MeSH term | MeSH ID | Detail |
---|---|---|
Psoriasis | D011565 | 47 associated lipids |
Seizures | D012640 | 87 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Pivalic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Psoriasis | D011565 | 47 associated lipids |
Seizures | D012640 | 87 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Schmidt J et al. | Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. | 2011 | J. Biol. Chem. | pmid:21220428 |
Blanton MP et al. | Examining the noncompetitive antagonist-binding site in the ion channel of the nicotinic acetylcholine receptor in the resting state. | 2000 | J. Biol. Chem. | pmid:10652341 |
Mascolo G et al. | Effectiveness of UV-based advanced oxidation processes for the remediation of hydrocarbon pollution in the groundwater: a laboratory investigation. | 2008 | J. Hazard. Mater. | pmid:17890002 |
Mitani MM et al. | Kinetics and products of reactions of MTBE with ozone and ozone/hydrogen peroxide in water. | 2002 | J. Hazard. Mater. | pmid:11744205 |
Rasmussen J et al. | Primary carnitine deficiency and pivalic acid exposure causing encephalopathy and fatal cardiac events. | 2013 | J. Inherit. Metab. Dis. | pmid:22566287 |
Will KW et al. | Quantification and evidence for mechanically metered release of pygidial secretions in formic acid-producing carabid beetles. | 2010 | J. Insect Sci. | pmid:20575743 |
Shoman ME et al. | Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties. | 2011 | J. Med. Chem. | pmid:21247168 |
Berkovitch G et al. | Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation. | 2008 | J. Med. Chem. | pmid:19007111 |
Haradahira T et al. | Potential tumor- or organ-imaging agents. 29. Radioiodinated esters and amides of 20-hydroxy- and 20-aminopregn-5-en-3 beta-ols. | 1989 | J. Med. Chem. | pmid:2918507 |
Wurm A et al. | Endogenous purinergic signaling is required for osmotic volume regulation of retinal glial cells. | 2010 | J. Neurochem. | pmid:20002522 |
Deutsch C et al. | Synaptosomes from rat brain: morphology, compartmentation, and transmembrane pH and electrical gradients. | 1981 | J. Neurochem. | pmid:7241148 |
Witney TH et al. | Preclinical evaluation of 3-18F-fluoro-2,2-dimethylpropionic acid as an imaging agent for tumor detection. | 2014 | J. Nucl. Med. | pmid:25012458 |
Bianchi PB and Davis AT | Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats. | 1991 | J. Nutr. | pmid:1941267 |
Nakajima H et al. | Pivalate affects carnitine status but causes no severe metabolic changes in rat liver. | 1996 | J. Nutr. | pmid:8648443 |
Bianchi PB and Davis AT | beta-Hydroxybutyrate oxidation is reduced and hepatic balance of ketone bodies and free fatty acids is unaltered in carnitine-depleted, pivalate-treated rats. | 1996 | J. Nutr. | pmid:8914959 |
Bianchi PB et al. | Carnitine supplementation ameliorates the steatosis and ketosis induced by pivalate in rats. | 1996 | J. Nutr. | pmid:8914960 |
Davis AT and Monroe TJ | Carnitine deficiency and supplementation do not affect the gene expression of carnitine biosynthetic enzymes in rats. | 2005 | J. Nutr. | pmid:15795431 |
Nakamura T et al. | Effect of d,l-alpha-tocopheryl esters on vitamin E-deficient rats. | 1978 | J. Nutr. Sci. Vitaminol. | pmid:731332 |
Hong AW et al. | An expedient route to Montanine-type Amaryllidaceae alkaloids: total syntheses of (-)-brunsvigine and (-)-manthine. | 2008 | J. Org. Chem. | pmid:18781802 |
Liégault B et al. | Intramolecular Pd(II)-catalyzed oxidative biaryl synthesis under air: reaction development and scope. | 2008 | J. Org. Chem. | pmid:18543991 |