| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dihydropyrimidine Dehydrogenase Deficiency | D054067 | 1 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Vitamin B Deficiency | D014804 | 4 associated lipids |
| Urinary Tract Infections | D014552 | 11 associated lipids |
| Toxocariasis | D014120 | 3 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Purine-Pyrimidine Metabolism, Inborn Errors | D011686 | 5 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
Pivalic acid
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Pivalic acid?
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Pivalic acid
PubChem Associated disorders and diseases
What pathways are associated with Pivalic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Pivalic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Pivalic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Pivalic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Pivalic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with Pivalic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Pivalic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fujii R et al. | [Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients]. | 1993 | Jpn J Antibiot | pmid:8254895 |
| Dilks JR and Flaumenhaft R | Fluoxetine (Prozac) augments platelet activation mediated through protease-activated receptors. | 2008 | J. Thromb. Haemost. | pmid:18194419 |
| Sloan CA | Proceedings: Comparison of dexamethasone trimethylacetate and prostaglandin F-2alpha as abortifacients in the cow. | 1976 | J. Reprod. Fertil. | pmid:1255625 |
| Li C et al. | In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12649376 |
| Ohashi R et al. | Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10525100 |
| Hong AW et al. | An expedient route to Montanine-type Amaryllidaceae alkaloids: total syntheses of (-)-brunsvigine and (-)-manthine. | 2008 | J. Org. Chem. | pmid:18781802 |
| Demory E et al. | Fast Pd- and Pd/Cu-catalyzed direct C-H arylation of cyclic nitrones. Application to the synthesis of enantiopure quaternary α-amino esters. | 2012 | J. Org. Chem. | pmid:22946756 |
| Aljaar N et al. | Cu-catalyzed reaction of 1,2-dihalobenzenes with 1,3-cyclohexanediones for the synthesis of 3,4-dihydrodibenzo[b,d]furan-1(2H)-ones. | 2012 | J. Org. Chem. | pmid:22917488 |
| Rao ChB et al. | An efficient protocol for alcohol protection under solvent- and catalyst-free conditions. | 2009 | J. Org. Chem. | pmid:19839567 |
| Chakraborti AK and Shivani S | Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst. | 2006 | J. Org. Chem. | pmid:16839166 |
| Liégault B et al. | Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds. | 2009 | J. Org. Chem. | pmid:19206211 |
| Darbeau RW et al. | Boundary conditions on the partitioning of deaminatively generated benzyl cations. | 2001 | J. Org. Chem. | pmid:11304187 |
| Zhou Q et al. | In situ generation of palladium nanoparticles: ligand-free palladium catalyzed pivalic acid assisted carbonylative Suzuki reactions at ambient conditions. | 2014 | J. Org. Chem. | pmid:24397578 |
| Liégault B et al. | Intramolecular Pd(II)-catalyzed oxidative biaryl synthesis under air: reaction development and scope. | 2008 | J. Org. Chem. | pmid:18543991 |
| Nakamura T et al. | Effect of d,l-alpha-tocopheryl esters on vitamin E-deficient rats. | 1978 | J. Nutr. Sci. Vitaminol. | pmid:731332 |
| Bianchi PB and Davis AT | Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats. | 1991 | J. Nutr. | pmid:1941267 |
| Nakajima H et al. | Pivalate affects carnitine status but causes no severe metabolic changes in rat liver. | 1996 | J. Nutr. | pmid:8648443 |
| Bianchi PB and Davis AT | beta-Hydroxybutyrate oxidation is reduced and hepatic balance of ketone bodies and free fatty acids is unaltered in carnitine-depleted, pivalate-treated rats. | 1996 | J. Nutr. | pmid:8914959 |
| Bianchi PB et al. | Carnitine supplementation ameliorates the steatosis and ketosis induced by pivalate in rats. | 1996 | J. Nutr. | pmid:8914960 |
| Davis AT and Monroe TJ | Carnitine deficiency and supplementation do not affect the gene expression of carnitine biosynthetic enzymes in rats. | 2005 | J. Nutr. | pmid:15795431 |