(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Congenital Abnormalities D000013 11 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Abortion, Veterinary D000034 5 associated lipids
Acid-Base Imbalance D000137 3 associated lipids
Acidosis D000138 13 associated lipids
Acromegaly D000172 6 associated lipids
Adenocarcinoma D000230 166 associated lipids
Albuminuria D000419 18 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Alkalosis D000471 3 associated lipids
Alkalosis, Respiratory D000472 4 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amyotrophic Lateral Sclerosis D000690 11 associated lipids
Anorexia D000855 8 associated lipids
Hypoxia D000860 23 associated lipids
Aortopulmonary Septal Defect D001028 1 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Asphyxia D001237 5 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Brain Neoplasms D001932 15 associated lipids
Bulimia D002032 3 associated lipids
Cachexia D002100 21 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cardiac Output, Low D002303 2 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cholestasis D002779 23 associated lipids
Corneal Diseases D003316 13 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Cysticercosis D003551 2 associated lipids
Death, Sudden D003645 12 associated lipids
Dehydration D003681 11 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Dwarfism, Pituitary D004393 3 associated lipids
Dystocia D004420 3 associated lipids
Endometritis D004716 6 associated lipids
Epilepsy D004827 35 associated lipids
Epilepsy, Generalized D004829 2 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Exostoses, Multiple Hereditary D005097 3 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

Download all related citations
Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Zou Z et al. dl-3-Hydroxybutyrate administration prevents myocardial damage after coronary occlusion in rat hearts. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12384475
Bigrigg JK et al. Carbohydrate refeeding after a high-fat diet rapidly reverses the adaptive increase in human skeletal muscle PDH kinase activity. 2009 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:19625693
Bernard SF et al. Blockade of fatty acid oxidation mimics phase II-phase III transition in a fasting bird, the king penguin. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12069939
Bernard SF et al. Lipolytic and metabolic response to glucagon in fasting king penguins: phase II vs. phase III. 2003 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12388477
Becskei C et al. Reduced fasting-induced activation of hypothalamic arcuate neurons is associated with hyperleptinemia and increased leptin sensitivity in obese mice. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20538900
Connolly CC et al. Hepatic and muscle insulin action during late pregnancy in the dog. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:16973936
Luci S et al. Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17363680
Díaz-Muñoz M et al. Anticipatory changes in liver metabolism and entrainment of insulin, glucagon, and corticosterone in food-restricted rats. 2000 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11080068
Verrier D et al. Physiological response to extreme fasting in subantarctic fur seal (Arctocephalus tropicalis) pups: metabolic rates, energy reserve utilization, and water fluxes. 2009 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:19776248
Andrews MT et al. Adaptive mechanisms regulate preferred utilization of ketones in the heart and brain of a hibernating mammal during arousal from torpor. 2009 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:19052316
Li M et al. GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy. 2013 Am. J. Physiol. Renal Physiol. pmid:23467425
Aromolaran AS et al. Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. 2007 Am. J. Physiol., Cell Physiol. pmid:17344311
MacDonald MJ et al. Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion. 2008 Am. J. Physiol., Cell Physiol. pmid:18160486
Mori K et al. Insulinopenia as a risk factor in hepatectomy and its resolution by intraportal insulin administration. 1991 Am. J. Surg. pmid:2063969
Sasi P et al. Metabolic acidosis and other determinants of hemoglobin-oxygen dissociation in severe childhood Plasmodium falciparum malaria. 2007 Am. J. Trop. Med. Hyg. pmid:17690396
Lacetera N et al. Effects of nonesterified fatty acids and beta-hydroxybutyrate on functions of mononuclear cells obtained from ewes. 2002 Am. J. Vet. Res. pmid:11911577
Oikawa S et al. Decreased serum apolipoprotein B-100 and A-I concentrations in cows with ketosis and left displacement of the abomasum. 1997 Am. J. Vet. Res. pmid:9028472
Herdt TH et al. Blood concentrations of beta hydroxybutyrate in clinically normal Holstein-Friesian herds and in those with a high prevalence of clinical ketosis. 1981 Am. J. Vet. Res. pmid:7271015
Herdt TH et al. Influence of ration composition and energy balance on blood beta-hydroxybutyrate (ketone) and plasma glucose concentrations of dairy cows in early lactation. 1981 Am. J. Vet. Res. pmid:7271038
Targowski SP et al. Suppression of mitogenic response of bovine lymphocytes during experimental ketosis in calves. 1985 Am. J. Vet. Res. pmid:4026018
Cebra CK and Tornquist SJ Assessment of the effects of epinephrine and insulin on plasma and serum biochemical variables in llamas and alpacas. 2004 Am. J. Vet. Res. pmid:15631035
de Graaf-Roelfsema E et al. Effects of short- and long-term recombinant equine growth hormone and short-term hydrocortisone administration on tissue sensitivity to insulin in horses. 2005 Am. J. Vet. Res. pmid:16334949
Gossett KA et al. Contribution of whole blood L-lactate, pyruvate, D-lactate, acetoacetate, and 3-hydroxybutyrate concentrations to the plasma anion gap in horses with intestinal disorders. 1987 Am. J. Vet. Res. pmid:3826846
Dufva GS et al. Effect of dietary niacin supplementation on phlorhizin and 1,3-butanediol-induced ketonemia and hypoglycemia in steers. 1984 Am. J. Vet. Res. pmid:6497141
Cebra CK et al. Effects of hydrocortisone on substrates of energy metabolism in alpacas. 2002 Am. J. Vet. Res. pmid:12224859
Fallin CW and Christopher MM In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. 1996 Am. J. Vet. Res. pmid:8712507
Pravettoni D et al. Insulin resistance and abomasal motility disorders in cows detected by use of abomasoduodenal electromyography after surgical correction of left displaced abomasum. 2004 Am. J. Vet. Res. pmid:15524316
Reist M et al. Use of threshold serum and milk ketone concentrations to identify risk for ketosis and endometritis in high-yielding dairy cows. 2003 Am. J. Vet. Res. pmid:12602588
Eicher R et al. Effect of cow-specific factors and feeding frequency of concentrate on diurnal variations of blood metabolites in dairy cows. 1999 Am. J. Vet. Res. pmid:10622157
Hornig KJ et al. Evaluation of a point-of-care glucose and β-hydroxybutyrate meter operated in various environmental conditions in prepartum and postpartum sheep. 2013 Am. J. Vet. Res. pmid:23879842
Wagner SA and Schimek DE Evaluation of the effect of bolus administration of 50% dextrose solution on measures of electrolyte and energy balance in postpartum dairy cows. 2010 Am. J. Vet. Res. pmid:20807148
Geishauser T et al. Evaluation of aspartate transaminase activity and beta-hydroxybutyrate concentration in blood as tests for prediction of left displaced abomasum in dairy cows. 1997 Am. J. Vet. Res. pmid:9361881
Westermann CM et al. Plasma acylcarnitine and fatty acid profiles during exercise and training in Standardbreds. 2008 Am. J. Vet. Res. pmid:18980429
Lacetera N et al. Effects of subclinical pregnancy toxemia on immune responses in sheep. 2001 Am. J. Vet. Res. pmid:11453474
Tornquist SJ et al. Metabolic changes and induction of hepatic lipidosis during feed restriction in llamas. 2001 Am. J. Vet. Res. pmid:11453484
Lei J et al. Regulation of leucine catabolism by metabolic fuels in mammary epithelial cells. 2012 Amino Acids pmid:22543725
Reyes-Toso CF et al. Effect of melatonin treatment on oxygen consumption by rat liver mitochondria. 2006 Amino Acids pmid:16554975
López Siguero JP et al. [Blood glucose and ketone monitoring in type 1 diabetic patients in the controlled environment of a summer camp]. 2007 An Pediatr (Barc) pmid:17430716
Scrutton MJ et al. Eating in labour. A randomised controlled trial assessing the risks and benefits. 1999 Anaesthesia pmid:10455830
Altemeyer KH et al. [The stress reaction in knee operations under continuous peridural anesthesia in comparison with neuroleptanalgesia]. 1983 Anaesthesist pmid:6346939
Tsutsui H et al. Simultaneous determination of DL-lactic acid and DL-3-hydroxybutyric acid enantiomers in saliva of diabetes mellitus patients by high-throughput LC-ESI-MS/MS. 2012 Anal Bioanal Chem pmid:22895741
Shimomura T et al. A novel, disposable, screen-printed amperometric biosensor for ketone 3-β-hydroxybutyrate fabricated using a 3-β-hydroxybutyrate dehydrogenase-mesoporous silica conjugate. 2013 Anal Bioanal Chem pmid:23096941
Lam le H et al. Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyrate with water-soluble tetrazolium salt. 2008 Anal Sci pmid:18689950
Kiba N et al. Simultaneous determination of D-glucose and 3-hydroxybutyrate by chemiluminescence detection with immobilized enzymes in a flow injection system. 2003 Anal Sci pmid:12945679
Yamai K et al. Acetone concentration in gas emanating from tails of diabetic rats. 2012 Anal Sci pmid:22687932
Desrochers S et al. Quantitation of 1,3-butanediol and its acidic metabolites by gas chromatography-mass spectrometry. 1990 Anal. Biochem. pmid:2356962
Tabata M and Totani M A chemiluminescence-flow injection analysis of serum 3-hydroxybutyrate using a bioreactor consisting of 3-hydroxybutyrate dehydrogenase and NADH oxidase. 1995 Anal. Biochem. pmid:8533882
Sener A and Malaisse WJ A sensitive radioisotopic method for the measurement of NAD(P)H: its application to the assay of metabolites and enzymatic activities. 1990 Anal. Biochem. pmid:2363494
Takayama N et al. Enzymatic fluorometric microplate assay for quantitative analysis of 3-hydroxybutyric acid in mouse plasma. 2012 Anal. Biochem. pmid:22449496
Tsai YC et al. Identification of L-3-hydroxybutyrate as an original ketone body in rat serum by column-switching high-performance liquid chromatography and fluorescence derivatization. 2003 Anal. Biochem. pmid:12842104