(r)-3-hydroxybutanoic acid

(r)-3-hydroxybutanoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2725 references associated with (r)-3-hydroxybutanoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (r)-3-hydroxybutanoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (r)-3-hydroxybutanoic acid

MeSH term MeSH ID Detail
Uremia D014511 33 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Sheep Diseases D012757 10 associated lipids
Stomach Diseases D013272 7 associated lipids
Per page 10 20 50 100 | Total 185

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with (r)-3-hydroxybutanoic acid

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Per page 10 20 50 100 | Total 2707
Authors Title Published Journal PubMed Link
Arase K et al. Intracerebroventricular infusions of 3-OHB and insulin in a rat model of dietary obesity. 1988 Am. J. Physiol. pmid:3059829
Pere MC et al. Hepatic metabolism during fasting-refeeding transition in conscious pregnant rabbits. 1992 Am. J. Physiol. pmid:1616023
Vanoverschelde JL et al. Competition between palmitate and ketone bodies as fuels for the heart: study with positron emission tomography. 1993 Am. J. Physiol. pmid:8456973
Cherel Y and Le Maho Y Five months of fasting in king penguin chicks: body mass loss and fuel metabolism. 1985 Am. J. Physiol. pmid:4051024
Sindelar DK et al. Interaction of equal increments in arterial and portal vein insulin on hepatic glucose production in the dog. 1997 Am. J. Physiol. pmid:9374684
Swithers SE Development of independent ingestive responding to blockade of fatty acid oxidation in rats. 1997 Am. J. Physiol. pmid:9374805
Fery F et al. Mechanisms of starvation diabetes: a study with double tracer and indirect calorimetry. 1990 Am. J. Physiol. pmid:2260646
Stallknecht B et al. Effect of training on epinephrine-stimulated lipolysis determined by microdialysis in human adipose tissue. 1995 Am. J. Physiol. pmid:8572197
Goodwin GW and Taegtmeyer H Metabolic recovery of isolated working rat heart after brief global ischemia. 1994 Am. J. Physiol. pmid:8067397
Beaufrère B et al. Effects of D-beta-hydroxybutyrate and long- and medium-chain triglycerides on leucine metabolism in humans. 1992 Am. J. Physiol. pmid:1312786
De Feo P et al. Contribution of cortisol to glucose counterregulation in humans. 1989 Am. J. Physiol. pmid:2665516
Cersosimo E et al. Glutamine blocks lipolysis and ketogenesis of fasting. 1986 Am. J. Physiol. pmid:3513612
Laughlin MR et al. Nonglucose substrates increase glycogen synthesis in vivo in dog heart. 1994 Am. J. Physiol. pmid:8048587
Tuttle KR et al. Glucagon, not insulin, may play a secondary role in defense against hypoglycemia during exercise. 1988 Am. J. Physiol. pmid:3287952
Bailey JW et al. Validation of two-pool model for in vivo ketone body kinetics. 1990 Am. J. Physiol. pmid:2185666
McCall AL et al. Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels. 1988 Am. J. Physiol. pmid:2964787
Monti LD et al. Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16174656
Pelletier A and Coderre L Ketone bodies alter dinitrophenol-induced glucose uptake through AMPK inhibition and oxidative stress generation in adult cardiomyocytes. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17227964
Chu CA et al. Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11788373
Galassetti P et al. Effects of antecedent prolonged exercise on subsequent counterregulatory responses to hypoglycemia. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11350772
McGregor VP et al. Elevated endogenous cortisol reduces autonomic neuroendocrine and symptom responses to subsequent hypoglycemia. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11882496
Everett-Grueter C et al. The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16608886
El Midaoui A et al. Physical training reverses defect in 3-ketoacid CoA-transferase activity in skeletal muscle of diabetic rats. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15774485
Vannucci SJ and Simpson IA Developmental switch in brain nutrient transporter expression in the rat. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:14534079
Ravikumar B et al. Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15572652
Blomqvist G et al. Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:12067838
El Midaoui A et al. Physical training reverses the increased activity of the hepatic ketone body synthesis pathway in chronically diabetic rats. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16403781
Hodson L et al. Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation? 2010 Am. J. Physiol. Endocrinol. Metab. pmid:20628024
Stannard SR et al. Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:12388154
Yamada T et al. {beta}-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle. 2010 Am. J. Physiol. Endocrinol. Metab. pmid:20516259
Song H et al. Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet. 2010 Am. J. Physiol. Endocrinol. Metab. pmid:20179248
Takehiro M et al. Chronic exposure to beta-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15479955
Zhang D et al. Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:20959534
Chalhoub E et al. A computer model of gluconeogenesis and lipid metabolism in the perfused liver. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17911349
Bielohuby M et al. Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:20943751
Puchowicz MA et al. Diet-induced ketosis increases capillary density without altered blood flow in rat brain. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17284577
Malkova D et al. Prior exercise and postprandial substrate extraction across the human leg. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:11052956
Connolly CC et al. Alterations in basal glucose metabolism during late pregnancy in the conscious dog. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:11052973
Jackson PA et al. Effect of hepatic denervation on the counterregulatory response to insulin-induced hypoglycemia in the dog. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:11093911
Tardif A et al. Chronic exposure to beta-hydroxybutyrate impairs insulin action in primary cultures of adult cardiomyocytes. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11701435
Jensen MD et al. Lipid metabolism during fasting. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11551856
St Amand TA et al. Pyruvate overrides inhibition of PDH during exercise after a low-carbohydrate diet. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913026
Stallknecht B et al. Effect of training on insulin sensitivity of glucose uptake and lipolysis in human adipose tissue. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913038
Chu CA et al. The direct effects of catecholamines on hepatic glucose production occur via alpha(1)- and beta(2)-receptors in the dog. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913048
Plaisance EP et al. Niacin stimulates adiponectin secretion through the GPR109A receptor. 2009 Am. J. Physiol. Endocrinol. Metab. pmid:19141678
Dasarathy S et al. Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19571235
Cremin JD et al. Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12637251
Stanley WC et al. beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12969881
Linke A et al. Shift in metabolic substrate uptake by the heart during development of alloxan-induced diabetes. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12915387
White RL and Wittenberg BA Mitochondrial NAD(P)H, ADP, oxidative phosphorylation, and contraction in isolated heart cells. 2000 Am. J. Physiol. Heart Circ. Physiol. pmid:11009472