Pivalic acid

Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pivalic acid?

Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pivalic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Hemolysis D006461 131 associated lipids
Seizures D012640 87 associated lipids
Psoriasis D011565 47 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Dermatitis D003872 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hyperinsulinism D006946 27 associated lipids
Otitis Media D010033 12 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Purine-Pyrimidine Metabolism, Inborn Errors D011686 5 associated lipids
Vitamin B Deficiency D014804 4 associated lipids
Toxocariasis D014120 3 associated lipids
Dihydropyrimidine Dehydrogenase Deficiency D054067 1 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Pivalic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pivalic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pivalic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pivalic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pivalic acid

Download all related citations
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Authors Title Published Journal PubMed Link
St Michael F et al. Investigating the candidacy of lipopolysaccharide-based glycoconjugates as vaccines to combat Mannheimia haemolytica. 2011 Glycoconj. J. pmid:21701793
Cox AD et al. Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: chemical strategies to prepare glycoconjugates with good carbohydrate loading. 2010 Glycoconj. J. pmid:20340043
Weis R et al. Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols. 2006 Eur J Pharm Sci pmid:16713699
Sauber K et al. A new esterase for the cleavage of pivalic acid-containing prodrug esters of cephalosporins. 1996 Enzyme Microb. Technol. pmid:8672280
Rezanka T et al. Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces. 2011 Environ. Microbiol. pmid:21450004
Broderick TL Hypocarnitinaemia induced by sodium pivalate in the rat is associated with left ventricular dysfunction and impaired energy metabolism. 2006 Drugs R D pmid:16752941
Arrigoni-Martelli E and Caso V Carnitine protects mitochondria and removes toxic acyls from xenobiotics. 2001 Drugs Exp Clin Res pmid:11276827
Ohnishi S et al. Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment. 2008 Drug Metab. Pharmacokinet. pmid:18762717
Vickers S et al. Metabolism of methyldopa in man after oral administration of the pivaloyloxyethyl ester. 1984 Mar-Apr Drug Metab. Dispos. pmid:6144491
Shishilov ON et al. Palladium(II) carboxylates and palladium(I) carbonyl carboxylate complexes as catalysts for olefin cyclopropanation with ethyl diazoacetate. 2009 Dalton Trans pmid:19672507
Kotzabasaki V et al. Hexametallic manganese clusters with bulky derivatised salicylaldoximes. 2011 Dalton Trans pmid:21249253
Zhao XQ et al. Synthesis, structures and magnetic properties of a series of 3d-4f tetranuclear Co(II)â‚‚Ln(III)â‚‚ cubanes. 2010 Dalton Trans pmid:20401413
Milios CJ et al. 1,1,1-Tris(hydroxymethyl)propane in manganese carboxylate chemistry: synthesis, structure and magnetic properties of a mixed-valence [MnIII4MnII4] cluster featuring the novel [MnIII4MnII4(mu3-OR)6(mu2-OR)8]6+ core. 2006 Dalton Trans pmid:16365649
Liu TF et al. An alcoholysis route to a Cu16 cluster, and the influence of the alcohol. 2010 Dalton Trans pmid:20354607
Wittick LM et al. New mixed-valence MnII2MnIII2 clusters exhibiting an unprecedented MnII/III oxidation state distribution in their magnetically coupled cores. 2006 Dalton Trans pmid:16538272
Chaboussant G et al. Nickel pivalate complexes: structural variations and magnetic susceptibility and inelastic neutron scattering studies. 2004 Dalton Trans pmid:15514763
Christian P et al. Synthesis and studies of a trinuclear Mn(II) carboxylate complex. 2004 Dalton Trans pmid:15303171
Christian P et al. Structural, magnetic and DFT studies of a hydroxide-bridged [Cr8] wheel. 2004 Dalton Trans pmid:15252595
Jarenmark M et al. Unsymmetrical dizinc complexes as models for the active sites of phosphohydrolases. 2010 Dalton Trans pmid:20683537
Leone G et al. Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias. 2008 Curr. Med. Chem. pmid:18537607
Kalavala M et al. Tixocortol pivalate: what is the right concentration? 2007 Contact Derm. pmid:17577357
Singh S and Mann BK Clinical utility of clocortolone pivalate for the treatment of corticosteroid-responsive skin disorders: a systematic review. 2012 Clin Cosmet Investig Dermatol pmid:22791998
Walling HW and Swick BL Update on the management of chronic eczema: new approaches and emerging treatment options. 2010 Clin Cosmet Investig Dermatol pmid:21437065
Illg T et al. Continuous synthesis of tert-butyl peroxypivalate using a single-channel microreactor equipped with orifices as emulsification units. 2011 ChemSusChem pmid:21302363
Dorofeeva VN et al. 2D porous honeycomb polymers versus discrete nanocubes from trigonal trinuclear complexes and ligands with variable topology. 2012 Chemistry pmid:22407897
Gensch T et al. Snapshot of the palladium(II)-catalyzed oxidative biaryl bond formation by X-ray analysis of the intermediate diaryl palladium(II) complex. 2012 Chemistry pmid:22170766
Zhao D et al. Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst. 2009 Chemistry pmid:19115287
Langley SK et al. Structure, magnetism and theory of a family of nonanuclear Cu(II)5Ln(III)4-triethanolamine clusters displaying single-molecule magnet behaviour. 2011 Chemistry pmid:21732432
Boeer AB et al. Linkage isomerism and spin frustration in heterometallic rings: synthesis, structural characterization, and magnetic and EPR spectroscopic studies of Cr(7)Ni, Cr(6)Ni(2), and Cr(7)Ni(2) rings templated about imidazolium cations. 2009 Chemistry pmid:19859922
Shanmugam M et al. Studies of a molecular hourglass: synthesis and magnetic characterisation of a cyclic dodecanuclear {Cr10Cu2} complex. 2006 Chemistry pmid:17009364
Aromí G et al. Synthetic and structural studies of cobalt-pivalate complexes. 2003 Chemistry pmid:14562332
Overgaard J et al. Host-guest chemistry of the chromium-wheel complex [Cr8F8(tBuCO2)16]: prediction of inclusion capabilities by using an electrostatic potential distribution determined by modeling synchrotron X-ray structure factors at 16 K. 2002 Chemistry pmid:12391657
Manolikakes SM et al. Air-stable solid aryl and heteroaryl organozinc pivalates: syntheses and applications in organic synthesis. 2014 Chemistry pmid:25116852
Grillo MP and Hua F Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes. 2008 Chem. Res. Toxicol. pmid:18680316
Li C et al. Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes. 2002 Chem. Res. Toxicol. pmid:12437340
Tobisu M et al. Nickel-catalyzed reductive cleavage of aryl-oxygen bonds in alkoxy- and pivaloxyarenes using hydrosilanes as a mild reducing agent. 2011 Chem. Commun. (Camb.) pmid:21264420
Langley SK et al. A high nuclearity mixed valence {Mn32} complex. 2011 Chem. Commun. (Camb.) pmid:21503362
Rajaraman G et al. Theoretical studies on di- and tetra-nuclear Ni pivalate complexes. 2005 Chem. Commun. (Camb.) pmid:15959582
Goossen LJ and Rodríguez N A mild and efficient protocol for the conversion of carboxylic acids to olefins by a catalytic decarbonylative elimination reaction. 2004 Chem. Commun. (Camb.) pmid:15010800
Lin Y et al. Cooperative catalysis of N-heterocyclic carbene and Brønsted acid for a highly enantioselective route to unprotected spiro-indoline-pyrans. 2015 Chem. Commun. (Camb.) pmid:25882587
Todesco L et al. Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2. 2009 Chem. Biol. Interact. pmid:19539806
Ercolani L and Schulte WE Metabolic and morphologic effects of colchicine on human T-lymphocyte expression of Fc mu and Fc gamma receptors. 1983 Cell. Immunol. pmid:6303602
Kuka J et al. A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function. 2012 Cardiovasc. Toxicol. pmid:22539084
Broderick TL et al. L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts. 1995 Cardiovasc. Res. pmid:8595631
Barroca N and Jacquinet JC An access to various sulfation patterns in dermatan sulfate: chemical syntheses of sulfoforms of trisaccharide methyl glycosides. 2002 Carbohydr. Res. pmid:11950464
Tomić S et al. Partial purification of esterases from rabbit serum and their use in regioselective deacylations of sugars. 1991 Carbohydr. Res. pmid:1878876
Kornilov AV et al. Preparative route to glucuronyl donors bearing temporary protecting group at O-3 via 6,3-lactonisation by Bz(2)O or Piv(2)O. 2001 Carbohydr. Res. pmid:11728399
Cutts SM et al. Molecular basis for the synergistic interaction of adriamycin with the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate (AN-9). 2001 Cancer Res. pmid:11719450
Mattocks AR and Cabral JR Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues. 1982 Cancer Lett. pmid:6817913
Broderick TL et al. Short-term carnitine deficiency does not alter aerobic rat heart function but depresses reperfusion recovery after ischemia. 2001 Can. J. Physiol. Pharmacol. pmid:11697749