sodium beta-hydroxybutyrate infusion in the baboon. 1989 Pediatr. Res. pmid:2717257
Costa CC et al. Dynamic changes of plasma acylcarnitine levels induced by fasting and sunflower oil challenge test in children. 1999 Pediatr. Res. pmid:10509365
Bossi E et al. Age-dependent utilization of D-beta-OH-butyrate and oleic acid as glucose substitutes by neonatal mouse brain cell cultures. 1982 Pediatr. Res. pmid:6810297
Almeida A et al. Fuel utilization by early newborn brain is preserved under congenital hypothyroidism in the rat. 1996 Pediatr. Res. pmid:8865277
Dardzinski BJ et al. Increased plasma beta-hydroxybutyrate, preserved cerebral energy metabolism, and amelioration of brain damage during neonatal hypoxia ischemia with dexamethasone pretreatment. 2000 Pediatr. Res. pmid:10926303
Yoshida I et al. Effect of lipoic acid in a patient with defective activity of pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase, and branched-chain keto acid dehydrogenase. 1990 Pediatr. Res. pmid:2104971
Hack A et al. Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis. 2006 Pediatr. Res. pmid:16690958
Bazaes RA et al. Glucose and lipid metabolism in small for gestational age infants at 48 hours of age. 2003 Pediatrics pmid:12671116
Stenerson MB et al. Bilateral basal ganglia infarctions in a neonate born during maternal diabetic ketoacidosis. 2011 Pediatrics pmid:21807693
Chow G et al. Stöckert roller pump generated pulsatile flow: cerebral metabolic changes in adult cardiopulmonary bypass. 1997 Perfusion pmid:9160362
Minaire Y et al. Effect of cold ambient temperature on glucose and alanine turnover in dogs. 1982 Pflugers Arch. pmid:7177779
Cherel Y et al. Ambient temperature and ketone body plasma concentration in fasting geese. 1986 Pflugers Arch. pmid:3737378
Barac-Nieto M D(-)3-hydroxybutyrate cotransport with Na in rat renal brush border membrane vesicles. 1987 Pflugers Arch. pmid:3588250
Peng Q et al. The implantable and biodegradable PHBHHx 3D scaffolds loaded with protein-phospholipid complex for sustained delivery of proteins. 2013 Pharm. Res. pmid:23224980