| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
Total
1
2-Methylbutanoic acid
2-Methylbutanoic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Binding (Molecular Function), Oxidation, isoleucine catabolic process, Anabolism and physiological aspects. 2-methylbutanoic acid often locates in Membrane, soluble and host. The associated genes with 2-Methylbutanoic acid are Homologous Gene, Genome, NKS1 gene, HM13 gene and ACSM1 gene. The related lipids are Fatty Acids, Butyric Acids, branched chain fatty acid, Propionate and 2-methylvalerate.
Cross Reference
Introduction
To understand associated biological information of 2-Methylbutanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-Methylbutanoic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-Methylbutanoic acid
PubChem Associated disorders and diseases
What pathways are associated with 2-Methylbutanoic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-Methylbutanoic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 2-Methylbutanoic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2-Methylbutanoic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 2-Methylbutanoic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-Methylbutanoic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 2-Methylbutanoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Giglio A et al. | Current knowledge on exocrine glands in carabid beetles: structure, function and chemical compounds. | 2011 | Zookeys | pmid:21738412 |
| Wu C et al. | Syntrophomonas wolfei subsp. methylbutyratica subsp. nov., and assignment of Syntrophomonas wolfei subsp. saponavida to Syntrophomonas saponavida sp. nov. comb. nov. | 2007 | Syst. Appl. Microbiol. | pmid:17223300 |
| Sun H et al. | Complete genome sequence of Desulfarculus baarsii type strain (2st14). | 2010 | Stand Genomic Sci | pmid:21304732 |
| Labutti K et al. | Permanent draft genome sequence of Dethiosulfovibrio peptidovorans type strain (SEBR 4207). | 2010 | Stand Genomic Sci | pmid:21304695 |
| Tanaka K et al. | Isovaleric and -methylbutyric acidemias induced by hypoglycin A: mechanism of Jamaican vomiting sickness. | 1972 | Science | pmid:5008580 |
| Kennedy J et al. | Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. | 1999 | Science | pmid:10334994 |
| Høverstad T et al. | Influence of oral intake of seven different antibiotics on faecal short-chain fatty acid excretion in healthy subjects. | 1986 | Scand. J. Gastroenterol. | pmid:3775265 |
| Høverstad T et al. | Short-chain fatty acids in intestinal content of germfree mice monocontaminated with Escherichia coli or Clostridium difficile. | 1985 | Scand. J. Gastroenterol. | pmid:3890142 |
| Zhang A et al. | Sex pheromone of the pink hibiscus mealybug, Maconellicoccus hirsutus, contains an unusual cyclobutanoid monoterpene. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15197282 |
| Cherian G et al. | Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. | 2002 | Poult. Sci. | pmid:12412926 |
| Leahy SC et al. | The genome sequence of the rumen methanogen Methanobrevibacter ruminantium reveals new possibilities for controlling ruminant methane emissions. | 2010 | PLoS ONE | pmid:20126622 |
| Dalmasso M et al. | A temporal-omic study of Propionibacterium freudenreichii CIRM-BIA1 adaptation strategies in conditions mimicking cheese ripening in the cold. | 2012 | PLoS ONE | pmid:22253706 |
| Seemann A et al. | Variation of sesquiterpene lactone contents in different Arnica montana populations: influence of ecological parameters. | 2010 | Planta Med. | pmid:20101561 |
| Schilmiller A et al. | Mass spectrometry screening reveals widespread diversity in trichome specialized metabolites of tomato chromosomal substitution lines. | 2010 | Plant J. | pmid:20113441 |
| Alvarez-GarcÃa R et al. | Absolute configuration of the alpha-methylbutyryl residue in longipinene derivatives from Stevia pilosa. | 2005 | Phytochemistry | pmid:15771882 |
| Matich AJ et al. | Actinidia arguta: volatile compounds in fruit and flowers. | 2003 | Phytochemistry | pmid:12737978 |
| Socaci SA et al. | In-tube extraction and GC-MS analysis of volatile components from wild and cultivated sea buckthorn (Hippophae rhamnoides L. ssp. Carpatica) berry varieties and juice. | 2013 Jul-Aug | Phytochem Anal | pmid:23319448 |
| Dementyev P et al. | Chirally-modified metal surfaces: energetics of interaction with chiral molecules. | 2015 | Phys Chem Chem Phys | pmid:26256836 |
| Pareek A et al. | Feverfew (Tanacetum parthenium L.): A systematic review. | 2011 | Pharmacogn Rev | pmid:22096324 |
| Iden P et al. | 3-Oxothiolase activities and [14C]-2-methylbutanoic acid incorporation in cultured fibroblasts from 13 cases of suspected 3-oxothiolase deficiency. | 1990 | Pediatr. Res. | pmid:2255576 |
| Kølvraa S et al. | Studies of the glycine metabolism in a patient with D-glyceric acidemia and hyperglycinemia. | 1980 | Pediatr. Res. | pmid:7454444 |
| Queenan KM et al. | Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial. | 2007 | Nutr J | pmid:17386092 |
| Sung K et al. | Possible effects of nitric oxide synthases on odor-induced behavioral changes in mice. | 2014 | Neurosci. Lett. | pmid:24747686 |
| Westermann CM et al. | Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy. | 2008 | Neuromuscul. Disord. | pmid:18406615 |
| MurÃn R et al. | Glial metabolism of isoleucine. | 2009 | Neurochem. Res. | pmid:18787950 |
| Kenakin TP and Beek D | The effects on Schild regressions of antagonist removal from the receptor compartment by a saturable process. | 1987 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3561525 |
| Kobayakawa K et al. | Innate versus learned odour processing in the mouse olfactory bulb. | 2007 | Nature | pmid:17989651 |
| Xiao ZB et al. | Comparison of volatile components in Chinese traditional pickled peppers using HS-SPME-GC-MS, GC-O and multivariate analysis. | 2010 | Nat. Prod. Res. | pmid:21108121 |
| Orav A et al. | Essential oil composition of Pimpinella anisum L. fruits from various European countries. | 2008 | Nat. Prod. Res. | pmid:18266152 |
| Komuniecki PR and Vanover L | Biochemical changes during the aerobic-anaerobic transition in Ascaris suum larvae. | 1987 | Mol. Biochem. Parasitol. | pmid:3033496 |
| Komuniecki R et al. | NADH-dependent tiglyl-CoA reduction in disrupted mitochondria of Ascaris suum. | 1984 | Mol. Biochem. Parasitol. | pmid:6694671 |
| Zhu K et al. | Precursor and temperature modulation of fatty acid composition and growth of Listeria monocytogenes cold-sensitive mutants with transposon-interrupted branched-chain alpha-keto acid dehydrogenase. | 2005 | Microbiology (Reading, Engl.) | pmid:15699210 |
| Narihiro T et al. | Comparative Genomics of Syntrophic Branched-Chain Fatty Acid Degrading Bacteria. | 2016 | Microbes Environ. | pmid:27431485 |
| Ren Y et al. | Geobacillus sp., a thermophilic soil bacterium producing volatile antibiotics. | 2010 | Microb. Ecol. | pmid:20091406 |
| Heymann E and Mentlein R | Carboxylesterases-amidases. | 1981 | Meth. Enzymol. | pmid:7329311 |
| Verhulst NO et al. | Cultured skin microbiota attracts malaria mosquitoes. | 2009 | Malar. J. | pmid:20017925 |
| Schreiberová O et al. | RP-HPLC/MS-APCI analysis of branched chain TAG prepared by precursor-directed biosynthesis with Rhodococcus erythropolis. | 2010 | Lipids | pmid:20635225 |
| Taniguchi A et al. | Regional differences in carboxylesterase activity between human subcutaneous and omental adipose tissue. | 1985 | Life Sci. | pmid:3982221 |
| Igarashi KM et al. | Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex. | 2012 | J. Neurosci. | pmid:22674272 |
| Banskota AH et al. | Three new C-14 oxygenated taxanes from the wood of Taxus yunnanensis. | 2002 | J. Nat. Prod. | pmid:12444707 |
| Okamoto S et al. | New decalin derivatives, eujavanoic acids A and B, from Eupenicillium javanicum. | 2004 | J. Nat. Prod. | pmid:15387665 |
| Sosath S et al. | Irritant principles of the spurge family (Euphorbiaceae). XIII. Oligocyclic and macrocyclic diterpene esters from latices of some Euphorbia species utilized as source plants of honey. | 1988 Nov-Dec | J. Nat. Prod. | pmid:3236005 |
| Reineri F et al. | Effect of low and zero magnetic field on the hyperpolarization lifetime in parahydrogenated perdeuterated molecules. | 2009 | J. Magn. Reson. | pmid:19535274 |
| Araújo SM et al. | Biotechnological process for obtaining new fermented products from cashew apple fruit by Saccharomyces cerevisiae strains. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21069555 |
| Monticello DJ et al. | Isoleucine synthesis by Clostridium sporogenes from propionate or alpha-methylbutyrate. | 1984 | J. Gen. Microbiol. | pmid:6726176 |
| Lee GH et al. | Aroma-active components of Lycii fructus (kukija). | 2008 | J. Food Sci. | pmid:19241541 |
| Antón MJ et al. | Aromatic profile of ciders by chemical quantitative, gas chromatography-olfactometry, and sensory analysis. | 2014 | J. Food Sci. | pmid:24313985 |
| Aiello RJ and Armentano LE | Effects of volatile fatty acids on propionate metabolism and gluconeogenesis in caprine hepatocytes. | 1987 | J. Dairy Sci. | pmid:3448105 |
| Peirce-Sandner SB et al. | Supplementation of dairy cow diets with ammonium salts of volatile fatty acids. | 1985 | J. Dairy Sci. | pmid:4078120 |
| Johnson BA and Leon M | Odorant molecular length: one aspect of the olfactory code. | 2000 | J. Comp. Neurol. | pmid:10982472 |
| Kaneda T | Gas-liquid chromatographic separation of enantiomers as their diastereomeric derivatives, illustrated with 2-methylbutyric acid. | 1986 | J. Chromatogr. | pmid:3782319 |
| Schatowitz B and Gercken G | Simultaneous determination of C2-C22 non-esterified fatty acids and other metabolically relevant carboxylic acids in biological material by gas chromatography of their benzyl esters. | 1988 | J. Chromatogr. | pmid:3372640 |
| Kim J et al. | 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. | 2005 | J. Chem. Ecol. | pmid:16222778 |
| Manrique G et al. | Chemical communication in Chagas disease vectors. Source, identity, and potential function of volatiles released by the metasternal and Brindley's glands of Triatoma infestans adults. | 2006 | J. Chem. Ecol. | pmid:16902820 |
| Ho HY et al. | Identification and synthesis of the sex pheromone of the Madeira mealybug, Phenacoccus madeirensis Green. | 2009 | J. Chem. Ecol. | pmid:19529970 |
| Hamilton JG et al. | Identification of a male-produced aggregation pheromone in the western flower thrips Frankliniella occidentalis. | 2005 | J. Chem. Ecol. | pmid:16222777 |
| Attygalle AB et al. | Biosynthesis of tiglic, ethacrylic, and 2-methylbutyric acids in a carabid beetle, Pterostichus (Hypherpes) californicus. | 2007 | J. Chem. Ecol. | pmid:17404818 |
| Snyder SE et al. | Radiolabeled cholinesterase substrates: in vitro methods for determining structure-activity relationships and identification of a positron emission tomography radiopharmaceutical for in vivo measurement of butyrylcholinesterase activity. | 2001 | J. Cereb. Blood Flow Metab. | pmid:11176278 |
| Dickinson JR et al. | An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae. | 2000 | J. Biol. Chem. | pmid:10753893 |
| Liou JS et al. | Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species. | 2000 | J. Biol. Chem. | pmid:10967125 |
| SAZ HJ and WEIL A | The mechanism of the formation of alpha-methylbutyrate from carbohydrate by Ascaris lumbricoides muscle. | 1960 | J. Biol. Chem. | pmid:14442156 |
| Schmidt J et al. | Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. | 2011 | J. Biol. Chem. | pmid:21220428 |
| COON MJ et al. | The relation of alpha-methyl-butyrate to isoleucine metabolism. II. Propionate formation. | 1952 | J. Biol. Chem. | pmid:12999817 |
| COON MJ and ABRAHAMSEN NS | The relation of alpha-methylbutyrate to isoleucine metabolism. I. Acetoacetate formation. | 1952 | J. Biol. Chem. | pmid:14946192 |
| Rey FE et al. | Dissecting the in vivo metabolic potential of two human gut acetogens. | 2010 | J. Biol. Chem. | pmid:20444704 |
| Tsujita T et al. | Methyl butyrate-hydrolyzing activity of hepatic triglyceride lipase from rat post-heparin plasma. | 1984 | J. Biol. Chem. | pmid:6469999 |
| LARSON AD et al. | VOLATILE FATTY ACID REQUIREMENT OF A STRAIN OF LISTERIA MONOCYTOGENES. | 1965 | J. Bacteriol. | pmid:14273667 |
| HUNGATE RE | POLYSACCHARIDE STORAGE AND GROWTH EFFICIENCY IN RUMINOCOCCUS ALBUS. | 1963 | J. Bacteriol. | pmid:14066484 |
| Meng Y et al. | Characterization of an archaeal medium-chain acyl coenzyme A synthetase from Methanosarcina acetivorans. | 2010 | J. Bacteriol. | pmid:20851904 |
| Hayashida-Soiza G et al. | Purification and characterization of antibacterial substances produced by a marine bacterium Pseudoalteromonas haloplanktis strain. | 2008 | J. Appl. Microbiol. | pmid:18828792 |
| Czerkawski JW et al. | Microbial metabolism of 1,2-propanediol studied by the Rumen Simulation Technique (Rusitec). | 1984 | J. Appl. Bacteriol. | pmid:6423608 |
| Marshall VP et al. | Precursor directed biosynthesis of paulomycins A and B. The effects of valine, isoleucine, isobutyric acid and 2-methylbutyric acid. | 1984 | J. Antibiot. | pmid:6480507 |
| Samii SS et al. | Effects of limonene on ruminal concentrations, fermentation, and lysine degradation in cattle. | 2016 | J. Anim. Sci. | pmid:27695807 |
| Xie X et al. | Acyltransferase mediated polyketide release from a fungal megasynthase. | 2009 | J. Am. Chem. Soc. | pmid:19530726 |
| Lee I and Zaera F | Chiral templating of surfaces: adsorption of (S)-2-methylbutanoic acid on Pt(111) single-crystal surfaces. | 2006 | J. Am. Chem. Soc. | pmid:16819884 |
| Pérez AG et al. | Biosynthesis of strawberry aroma compounds through amino acid metabolism. | 2002 | J. Agric. Food Chem. | pmid:12083879 |
| Kwon DY et al. | Enantiomeric synthesis of (S)-2-methylbutanoic acid methyl ester, apple flavor, using lipases in organic solvent. | 2000 | J. Agric. Food Chem. | pmid:10691670 |
| Dregus M et al. | Enantioselective analysis of methyl-branched alcohols and acids in rhubarb (Rheum rhabarbarum L.) stalks. | 2003 | J. Agric. Food Chem. | pmid:14611176 |
| Matich A and Rowan D | Pathway analysis of branched-chain ester biosynthesis in apple using deuterium labeling and enantioselective gas chromatography-mass spectrometry. | 2007 | J. Agric. Food Chem. | pmid:17335222 |
| Willner B et al. | Characterization of the key aroma compounds in Bartlett pear brandies by means of the sensomics concept. | 2013 | J. Agric. Food Chem. | pmid:24004345 |
| de Souza MD et al. | Characterization of cachaça and rum aroma. | 2006 | J. Agric. Food Chem. | pmid:16417309 |
| Valim MF et al. | Gas chromatographic-olfactometric characterization of aroma compounds in two types of cashew apple nectar. | 2003 | J. Agric. Food Chem. | pmid:12568564 |
| Zhang A and Nie J | Enantioselective synthesis of the female sex pheromone of the pink hibiscus Mealybug, Maconellicoccus hirsutus. | 2005 | J. Agric. Food Chem. | pmid:15796578 |
| Rodrigues VM et al. | Supercritical extraction of essential oil from aniseed (Pimpinella anisum L) using CO2: solubility, kinetics, and composition data. | 2003 | J. Agric. Food Chem. | pmid:12617576 |
| Matheis K and Granvogl M | Characterization of Key Odorants Causing a Fusty/Musty Off-Flavor in Native Cold-Pressed Rapeseed Oil by Means of the Sensomics Approach. | 2016 | J. Agric. Food Chem. | pmid:27712066 |
| Goubet I et al. | Competitive binding of aroma compounds by beta-cyclodextrin. | 2001 | J. Agric. Food Chem. | pmid:11743785 |
| Jirovetz L et al. | Aroma compound analysis of Eruca sativa (Brassicaceae) SPME headspace leaf samples using GC, GC-MS, and olfactometry. | 2002 | J. Agric. Food Chem. | pmid:12137490 |
| Tanaka K et al. | Resistance to the skeletal muscle injury expressed by repeated treatment with compound A that has HMG-CoA reductase inhibitory activity. | 2007 | J Toxicol Sci | pmid:17327690 |
| Ferreira L et al. | Characterization of volatile substances in apples from Rosaceae family by headspace solid-phase microextraction followed by GC-qMS. | 2009 | J Sep Sci | pmid:19425016 |
| Stacchiola D et al. | Requirements for the formation of a chiral template. | 2005 | J Phys Chem B | pmid:16866451 |
| Huynh LK et al. | Kinetic modeling of methyl butanoate in shock tube. | 2008 | J Phys Chem A | pmid:19035670 |
| El-Nahas AM et al. | Enthalpies of formation, bond dissociation energies and reaction paths for the decomposition of model biofuels: ethyl propanoate and methyl butanoate. | 2007 | J Phys Chem A | pmid:17286391 |
| Hajhashemi V et al. | Anti-inflammatory and analgesic properties of Heracleum persicum essential oil and hydroalcoholic extract in animal models. | 2009 | J Ethnopharmacol | pmid:19467316 |
| Velasco-Negueruela A et al. | Analysis by gas chromatography-mass spectrometry of the essential oil from the aerial parts of Pimpinella junoniae Ceb. & Ort., gathered in La Gomera, Canary Islands, Spain. | 2003 | J Chromatogr A | pmid:14518782 |
| Goldstein EJ and Arias IM | Interaction of ligandin with radiographic contrast media. | 1976 Nov-Dec | Invest Radiol | pmid:1002414 |
| Savant DV et al. | Methanobrevibacter acididurans sp. nov., a novel methanogen from a sour anaerobic digester. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12148611 |
| Suzuki D et al. | Desulfovibrio butyratiphilus sp. nov., a Gram-negative, butyrate-oxidizing, sulfate-reducing bacterium isolated from an anaerobic municipal sewage sludge digester. | 2010 | Int. J. Syst. Evol. Microbiol. | pmid:19654341 |
| Kato T et al. | Survey of conformational role of ester bonds in a cyclic depsipeptide. Study on cyclo(-L-Ala-L-Hmb-)2 by energy calculation and NMR spectroscopy. | 1992 | Int. J. Pept. Protein Res. | pmid:1399269 |
| Inoue H et al. | Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. | 2002 | Int. J. Mol. Med. | pmid:11956660 |
| Kitazono M et al. | Reversal of LRP-associated drug resistance in colon carcinoma SW-620 cells. | 2001 | Int. J. Cancer | pmid:11149411 |