MeSH term | MeSH ID | Detail |
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Adenocarcinoma | D000230 | 166 associated lipids |
2-Methylbutanoic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Binding (Molecular Function), Oxidation, isoleucine catabolic process, Anabolism and physiological aspects. 2-methylbutanoic acid often locates in Membrane, soluble and host. The associated genes with 2-Methylbutanoic acid are Homologous Gene, Genome, NKS1 gene, HM13 gene and ACSM1 gene. The related lipids are Fatty Acids, Butyric Acids, branched chain fatty acid, Propionate and 2-methylvalerate.
To understand associated biological information of 2-Methylbutanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with 2-Methylbutanoic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Wang F et al. | Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. | 2015 | ACS Chem. Biol. | pmid:25581064 |
Vallejos J et al. | Butane-1,4-diyl bis-(pyridine-3-carboxyl-ate). | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22807836 |
Fun HK et al. | Absolute configuration of odorine. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21588760 |
Vitali B et al. | An in vitro evaluation of the effect of probiotics and prebiotics on the metabolic profile of human microbiota. | 2012 | Anaerobe | pmid:22579985 |
Siebert TE et al. | Stable isotope dilution analysis of wine fermentation products by HS-SPME-GC-MS. | 2005 | Anal Bioanal Chem | pmid:15660221 |
Hutchinson CR et al. | Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases. | 2000 | Antonie Van Leeuwenhoek | pmid:11386351 |
Serrazanetti DI et al. | Acid stress-mediated metabolic shift in Lactobacillus sanfranciscensis LSCE1. | 2011 | Appl. Environ. Microbiol. | pmid:21335381 |
Giotis ES et al. | Role of branched-chain fatty acids in pH stress tolerance in Listeria monocytogenes. | 2007 | Appl. Environ. Microbiol. | pmid:17114323 |
Ganesan B et al. | Identification of the leucine-to-2-methylbutyric acid catabolic pathway of Lactococcus lactis. | 2006 | Appl. Environ. Microbiol. | pmid:16751541 |
Singh VK et al. | Insertional inactivation of branched-chain alpha-keto acid dehydrogenase in Staphylococcus aureus leads to decreased branched-chain membrane fatty acid content and increased susceptibility to certain stresses. | 2008 | Appl. Environ. Microbiol. | pmid:18689519 |
Tanner RS and Wolfe RS | Nutritional requirements of Methanomicrobium mobile. | 1988 | Appl. Environ. Microbiol. | pmid:3377488 |
Annous BA et al. | Critical role of anteiso-C15:0 fatty acid in the growth of Listeria monocytogenes at low temperatures. | 1997 | Appl. Environ. Microbiol. | pmid:9327552 |
Suarez de Mata Z et al. | Propionyl-CoA condensing enzyme from Ascaris muscle mitochondria. I. Isolation and characterization of multiple forms. | 1991 | Arch. Biochem. Biophys. | pmid:1990976 |
Suarez de Mata Z et al. | 2-Methylacetoacetyl-coenzyme A reductase from Ascaris muscle: purification and properties. | 1983 | Arch. Biochem. Biophys. | pmid:6357089 |
Jones SL et al. | Correlation of long-range membrane order with temperature-dependent growth characteristics of parent and a cold-sensitive, branched-chain-fatty-acid-deficient mutant of Listeria monocytogenes. | 2002 | Arch. Microbiol. | pmid:11907677 |
Kaler G et al. | Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17094945 |
Mamer OA et al. | Demonstration of a new mammalian isoleucine catabolic pathway yielding an Rseries of metabolites. | 1976 | Biochem. J. | pmid:1016232 |
Meehan MJ et al. | FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF. | 2011 | Biochemistry | pmid:21069965 |
Kaneda T | Stereoselectivity in the 2-methylbutyrate incorporation into anteiso fatty acids in Bacillus subtilis mutants. | 1988 | Biochim. Biophys. Acta | pmid:3129014 |
Toyama T et al. | Isolation and characterization of a novel 2-sec-butylphenol-degrading bacterium Pseudomonas sp. strain MS-1. | 2010 | Biodegradation | pmid:19705287 |
Prakash S et al. | Gut microbiota: next frontier in understanding human health and development of biotherapeutics. | 2011 | Biologics | pmid:21847343 |
Wang J et al. | Study on pharmacokinetics and tissue distribution of pteryxin in mice by ultra-pressure liquid chromatography with tandem mass spectrometry. | 2012 | Biomed. Chromatogr. | pmid:22102402 |
Tokitomo Y et al. | Odor-active constituents in fresh pineapple (Ananas comosus [L.] Merr.) by quantitative and sensory evaluation. | 2005 | Biosci. Biotechnol. Biochem. | pmid:16041138 |
Batstone DJ et al. | Kinetics of thermophilic, anaerobic oxidation of straight and branched chain butyrate and valerate. | 2003 | Biotechnol. Bioeng. | pmid:12966576 |
Pind PF et al. | Dynamics of the anaerobic process: effects of volatile fatty acids. | 2003 | Biotechnol. Bioeng. | pmid:12701145 |
Knebel LA et al. | 2-Methylbutyrylglycine induces lipid oxidative damage and decreases the antioxidant defenses in rat brain. | 2012 | Brain Res. | pmid:22967964 |
El Amine Dib M et al. | Characterization of volatile compounds of Daucus crinitus Desf. Headspace Solid Phase Microextraction as alternative technique to Hydrodistillation. | 2010 | Chem Cent J | pmid:20858266 |
Sellami HK et al. | Composition of the essential oils in various organs at different developmental stages of Ammi visnaga (L.) Lam. from Tunisia. | 2011 | Chem. Biodivers. | pmid:22083912 |
Ortet R et al. | Composition and biological properties of the volatile oil of Artemisia gorgonum Webb. | 2010 | Chem. Biodivers. | pmid:20491086 |
Tabanca N et al. | Bioactive constituents from Turkish Pimpinella species. | 2005 | Chem. Biodivers. | pmid:17191975 |
Korman SH et al. | 2-ethylhydracrylic aciduria in short/branched-chain acyl-CoA dehydrogenase deficiency: application to diagnosis and implications for the R-pathway of isoleucine oxidation. | 2005 | Clin. Chem. | pmid:15615815 |
Bachmann C et al. | Short chain fatty acids in plasma and brain: quantitative determination by gas chromatography. | 1979 | Clin. Chim. Acta | pmid:487569 |
Kumar PA et al. | Identification of fruity aroma-producing compounds from Chryseobacterium sp. isolated from the Western Ghats, India. | 2011 | Curr. Microbiol. | pmid:21667308 |
Hauck T et al. | Metabolism of ethyl tiglate in apple fruits leads to the formation of small amounts of (R)-ethyl 2-methylbutanoate. | 2000 | Enantiomer | pmid:11143814 |
Rezanka T et al. | Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces. | 2011 | Environ. Microbiol. | pmid:21450004 |
Wyss C | Fatty acids synthesized by oral treponemes in chemically defined media. | 2007 | FEMS Microbiol. Lett. | pmid:17229060 |
Novák J et al. | Nitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis. | 1992 | FEMS Microbiol. Lett. | pmid:1612418 |
Danyluk MD et al. | Prevalence, concentration, spoilage, and mitigation of Alicyclobacillus spp. in tropical and subtropical fruit juice concentrates. | 2011 | Food Microbiol. | pmid:21356453 |
Seenivasan A et al. | Microbial production and biomedical applications of lovastatin. | 2008 | Indian J Pharm Sci | pmid:21369428 |
Kitazono M et al. | Reversal of LRP-associated drug resistance in colon carcinoma SW-620 cells. | 2001 | Int. J. Cancer | pmid:11149411 |
Inoue H et al. | Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. | 2002 | Int. J. Mol. Med. | pmid:11956660 |
Kato T et al. | Survey of conformational role of ester bonds in a cyclic depsipeptide. Study on cyclo(-L-Ala-L-Hmb-)2 by energy calculation and NMR spectroscopy. | 1992 | Int. J. Pept. Protein Res. | pmid:1399269 |
Savant DV et al. | Methanobrevibacter acididurans sp. nov., a novel methanogen from a sour anaerobic digester. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12148611 |
Suzuki D et al. | Desulfovibrio butyratiphilus sp. nov., a Gram-negative, butyrate-oxidizing, sulfate-reducing bacterium isolated from an anaerobic municipal sewage sludge digester. | 2010 | Int. J. Syst. Evol. Microbiol. | pmid:19654341 |
Goldstein EJ and Arias IM | Interaction of ligandin with radiographic contrast media. | 1976 Nov-Dec | Invest Radiol | pmid:1002414 |
Velasco-Negueruela A et al. | Analysis by gas chromatography-mass spectrometry of the essential oil from the aerial parts of Pimpinella junoniae Ceb. & Ort., gathered in La Gomera, Canary Islands, Spain. | 2003 | J Chromatogr A | pmid:14518782 |
Hajhashemi V et al. | Anti-inflammatory and analgesic properties of Heracleum persicum essential oil and hydroalcoholic extract in animal models. | 2009 | J Ethnopharmacol | pmid:19467316 |
Huynh LK et al. | Kinetic modeling of methyl butanoate in shock tube. | 2008 | J Phys Chem A | pmid:19035670 |
El-Nahas AM et al. | Enthalpies of formation, bond dissociation energies and reaction paths for the decomposition of model biofuels: ethyl propanoate and methyl butanoate. | 2007 | J Phys Chem A | pmid:17286391 |
Stacchiola D et al. | Requirements for the formation of a chiral template. | 2005 | J Phys Chem B | pmid:16866451 |
Ferreira L et al. | Characterization of volatile substances in apples from Rosaceae family by headspace solid-phase microextraction followed by GC-qMS. | 2009 | J Sep Sci | pmid:19425016 |
Tanaka K et al. | Resistance to the skeletal muscle injury expressed by repeated treatment with compound A that has HMG-CoA reductase inhibitory activity. | 2007 | J Toxicol Sci | pmid:17327690 |
Pérez AG et al. | Biosynthesis of strawberry aroma compounds through amino acid metabolism. | 2002 | J. Agric. Food Chem. | pmid:12083879 |
Kwon DY et al. | Enantiomeric synthesis of (S)-2-methylbutanoic acid methyl ester, apple flavor, using lipases in organic solvent. | 2000 | J. Agric. Food Chem. | pmid:10691670 |
Dregus M et al. | Enantioselective analysis of methyl-branched alcohols and acids in rhubarb (Rheum rhabarbarum L.) stalks. | 2003 | J. Agric. Food Chem. | pmid:14611176 |
Matich A and Rowan D | Pathway analysis of branched-chain ester biosynthesis in apple using deuterium labeling and enantioselective gas chromatography-mass spectrometry. | 2007 | J. Agric. Food Chem. | pmid:17335222 |
Willner B et al. | Characterization of the key aroma compounds in Bartlett pear brandies by means of the sensomics concept. | 2013 | J. Agric. Food Chem. | pmid:24004345 |
de Souza MD et al. | Characterization of cachaça and rum aroma. | 2006 | J. Agric. Food Chem. | pmid:16417309 |
Valim MF et al. | Gas chromatographic-olfactometric characterization of aroma compounds in two types of cashew apple nectar. | 2003 | J. Agric. Food Chem. | pmid:12568564 |
Zhang A and Nie J | Enantioselective synthesis of the female sex pheromone of the pink hibiscus Mealybug, Maconellicoccus hirsutus. | 2005 | J. Agric. Food Chem. | pmid:15796578 |
Rodrigues VM et al. | Supercritical extraction of essential oil from aniseed (Pimpinella anisum L) using CO2: solubility, kinetics, and composition data. | 2003 | J. Agric. Food Chem. | pmid:12617576 |
Matheis K and Granvogl M | Characterization of Key Odorants Causing a Fusty/Musty Off-Flavor in Native Cold-Pressed Rapeseed Oil by Means of the Sensomics Approach. | 2016 | J. Agric. Food Chem. | pmid:27712066 |
Goubet I et al. | Competitive binding of aroma compounds by beta-cyclodextrin. | 2001 | J. Agric. Food Chem. | pmid:11743785 |
Jirovetz L et al. | Aroma compound analysis of Eruca sativa (Brassicaceae) SPME headspace leaf samples using GC, GC-MS, and olfactometry. | 2002 | J. Agric. Food Chem. | pmid:12137490 |
Xie X et al. | Acyltransferase mediated polyketide release from a fungal megasynthase. | 2009 | J. Am. Chem. Soc. | pmid:19530726 |
Lee I and Zaera F | Chiral templating of surfaces: adsorption of (S)-2-methylbutanoic acid on Pt(111) single-crystal surfaces. | 2006 | J. Am. Chem. Soc. | pmid:16819884 |
Samii SS et al. | Effects of limonene on ruminal concentrations, fermentation, and lysine degradation in cattle. | 2016 | J. Anim. Sci. | pmid:27695807 |
Marshall VP et al. | Precursor directed biosynthesis of paulomycins A and B. The effects of valine, isoleucine, isobutyric acid and 2-methylbutyric acid. | 1984 | J. Antibiot. | pmid:6480507 |
Czerkawski JW et al. | Microbial metabolism of 1,2-propanediol studied by the Rumen Simulation Technique (Rusitec). | 1984 | J. Appl. Bacteriol. | pmid:6423608 |
Hayashida-Soiza G et al. | Purification and characterization of antibacterial substances produced by a marine bacterium Pseudoalteromonas haloplanktis strain. | 2008 | J. Appl. Microbiol. | pmid:18828792 |
LARSON AD et al. | VOLATILE FATTY ACID REQUIREMENT OF A STRAIN OF LISTERIA MONOCYTOGENES. | 1965 | J. Bacteriol. | pmid:14273667 |
HUNGATE RE | POLYSACCHARIDE STORAGE AND GROWTH EFFICIENCY IN RUMINOCOCCUS ALBUS. | 1963 | J. Bacteriol. | pmid:14066484 |
Meng Y et al. | Characterization of an archaeal medium-chain acyl coenzyme A synthetase from Methanosarcina acetivorans. | 2010 | J. Bacteriol. | pmid:20851904 |
Dickinson JR et al. | An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae. | 2000 | J. Biol. Chem. | pmid:10753893 |
Liou JS et al. | Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species. | 2000 | J. Biol. Chem. | pmid:10967125 |
SAZ HJ and WEIL A | The mechanism of the formation of alpha-methylbutyrate from carbohydrate by Ascaris lumbricoides muscle. | 1960 | J. Biol. Chem. | pmid:14442156 |
Schmidt J et al. | Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. | 2011 | J. Biol. Chem. | pmid:21220428 |
COON MJ et al. | The relation of alpha-methyl-butyrate to isoleucine metabolism. II. Propionate formation. | 1952 | J. Biol. Chem. | pmid:12999817 |
COON MJ and ABRAHAMSEN NS | The relation of alpha-methylbutyrate to isoleucine metabolism. I. Acetoacetate formation. | 1952 | J. Biol. Chem. | pmid:14946192 |
Rey FE et al. | Dissecting the in vivo metabolic potential of two human gut acetogens. | 2010 | J. Biol. Chem. | pmid:20444704 |
Tsujita T et al. | Methyl butyrate-hydrolyzing activity of hepatic triglyceride lipase from rat post-heparin plasma. | 1984 | J. Biol. Chem. | pmid:6469999 |
Snyder SE et al. | Radiolabeled cholinesterase substrates: in vitro methods for determining structure-activity relationships and identification of a positron emission tomography radiopharmaceutical for in vivo measurement of butyrylcholinesterase activity. | 2001 | J. Cereb. Blood Flow Metab. | pmid:11176278 |
Kim J et al. | 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. | 2005 | J. Chem. Ecol. | pmid:16222778 |
Manrique G et al. | Chemical communication in Chagas disease vectors. Source, identity, and potential function of volatiles released by the metasternal and Brindley's glands of Triatoma infestans adults. | 2006 | J. Chem. Ecol. | pmid:16902820 |
Ho HY et al. | Identification and synthesis of the sex pheromone of the Madeira mealybug, Phenacoccus madeirensis Green. | 2009 | J. Chem. Ecol. | pmid:19529970 |
Hamilton JG et al. | Identification of a male-produced aggregation pheromone in the western flower thrips Frankliniella occidentalis. | 2005 | J. Chem. Ecol. | pmid:16222777 |
Attygalle AB et al. | Biosynthesis of tiglic, ethacrylic, and 2-methylbutyric acids in a carabid beetle, Pterostichus (Hypherpes) californicus. | 2007 | J. Chem. Ecol. | pmid:17404818 |
Kaneda T | Gas-liquid chromatographic separation of enantiomers as their diastereomeric derivatives, illustrated with 2-methylbutyric acid. | 1986 | J. Chromatogr. | pmid:3782319 |
Schatowitz B and Gercken G | Simultaneous determination of C2-C22 non-esterified fatty acids and other metabolically relevant carboxylic acids in biological material by gas chromatography of their benzyl esters. | 1988 | J. Chromatogr. | pmid:3372640 |
Johnson BA and Leon M | Odorant molecular length: one aspect of the olfactory code. | 2000 | J. Comp. Neurol. | pmid:10982472 |
Aiello RJ and Armentano LE | Effects of volatile fatty acids on propionate metabolism and gluconeogenesis in caprine hepatocytes. | 1987 | J. Dairy Sci. | pmid:3448105 |
Peirce-Sandner SB et al. | Supplementation of dairy cow diets with ammonium salts of volatile fatty acids. | 1985 | J. Dairy Sci. | pmid:4078120 |
Lee GH et al. | Aroma-active components of Lycii fructus (kukija). | 2008 | J. Food Sci. | pmid:19241541 |
Antón MJ et al. | Aromatic profile of ciders by chemical quantitative, gas chromatography-olfactometry, and sensory analysis. | 2014 | J. Food Sci. | pmid:24313985 |
Monticello DJ et al. | Isoleucine synthesis by Clostridium sporogenes from propionate or alpha-methylbutyrate. | 1984 | J. Gen. Microbiol. | pmid:6726176 |
Araújo SM et al. | Biotechnological process for obtaining new fermented products from cashew apple fruit by Saccharomyces cerevisiae strains. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21069555 |
Reineri F et al. | Effect of low and zero magnetic field on the hyperpolarization lifetime in parahydrogenated perdeuterated molecules. | 2009 | J. Magn. Reson. | pmid:19535274 |
Banskota AH et al. | Three new C-14 oxygenated taxanes from the wood of Taxus yunnanensis. | 2002 | J. Nat. Prod. | pmid:12444707 |
Okamoto S et al. | New decalin derivatives, eujavanoic acids A and B, from Eupenicillium javanicum. | 2004 | J. Nat. Prod. | pmid:15387665 |