(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Insulin Resistance D007333 99 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Hyperlipidemias D006949 73 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Coronary Disease D003327 70 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Reperfusion Injury D015427 65 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Weight Loss D015431 56 associated lipids
Parkinson Disease D010300 53 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Fatty Liver D005234 48 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Starvation D013217 47 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Lung Diseases D008171 37 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Epilepsy D004827 35 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Uremia D014511 33 associated lipids
Hypothyroidism D007037 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Liver Diseases D008107 31 associated lipids
Obesity D009765 29 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Hyperinsulinism D006946 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Cattle Diseases D002418 24 associated lipids
Cholestasis D002779 23 associated lipids
Hypoxia D000860 23 associated lipids
Birth Weight D001724 23 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Vomiting D014839 21 associated lipids
Hyperglycemia D006943 21 associated lipids
Cachexia D002100 21 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Pregnancy Complications D011248 19 associated lipids
Albuminuria D000419 18 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Brain Neoplasms D001932 15 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Reye Syndrome D012202 14 associated lipids
Glucose Intolerance D018149 13 associated lipids
Hypoglycemia D007003 13 associated lipids
Acidosis D000138 13 associated lipids
Ketosis D007662 13 associated lipids
Corneal Diseases D003316 13 associated lipids
Critical Illness D016638 13 associated lipids
Hypocalcemia D006996 12 associated lipids
Disease Resistance D060467 12 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Death, Sudden D003645 12 associated lipids
Cat Diseases D002371 12 associated lipids
Metabolic Diseases D008659 12 associated lipids
Dehydration D003681 11 associated lipids
Thinness D013851 11 associated lipids
Shock D012769 11 associated lipids
Congenital Abnormalities D000013 11 associated lipids
Amyotrophic Lateral Sclerosis D000690 11 associated lipids
Sheep Diseases D012757 10 associated lipids
Fatigue D005221 10 associated lipids
Glycosuria D006029 10 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Lung Diseases, Obstructive D008173 10 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Trematode Infections D014201 8 associated lipids
Anorexia D000855 8 associated lipids
Irritable Bowel Syndrome D043183 8 associated lipids
Mastitis, Bovine D008414 8 associated lipids
Obesity, Morbid D009767 8 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

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Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Sarentonglaga B et al. The developmental potential of oocytes is impaired in cattle with liver abnormalities. 2013 J. Reprod. Dev. pmid:23291712
White H et al. Effect of a hypertonic balanced ketone solution on plasma, CSF and brain beta-hydroxybutyrate levels and acid-base status. 2013 Intensive Care Med pmid:23291733
Davidson TL et al. Inter-relationships among diet, obesity and hippocampal-dependent cognitive function. 2013 Neuroscience pmid:23999121
Volova TG et al. Cell growth and accumulation of polyhydroxyalkanoates from CO2 and H2 of a hydrogen-oxidizing bacterium, Cupriavidus eutrophus B-10646. 2013 Bioresour. Technol. pmid:23934338
Parkkola A et al. Extended family history of type 1 diabetes and phenotype and genotype of newly diagnosed children. 2013 Diabetes Care pmid:23033245
Zheng J et al. Lotus-leaf-like topography predominates over adsorbed ECM proteins in poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) surface/cell interactions. 2013 ACS Appl Mater Interfaces pmid:23721174
Zhou C et al. Basal epithelial formalin pigment deposition in the kidneys--a useful marker for ketoacidosis at autopsy. 2013 J Forensic Leg Med pmid:23622479
Palmiere C et al. Preliminary results on the postmortem measurement of 3-beta-hydroxybutyrate in liver homogenates. 2013 Int. J. Legal Med. pmid:23722498
Venishetty VK et al. β-Hydroxybutyric acid grafted solid lipid nanoparticles: a novel strategy to improve drug delivery to brain. 2013 Nanomedicine pmid:22960191
Matsumoto K et al. Efficient (R)-3-hydroxybutyrate production using acetyl CoA-regenerating pathway catalyzed by coenzyme A transferase. 2013 Appl. Microbiol. Biotechnol. pmid:22592551
Zhou C et al. Renal cortical pallor--a useful macroscopic marker for metabolic derangements at autopsy. 2013 J. Forensic Sci. pmid:23488620
Maksymiak M et al. Structural characterization of biocompatible lipoic acid-oligo-(3-hydroxybutyrate) conjugates by electrospray ionization mass spectrometry. 2013 Rapid Commun. Mass Spectrom. pmid:23495024
Zhang S et al. Short-term feed restriction impairs the absorptive function of the reticulo-rumen and total tract barrier function in beef cattle. 2013 J. Anim. Sci. pmid:23422009
Damgaard BM et al. Priming the cow for lactation by rapeseed supplementation in the dry period. 2013 J. Dairy Sci. pmid:23608494
Doré V et al. Short communication: evaluation of the accuracy of an electronic on-farm test to quantify blood β-hydroxybutyrate concentration in dairy goats. 2013 J. Dairy Sci. pmid:23628255
Cotter DG et al. Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth. 2013 J. Biol. Chem. pmid:23689508
Wittrock JA et al. Short communication: validation of a point-of-care glucometer for use in dairy cows. 2013 J. Dairy Sci. pmid:23684029
Schütz KE et al. Behavioral and physiological effects of a short-term feed restriction in lactating dairy cattle with different body condition scores at calving. 2013 J. Dairy Sci. pmid:23684030
Jacobs AA et al. Effects of short- and long-chain fatty acids on the expression of stearoyl-CoA desaturase and other lipogenic genes in bovine mammary epithelial cells. 2013 Animal pmid:23597233
Buffet A et al. Increased plasma β-hydroxybutyrate levels during the fasting test in patients with endogenous hyperinsulinaemic hypoglycaemia. 2013 Eur. J. Endocrinol. pmid:23657581
Silva PR et al. Effects of weekly regrouping of prepartum dairy cows on metabolic, health, reproductive, and productive parameters. 2013 J. Dairy Sci. pmid:23660147
Zilberter M et al. Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease. 2013 J. Neurochem. pmid:23241062
Lomas AJ et al. Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate)/collagen hybrid scaffolds for tissue engineering applications. 2013 Tissue Eng Part C Methods pmid:23281705
Trombold JR et al. Acute high-intensity endurance exercise is more effective than moderate-intensity exercise for attenuation of postprandial triglyceride elevation. 2013 J. Appl. Physiol. pmid:23372145
Shire J et al. Short communication: the effect of temperature on performance of milk ketone test strips. 2013 J. Dairy Sci. pmid:23357011
Palmiere C et al. Postmortem diagnosis of unsuspected diabetes mellitus. 2013 Forensic Sci. Int. pmid:23357227
Khorsand F et al. An electrochemical biosensor for 3-hydroxybutyrate detection based on screen-printed electrode modified by coenzyme functionalized carbon nanotubes. 2013 Mol. Biol. Rep. pmid:23187739
Souza SK et al. Metabolic effects of perinatal asphyxia in the rat cerebral cortex. 2013 Metab Brain Dis pmid:23196669
McArt JA et al. Dry period and parturient predictors of early lactation hyperketonemia in dairy cattle. 2013 J. Dairy Sci. pmid:23102961
Zebeli Q et al. Oral challenge with increasing doses of LPS modulated the patterns of plasma metabolites and minerals in periparturient dairy cows. 2013 Innate Immun pmid:23109506
Dwyer JB and Tamama K Ketoacidosis and trace amounts of isopropanol in a chronic alcoholic patient. 2013 Clin. Chim. Acta pmid:23159845
Giuliodori MJ et al. Clinical endometritis in an Argentinean herd of dairy cows: risk factors and reproductive efficiency. 2013 J. Dairy Sci. pmid:23182361
Poff AM et al. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. 2013 PLoS ONE pmid:23755243
Al-Otaibi H et al. Biochemical studies in patients with hyperinsulinaemic hypoglycaemia. 2013 Eur. J. Pediatr. pmid:23756914
Kawata Y et al. Efficient secretion of (R)-3-hydroxybutyric acid from Halomonas sp. KM-1 cultured with saccharified Japanese cedar under microaerobic conditions. 2013 Bioresour. Technol. pmid:23719194
Nieto CA et al. Ewe lambs with higher breeding values for growth achieve higher reproductive performance when mated at age 8 months. 2013 Theriogenology pmid:23764010
Brinkmann L et al. Effect of long-term feed restriction on the health status and welfare of a robust horse breed, the Shetland pony (Equus ferus caballus). 2013 Res. Vet. Sci. pmid:23141417
Wang XT et al. Biocatalytic anti-Prelog stereoselective reduction of ethyl acetoacetate catalyzed by whole cells of Acetobacter sp. CCTCC M209061. 2013 J. Biotechnol. pmid:23142514
Kawamura T et al. Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults. 2012 Nov-Dec Nutrition pmid:22673596
Jendle J et al. [Measuring blood ketones--when, where and how]. 2012 Nov 7-13 Lakartidningen pmid:23240313
Xia C et al. Concentrations of plasma metabolites, hormones, and mRNA abundance of adipose leptin and hormone-sensitive lipase in ketotic and nonketotic dairy cows. 2012 Mar-Apr J. Vet. Intern. Med. pmid:22296673
Jiang T et al. Effect of oligochaete worm body fluids on biological phosphorus removal in a bench-scale EBPR system. 2012 Jul-Aug Environ Technol pmid:22988637
Zeugswetter FK and Rebuzzi L Point-of-care β-hydroxybutyrate measurement for the diagnosis of feline diabetic ketoacidaemia. 2012 J Small Anim Pract pmid:22533366
Clempson AM et al. Associations between bovine IGFBP2 polymorphisms with fertility, milk production, and metabolic status in UK dairy cows. 2012 Anim. Biotechnol. pmid:22537059
Quesada H et al. The lipid-lowering effect of dietary proanthocyanidins in rats involves both chylomicron-rich and VLDL-rich fractions. 2012 Br. J. Nutr. pmid:22011563
Wang Y et al. The differential effects of aligned electrospun PHBHHx fibers on adipogenic and osteogenic potential of MSCs through the regulation of PPARγ signaling. 2012 Biomaterials pmid:22014456
Zhao Q et al. Phase morphology, physical properties, and biodegradation behavior of novel PLA/PHBHHx blends. 2012 J. Biomed. Mater. Res. Part B Appl. Biomater. pmid:21953878
Saadeh M et al. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. 2012 PLoS ONE pmid:22272304
Oh SJ et al. Hepatic expression of cytochrome P450 in type 2 diabetic Goto-Kakizaki rats. 2012 Chem. Biol. Interact. pmid:22244987
Weingart C et al. Validation of a portable hand-held whole-blood ketone meter for use in cats. 2012 Vet Clin Pathol pmid:22250845
McArt JA et al. Epidemiology of subclinical ketosis in early lactation dairy cattle. 2012 J. Dairy Sci. pmid:22916909
Zurr L and Leonhard-Marek S Effects of β-hydroxybutyrate and different calcium and potassium concentrations on the membrane potential and motility of abomasal smooth muscle cells in cattle. 2012 J. Dairy Sci. pmid:22921615
García-García JM et al. Novel poly(hydroxyalkanoates)-based composites containing Bioglass® and calcium sulfate for bone tissue engineering. 2012 Biomed Mater pmid:22972204
Kabiraj P et al. Nitrosative stress mediated misfolded protein aggregation mitigated by Na-D-β-hydroxybutyrate intervention. 2012 Biochem. Biophys. Res. Commun. pmid:22974977
Gao X et al. Production of copolyesters of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoates by E. coli containing an optimized PHA synthase gene. 2012 Microb. Cell Fact. pmid:22978778
Carbonneau E et al. The effect of incomplete milking or nursing on milk production, blood metabolites, and immune functions of dairy cows. 2012 J. Dairy Sci. pmid:22981581
Hartman AL et al. The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice. 2012 PLoS ONE pmid:22984623
Dahl SR et al. Determination of γ-hydroxybutyrate (GHB), β-hydroxybutyrate (BHB), pregabalin, 1,4-butane-diol (1,4BD) and γ-butyrolactone (GBL) in whole blood and urine samples by UPLC-MSMS. 2012 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:22226469
Crocker DE et al. Hormone and metabolite changes associated with extended breeding fasts in male northern elephant seals (Mirounga angustirostris). 2012 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:22227222
Trevisi E et al. Metabolic stress and inflammatory response in high-yielding, periparturient dairy cows. 2012 Res. Vet. Sci. pmid:22197526
Żarnowski T et al. Ketogenic diet increases concentrations of kynurenic acid in discrete brain structures of young and adult rats. 2012 J Neural Transm pmid:22200857
Steele MA et al. Rumen epithelial adaptation to ruminal acidosis in lactating cattle involves the coordinated expression of insulin-like growth factor-binding proteins and a cholesterolgenic enzyme. 2012 J. Dairy Sci. pmid:22192211
Palmiere C et al. Usefulness of postmortem biochemistry in forensic pathology: illustrative case reports. 2012 Leg Med (Tokyo) pmid:22177826
Palmiere C et al. Blood, urine and vitreous isopropyl alcohol as biochemical markers in forensic investigations. 2012 Leg Med (Tokyo) pmid:22177827
Hancock SN et al. Size at birth and adult fat mass in twin sheep are determined in early gestation. 2012 J. Physiol. (Lond.) pmid:22183720
Gao F et al. Effect of prepartum maternal energy density on the growth performance, immunity, and antioxidation capability of neonatal calves. 2012 J. Dairy Sci. pmid:22818465
Takayama N et al. Enzymatic fluorometric microplate assay for quantitative analysis of 3-hydroxybutyric acid in mouse plasma. 2012 Anal. Biochem. pmid:22449496
Senosy W et al. Association between energy status early postpartum and subsequent embryonic mortality in high-yielding recipient cows. 2012 Anim. Sci. J. pmid:22515687
Hiraishi T et al. Display of functionally active PHB depolymerase on Escherichia coli cell surface. 2012 Macromol Biosci pmid:22095689
Peng Q et al. A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles. 2012 Biomaterials pmid:22112760
Burgess SJ et al. Artificial microRNA-mediated knockdown of pyruvate formate lyase (PFL1) provides evidence for an active 3-hydroxybutyrate production pathway in the green alga Chlamydomonas reinhardtii. 2012 J. Biotechnol. pmid:22687249
Yamai K et al. Acetone concentration in gas emanating from tails of diabetic rats. 2012 Anal Sci pmid:22687932
Senosy WS et al. Influences of metabolic traits on subclinical endometritis at different intervals postpartum in high milking cows. 2012 Reprod. Domest. Anim. pmid:22053752
Mestdagh R et al. Gut microbiota modulate the metabolism of brown adipose tissue in mice. 2012 J. Proteome Res. pmid:22053906
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Chee JY et al. Expression of Aeromonas caviae polyhydroxyalkanoate synthase gene in Burkholderia sp. USM (JCM15050) enables the biosynthesis of SCL-MCL PHA from palm oil products. 2012 J. Appl. Microbiol. pmid:22054430
Aubert J et al. Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. 2012 J. Pharmacol. Exp. Ther. pmid:22647274
Konold T et al. Experimental H-type and L-type bovine spongiform encephalopathy in cattle: observation of two clinical syndromes and diagnostic challenges. 2012 BMC Vet. Res. pmid:22401036
Laeger T et al. The ketone body β-hydroxybutyric acid influences agouti-related peptide expression via AMP-activated protein kinase in hypothalamic GT1-7 cells. 2012 J. Endocrinol. pmid:22357971
Weingart C et al. Measurement of β-hydroxybutyrate in cats with nonketotic diabetes mellitus, diabetic ketosis, and diabetic ketoacidosis. 2012 J. Vet. Diagn. Invest. pmid:22362525
Aroch I et al. A retrospective study of serum β-hydroxybutyric acid in 215 ill cats: clinical signs, laboratory findings and diagnoses. 2012 Vet. J. pmid:21316992
Srivastava S et al. Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet. 2012 FASEB J. pmid:22362892
Matoba S et al. The association between metabolic parameters and oocyte quality early and late postpartum in Holstein dairy cows. 2012 J. Dairy Sci. pmid:22365209
Chapinal N et al. The association of serum metabolites in the transition period with milk production and early-lactation reproductive performance. 2012 J. Dairy Sci. pmid:22365212
McCarthy B et al. The effect of stocking rate and calving date on reproductive performance, body state, and metabolic and health parameters of Holstein-Friesian dairy cows. 2012 J. Dairy Sci. pmid:22365215
Álvarez-Rodríguez J et al. Rumen fermentation and histology in light lambs as affected by forage supply and lactation length. 2012 Res. Vet. Sci. pmid:21458834
Rehman HU A woman with ketoacidosis but not diabetes. 2012 BMJ pmid:22381524
Parkkila S et al. Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases. 2012 Chem. Commun. (Camb.) pmid:22382897
Devenny JJ et al. Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats. 2012 Obesity (Silver Spring) pmid:22402735
Riedel SL et al. Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by Ralstonia eutropha in high cell density palm oil fermentations. 2012 Biotechnol. Bioeng. pmid:21809332
Moallem U et al. Plasma concentrations of key metabolites and insulin in late-pregnant ewes carrying 1 to 5 fetuses. 2012 J. Anim. Sci. pmid:21873536
García-Hidalgo J et al. Extracellular production of Streptomyces exfoliatus poly(3-hydroxybutyrate) depolymerase in Rhodococcus sp. T104: determination of optimal biocatalyst conditions. 2012 Appl. Microbiol. Biotechnol. pmid:21845385
Hockenhull J et al. Investigation of markers to indicate and distinguish death due to alcoholic ketoacidosis, diabetic ketoacidosis and hyperosmolar hyperglycemic state using post-mortem samples. 2012 Forensic Sci. Int. pmid:21840144
Rains JL et al. Hyperketonemia induces upregulation of LFA-1 in monocytes, which is mediated by ROS and P38 MAPK activation. 2012 Can. J. Physiol. Pharmacol. pmid:23210443
Kafi M et al. Relationships between thyroid hormones and serum energy metabolites with different patterns of postpartum luteal activity in high-producing dairy cows. 2012 Animal pmid:23217229
Lü H et al. [Biocompatibility of surface modified PHBHHx with rat embryonic neural stem cells]. 2012 Sheng Wu Gong Cheng Xue Bao pmid:23311136
McKenna MC Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain. 2012 Neurochem. Res. pmid:23079895
Fung KY et al. Identification of potential pathways involved in induction of apoptosis by butyrate and 4-benzoylbutyrate in HT29 colorectal cancer cells. 2012 J. Proteome Res. pmid:23057685
Snorek M et al. Short-term fasting reduces the extent of myocardial infarction and incidence of reperfusion arrhythmias in rats. 2012 Physiol Res pmid:23098657
Lomander H et al. Test accuracy of metabolic indicators in predicting decreased fertility in dairy cows. 2012 J. Dairy Sci. pmid:23021753