(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Congenital Abnormalities D000013 11 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Abortion, Veterinary D000034 5 associated lipids
Acid-Base Imbalance D000137 3 associated lipids
Acidosis D000138 13 associated lipids
Acromegaly D000172 6 associated lipids
Adenocarcinoma D000230 166 associated lipids
Albuminuria D000419 18 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Alkalosis D000471 3 associated lipids
Alkalosis, Respiratory D000472 4 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amyotrophic Lateral Sclerosis D000690 11 associated lipids
Anorexia D000855 8 associated lipids
Hypoxia D000860 23 associated lipids
Aortopulmonary Septal Defect D001028 1 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Asphyxia D001237 5 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Brain Neoplasms D001932 15 associated lipids
Bulimia D002032 3 associated lipids
Cachexia D002100 21 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cardiac Output, Low D002303 2 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cholestasis D002779 23 associated lipids
Corneal Diseases D003316 13 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Cysticercosis D003551 2 associated lipids
Death, Sudden D003645 12 associated lipids
Dehydration D003681 11 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Dwarfism, Pituitary D004393 3 associated lipids
Dystocia D004420 3 associated lipids
Endometritis D004716 6 associated lipids
Epilepsy D004827 35 associated lipids
Epilepsy, Generalized D004829 2 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Exostoses, Multiple Hereditary D005097 3 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

Download all related citations
Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Caamaño GJ et al. In vivo utilization of D(-)-3-hydroxybutyrate by chick brain and spinal cord. 1990 Neurochem. Res. pmid:2370945
Rotta LN et al. Utilization of energy nutrients by cerebellar slices. 2002 Neurochem. Res. pmid:11958517
Cheng B et al. D-beta-hydroxybutyrate prevents MPP+-induced neurotoxicity in PC12 cells. 2010 Neurochem. Res. pmid:19851865
Lai JC and Sheu KF The effect of 2-oxoglutarate or 3-hydroxybutyrate on pyruvate dehydrogenase complex in isolated cerebrocortical mitochondria. 1987 Neurochem. Res. pmid:3627360
Tildon JT et al. Transport of 3-hydroxybutyrate by cultured rat brain astrocytes. 1994 Neurochem. Res. pmid:7891839
McKenna MC Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain. 2012 Neurochem. Res. pmid:23079895
Samala R et al. The ketogenic diet changes metabolite levels in hippocampal extracellular fluid. 2011 Neurochem. Int. pmid:21070829
Lund TM et al. β-Hydroxybutyrate is the preferred substrate for GABA and glutamate synthesis while glucose is indispensable during depolarization in cultured GABAergic neurons. 2011 Neurochem. Int. pmid:21684314
Cheng B et al. d-β-Hydroxybutyrate inhibited the apoptosis of PC12 cells induced by H2O2 via inhibiting oxidative stress. 2013 Neurochem. Int. pmid:23022628
Li FY et al. Canine spongiform leukoencephalomyelopathy is associated with a missense mutation in cytochrome b. 2006 Neurobiol. Dis. pmid:16026996
Reger MA et al. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. 2004 Neurobiol. Aging pmid:15123336
Reyes-Toso CF et al. In vitro effect of melatonin on oxygen consumption in liver mitochondria of rats. 2003 Neuro Endocrinol. Lett. pmid:14647009
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Riegel W and Hörl WH Role of energy charge and redox state for hepatocyte gluconeogenesis of acutely uremic rats. 1985 Nephron pmid:4000349
Litten JC et al. Effect of Acute Administration of Recombinant Human Leptin during the Neonatal Period on Body Temperature and Endocrine Profile of the Piglet. 2008 Neonatology pmid:17895632
Tyo KE et al. Stabilized gene duplication enables long-term selection-free heterologous pathway expression. 2009 Nat. Biotechnol. pmid:19633654
Padidela R et al. Focal congenital hyperinsulinism in a patient with septo-optic dysplasia. 2010 Nat Rev Endocrinol pmid:20842182
Venishetty VK et al. β-Hydroxybutyric acid grafted solid lipid nanoparticles: a novel strategy to improve drug delivery to brain. 2013 Nanomedicine pmid:22960191
Zhao NQ et al. [Role of apoptosis and mitochondrial apoptotic pathway in glucolipotoxicity-induced islet beta-cell dysfunction]. 2008 Nan Fang Yi Ke Da Xue Xue Bao pmid:19033115
Kamei I et al. Effects of lipolytic and antilipolytic agents on glycerol and free fatty acid release from isolated adipocytes of normal and diabetic rats. 1989 Nagoya J Med Sci pmid:2549422
Galanello R et al. Induction of fetal hemoglobin in the presence of increased 3-hydroxybutyric acid associated with beta-ketothiolase deficiency. 1994 N. Engl. J. Med. pmid:7520129
Jenkins DJ et al. Nibbling versus gorging: metabolic advantages of increased meal frequency. 1989 N. Engl. J. Med. pmid:2674713
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White NJ et al. Severe hypoglycemia and hyperinsulinemia in falciparum malaria. 1983 N. Engl. J. Med. pmid:6343877
Rizzo T et al. Correlations between antepartum maternal metabolism and child intelligence. 1991 N. Engl. J. Med. pmid:1881416
Ashby RD et al. Biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium Propionibacterium acnes. 2011 N Biotechnol pmid:20708720
Wetzel DM and Salpeter MM Fibrillation and accelerated AChR degradation in long-term muscle organ culture. 1991 Muscle Nerve pmid:1944400
Bellward GD et al. Hepatic cytochrome P-450j induction in the spontaneously diabetic BB rat. 1988 Mol. Pharmacol. pmid:3277033
Ladrière L et al. Assessment of the nutritional value of glycerol-1,2, 3-tris(methylsuccinate) in fed and starved rats. 1999 Mol. Genet. Metab. pmid:10381333
Schutz PW et al. Protective effects of d-3-hydroxybutyrate and propionate during hypoglycemic coma: clinical and biochemical insights from infant rats. 2011 Mol. Genet. Metab. pmid:21439874
Gillingham MB et al. Metabolic control during exercise with and without medium-chain triglycerides (MCT) in children with long-chain 3-hydroxy acyl-CoA dehydrogenase (LCHAD) or trifunctional protein (TFP) deficiency. 2006 Sep-Oct Mol. Genet. Metab. pmid:16876451
Hiroyama M et al. Hypermetabolism of fat in V1a vasopressin receptor knockout mice. 2007 Mol. Endocrinol. pmid:17021052
Matković M et al. Synthesis of novel adamantyl and homoadamantyl-substituted β-hydroxybutyric acids. 2013 Mol. Divers. pmid:24043584
Sultan AM The effect of fasting on D-3-hydroxybutyrate metabolism in the perfused rat heart. 1990 Mol. Cell. Biochem. pmid:2345539
Sultan AM Effects of diabetes and insulin on ketone bodies metabolism in heart. 1992 Mol. Cell. Biochem. pmid:1579130
Sultan AM D-3-hydroxybutyrate metabolism in the perfused rat heart. 1988 Mol. Cell. Biochem. pmid:3398833
Pelletier A et al. Chronic exposure to ketone bodies impairs glucose uptake in adult cardiomyocytes in response to insulin but not vanadate: the role of PI3-K. 2007 Mol. Cell. Biochem. pmid:16960657
Rains JL and Jain SK Hyperketonemia decreases mitochondrial membrane potential and its normalization with chromium (III) supplementation in monocytes. 2011 Mol. Cell. Biochem. pmid:21153866
Geraldes CF et al. Influence of vanadate on glycolysis, intracellular sodium, and pH in perfused rat hearts. 1997 Mol. Cell. Biochem. pmid:9144318
Khorsand F et al. An electrochemical biosensor for 3-hydroxybutyrate detection based on screen-printed electrode modified by coenzyme functionalized carbon nanotubes. 2013 Mol. Biol. Rep. pmid:23187739
Shah TD et al. The characterization of a unique Trypanosoma brucei β-hydroxybutyrate dehydrogenase. 2011 Mol. Biochem. Parasitol. pmid:21767577
Negoda A et al. Importance of oligo-R-3-hydroxybutyrates to S. lividans KcsA channel structure and function. 2010 Mol Biosyst pmid:20862428
Bachmann W et al. [Coma--management and early treatment with regular and basal BHI]. 1983 MMW Munch Med Wochenschr pmid:6408439
D'Amelio G et al. [Lipolysis and ketosis during swimming in thermal water]. 1991 Minerva Med. pmid:1766571
Riegel W and Hörl WH Ketone body-induced dissociation between hepatocyte gluconeogenesis and ureagenesis in acutely uremic rats. 1992 Miner Electrolyte Metab pmid:1465055
Lütke-Eversloh T et al. Identification of a new class of biopolymer: bacterial synthesis of a sulfur-containing polymer with thioester linkages. 2001 Microbiology (Reading, Engl.) pmid:11160796
Tessmer N et al. Heat-shock protein HspA mimics the function of phasins sensu stricto in recombinant strains of Escherichia coli accumulating polythioesters or polyhydroxyalkanoates. 2007 Microbiology (Reading, Engl.) pmid:17259608
Esteve I et al. Cellular content of storage inclusions in purple sulfur bacteria determined by ultrathin sections. 1996 Microbiologia pmid:9018690
Gao X et al. Production of copolyesters of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoates by E. coli containing an optimized PHA synthase gene. 2012 Microb. Cell Fact. pmid:22978778
Puchowicz MA et al. Single-pass dual-label indicator method. Blood-to-brain transport of glucose and short-chain monocarboxylic acids. 2003 Methods Mol. Med. pmid:12958426