(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Mastitis, Bovine D008414 8 associated lipids
Metabolic Diseases D008659 12 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Muscle Rigidity D009127 4 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Neural Tube Defects D009436 5 associated lipids
Obesity D009765 29 associated lipids
Obesity, Morbid D009767 8 associated lipids
Pallor D010167 1 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Parkinson Disease D010300 53 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Placental Insufficiency D010927 6 associated lipids
Plant Poisoning D010939 5 associated lipids
Pregnancy Complications D011248 19 associated lipids
Puerperal Disorders D011644 4 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Reye Syndrome D012202 14 associated lipids
Sandhoff Disease D012497 2 associated lipids
Seizures D012640 87 associated lipids
Sheep Diseases D012757 10 associated lipids
Shock D012769 11 associated lipids
Short Bowel Syndrome D012778 3 associated lipids
Sleep Deprivation D012892 5 associated lipids
Spasms, Infantile D013036 3 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Starvation D013217 47 associated lipids
Status Epilepticus D013226 1 associated lipids
Stomach Diseases D013272 7 associated lipids
Syndrome D013577 4 associated lipids
Thinness D013851 11 associated lipids
Thyrotoxicosis D013971 3 associated lipids
Trematode Infections D014201 8 associated lipids
Trichostrongyloidiasis D014252 7 associated lipids
Trypanosomiasis, African D014353 5 associated lipids
Uremia D014511 33 associated lipids
Uterine Diseases D014591 6 associated lipids
Vibrio Infections D014735 5 associated lipids
Vomiting D014839 21 associated lipids
Spinal Muscular Atrophies of Childhood D014897 1 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Wrist Injuries D014954 1 associated lipids
Fructose-1,6-Diphosphatase Deficiency D015319 1 associated lipids
Pyruvate Metabolism, Inborn Errors D015323 3 associated lipids
Pyruvate Dehydrogenase Complex Deficiency Disease D015325 3 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

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Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Caamaño GJ et al. In vivo utilization of D(-)-3-hydroxybutyrate by chick brain and spinal cord. 1990 Neurochem. Res. pmid:2370945
Lai JC and Sheu KF The effect of 2-oxoglutarate or 3-hydroxybutyrate on pyruvate dehydrogenase complex in isolated cerebrocortical mitochondria. 1987 Neurochem. Res. pmid:3627360
Tildon JT et al. Transport of 3-hydroxybutyrate by cultured rat brain astrocytes. 1994 Neurochem. Res. pmid:7891839
Mejía-Toiber J et al. D-beta-hydroxybutyrate prevents glutamate-mediated lipoperoxidation and neuronal damage elicited during glycolysis inhibition in vivo. 2006 Neurochem. Res. pmid:17115265
McKenna MC Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain. 2012 Neurochem. Res. pmid:23079895
Linares A et al. Utilization of ketone bodies by chick brain and spinal cord during embryonic and postnatal development. 1993 Neurochem. Res. pmid:8255360
Samala R et al. The ketogenic diet changes metabolite levels in hippocampal extracellular fluid. 2011 Neurochem. Int. pmid:21070829
Lund TM et al. β-Hydroxybutyrate is the preferred substrate for GABA and glutamate synthesis while glucose is indispensable during depolarization in cultured GABAergic neurons. 2011 Neurochem. Int. pmid:21684314
Cheng B et al. d-β-Hydroxybutyrate inhibited the apoptosis of PC12 cells induced by H2O2 via inhibiting oxidative stress. 2013 Neurochem. Int. pmid:23022628
Li FY et al. Canine spongiform leukoencephalomyelopathy is associated with a missense mutation in cytochrome b. 2006 Neurobiol. Dis. pmid:16026996
Reger MA et al. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. 2004 Neurobiol. Aging pmid:15123336
Reyes-Toso CF et al. In vitro effect of melatonin on oxygen consumption in liver mitochondria of rats. 2003 Neuro Endocrinol. Lett. pmid:14647009
Hörl WH et al. Kidney independent serine synthesis in the rat. Effect of dietary serine and glycine restriction. 1985 Nephron pmid:3925357
Riegel W and Hörl WH Role of energy charge and redox state for hepatocyte gluconeogenesis of acutely uremic rats. 1985 Nephron pmid:4000349
Litten JC et al. Effect of Acute Administration of Recombinant Human Leptin during the Neonatal Period on Body Temperature and Endocrine Profile of the Piglet. 2008 Neonatology pmid:17895632
Tyo KE et al. Stabilized gene duplication enables long-term selection-free heterologous pathway expression. 2009 Nat. Biotechnol. pmid:19633654
Padidela R et al. Focal congenital hyperinsulinism in a patient with septo-optic dysplasia. 2010 Nat Rev Endocrinol pmid:20842182
Venishetty VK et al. β-Hydroxybutyric acid grafted solid lipid nanoparticles: a novel strategy to improve drug delivery to brain. 2013 Nanomedicine pmid:22960191
Zhao NQ et al. [Role of apoptosis and mitochondrial apoptotic pathway in glucolipotoxicity-induced islet beta-cell dysfunction]. 2008 Nan Fang Yi Ke Da Xue Xue Bao pmid:19033115
Kamei I et al. Effects of lipolytic and antilipolytic agents on glycerol and free fatty acid release from isolated adipocytes of normal and diabetic rats. 1989 Nagoya J Med Sci pmid:2549422
Galanello R et al. Induction of fetal hemoglobin in the presence of increased 3-hydroxybutyric acid associated with beta-ketothiolase deficiency. 1994 N. Engl. J. Med. pmid:7520129
Jenkins DJ et al. Nibbling versus gorging: metabolic advantages of increased meal frequency. 1989 N. Engl. J. Med. pmid:2674713
Stacpoole PW et al. Treatment of lactic acidosis with dichloroacetate. 1983 N. Engl. J. Med. pmid:6877297
White NJ et al. Severe hypoglycemia and hyperinsulinemia in falciparum malaria. 1983 N. Engl. J. Med. pmid:6343877
Rizzo T et al. Correlations between antepartum maternal metabolism and child intelligence. 1991 N. Engl. J. Med. pmid:1881416
Ashby RD et al. Biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium Propionibacterium acnes. 2011 N Biotechnol pmid:20708720
Wetzel DM and Salpeter MM Fibrillation and accelerated AChR degradation in long-term muscle organ culture. 1991 Muscle Nerve pmid:1944400
Bellward GD et al. Hepatic cytochrome P-450j induction in the spontaneously diabetic BB rat. 1988 Mol. Pharmacol. pmid:3277033
Ladrière L et al. Assessment of the nutritional value of glycerol-1,2, 3-tris(methylsuccinate) in fed and starved rats. 1999 Mol. Genet. Metab. pmid:10381333
Schutz PW et al. Protective effects of d-3-hydroxybutyrate and propionate during hypoglycemic coma: clinical and biochemical insights from infant rats. 2011 Mol. Genet. Metab. pmid:21439874
Gillingham MB et al. Metabolic control during exercise with and without medium-chain triglycerides (MCT) in children with long-chain 3-hydroxy acyl-CoA dehydrogenase (LCHAD) or trifunctional protein (TFP) deficiency. 2006 Sep-Oct Mol. Genet. Metab. pmid:16876451
Hiroyama M et al. Hypermetabolism of fat in V1a vasopressin receptor knockout mice. 2007 Mol. Endocrinol. pmid:17021052
Matković M et al. Synthesis of novel adamantyl and homoadamantyl-substituted β-hydroxybutyric acids. 2013 Mol. Divers. pmid:24043584
Sultan AM The effect of fasting on D-3-hydroxybutyrate metabolism in the perfused rat heart. 1990 Mol. Cell. Biochem. pmid:2345539
Sultan AM Effects of diabetes and insulin on ketone bodies metabolism in heart. 1992 Mol. Cell. Biochem. pmid:1579130
Sultan AM D-3-hydroxybutyrate metabolism in the perfused rat heart. 1988 Mol. Cell. Biochem. pmid:3398833
Pelletier A et al. Chronic exposure to ketone bodies impairs glucose uptake in adult cardiomyocytes in response to insulin but not vanadate: the role of PI3-K. 2007 Mol. Cell. Biochem. pmid:16960657
Rains JL and Jain SK Hyperketonemia decreases mitochondrial membrane potential and its normalization with chromium (III) supplementation in monocytes. 2011 Mol. Cell. Biochem. pmid:21153866
Geraldes CF et al. Influence of vanadate on glycolysis, intracellular sodium, and pH in perfused rat hearts. 1997 Mol. Cell. Biochem. pmid:9144318
Khorsand F et al. An electrochemical biosensor for 3-hydroxybutyrate detection based on screen-printed electrode modified by coenzyme functionalized carbon nanotubes. 2013 Mol. Biol. Rep. pmid:23187739
Shah TD et al. The characterization of a unique Trypanosoma brucei β-hydroxybutyrate dehydrogenase. 2011 Mol. Biochem. Parasitol. pmid:21767577
Negoda A et al. Importance of oligo-R-3-hydroxybutyrates to S. lividans KcsA channel structure and function. 2010 Mol Biosyst pmid:20862428
Bachmann W et al. [Coma--management and early treatment with regular and basal BHI]. 1983 MMW Munch Med Wochenschr pmid:6408439
D'Amelio G et al. [Lipolysis and ketosis during swimming in thermal water]. 1991 Minerva Med. pmid:1766571
Riegel W and Hörl WH Ketone body-induced dissociation between hepatocyte gluconeogenesis and ureagenesis in acutely uremic rats. 1992 Miner Electrolyte Metab pmid:1465055
Lütke-Eversloh T et al. Identification of a new class of biopolymer: bacterial synthesis of a sulfur-containing polymer with thioester linkages. 2001 Microbiology (Reading, Engl.) pmid:11160796
Tessmer N et al. Heat-shock protein HspA mimics the function of phasins sensu stricto in recombinant strains of Escherichia coli accumulating polythioesters or polyhydroxyalkanoates. 2007 Microbiology (Reading, Engl.) pmid:17259608
Esteve I et al. Cellular content of storage inclusions in purple sulfur bacteria determined by ultrathin sections. 1996 Microbiologia pmid:9018690
Gao X et al. Production of copolyesters of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoates by E. coli containing an optimized PHA synthase gene. 2012 Microb. Cell Fact. pmid:22978778
Puchowicz MA et al. Single-pass dual-label indicator method. Blood-to-brain transport of glucose and short-chain monocarboxylic acids. 2003 Methods Mol. Med. pmid:12958426
Tyo KE et al. Analysis of polyhydroxybutyrate flux limitations by systematic genetic and metabolic perturbations. 2010 Metab. Eng. pmid:19879956
Wang B et al. Engineering cyanobacteria for photosynthetic production of 3-hydroxybutyrate directly from CO2. 2013 Metab. Eng. pmid:23333586
Metcalfe HK et al. Effects of D-3-hydroxybutyrate and acetoacetate on lactate removal in isolated perfused livers from starved and fed rats. 1992 Metab. Clin. Exp. pmid:1556952
Farrer M et al. Effect of acute inhibition of lipolysis on operation of the glucose-fatty acid cycle in hepatic cirrhosis. 1992 Metab. Clin. Exp. pmid:1588824
Fletcher JM and Pitt JJ Fasting medium chain acyl-coenzyme A dehydrogenase--deficient children can make ketones. 2001 Metab. Clin. Exp. pmid:11229423
Møller N et al. Substrate metabolism during modest hyperinsulinemia in response to isolated hyperketonemia in insulin-dependent diabetic subjects. 1990 Metab. Clin. Exp. pmid:2246973
Ferré P et al. Hypoglycemic effects of a beta-agonist, Ro 16-8714, in streptozotocin-diabetic rats: decreased hepatic glucose production and increased glucose utilization in oxidative muscles. 1992 Metab. Clin. Exp. pmid:1346545
Gitomer WL et al. In vivo effects of lipopolysaccharide on hepatic free-NAD(P)(+)-linked redox states and cytosolic phosphorylation potential in 48-hour-fasted rats. 1995 Metab. Clin. Exp. pmid:7666791
Pontiroli AE et al. Metabolic effects of graded glucagon infusions in man: inhibition of glucagon, insulin, and somatostatin response to arginine. 1993 Metab. Clin. Exp. pmid:8105365
Hoffer LJ et al. Metabolic effects of carbohydrate in low-calorie diets. 1984 Metab. Clin. Exp. pmid:6472116
Gray DS et al. Effect of carbohydrate refeeding on free fatty acids after a fast in obese diabetic and obese non-diabetic females. 1989 Metab. Clin. Exp. pmid:2645502
Vice E et al. Ketone body metabolism in lean and obese women. 2005 Metab. Clin. Exp. pmid:16253646
Tuchman M et al. Clinical and laboratory observations in a child with hepatic phosphorylase kinase deficiency. 1986 Metab. Clin. Exp. pmid:3459948
Broussolle C et al. Effects of different lipid substrates on glucose metabolism in normal postabsorptive humans. 1992 Metab. Clin. Exp. pmid:1461133
Zuniga-Guajardo S et al. Effects of massive obesity on insulin sensitivity and insulin clearance and the metabolic response to insulin as assessed by the euglycemic clamp technique. 1986 Metab. Clin. Exp. pmid:3512959
Akanji AO et al. The effects of changes in plasma nonesterified fatty acid levels on oxidative metabolism during moderate exercise in patients with non-insulin-dependent diabetes mellitus. 1993 Metab. Clin. Exp. pmid:8487664
Albisser AM et al. Intermediary metabolism in diabetic dogs treated with pancreatic autotransplants and insulin pumps. 1986 Metab. Clin. Exp. pmid:3515120
Wolever TM Metabolic effects of continuous feeding. 1990 Metab. Clin. Exp. pmid:2202886
Christopher MM et al. Increased serum D-lactate associated with diabetic ketoacidosis. 1995 Metab. Clin. Exp. pmid:7885271
Khamaisi M et al. Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. 1999 Metab. Clin. Exp. pmid:10206446
Denne SC et al. Leucine kinetics and fuel utilization during a brief fast in human pregnancy. 1991 Metab. Clin. Exp. pmid:1961116
Nomura M et al. The metabolic and hormonal adaptations of normal dogs to long-term exogenous sulfated insulin infusions. 1986 Metab. Clin. Exp. pmid:3531758
Ikeda T et al. Uptake of beta-hydroxybutyrate in perfused hindquarter of starved and diabetic rats. 1991 Metab. Clin. Exp. pmid:1961122
Schweiger U et al. Effects of carbohydrate and protein meals on plasma large neutral amino acids, glucose, and insulin plasma levels of anorectic patients. 1986 Metab. Clin. Exp. pmid:3531760
Press M et al. Effect of insulin on growth hormone-induced metabolic derangements in diabetes. 1986 Metab. Clin. Exp. pmid:3531761
Jacob RJ et al. Brain glucose levels are elevated in chronically hyperglycemic diabetic rats: no evidence for protective adaptation by the blood brain barrier. 2002 Metab. Clin. Exp. pmid:12489061
Mori K et al. Effects of tolbutamide on fructose-2,6-bisphosphate formation and ketogenesis in hepatocytes from diabetic rats. 1992 Metab. Clin. Exp. pmid:1535678
Zuniga-Guajardo S et al. Changes in insulin sensitivity and clearance in anorexia nervosa. 1986 Metab. Clin. Exp. pmid:3537630
Lowell BB et al. Regulation of myofibrillar protein degradation in rat skeletal muscle during brief and prolonged starvation. 1986 Metab. Clin. Exp. pmid:3537631
Weekes TE Influence of experimental hyperthyroidism on insulin action in growing sheep. 1992 Metab. Clin. Exp. pmid:1542262
Rooney DP et al. Insulin action and hepatic glucose cycling in essential hypertension. 1992 Metab. Clin. Exp. pmid:1542271
Adibi SA et al. Modulation of leucine oxidation and turnover by graded amounts of carbohydrate intake in obese subjects. 1982 Metab. Clin. Exp. pmid:7043183
Courtney CH et al. Comparison of the priming effects of pulsatile and continuous insulin delivery on insulin action in man. 2003 Metab. Clin. Exp. pmid:12898472
Nosadini R et al. The antiketogenic effect of alanine in normal man: evidence for an alanine-ketone body cycle. 1981 Metab. Clin. Exp. pmid:6112656
Hill JO et al. Thermogenesis in humans during overfeeding with medium-chain triglycerides. 1989 Metab. Clin. Exp. pmid:2739575
Stewart JK et al. Effects of branched-chain amino acids on postprandial 3-OH butyrate and glucagon in the baboon. 1988 Metab. Clin. Exp. pmid:3285128
Spanheimer RG Direct inhibition of collagen production in vitro by diabetic rat serum. 1988 Metab. Clin. Exp. pmid:3285135
Gustafson AB et al. Impaired plasma catecholamine response to submaximal treadmill exercise in obese women. 1990 Metab. Clin. Exp. pmid:2182975
Buchanan TA et al. Hypothermia is critical for survival during prolonged insulin-induced hypoglycemia in rats. 1991 Metab. Clin. Exp. pmid:2000047
Johnson AB et al. Impaired activation of skeletal muscle glycogen synthase in non-insulin-dependent diabetes mellitus is unrelated to the degree of obesity. 1991 Metab. Clin. Exp. pmid:1900343
Matsuo T et al. The thermic effect is greater for structured medium- and long-chain triacylglycerols versus long-chain triacylglycerols in healthy young women. 2001 Metab. Clin. Exp. pmid:11172486
Mansell PI and Macdonald IA The effect of starvation on insulin-induced glucose disposal and thermogenesis in humans. 1990 Metab. Clin. Exp. pmid:2186256
D'Souza NB et al. The effect of ethanol infusion on the altered glucose turnover during bacterial infection. 1990 Metab. Clin. Exp. pmid:2191187
Asplin CM et al. Glucose counterregulation during recovery from neuroglucopenia: which mechanism is important? 1985 Metab. Clin. Exp. pmid:2857049
Hoffer LJ Nutritional status affects renal 3-methylhistidine handling in humans. 1990 Metab. Clin. Exp. pmid:2195297
Koutsari C et al. Postprandial lipemia after short-term variation in dietary fat and carbohydrate. 2000 Metab. Clin. Exp. pmid:11016896
Snyder AK and Singh SP Effects of ethanol on glucose turnover in pregnant rats. 1989 Metab. Clin. Exp. pmid:2913465
Zuniga-Guajardo S and Zinman B The metabolic response to the euglycemic insulin clamp in type I diabetes and normal humans. 1985 Metab. Clin. Exp. pmid:3900631
Chu CA et al. Portal adrenergic blockade does not inhibit the gluconeogenic effects of circulating catecholamines on the liver. 1997 Metab. Clin. Exp. pmid:9109855
Phillips LS et al. Nutrition and somatomedin. XIV. Altered levels of somatomedins and somatomedin inhibitors in rats with streptozotocin-induced diabetes. 1985 Metab. Clin. Exp. pmid:3160912