Pivalic acid

Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pivalic acid?

Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pivalic acid

MeSH term MeSH ID Detail
Dihydropyrimidine Dehydrogenase Deficiency D054067 1 associated lipids
Toxocariasis D014120 3 associated lipids
Vitamin B Deficiency D014804 4 associated lipids
Purine-Pyrimidine Metabolism, Inborn Errors D011686 5 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Otitis Media D010033 12 associated lipids
Hyperinsulinism D006946 27 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Dermatitis D003872 30 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Pivalic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pivalic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pivalic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pivalic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pivalic acid

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Authors Title Published Journal PubMed Link
Goikhman R et al. C-H bonds as ubiquitous functionality: a general approach to complex arylated pyrazoles via sequential regioselective C-arylation and N-alkylation enabled by SEM-group transposition. 2009 J. Am. Chem. Soc. pmid:19206533
Huang JK et al. Effect of MK-886 on Ca2+ level and viability in PC3 human prostate cancer cells. 2009 Basic Clin. Pharmacol. Toxicol. pmid:19371256
Goossen LJ et al. C(aryl)-O activation of aryl carboxylates in nickel-catalyzed biaryl syntheses. 2009 Angew. Chem. Int. Ed. Engl. pmid:19280618
Zhao D et al. Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst. 2009 Chemistry pmid:19115287
Ito T Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism. 2009 J Toxicol Sci pmid:19571472
Todesco L et al. Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2. 2009 Chem. Biol. Interact. pmid:19539806
Quintas C et al. The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. 2009 Neurochem. Int. pmid:19447154
Akhtar MN et al. Family of heterometallic semicircular Mn(III)2Ln(III)3 strands. 2009 Inorg Chem pmid:19317423
Liégault B et al. Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds. 2009 J. Org. Chem. pmid:19206211
Mandal D et al. Tetra-, tri-, and mononuclear manganese(II/III) complexes of a phenol-based N2O2 capping ligand: use of carboxylates as ancillary ligands in tuning the nuclearity of the complexes. 2009 Inorg Chem pmid:19235946