(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Insulin Resistance D007333 99 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Hyperlipidemias D006949 73 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Coronary Disease D003327 70 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Reperfusion Injury D015427 65 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Weight Loss D015431 56 associated lipids
Parkinson Disease D010300 53 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Fatty Liver D005234 48 associated lipids
Starvation D013217 47 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Lung Diseases D008171 37 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Epilepsy D004827 35 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Uremia D014511 33 associated lipids
Hypothyroidism D007037 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Liver Diseases D008107 31 associated lipids
Obesity D009765 29 associated lipids
Hyperinsulinism D006946 27 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Cattle Diseases D002418 24 associated lipids
Cholestasis D002779 23 associated lipids
Hypoxia D000860 23 associated lipids
Birth Weight D001724 23 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Vomiting D014839 21 associated lipids
Cachexia D002100 21 associated lipids
Hyperglycemia D006943 21 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Pregnancy Complications D011248 19 associated lipids
Albuminuria D000419 18 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Brain Neoplasms D001932 15 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Reye Syndrome D012202 14 associated lipids
Hypoglycemia D007003 13 associated lipids
Acidosis D000138 13 associated lipids
Critical Illness D016638 13 associated lipids
Corneal Diseases D003316 13 associated lipids
Ketosis D007662 13 associated lipids
Glucose Intolerance D018149 13 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Death, Sudden D003645 12 associated lipids
Cat Diseases D002371 12 associated lipids
Metabolic Diseases D008659 12 associated lipids
Hypocalcemia D006996 12 associated lipids
Disease Resistance D060467 12 associated lipids
Thinness D013851 11 associated lipids
Shock D012769 11 associated lipids
Congenital Abnormalities D000013 11 associated lipids
Amyotrophic Lateral Sclerosis D000690 11 associated lipids
Dehydration D003681 11 associated lipids
Fatigue D005221 10 associated lipids
Sheep Diseases D012757 10 associated lipids
Glycosuria D006029 10 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Lung Diseases, Obstructive D008173 10 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Irritable Bowel Syndrome D043183 8 associated lipids
Mastitis, Bovine D008414 8 associated lipids
Obesity, Morbid D009767 8 associated lipids
Diabetes, Gestational D016640 8 associated lipids
Trematode Infections D014201 8 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

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Authors Title Published Journal PubMed Link
Robin JP et al. Restoration of body energy reserves during refeeding in rats is dependent on both the intensity of energy restriction and the metabolic status at the onset of refeeding [corrected]. 2008 J. Nutr. pmid:18424592
Ugwu CU et al. UV mutagenesis of Cupriavidus necator for extracellular production of (R)-3-hydroxybutyric acid. 2008 J. Appl. Microbiol. pmid:18399978
Lee SH et al. Biosynthesis of enantiopure (S)-3-hydroxybutyric acid in metabolically engineered Escherichia coli. 2008 Appl. Microbiol. Biotechnol. pmid:18461320
Wang Y et al. Evaluation of three-dimensional scaffolds prepared from poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) for growth of allogeneic chondrocytes for cartilage repair in rabbits. 2008 Biomaterials pmid:18406457
Heo K et al. Structural evolution in microbial polyesters. 2008 J Phys Chem B pmid:18363398
Grinberg N et al. Beta-hydroxybutyrate abrogates formation of bovine neutrophil extracellular traps and bactericidal activity against mammary pathogenic Escherichia coli. 2008 Infect. Immun. pmid:18411287
Knapp AC et al. Effect of carnitine deprivation on carnitine homeostasis and energy metabolism in mice with systemic carnitine deficiency. 2008 Ann. Nutr. Metab. pmid:18417958
Wu S et al. [Intravascular biocompatibility of decellularized xenogenic vascular scaffolds/PHBHHx hybrid material for cardiovascular tissue engineering]. 2008 Sheng Wu Gong Cheng Xue Bao pmid:18616171
Smith SW et al. Bedside detection of urine beta-hydroxybutyrate in diagnosing metabolic acidosis. 2008 Acad Emerg Med pmid:18637083
Beskow AP et al. Influence of ketone bodies on oxidative stress parameters in brain of developing rats in vitro. 2008 Metab Brain Dis pmid:18777091
Osman MA et al. Acute metabolic responses of postpartal dairy cows to subcutaneous glucagon injections, oral glycerol, or both. 2008 J. Dairy Sci. pmid:18765590
Chibisa GE et al. Effects of peripartum propylene glycol supplementation on nitrogen metabolism, body composition, and gene expression for the major protein degradation pathways in skeletal muscle in dairy cows. 2008 J. Dairy Sci. pmid:18765610
Purdie NG et al. Milk synthetic response of the bovine mammary gland to an increase in the local concentration of amino acids and acetate. 2008 J. Dairy Sci. pmid:18096943
Corbel H et al. Is fledging in king penguin chicks related to changes in metabolic or endocrinal status? 2008 Gen. Comp. Endocrinol. pmid:18155218
Nath A et al. Enhanced PHB production and scale up studies using cheese whey in fed batch culture of Methylobacterium sp. ZP24. 2008 Bioresour. Technol. pmid:18032031
Uchino K et al. Poly(3-hydroxybutyrate) (PHB) depolymerase PhaZa1 is involved in mobilization of accumulated PHB in Ralstonia eutropha H16. 2008 Appl. Environ. Microbiol. pmid:18156336
Ghorbani B et al. Effects of niacin on milk production and blood parameters in early lactation of dairy cows. 2008 Pak. J. Biol. Sci. pmid:18819645
Rosak C et al. Insulin glargine maintains equivalent glycemic control and better lipometabolic control than NPH insulin in type 1 diabetes patients who missed a meal. 2008 Horm. Metab. Res. pmid:18493882
Vega GL et al. Oxandrolone enhances hepatic ketogenesis in adult men. 2008 J. Investig. Med. pmid:18797410
Westermann CM et al. Plasma acylcarnitine and fatty acid profiles during exercise and training in Standardbreds. 2008 Am. J. Vet. Res. pmid:18980429
Felby S et al. The postmortem distribution of ketone bodies between blood, vitreous humor, spinal fluid, and urine. 2008 Forensic Sci Med Pathol pmid:19291479
Chen S et al. Guided growth of smooth muscle cell on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds with uniaxial microtubular structures. 2008 J Biomed Mater Res A pmid:18186065
Kwon YS et al. Effects of the ketogenic diet on neurogenesis after kainic acid-induced seizures in mice. 2008 Epilepsy Res. pmid:18201870
Abdel-Sayed A et al. A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjects. 2008 Br. J. Nutr. pmid:18205992
MacDonald MJ et al. Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion. 2008 Am. J. Physiol., Cell Physiol. pmid:18160486
Fuglsang J et al. Effects of glucose, glycerol, 3-hydroxybutyrate, insulin, and leptin on placental growth hormone secretion in placental explants. 2008 Horm. Metab. Res. pmid:18246527
Shishatskaya EI et al. Biocompatibility of polyhydroxybutyrate microspheres: in vitro and in vivo evaluation. 2008 J Mater Sci Mater Med pmid:18253816
Rizos D et al. The effect of feeding propylene glycol to dairy cows during the early postpartum period on follicular dynamics and on metabolic parameters related to fertility. 2008 Theriogenology pmid:18262261
Wylie AR et al. Periprandial changes in metabolite and metabolic hormone concentrations in high-genetic-merit dairy heifers and their relationship to energy balance in early lactation. 2008 J. Dairy Sci. pmid:18218744
Siddiqui SM et al. Dietary intervention with vitamin D, calcium, and whey protein reduced fat mass and increased lean mass in rats. 2008 Nutr Res pmid:19083488
Weiss WP et al. Effect of feeding propionibacteria on milk production by early lactation dairy cows. 2008 J. Dairy Sci. pmid:18218752
Mayr M et al. Combined metabolomic and proteomic analysis of human atrial fibrillation. 2008 J. Am. Coll. Cardiol. pmid:18237690
Faria MH et al. Ketone bodies metabolism during ischemic and reperfusion brain injuries following bilateral occlusion of common carotid arteries in rats. 2007 Mar-Apr Acta Cir Bras pmid:17375219
Panagia M et al. Abnormal function and glucose metabolism in the type-2 diabetic db/db mouse heart. 2007 Mar-Apr Can. J. Physiol. Pharmacol. pmid:17612636
Buszewicz G et al. [Diagnostic usefulness of the beta-hydroxybutyrate/acetone ratio in medico-legal diagnostics of sudden deaths]. 2007 Jul-Sep Arch Med Sadowej Kryminol pmid:17907621
Torres MD et al. Breakfast, plasma glucose and beta-hydroxybutyrate, body mass index and academic performance in children from Extremadura, Spain. 2007 Jul-Aug Nutr Hosp pmid:17650890
Compton CW et al. Risk factors for peripartum mastitis in pasture-grazed dairy heifers. 2007 J. Dairy Sci. pmid:17699035
Sasi P et al. Metabolic acidosis and other determinants of hemoglobin-oxygen dissociation in severe childhood Plasmodium falciparum malaria. 2007 Am. J. Trop. Med. Hyg. pmid:17690396
Cooke RF et al. Supplemental choline for prevention and alleviation of fatty liver in dairy cattle. 2007 J. Dairy Sci. pmid:17430945
Pelletier A and Coderre L Ketone bodies alter dinitrophenol-induced glucose uptake through AMPK inhibition and oxidative stress generation in adult cardiomyocytes. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17227964
Bowen RA et al. Differential effect of blood collection tubes on total free fatty acids (FFA) and total triiodothyronine (TT3) concentration: a model for studying interference from tube constituents. 2007 Clin. Chim. Acta pmid:17234171
Toscano MJ et al. Assessing the adaptation of swine to fifty-seven hours of feed deprivation in terms of behavioral and physiological responses. 2007 J. Anim. Sci. pmid:17235029
Patton J et al. Relationships among milk production, energy balance, plasma analytes, and reproduction in Holstein-Friesian cows. 2007 J. Dairy Sci. pmid:17235140
Kuhls DA et al. Beta-hydroxy-beta-methylbutyrate supplementation in critically ill trauma patients. 2007 J Trauma pmid:17215743
Defoirdt T et al. The bacterial storage compound poly-beta-hydroxybutyrate protects Artemia franciscana from pathogenic Vibrio campbellii. 2007 Environ. Microbiol. pmid:17222142
Maalouf M et al. Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. 2007 Neuroscience pmid:17240074
López Siguero JP et al. [Blood glucose and ketone monitoring in type 1 diabetic patients in the controlled environment of a summer camp]. 2007 An Pediatr (Barc) pmid:17430716
Sakha M et al. Bovine subclinical ketosis in dairy herds in Iran. 2007 Vet. Res. Commun. pmid:17287886
Connolly CC et al. Hepatic and muscle insulin action during late pregnancy in the dog. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:16973936
Chalhoub E et al. A computer model of gluconeogenesis and lipid metabolism in the perfused liver. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17911349
Zhao YH et al. Disruption of the polyhydroxyalkanoate synthase gene in Aeromonas hydrophila reduces its survival ability under stress conditions. 2007 FEMS Microbiol. Lett. pmid:17888005
Paithankar KS et al. Cosubstrate-induced dynamics of D-3-hydroxybutyrate dehydrogenase from Pseudomonas putida. 2007 FEBS J. pmid:17958702
Charles RA et al. Point-of-care blood ketone testing: screening for diabetic ketoacidosis at the emergency department. 2007 Singapore Med J pmid:17975686
Padilla L et al. Relationship between plasma vitamin C and serum diagnostic biochemical markers in lactating cows. 2007 J. Vet. Med. Sci. pmid:17917375
Amark K et al. Myocardial substrates in children with congenital heart disease: relationship to substrate supply, age, growth and desaturation. 2007 Acta Paediatr. pmid:17937693
Uchino K et al. Purification and molecular cloning of an intracellular 3-hydroxybutyrate-oligomer hydrolase from Paucimonas lemoignei. 2007 J. Biosci. Bioeng. pmid:17964488
Loh XJ et al. New biodegradable thermogelling copolymers having very low gelation concentrations. 2007 Biomacromolecules pmid:17291082
Zou XH and Chen GQ Metabolic engineering for microbial production and applications of copolyesters consisting of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoates. 2007 Macromol Biosci pmid:17295404
Duska F et al. Analysis of factors influencing nitrogen balance during acute starvation in obese subject with and without type 2 diabetes. 2007 Clin Nutr pmid:17374420
Luci S et al. Feeding of a deep-fried fat causes PPARalpha activation in the liver of pigs as a non-proliferating species. 2007 Br. J. Nutr. pmid:17381980
Lam le H et al. Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyric acid. 2007 Anal. Biochem. pmid:17386920
Puchowicz MA et al. Diet-induced ketosis increases capillary density without altered blood flow in rat brain. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17284577
Luci S et al. Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17363680
Cheng B et al. D-beta-hydroxybutyrate inhibits the apoptosis of PC12 cells induced by 6-OHDA in relation to up-regulating the ratio of Bcl-2/Bax mRNA. 2007 Auton Neurosci pmid:17369104
de Roos AP et al. Screening for subclinical ketosis in dairy cattle by Fourier transform infrared spectrometry. 2007 J. Dairy Sci. pmid:17369216
Dann HM et al. Effect of partial replacement of forage neutral detergent fiber with by-product neutral detergent fiber in close-up diets on periparturient performance of dairy cows. 2007 J. Dairy Sci. pmid:17369220
Tillard E et al. Precalving factors affecting conception risk in Holstein dairy cows in tropical conditions. 2007 Theriogenology pmid:17572480
Sun J et al. In vitro effect of oligo-hydroxyalkanoates on the growth of mouse fibroblast cell line L929. 2007 Biomaterials pmid:17574664
Cerone SI et al. Effects of beta-hydroxybutyric acid on bovine milk leukocytes function in vitro. 2007 Gen. Physiol. Biophys. pmid:17579249
Caperuto EC et al. Beta-hydoxy-beta-methylbutyrate supplementation affects Walker 256 tumor-bearing rats in a time-dependent manner. 2007 Clin Nutr pmid:17011676
Noyes KJ et al. Hydroxybutyrate near-patient testing to evaluate a new end-point for intravenous insulin therapy in the treatment of diabetic ketoacidosis in children. 2007 Pediatr Diabetes pmid:17550425
Phiri IK et al. The serum glucose and beta-hydroxybutyrate levels in sheep with experimental Fasciola hepatica and Fasciola gigantica infection. 2007 Vet. Parasitol. pmid:17011709
Hiroyama M et al. Hypermetabolism of fat in V1a vasopressin receptor knockout mice. 2007 Mol. Endocrinol. pmid:17021052
Geddes J et al. Cardiac troponin I concentrations in people presenting with diabetic ketoacidosis. 2007 Ann. Clin. Biochem. pmid:17594788
Maciejewska-Paszek I et al. The influence of small doses of paracetamol on rabbit liver. 2007 Exp. Toxicol. Pathol. pmid:17601712
Gorke JT et al. Enzymatic synthesis of poly(hydroxyalkanoates) in ionic liquids. 2007 J. Biotechnol. pmid:17543408
Schmid SM et al. Sleep loss alters basal metabolic hormone secretion and modulates the dynamic counterregulatory response to hypoglycemia. 2007 J. Clin. Endocrinol. Metab. pmid:17519315
Kinzig KP et al. Energy balance and hypothalamic effects of a high-protein/low-carbohydrate diet. 2007 Physiol. Behav. pmid:17512959
Fujii T et al. Three Japanese patients with glucose transporter type 1 deficiency syndrome. 2007 Brain Dev. pmid:16949238
Pietrini M et al. Comparative life cycle studies on poly(3-hydroxybutyrate)-based composites as potential replacement for conventional petrochemical plastics. 2007 Biomacromolecules pmid:17583946
Artacho P et al. Blood biochemistry reveals malnutrition in black-necked swans (Cygnus melanocoryphus) living in a conservation priority area. 2007 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:17158079
Hachenberg S et al. Evaluation of classification modes potentially suitable to identify metabolic stress in healthy dairy cows during the peripartal period. 2007 J. Anim. Sci. pmid:17468419
Aromolaran AS et al. Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. 2007 Am. J. Physiol., Cell Physiol. pmid:17344311
Brandt K et al. Vagal afferents mediate the feeding response to mercaptoacetate but not to the beta (3) adrenergic receptor agonist CL 316,243. 2007 Neurosci. Lett. pmid:17112664
Vinaud MC et al. Taenia crassiceps organic acids detected in cysticerci. 2007 Exp. Parasitol. pmid:17346707
Hamano Y Continuous infusion of lipoic acid rapidly reduces plasma beta-hydroxybutyrate with elevation of non-esterified fatty acids in broiler chickens. 2007 Br. J. Nutr. pmid:17313711
Marcus C et al. Insufficient ketone body use is the cause of ketotic hypoglycemia in one of a pair of homozygotic twins. 2007 J. Clin. Endocrinol. Metab. pmid:17684053
Smith KL et al. Prepartum 2,4-thiazolidinedione alters metabolic dynamics and dry matter intake of dairy cows. 2007 J. Dairy Sci. pmid:17638977
Moallem U et al. Effects of peripartum propylene glycol or fats differing in fatty acid profiles on feed intake, production, and plasma metabolites in dairy cows. 2007 J. Dairy Sci. pmid:17638995
Liu Q et al. Microbial production of R-3-hydroxybutyric acid by recombinant E. coli harboring genes of phbA, phbB, and tesB. 2007 Appl. Microbiol. Biotechnol. pmid:17609944
Adamus G Structural analysis of poly[(R,S)-3-hydroxybutyrate-co-L-lactide] copolyesters by electrospray ionization ion trap mass spectrometry. 2007 Rapid Commun. Mass Spectrom. pmid:17610241
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Taboulet P et al. Correlation between urine ketones (acetoacetate) and capillary blood ketones (3-beta-hydroxybutyrate) in hyperglycaemic patients. 2007 Diabetes Metab. pmid:17320448
Tessmer N et al. Heat-shock protein HspA mimics the function of phasins sensu stricto in recombinant strains of Escherichia coli accumulating polythioesters or polyhydroxyalkanoates. 2007 Microbiology (Reading, Engl.) pmid:17259608
Impallomeni G et al. Sequencing microbial copolymers of 3-hydroxybutyric and 3-mercaptoalkanoic acids by NMR, electrospray ionization mass spectrometry, and size exclusion chromatography NMR. 2007 Biomacromolecules pmid:17261066
Chung YH et al. Effects of feeding dry glycerin to early postpartum Holstein dairy cows on lactational performance and metabolic profiles. 2007 J. Dairy Sci. pmid:18024760
Kuwajima M et al. Reduced carnitine level causes death from hypoglycemia: possible involvement of suppression of hypothalamic orexin expression during weaning period. 2007 Endocr. J. pmid:18025760
Hallböök T et al. Effects of ketogenic diet on epileptiform activity in children with therapy resistant epilepsy. 2007 Epilepsy Res. pmid:17996423
Wathes DC et al. Differences between primiparous and multiparous dairy cows in the inter-relationships between metabolic traits, milk yield and body condition score in the periparturient period. 2007 Domest. Anim. Endocrinol. pmid:16806790
Vogel C et al. Thermal degradation of poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) in nitrogen and oxygen studied by thermogravimetric-Fourier transform infrared spectroscopy. 2007 Appl Spectrosc pmid:17697470