MeSH term | MeSH ID | Detail |
---|---|---|
Psoriasis | D011565 | 47 associated lipids |
Seizures | D012640 | 87 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Pivalic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Psoriasis | D011565 | 47 associated lipids |
Seizures | D012640 | 87 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Dorofeeva VN et al. | 2D porous honeycomb polymers versus discrete nanocubes from trigonal trinuclear complexes and ligands with variable topology. | 2012 | Chemistry | pmid:22407897 |
Kuka J et al. | A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function. | 2012 | Cardiovasc. Toxicol. | pmid:22539084 |
Shan Y et al. | Rapid acyl migration between pyrogallyl 1,2- and 1,3-dipivaloates. | 2012 | Nat Prod Commun | pmid:22545406 |
Rasmussen J et al. | Primary carnitine deficiency and pivalic acid exposure causing encephalopathy and fatal cardiac events. | 2013 | J. Inherit. Metab. Dis. | pmid:22566287 |
Lam KK et al. | Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis. | 2012 | PLoS Pathog. | pmid:22589723 |
Xu S and Shen Y | (1H-1,2,3-Benzotriazol-1-yl)methyl 2,2-dimethyl-propano-ate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22589933 |
Cao G et al. | Bis[(1H-1,2,3-benzotriazol-1-yl)methyl 2,2-dimethyl-propano-ato-κN(3)]dichlorido-copper(II). | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22590111 |
Tomkowicz Z et al. | Magnetooptical and structural investigations of five dimeric cobalt(II) complexes mimicking metalloenzyme active sites. | 2012 | Inorg Chem | pmid:22621284 |
Barberán J et al. | Update on the clinical utility and optimal use of cefditoren. | 2012 | Int J Gen Med | pmid:22675264 |
Rezanka T et al. | Biosynthesis and metabolic pathways of pivalic acid. | 2012 | Appl. Microbiol. Biotechnol. | pmid:22790609 |
Singh S and Mann BK | Clinical utility of clocortolone pivalate for the treatment of corticosteroid-responsive skin disorders: a systematic review. | 2012 | Clin Cosmet Investig Dermatol | pmid:22791998 |
Del Rosso JQ and Kircik L | A Comprehensive Review of Clocortolone Pivalate 0.1% Cream: Structural Development, Formulation Characteristics, and Studies Supporting Treatment of Corticosteroid-responsive Dermatoses. | 2012 | J Clin Aesthet Dermatol | pmid:22798972 |
Aljaar N et al. | Cu-catalyzed reaction of 1,2-dihalobenzenes with 1,3-cyclohexanediones for the synthesis of 3,4-dihydrodibenzo[b,d]furan-1(2H)-ones. | 2012 | J. Org. Chem. | pmid:22917488 |
Demory E et al. | Fast Pd- and Pd/Cu-catalyzed direct C-H arylation of cyclic nitrones. Application to the synthesis of enantiopure quaternary α-amino esters. | 2012 | J. Org. Chem. | pmid:22946756 |
Trost BM et al. | Palladium-catalyzed asymmetric allylic alkylation of 3-aryloxindoles with allylidene dipivalate: a useful enol pivalate product. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23335176 |
Zhou Q et al. | Nickel-catalyzed cross-couplings of benzylic pivalates with arylboroxines: stereospecific formation of diarylalkanes and triarylmethanes. | 2013 | J. Am. Chem. Soc. | pmid:23425080 |
Muto K et al. | Isolation, structure, and reactivity of an arylnickel(II) pivalate complex in catalytic C-H/C-O biaryl coupling. | 2013 | J. Am. Chem. Soc. | pmid:24152083 |
Boemer F et al. | Surprising causes of C5-carnitine false positive results in newborn screening. | 2014 | Mol. Genet. Metab. | pmid:24291264 |
Zhou Q et al. | In situ generation of palladium nanoparticles: ligand-free palladium catalyzed pivalic acid assisted carbonylative Suzuki reactions at ambient conditions. | 2014 | J. Org. Chem. | pmid:24397578 |
Lu Q et al. | Mechanistic study of chemoselectivity in Ni-catalyzed coupling reactions between azoles and aryl carboxylates. | 2014 | J. Am. Chem. Soc. | pmid:24823646 |