(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Lipidoses D008064 7 associated lipids
Lipoma D008067 1 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Liver Diseases D008107 31 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Diseases, Obstructive D008173 10 associated lipids
Lung Neoplasms D008175 171 associated lipids
Mastitis D008413 3 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

Download all related citations
Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Pere MC et al. Hepatic metabolism during fasting-refeeding transition in conscious pregnant rabbits. 1992 Am. J. Physiol. pmid:1616023
Nosadini R et al. Ketone body metabolism in normal and diabetic human skeletal muscle. 1985 Am. J. Physiol. pmid:4025538
Desrochers S et al. Metabolism of (R,S)-1,3-butanediol acetoacetate esters, potential parenteral and enteral nutrients in conscious pigs. 1995 Am. J. Physiol. pmid:7733265
Fery F et al. Mechanisms of starvation diabetes: a study with double tracer and indirect calorimetry. 1990 Am. J. Physiol. pmid:2260646
Scharrer E and Langhans W Control of food intake by fatty acid oxidation. 1986 Am. J. Physiol. pmid:3717372
Harris RB and Martin RJ Specific depletion of body fat in parabiotic partners of tube-fed obese rats. 1984 Am. J. Physiol. pmid:6431831
De Feo P et al. Contribution of cortisol to glucose counterregulation in humans. 1989 Am. J. Physiol. pmid:2665516
Mikines KJ et al. Effect of 7 days of bed rest on dose-response relation between plasma glucose and insulin secretion. 1989 Am. J. Physiol. pmid:2665517
Bonadonna RC et al. Time dependence of the interaction between lipid and glucose in humans. 1989 Am. J. Physiol. pmid:2665518
Marker JC et al. Reduced epinephrine clearance and glycemic sensitivity to epinephrine in older individuals. 1998 Am. J. Physiol. pmid:9814995
Benavides A et al. Circadian rhythms of lipoprotein lipase and hepatic lipase activities in intermediate metabolism of adult rat. 1998 Am. J. Physiol. pmid:9728079
Butler P et al. Mechanism of growth hormone-induced postprandial carbohydrate intolerance in humans. 1991 Am. J. Physiol. pmid:2018116
Tsalikian E et al. Glucose production and utilization in children with glycogen storage disease type I. 1984 Am. J. Physiol. pmid:6388348
Cameron JL et al. Metabolic changes during maturation of male monkeys: possible signals for onset of puberty. 1985 Am. J. Physiol. pmid:3901775
Vissing J et al. Role of metabolic feedback regulation in glucose production of running rats. 1988 Am. J. Physiol. pmid:3046377
Loucks AB and Verdun M Slow restoration of LH pulsatility by refeeding in energetically disrupted women. 1998 Am. J. Physiol. pmid:9756553
Monti LD et al. Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16174656
Pelletier A and Coderre L Ketone bodies alter dinitrophenol-induced glucose uptake through AMPK inhibition and oxidative stress generation in adult cardiomyocytes. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17227964
Chu CA et al. Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11788373
Galassetti P et al. Effects of antecedent prolonged exercise on subsequent counterregulatory responses to hypoglycemia. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11350772
McGregor VP et al. Elevated endogenous cortisol reduces autonomic neuroendocrine and symptom responses to subsequent hypoglycemia. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11882496
Everett-Grueter C et al. The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16608886
El Midaoui A et al. Physical training reverses defect in 3-ketoacid CoA-transferase activity in skeletal muscle of diabetic rats. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15774485
Vannucci SJ and Simpson IA Developmental switch in brain nutrient transporter expression in the rat. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:14534079
Ravikumar B et al. Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15572652
Blomqvist G et al. Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:12067838
El Midaoui A et al. Physical training reverses the increased activity of the hepatic ketone body synthesis pathway in chronically diabetic rats. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16403781
Hodson L et al. Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation? 2010 Am. J. Physiol. Endocrinol. Metab. pmid:20628024
Stannard SR et al. Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:12388154
Yamada T et al. {beta}-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle. 2010 Am. J. Physiol. Endocrinol. Metab. pmid:20516259
Song H et al. Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet. 2010 Am. J. Physiol. Endocrinol. Metab. pmid:20179248
Takehiro M et al. Chronic exposure to beta-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15479955
Zhang D et al. Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:20959534
Chalhoub E et al. A computer model of gluconeogenesis and lipid metabolism in the perfused liver. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17911349
Bielohuby M et al. Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:20943751
Puchowicz MA et al. Diet-induced ketosis increases capillary density without altered blood flow in rat brain. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17284577
Malkova D et al. Prior exercise and postprandial substrate extraction across the human leg. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:11052956
Connolly CC et al. Alterations in basal glucose metabolism during late pregnancy in the conscious dog. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:11052973
Jackson PA et al. Effect of hepatic denervation on the counterregulatory response to insulin-induced hypoglycemia in the dog. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:11093911
Tardif A et al. Chronic exposure to beta-hydroxybutyrate impairs insulin action in primary cultures of adult cardiomyocytes. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11701435
Jensen MD et al. Lipid metabolism during fasting. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11551856
St Amand TA et al. Pyruvate overrides inhibition of PDH during exercise after a low-carbohydrate diet. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913026
Stallknecht B et al. Effect of training on insulin sensitivity of glucose uptake and lipolysis in human adipose tissue. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913038
Chu CA et al. The direct effects of catecholamines on hepatic glucose production occur via alpha(1)- and beta(2)-receptors in the dog. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913048
Plaisance EP et al. Niacin stimulates adiponectin secretion through the GPR109A receptor. 2009 Am. J. Physiol. Endocrinol. Metab. pmid:19141678
Dasarathy S et al. Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19571235
Cremin JD et al. Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12637251
Zou Z et al. dl-3-Hydroxybutyrate administration prevents myocardial damage after coronary occlusion in rat hearts. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12384475
Stanley WC et al. beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12969881
Linke A et al. Shift in metabolic substrate uptake by the heart during development of alloxan-induced diabetes. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12915387
White RL and Wittenberg BA Mitochondrial NAD(P)H, ADP, oxidative phosphorylation, and contraction in isolated heart cells. 2000 Am. J. Physiol. Heart Circ. Physiol. pmid:11009472
Bigrigg JK et al. Carbohydrate refeeding after a high-fat diet rapidly reverses the adaptive increase in human skeletal muscle PDH kinase activity. 2009 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:19625693
Bernard SF et al. Blockade of fatty acid oxidation mimics phase II-phase III transition in a fasting bird, the king penguin. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12069939
Bernard SF et al. Lipolytic and metabolic response to glucagon in fasting king penguins: phase II vs. phase III. 2003 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12388477
Becskei C et al. Reduced fasting-induced activation of hypothalamic arcuate neurons is associated with hyperleptinemia and increased leptin sensitivity in obese mice. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20538900
Connolly CC et al. Hepatic and muscle insulin action during late pregnancy in the dog. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:16973936
Luci S et al. Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17363680
Díaz-Muñoz M et al. Anticipatory changes in liver metabolism and entrainment of insulin, glucagon, and corticosterone in food-restricted rats. 2000 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11080068
Verrier D et al. Physiological response to extreme fasting in subantarctic fur seal (Arctocephalus tropicalis) pups: metabolic rates, energy reserve utilization, and water fluxes. 2009 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:19776248
Andrews MT et al. Adaptive mechanisms regulate preferred utilization of ketones in the heart and brain of a hibernating mammal during arousal from torpor. 2009 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:19052316
Li M et al. GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy. 2013 Am. J. Physiol. Renal Physiol. pmid:23467425
Aromolaran AS et al. Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. 2007 Am. J. Physiol., Cell Physiol. pmid:17344311
MacDonald MJ et al. Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion. 2008 Am. J. Physiol., Cell Physiol. pmid:18160486
Mori K et al. Insulinopenia as a risk factor in hepatectomy and its resolution by intraportal insulin administration. 1991 Am. J. Surg. pmid:2063969
Sasi P et al. Metabolic acidosis and other determinants of hemoglobin-oxygen dissociation in severe childhood Plasmodium falciparum malaria. 2007 Am. J. Trop. Med. Hyg. pmid:17690396
Lacetera N et al. Effects of nonesterified fatty acids and beta-hydroxybutyrate on functions of mononuclear cells obtained from ewes. 2002 Am. J. Vet. Res. pmid:11911577
Oikawa S et al. Decreased serum apolipoprotein B-100 and A-I concentrations in cows with ketosis and left displacement of the abomasum. 1997 Am. J. Vet. Res. pmid:9028472
Herdt TH et al. Blood concentrations of beta hydroxybutyrate in clinically normal Holstein-Friesian herds and in those with a high prevalence of clinical ketosis. 1981 Am. J. Vet. Res. pmid:7271015
Herdt TH et al. Influence of ration composition and energy balance on blood beta-hydroxybutyrate (ketone) and plasma glucose concentrations of dairy cows in early lactation. 1981 Am. J. Vet. Res. pmid:7271038
Targowski SP et al. Suppression of mitogenic response of bovine lymphocytes during experimental ketosis in calves. 1985 Am. J. Vet. Res. pmid:4026018
Cebra CK and Tornquist SJ Assessment of the effects of epinephrine and insulin on plasma and serum biochemical variables in llamas and alpacas. 2004 Am. J. Vet. Res. pmid:15631035
de Graaf-Roelfsema E et al. Effects of short- and long-term recombinant equine growth hormone and short-term hydrocortisone administration on tissue sensitivity to insulin in horses. 2005 Am. J. Vet. Res. pmid:16334949
Gossett KA et al. Contribution of whole blood L-lactate, pyruvate, D-lactate, acetoacetate, and 3-hydroxybutyrate concentrations to the plasma anion gap in horses with intestinal disorders. 1987 Am. J. Vet. Res. pmid:3826846
Dufva GS et al. Effect of dietary niacin supplementation on phlorhizin and 1,3-butanediol-induced ketonemia and hypoglycemia in steers. 1984 Am. J. Vet. Res. pmid:6497141
Cebra CK et al. Effects of hydrocortisone on substrates of energy metabolism in alpacas. 2002 Am. J. Vet. Res. pmid:12224859
Fallin CW and Christopher MM In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. 1996 Am. J. Vet. Res. pmid:8712507
Pravettoni D et al. Insulin resistance and abomasal motility disorders in cows detected by use of abomasoduodenal electromyography after surgical correction of left displaced abomasum. 2004 Am. J. Vet. Res. pmid:15524316
Reist M et al. Use of threshold serum and milk ketone concentrations to identify risk for ketosis and endometritis in high-yielding dairy cows. 2003 Am. J. Vet. Res. pmid:12602588
Eicher R et al. Effect of cow-specific factors and feeding frequency of concentrate on diurnal variations of blood metabolites in dairy cows. 1999 Am. J. Vet. Res. pmid:10622157
Hornig KJ et al. Evaluation of a point-of-care glucose and β-hydroxybutyrate meter operated in various environmental conditions in prepartum and postpartum sheep. 2013 Am. J. Vet. Res. pmid:23879842
Wagner SA and Schimek DE Evaluation of the effect of bolus administration of 50% dextrose solution on measures of electrolyte and energy balance in postpartum dairy cows. 2010 Am. J. Vet. Res. pmid:20807148
Geishauser T et al. Evaluation of aspartate transaminase activity and beta-hydroxybutyrate concentration in blood as tests for prediction of left displaced abomasum in dairy cows. 1997 Am. J. Vet. Res. pmid:9361881
Westermann CM et al. Plasma acylcarnitine and fatty acid profiles during exercise and training in Standardbreds. 2008 Am. J. Vet. Res. pmid:18980429
Lacetera N et al. Effects of subclinical pregnancy toxemia on immune responses in sheep. 2001 Am. J. Vet. Res. pmid:11453474
Tornquist SJ et al. Metabolic changes and induction of hepatic lipidosis during feed restriction in llamas. 2001 Am. J. Vet. Res. pmid:11453484
Lei J et al. Regulation of leucine catabolism by metabolic fuels in mammary epithelial cells. 2012 Amino Acids pmid:22543725
Reyes-Toso CF et al. Effect of melatonin treatment on oxygen consumption by rat liver mitochondria. 2006 Amino Acids pmid:16554975
López Siguero JP et al. [Blood glucose and ketone monitoring in type 1 diabetic patients in the controlled environment of a summer camp]. 2007 An Pediatr (Barc) pmid:17430716
Scrutton MJ et al. Eating in labour. A randomised controlled trial assessing the risks and benefits. 1999 Anaesthesia pmid:10455830
Altemeyer KH et al. [The stress reaction in knee operations under continuous peridural anesthesia in comparison with neuroleptanalgesia]. 1983 Anaesthesist pmid:6346939
Tsutsui H et al. Simultaneous determination of DL-lactic acid and DL-3-hydroxybutyric acid enantiomers in saliva of diabetes mellitus patients by high-throughput LC-ESI-MS/MS. 2012 Anal Bioanal Chem pmid:22895741
Shimomura T et al. A novel, disposable, screen-printed amperometric biosensor for ketone 3-β-hydroxybutyrate fabricated using a 3-β-hydroxybutyrate dehydrogenase-mesoporous silica conjugate. 2013 Anal Bioanal Chem pmid:23096941
Lam le H et al. Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyrate with water-soluble tetrazolium salt. 2008 Anal Sci pmid:18689950
Kiba N et al. Simultaneous determination of D-glucose and 3-hydroxybutyrate by chemiluminescence detection with immobilized enzymes in a flow injection system. 2003 Anal Sci pmid:12945679
Yamai K et al. Acetone concentration in gas emanating from tails of diabetic rats. 2012 Anal Sci pmid:22687932
Miles JM et al. Determination of ketone body turnover in vivo with stable isotopes, utilizing gas chromatography/mass spectrometry. 1984 Anal. Biochem. pmid:6496922
Sener A and Malaisse WJ A sensitive radioisotopic method for the measurement of NAD(P)H: its application to the assay of metabolites and enzymatic activities. 1990 Anal. Biochem. pmid:2363494
Tsai YC et al. Identification of L-3-hydroxybutyrate as an original ketone body in rat serum by column-switching high-performance liquid chromatography and fluorescence derivatization. 2003 Anal. Biochem. pmid:12842104
Lam le H et al. Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyric acid. 2007 Anal. Biochem. pmid:17386920
Persson M et al. Measurement of plasma acetate kinetics using high-performance liquid chromatography. 1991 Anal. Biochem. pmid:1789417