(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Shock D012769 11 associated lipids
Congenital Abnormalities D000013 11 associated lipids
Amyotrophic Lateral Sclerosis D000690 11 associated lipids
Disease Resistance D060467 12 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Death, Sudden D003645 12 associated lipids
Cat Diseases D002371 12 associated lipids
Metabolic Diseases D008659 12 associated lipids
Hypocalcemia D006996 12 associated lipids
Glucose Intolerance D018149 13 associated lipids
Hypoglycemia D007003 13 associated lipids
Acidosis D000138 13 associated lipids
Ketosis D007662 13 associated lipids
Corneal Diseases D003316 13 associated lipids
Critical Illness D016638 13 associated lipids
Reye Syndrome D012202 14 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Brain Neoplasms D001932 15 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Albuminuria D000419 18 associated lipids
Pregnancy Complications D011248 19 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Vomiting D014839 21 associated lipids
Hyperglycemia D006943 21 associated lipids
Cachexia D002100 21 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Cholestasis D002779 23 associated lipids
Hypoxia D000860 23 associated lipids
Birth Weight D001724 23 associated lipids
Cattle Diseases D002418 24 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Hyperinsulinism D006946 27 associated lipids
Obesity D009765 29 associated lipids
Liver Diseases D008107 31 associated lipids
Hypothyroidism D007037 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Uremia D014511 33 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Epilepsy D004827 35 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

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Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Porter WH et al. Laboratory and clinical evaluation of assays for beta-hydroxybutyrate. 1997 Am. J. Clin. Pathol. pmid:9052387
Custer EM et al. The storage stability of 3-hydroxybutyrate in serum, plasma, and whole blood. 1983 Am. J. Clin. Pathol. pmid:6410906
Eckfeldt JH et al. Error in calibration. 1984 Am. J. Clin. Pathol. pmid:6695863
Wolfsdorf JI et al. Ketonuria does not exclude hyperinsulinemic hypoglycemia. 1984 Am. J. Dis. Child. pmid:6364785
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Umpierrez GE et al. Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis. 2004 Am. J. Med. pmid:15336577
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Davies AO Effects of endogenous redox-active compounds on coupling of human beta 2-adrenergic receptors. 1986 Am. J. Med. Sci. pmid:3022589
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Harding JE et al. Effects of beta-hydroxybutyrate infusion on hind limb metabolism in fetal sheep. 1992 Am. J. Obstet. Gynecol. pmid:1536251
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Nosadini R et al. Ketone body metabolism in normal and diabetic human skeletal muscle. 1985 Am. J. Physiol. pmid:4025538
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Bougneres PF and Ferre P Study of ketone body kinetics in children by a combined perfusion of 13C and 2H3 tracers. 1987 Am. J. Physiol. pmid:3688221
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Cherel Y and Le Maho Y Five months of fasting in king penguin chicks: body mass loss and fuel metabolism. 1985 Am. J. Physiol. pmid:4051024
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Desrochers S et al. Metabolism of (R,S)-1,3-butanediol acetoacetate esters, potential parenteral and enteral nutrients in conscious pigs. 1995 Am. J. Physiol. pmid:7733265
Blomqvist G et al. Use of R-beta-[1-11C]hydroxybutyrate in PET studies of regional cerebral uptake of ketone bodies in humans. 1995 Am. J. Physiol. pmid:7491948
Fery F et al. Mechanisms of starvation diabetes: a study with double tracer and indirect calorimetry. 1990 Am. J. Physiol. pmid:2260646
Rössle C et al. Medium-chain triglycerides induce alterations in carnitine metabolism. 1990 Am. J. Physiol. pmid:2360627
Hildebrandt LA et al. Utilization and preferred metabolic pathway of ketone bodies for lipid synthesis by isolated rat hepatoma cells. 1995 Am. J. Physiol. pmid:7631749
Ciraolo ST et al. Model of extreme hypoglycemia in dogs made ketotic with (R,S)-1,3-butanediol acetoacetate esters. 1995 Am. J. Physiol. pmid:7631780
Harris RB and Martin RJ Specific depletion of body fat in parabiotic partners of tube-fed obese rats. 1984 Am. J. Physiol. pmid:6431831
Beaufrère B et al. Effects of D-beta-hydroxybutyrate and long- and medium-chain triglycerides on leucine metabolism in humans. 1992 Am. J. Physiol. pmid:1312786
Chu CA et al. Direct effects of catecholamines on hepatic glucose production in conscious dog are due to glycogenolysis. 1996 Am. J. Physiol. pmid:8760090
Turcotte LP et al. Increased plasma FFA uptake and oxidation during prolonged exercise in trained vs. untrained humans. 1992 Am. J. Physiol. pmid:1319676
Des Rosiers C et al. Pseudoketogenesis in hepatectomized dogs. 1990 Am. J. Physiol. pmid:2316645
Tildon JT and Roeder LM Transport of 3-hydroxy[3-14C]butyrate by dissociated cells from rat brain. 1988 Am. J. Physiol. pmid:3407758
Avogaro A et al. Epinephrine's ketogenic effect in humans is mediated principally by lipolysis. 1992 Am. J. Physiol. pmid:1514604
De Feo P et al. Contribution of cortisol to glucose counterregulation in humans. 1989 Am. J. Physiol. pmid:2665516
Mikines KJ et al. Effect of 7 days of bed rest on dose-response relation between plasma glucose and insulin secretion. 1989 Am. J. Physiol. pmid:2665517
Bonadonna RC et al. Time dependence of the interaction between lipid and glucose in humans. 1989 Am. J. Physiol. pmid:2665518
Marker JC et al. Reduced epinephrine clearance and glycemic sensitivity to epinephrine in older individuals. 1998 Am. J. Physiol. pmid:9814995
Leturque A et al. Fetal glucose utilization in response to maternal starvation and acute hyperketonemia. 1989 Am. J. Physiol. pmid:2660583
Féry F and Balasse EO Response of ketone body metabolism to exercise during transition from postabsorptive to fasted state. 1986 Am. J. Physiol. pmid:3518484
Laughlin MR et al. Nonglucose substrates increase glycogen synthesis in vivo in dog heart. 1994 Am. J. Physiol. pmid:8048587
De Feo P et al. Evidence against important catecholamine compensation for absent glucagon counterregulation. 1991 Am. J. Physiol. pmid:1996624
Hawkins RA and Mans AM Regional blood-brain barrier transport of ketone bodies in portacaval-shunted rats. 1991 Am. J. Physiol. pmid:1951691
Shambaugh GE et al. Fetal fuels. VII. Ketone bodies inhibit synthesis of purines in fetal rat brain. 1984 Am. J. Physiol. pmid:6742185
Miles JM et al. A dual-isotope technique for determination of in vivo ketone body kinetics. 1986 Am. J. Physiol. pmid:3526920
Hirsch IB et al. Insulin and glucagon in prevention of hypoglycemia during exercise in humans. 1991 Am. J. Physiol. pmid:2035626
Davis TA et al. Response of muscle protein synthesis to fasting in suckling and weaned rats. 1991 Am. J. Physiol. pmid:1721504
Beattie MA and Winder WW Mechanism of training-induced attenuation of postexercise ketosis. 1984 Am. J. Physiol. pmid:6093602
Shaw JH and Wolfe RR Influence of beta-hydroxybutyrate infusion on glucose and free fatty acid metabolism in dogs. 1984 Am. J. Physiol. pmid:6095672
Bougnères PF et al. Medium-chain fatty acids increase glucose production in normal and low birth weight newborns. 1989 Am. J. Physiol. pmid:2719106
Stevenson RW et al. Metabolic responses to intraduodenal glucose loading in insulin-infused diabetic dogs. 1983 Am. J. Physiol. pmid:6349384
Castellini MA and Costa DP Relationships between plasma ketones and fasting duration in neonatal elephant seals. 1990 Am. J. Physiol. pmid:2240269
Deems RO et al. Hypoglycemic effects of a novel fatty acid oxidation inhibitor in rats and monkeys. 1998 Am. J. Physiol. pmid:9486313
Lundgren F et al. Substrate exchange in human limb muscle during exercise at reduced blood flow. 1988 Am. J. Physiol. pmid:3142276
Winder WW et al. Endurance training attenuates stress hormone responses to exercise in fasted rats. 1982 Am. J. Physiol. pmid:6283921
Tuttle KR et al. Glucagon, not insulin, may play a secondary role in defense against hypoglycemia during exercise. 1988 Am. J. Physiol. pmid:3287952
Tsalikian E et al. Glucose production and utilization in children with glycogen storage disease type I. 1984 Am. J. Physiol. pmid:6388348
Poggetti RS et al. Quantifying oxidative injury in the liver. 1995 Am. J. Physiol. pmid:7900808
Sussman I et al. Differential effect of metabolic fuels on the energy state and Na(+)-K(+)-ATPase in isolated cerebral microvessels. 1993 Am. J. Physiol. pmid:7902010
Goodman MN and del Pilar Gomez M Decreased myofibrillar proteolysis after refeeding requires dietary protein or amino acids. 1987 Am. J. Physiol. pmid:3300365
Féry F et al. Role of fat-derived substrates in the regulation of gluconeogenesis during fasting. 1996 Am. J. Physiol. pmid:8967471
Heller SR and Cryer PE Hypoinsulinemia is not critical to glucose recovery from hypoglycemia in humans. 1991 Am. J. Physiol. pmid:1858873
Hoffer LJ and Forse RA Protein metabolic effects of a prolonged fast and hypocaloric refeeding. 1990 Am. J. Physiol. pmid:2185664
Féry F and Balasse EO Ketone body turnover during and after exercise in overnight-fasted and starved humans. 1983 Am. J. Physiol. pmid:6353933
Bailey JW et al. Validation of two-pool model for in vivo ketone body kinetics. 1990 Am. J. Physiol. pmid:2185666
De Feo P et al. The pancreatic-adrenocortical-pituitary clamp technique for study of counterregulation in humans. 1987 Am. J. Physiol. pmid:2882686
Stunff CL and Bougnères PF Alterations of plasma lactate and glucose metabolism in obese children. 1996 Am. J. Physiol. pmid:8944666
Beattie MA and Winder WW Attenuation of postexercise ketosis in fasted endurance-trained rats. 1985 Am. J. Physiol. pmid:2982280
Uchida S and Endou H Substrate specificity to maintain cellular ATP along the mouse nephron. 1988 Am. J. Physiol. pmid:2847554
Malaisse WJ et al. Ketone bodies and islet function: 45Ca handling, insulin synthesis, and release. 1990 Am. J. Physiol. pmid:2196820
Tullson PC and Aprille JR Regulation of mitochondrial adenine nucleotide content in newborn rabbit liver. 1987 Am. J. Physiol. pmid:2891302
Malaisse WJ et al. Ketone bodies and islet function: 86Rb handling and metabolic data. 1990 Am. J. Physiol. pmid:2196821
Zhang C and Paul RJ Excitation-contraction coupling and relaxation in porcine carotid arteries are specifically dependent on glucose. 1994 Am. J. Physiol. pmid:7977831
Nosadini R et al. Acetoacetate and 3-hydroxybutyrate kinetics in obese and insulin-dependent diabetic humans. 1985 Am. J. Physiol. pmid:3922234
McCall AL et al. Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels. 1988 Am. J. Physiol. pmid:2964787
Gilbert M et al. Role of free fatty acids in hepatic insulin resistance during late pregnancy in conscious rabbits. 1991 Am. J. Physiol. pmid:2058668
Kim DK et al. Effects of beta-hydroxybutyrate on oxidative metabolism and phosphorylation potential in canine heart in vivo. 1991 Am. J. Physiol. pmid:2058715
Divertie GD et al. Lipolytic responsiveness to epinephrine in nondiabetic and diabetic humans. 1997 Am. J. Physiol. pmid:9227461
Hunter ES et al. A potential mechanism of DL-beta-hydroxybutyrate-induced malformations in mouse embryos. 1987 Am. J. Physiol. pmid:3111272
Geary N et al. Blood metabolites and feeding during postinsulin hypophagia. 1982 Am. J. Physiol. pmid:7051864
Cobelli C et al. Model of the kinetics of ketone bodies in humans. 1982 Am. J. Physiol. pmid:7091397
Goldstein L et al. Ketone body effects on glutamine metabolism in isolated kidneys and mitochondria. 1982 Am. J. Physiol. pmid:7114217
Vissing J et al. Role of metabolic feedback regulation in glucose production of running rats. 1988 Am. J. Physiol. pmid:3046377
Roch-Ramel F et al. Urate transport in brush-border membrane of human kidney. 1994 Am. J. Physiol. pmid:8203564
Loucks AB and Verdun M Slow restoration of LH pulsatility by refeeding in energetically disrupted women. 1998 Am. J. Physiol. pmid:9756553