(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Congenital Hyperinsulinism D044903 1 associated lipids
Spinal Muscular Atrophies of Childhood D014897 1 associated lipids
Status Epilepticus D013226 1 associated lipids
Pancreatitis, Chronic D050500 1 associated lipids
Aortopulmonary Septal Defect D001028 1 associated lipids
Septo-Optic Dysplasia D025962 1 associated lipids
Lipoma D008067 1 associated lipids
Azotemia D053099 1 associated lipids
Fructose-1,6-Diphosphatase Deficiency D015319 1 associated lipids
Lethargy D053609 1 associated lipids
Forearm Injuries D005543 1 associated lipids
Median Neuropathy D020423 1 associated lipids
Heredodegenerative Disorders, Nervous System D020271 1 associated lipids
Ulnar Neuropathies D020424 1 associated lipids
Adenocarcinoma, Clear Cell D018262 1 associated lipids
Lacrimal Apparatus Diseases D007766 1 associated lipids
Pallor D010167 1 associated lipids
Basal Ganglia Cerebrovascular Disease D020144 1 associated lipids
Wrist Injuries D014954 1 associated lipids
Insulin Coma D007331 2 associated lipids
Encephalopathy, Bovine Spongiform D016643 2 associated lipids
Heart Septal Defects D006343 2 associated lipids
Sandhoff Disease D012497 2 associated lipids
Epilepsy, Generalized D004829 2 associated lipids
Kearns-Sayre Syndrome D007625 2 associated lipids
Intracranial Hemorrhages D020300 2 associated lipids
Cardiac Output, Low D002303 2 associated lipids
Cysticercosis D003551 2 associated lipids
Glycogen Storage Disease Type III D006010 2 associated lipids
Multiple Endocrine Neoplasia Type 1 D018761 2 associated lipids
Hepatitis, Viral, Human D006525 3 associated lipids
Short Bowel Syndrome D012778 3 associated lipids
Mastitis D008413 3 associated lipids
Exostoses, Multiple Hereditary D005097 3 associated lipids
Placenta, Retained D018457 3 associated lipids
Dystocia D004420 3 associated lipids
Thyrotoxicosis D013971 3 associated lipids
Dwarfism, Pituitary D004393 3 associated lipids
Alkalosis D000471 3 associated lipids
Lipid Metabolism Disorders D052439 3 associated lipids
Fetal Macrosomia D005320 3 associated lipids
Acid-Base Imbalance D000137 3 associated lipids
HIV Wasting Syndrome D019247 3 associated lipids
Pyruvate Dehydrogenase Complex Deficiency Disease D015325 3 associated lipids
Hepatitis, Chronic D006521 3 associated lipids
Bulimia D002032 3 associated lipids
Spasms, Infantile D013036 3 associated lipids
Fascioliasis D005211 3 associated lipids
Pyruvate Metabolism, Inborn Errors D015323 3 associated lipids
Glycogen Storage Disease D006008 4 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

Download all related citations
Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Stanley WC et al. beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12969881
Bigrigg JK et al. Carbohydrate refeeding after a high-fat diet rapidly reverses the adaptive increase in human skeletal muscle PDH kinase activity. 2009 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:19625693
Bernard SF et al. Blockade of fatty acid oxidation mimics phase II-phase III transition in a fasting bird, the king penguin. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12069939
Bernard SF et al. Lipolytic and metabolic response to glucagon in fasting king penguins: phase II vs. phase III. 2003 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12388477
Becskei C et al. Reduced fasting-induced activation of hypothalamic arcuate neurons is associated with hyperleptinemia and increased leptin sensitivity in obese mice. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20538900
Connolly CC et al. Hepatic and muscle insulin action during late pregnancy in the dog. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:16973936
Luci S et al. Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17363680
Díaz-Muñoz M et al. Anticipatory changes in liver metabolism and entrainment of insulin, glucagon, and corticosterone in food-restricted rats. 2000 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11080068
Verrier D et al. Physiological response to extreme fasting in subantarctic fur seal (Arctocephalus tropicalis) pups: metabolic rates, energy reserve utilization, and water fluxes. 2009 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:19776248
Andrews MT et al. Adaptive mechanisms regulate preferred utilization of ketones in the heart and brain of a hibernating mammal during arousal from torpor. 2009 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:19052316
Li M et al. GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy. 2013 Am. J. Physiol. Renal Physiol. pmid:23467425
Aromolaran AS et al. Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. 2007 Am. J. Physiol., Cell Physiol. pmid:17344311
MacDonald MJ et al. Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion. 2008 Am. J. Physiol., Cell Physiol. pmid:18160486
Mori K et al. Insulinopenia as a risk factor in hepatectomy and its resolution by intraportal insulin administration. 1991 Am. J. Surg. pmid:2063969
Sasi P et al. Metabolic acidosis and other determinants of hemoglobin-oxygen dissociation in severe childhood Plasmodium falciparum malaria. 2007 Am. J. Trop. Med. Hyg. pmid:17690396
Lacetera N et al. Effects of nonesterified fatty acids and beta-hydroxybutyrate on functions of mononuclear cells obtained from ewes. 2002 Am. J. Vet. Res. pmid:11911577
Oikawa S et al. Decreased serum apolipoprotein B-100 and A-I concentrations in cows with ketosis and left displacement of the abomasum. 1997 Am. J. Vet. Res. pmid:9028472
Herdt TH et al. Blood concentrations of beta hydroxybutyrate in clinically normal Holstein-Friesian herds and in those with a high prevalence of clinical ketosis. 1981 Am. J. Vet. Res. pmid:7271015
Herdt TH et al. Influence of ration composition and energy balance on blood beta-hydroxybutyrate (ketone) and plasma glucose concentrations of dairy cows in early lactation. 1981 Am. J. Vet. Res. pmid:7271038
Targowski SP et al. Suppression of mitogenic response of bovine lymphocytes during experimental ketosis in calves. 1985 Am. J. Vet. Res. pmid:4026018
Cebra CK and Tornquist SJ Assessment of the effects of epinephrine and insulin on plasma and serum biochemical variables in llamas and alpacas. 2004 Am. J. Vet. Res. pmid:15631035
de Graaf-Roelfsema E et al. Effects of short- and long-term recombinant equine growth hormone and short-term hydrocortisone administration on tissue sensitivity to insulin in horses. 2005 Am. J. Vet. Res. pmid:16334949
Gossett KA et al. Contribution of whole blood L-lactate, pyruvate, D-lactate, acetoacetate, and 3-hydroxybutyrate concentrations to the plasma anion gap in horses with intestinal disorders. 1987 Am. J. Vet. Res. pmid:3826846
Dufva GS et al. Effect of dietary niacin supplementation on phlorhizin and 1,3-butanediol-induced ketonemia and hypoglycemia in steers. 1984 Am. J. Vet. Res. pmid:6497141
Cebra CK et al. Effects of hydrocortisone on substrates of energy metabolism in alpacas. 2002 Am. J. Vet. Res. pmid:12224859
Fallin CW and Christopher MM In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. 1996 Am. J. Vet. Res. pmid:8712507
Pravettoni D et al. Insulin resistance and abomasal motility disorders in cows detected by use of abomasoduodenal electromyography after surgical correction of left displaced abomasum. 2004 Am. J. Vet. Res. pmid:15524316
Reist M et al. Use of threshold serum and milk ketone concentrations to identify risk for ketosis and endometritis in high-yielding dairy cows. 2003 Am. J. Vet. Res. pmid:12602588
Eicher R et al. Effect of cow-specific factors and feeding frequency of concentrate on diurnal variations of blood metabolites in dairy cows. 1999 Am. J. Vet. Res. pmid:10622157
Hornig KJ et al. Evaluation of a point-of-care glucose and β-hydroxybutyrate meter operated in various environmental conditions in prepartum and postpartum sheep. 2013 Am. J. Vet. Res. pmid:23879842
Wagner SA and Schimek DE Evaluation of the effect of bolus administration of 50% dextrose solution on measures of electrolyte and energy balance in postpartum dairy cows. 2010 Am. J. Vet. Res. pmid:20807148
Geishauser T et al. Evaluation of aspartate transaminase activity and beta-hydroxybutyrate concentration in blood as tests for prediction of left displaced abomasum in dairy cows. 1997 Am. J. Vet. Res. pmid:9361881
Westermann CM et al. Plasma acylcarnitine and fatty acid profiles during exercise and training in Standardbreds. 2008 Am. J. Vet. Res. pmid:18980429
Lacetera N et al. Effects of subclinical pregnancy toxemia on immune responses in sheep. 2001 Am. J. Vet. Res. pmid:11453474
Tornquist SJ et al. Metabolic changes and induction of hepatic lipidosis during feed restriction in llamas. 2001 Am. J. Vet. Res. pmid:11453484
Lei J et al. Regulation of leucine catabolism by metabolic fuels in mammary epithelial cells. 2012 Amino Acids pmid:22543725
Reyes-Toso CF et al. Effect of melatonin treatment on oxygen consumption by rat liver mitochondria. 2006 Amino Acids pmid:16554975
López Siguero JP et al. [Blood glucose and ketone monitoring in type 1 diabetic patients in the controlled environment of a summer camp]. 2007 An Pediatr (Barc) pmid:17430716
Scrutton MJ et al. Eating in labour. A randomised controlled trial assessing the risks and benefits. 1999 Anaesthesia pmid:10455830
Altemeyer KH et al. [The stress reaction in knee operations under continuous peridural anesthesia in comparison with neuroleptanalgesia]. 1983 Anaesthesist pmid:6346939
Tsutsui H et al. Simultaneous determination of DL-lactic acid and DL-3-hydroxybutyric acid enantiomers in saliva of diabetes mellitus patients by high-throughput LC-ESI-MS/MS. 2012 Anal Bioanal Chem pmid:22895741
Shimomura T et al. A novel, disposable, screen-printed amperometric biosensor for ketone 3-β-hydroxybutyrate fabricated using a 3-β-hydroxybutyrate dehydrogenase-mesoporous silica conjugate. 2013 Anal Bioanal Chem pmid:23096941
Lam le H et al. Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyrate with water-soluble tetrazolium salt. 2008 Anal Sci pmid:18689950
Kiba N et al. Simultaneous determination of D-glucose and 3-hydroxybutyrate by chemiluminescence detection with immobilized enzymes in a flow injection system. 2003 Anal Sci pmid:12945679
Yamai K et al. Acetone concentration in gas emanating from tails of diabetic rats. 2012 Anal Sci pmid:22687932
Desrochers S et al. Quantitation of 1,3-butanediol and its acidic metabolites by gas chromatography-mass spectrometry. 1990 Anal. Biochem. pmid:2356962
Miles JM et al. Determination of ketone body turnover in vivo with stable isotopes, utilizing gas chromatography/mass spectrometry. 1984 Anal. Biochem. pmid:6496922
Sener A and Malaisse WJ A sensitive radioisotopic method for the measurement of NAD(P)H: its application to the assay of metabolites and enzymatic activities. 1990 Anal. Biochem. pmid:2363494
Tsai YC et al. Identification of L-3-hydroxybutyrate as an original ketone body in rat serum by column-switching high-performance liquid chromatography and fluorescence derivatization. 2003 Anal. Biochem. pmid:12842104
Lam le H et al. Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyric acid. 2007 Anal. Biochem. pmid:17386920