MeSH term | MeSH ID | Detail |
---|---|---|
Psoriasis | D011565 | 47 associated lipids |
Seizures | D012640 | 87 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Pivalic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Psoriasis | D011565 | 47 associated lipids |
Seizures | D012640 | 87 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Barroca N and Jacquinet JC | An access to various sulfation patterns in dermatan sulfate: chemical syntheses of sulfoforms of trisaccharide methyl glycosides. | 2002 | Carbohydr. Res. | pmid:11950464 |
Overgaard J et al. | Host-guest chemistry of the chromium-wheel complex [Cr8F8(tBuCO2)16]: prediction of inclusion capabilities by using an electrostatic potential distribution determined by modeling synchrotron X-ray structure factors at 16 K. | 2002 | Chemistry | pmid:12391657 |
Niezen JH et al. | The effect of feeding sulla (Hedysarum coronarium) or lucerne (Medicago sativa) on lamb parasite burdens and development of immunity to gastrointestinal nematodes. | 2002 | Vet. Parasitol. | pmid:11934463 |
Bursten BE et al. | Oxalate-bridged complexes of dimolybdenum and ditungsten supported by pivalate ligands: ((t)BuCO(2))(3)M(2)(mu-O(2)CCO(2))M(2)(O(2)C(t)Bu)(3). Correlation of the solid-state, molecular, and electronic structures with Raman, resonance Raman, and electronic spectral data. | 2002 | J. Am. Chem. Soc. | pmid:11902897 |
Mitani MM et al. | Kinetics and products of reactions of MTBE with ozone and ozone/hydrogen peroxide in water. | 2002 | J. Hazard. Mater. | pmid:11744205 |
Li C et al. | In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12649376 |
Färber K et al. | Selective desensitization of jasmonate- and pH-dependent signaling in the induction of benzophenanthridine biosynthesis in cells of Eschscholzia californica. | 2003 | Phytochemistry | pmid:12620362 |
Probian C et al. | Anaerobic mineralization of quaternary carbon atoms: isolation of denitrifying bacteria on pivalic acid (2,2-dimethylpropionic acid). | 2003 | Appl. Environ. Microbiol. | pmid:12620885 |
Spino C et al. | A stereodivergent approach to chiral nonracemic N-protected alpha,alpha-dialkylated amino acids. | 2003 | J. Am. Chem. Soc. | pmid:14518992 |
Aromà G et al. | Synthetic and structural studies of cobalt-pivalate complexes. | 2003 | Chemistry | pmid:14562332 |
Li C et al. | In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12649042 |
Carlsson H et al. | Structural and functional models of the active site of zinc phosphotriesterase. | 2004 | Inorg Chem | pmid:15332820 |
Solano-Serena F et al. | Degradation of isooctane by Mycobacterium austroafricanum IFP 2173: growth and catabolic pathway. | 2004 | J. Appl. Microbiol. | pmid:15281945 |
Stanley CA | Carnitine deficiency disorders in children. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15591002 |
Chaboussant G et al. | Nickel pivalate complexes: structural variations and magnetic susceptibility and inelastic neutron scattering studies. | 2004 | Dalton Trans | pmid:15514763 |
Christian P et al. | Synthesis and studies of a trinuclear Mn(II) carboxylate complex. | 2004 | Dalton Trans | pmid:15303171 |
Rispoli V et al. | Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats. | 2004 | Pharmacol. Biochem. Behav. | pmid:15301920 |
Qian H et al. | Platinum-catalyzed intramolecular hydroalkoxylation of gamma- and delta-hydroxy olefins to form cyclic ethers. | 2004 | J. Am. Chem. Soc. | pmid:15291546 |
Christian P et al. | Structural, magnetic and DFT studies of a hydroxide-bridged [Cr8] wheel. | 2004 | Dalton Trans | pmid:15252595 |
Rispoli V et al. | Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert. | 2004 | Neurosci. Lett. | pmid:15036629 |
Goossen LJ and RodrÃguez N | A mild and efficient protocol for the conversion of carboxylic acids to olefins by a catalytic decarbonylative elimination reaction. | 2004 | Chem. Commun. (Camb.) | pmid:15010800 |
ZÃdek Z et al. | Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir. | 2005 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:16601779 |
Davis AT and Monroe TJ | Carnitine deficiency and supplementation do not affect the gene expression of carnitine biosynthetic enzymes in rats. | 2005 | J. Nutr. | pmid:15795431 |
Wu M et al. | Synthesis of 9-[1-(substituted)-3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents. | 2005 | Nucleosides Nucleotides Nucleic Acids | pmid:16438034 |
Zhou JH et al. | Syntheses, structures, and magnetic properties of unusual nonlinear polynuclear copper(II) complexes containing derivatives of 1,2,4-triazole and pivalate ligands. | 2005 | Inorg Chem | pmid:16241151 |
Kumar P et al. | [131I]Iodoazomycin arabinoside for low-dose-rate isotope radiotherapy: radiolabeling, stability, long-term whole-body clearance and radiation dosimetry estimates in mice. | 2005 | Nucl. Med. Biol. | pmid:16026712 |
Rajaraman G et al. | Theoretical studies on di- and tetra-nuclear Ni pivalate complexes. | 2005 | Chem. Commun. (Camb.) | pmid:15959582 |
Wang X et al. | Direct C-arylation of free (NH)-indoles and pyrroles catalyzed by Ar-Rh(III) complexes assembled in situ. | 2005 | J. Am. Chem. Soc. | pmid:15810815 |
Rodemann T et al. | Isoelectric buffers for capillary electrophoresis. 2. Bismorpholine derivative of a carboxylic acid as a low molecular weight isoelectric buffer. | 2005 | Anal. Chem. | pmid:15623286 |
Biswas P et al. | Synthesis, reactivities, and magnetostructural properties of FeIII, FeIII-O-FeIII, and ZnIIFeIII-O-FeIIIZnII complexes of a tetraiminodiphenolate macrocycle. | 2006 | Inorg Chem | pmid:16749848 |
Milios CJ et al. | 1,1,1-Tris(hydroxymethyl)propane in manganese carboxylate chemistry: synthesis, structure and magnetic properties of a mixed-valence [MnIII4MnII4] cluster featuring the novel [MnIII4MnII4(mu3-OR)6(mu2-OR)8]6+ core. | 2006 | Dalton Trans | pmid:16365649 |
Lee J et al. | 2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands. | 2006 | Bioorg. Med. Chem. | pmid:16297629 |
Chakraborti AK and Shivani S | Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst. | 2006 | J. Org. Chem. | pmid:16839166 |
Yamaguchi T et al. | Possible mechanism for species difference on the toxicity of pivalic acid between dogs and rats. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16430936 |
Sibi MP and Zimmerman J | Pyrones to pyrans: enantioselective radical additions to acyloxy pyrones. | 2006 | J. Am. Chem. Soc. | pmid:17031933 |
Suga K et al. | Photocatalytic oxygenation of pivalic acid with molecular oxygen via photoinduced electron transfer using 10-methylacridinium ions. | 2006 | J Phys Chem A | pmid:16539406 |
Broderick TL | Hypocarnitinaemia induced by sodium pivalate in the rat is associated with left ventricular dysfunction and impaired energy metabolism. | 2006 | Drugs R D | pmid:16752941 |
Okamura N et al. | Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid. | 2006 | Pharm. Res. | pmid:16826461 |
Lafrance M and Fagnou K | Palladium-catalyzed benzene arylation: incorporation of catalytic pivalic acid as a proton shuttle and a key element in catalyst design. | 2006 | J. Am. Chem. Soc. | pmid:17177387 |
Shanmugam M et al. | Studies of a molecular hourglass: synthesis and magnetic characterisation of a cyclic dodecanuclear {Cr10Cu2} complex. | 2006 | Chemistry | pmid:17009364 |
Sugiura T et al. | 1D helical polymeric chain with a pseudo-5(3) screw axis formed by cuprophilicity. synthesis and crystal structure of copper(I) pivalate. | 2006 | Inorg Chem | pmid:16961347 |
Mansell PD et al. | Induction of parturition in dairy cattle and its effects on health and subsequent lactation and reproductive performance. | 2006 | Aust. Vet. J. | pmid:16958626 |
Ovcharenko V et al. | Synthesis, structure, and magnetic properties of (6-9)-nuclear Ni(II) trimethylacetates and their heterospin complexes with nitroxides. | 2006 | Inorg Chem | pmid:16813397 |
Weis R et al. | Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols. | 2006 | Eur J Pharm Sci | pmid:16713699 |
Wittick LM et al. | New mixed-valence MnII2MnIII2 clusters exhibiting an unprecedented MnII/III oxidation state distribution in their magnetically coupled cores. | 2006 | Dalton Trans | pmid:16538272 |
Sasahara A et al. | STM observation of a ruthenium dye adsorbed on a TiO2(110) surface. | 2006 | J Phys Chem B | pmid:16526711 |
Kalavala M et al. | Tixocortol pivalate: what is the right concentration? | 2007 | Contact Derm. | pmid:17577357 |
Zizzo MG et al. | Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon. | 2007 | Br. J. Pharmacol. | pmid:17351663 |
Doberenz J et al. | Pivalate lowers litter sizes and weights in female rats independent of its effect on carnitine status. | 2007 | Reprod. Toxicol. | pmid:17482425 |
Makino Y et al. | Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid. | 2007 | Pediatrics | pmid:17724113 |
Zizzo MG et al. | Inhibitory purinergic transmission in mouse caecum: role for P2Y1 receptors as prejunctional modulators of ATP release. | 2007 | Neuroscience | pmid:17997228 |
Milios CJ et al. | Toward a magnetostructural correlation for a family of Mn6 SMMs. | 2007 | J. Am. Chem. Soc. | pmid:17887755 |
Cornwell PD and Ulrich RG | Investigating the mechanistic basis for hepatic toxicity induced by an experimental chemokine receptor 5 (CCR5) antagonist using a compendium of gene expression profiles. | 2007 | Toxicol Pathol | pmid:17654398 |
Kaitner B and Stilinović V | Conformational enantiomeric disorder in tripivaloylmethane. | 2007 | Acta Crystallogr C | pmid:17551202 |
Murakami K et al. | Chromium-catalyzed arylmagnesiation of alkynes. | 2007 | Org. Lett. | pmid:17352489 |
Kvach MV et al. | 5(6)-carboxyfluorescein revisited: new protecting group, separation of isomers, and their spectral properties on oligonucleotides. | 2007 Sep-Oct | Bioconjug. Chem. | pmid:17696491 |
Berkovitch G et al. | Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation. | 2008 | J. Med. Chem. | pmid:19007111 |
Gupta SK et al. | Recent advances in pharmacotherapy of glaucoma. | 2008 | Indian J Pharmacol | pmid:20040958 |
Leone G et al. | Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias. | 2008 | Curr. Med. Chem. | pmid:18537607 |
Dilks JR and Flaumenhaft R | Fluoxetine (Prozac) augments platelet activation mediated through protease-activated receptors. | 2008 | J. Thromb. Haemost. | pmid:18194419 |
Grillo MP and Hua F | Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes. | 2008 | Chem. Res. Toxicol. | pmid:18680316 |
Xu WJ et al. | N-{N-[N-(1,1-Dimethyl-ethoxy-carbon-yl)-l-leuc-yl]-N-methyl-l-leuc-yl}-N-methyl-l-leucine benzyl ester. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581037 |
Overgaard J et al. | Tetra-kis(μ-pivalato-κO:O')bis-[(2-methyl-pyridine-κN)iron(II)](Fe-Fe). | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21201879 |
Chisholm MH | Mixed valence complexes involving MM quadruple bonds (M=Mo or W). | 2008 | Philos Trans A Math Phys Eng Sci | pmid:17846014 |
Hong AW et al. | An expedient route to Montanine-type Amaryllidaceae alkaloids: total syntheses of (-)-brunsvigine and (-)-manthine. | 2008 | J. Org. Chem. | pmid:18781802 |
Li BJ et al. | Cross-coupling of aryl/alkenyl pivalates with organozinc reagents through nickel-catalyzed C-O bond activation under mild reaction conditions. | 2008 | Angew. Chem. Int. Ed. Engl. | pmid:19016280 |
Greaves TL et al. | Protic ionic liquids: physicochemical properties and behavior as amphiphile self-assembly solvents. | 2008 | J Phys Chem B | pmid:18166036 |
Li G et al. | Au-catalyzed synthesis of (1Z,3E)-2-pivaloxy-1,3-dienes from propargylic pivalates. | 2008 | J. Am. Chem. Soc. | pmid:18311985 |
Quasdorf KW et al. | Cross-coupling reactions of aryl pivalates with boronic acids. | 2008 | J. Am. Chem. Soc. | pmid:18839946 |
Ikeda M et al. | Scanning tunneling microscopy study of black dye and deoxycholic acid adsorbed on a rutile TiO2(110). | 2008 | Langmuir | pmid:18590297 |
Wiemer AJ et al. | Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. | 2008 | Bioorg. Med. Chem. | pmid:18308574 |
Ohnishi S et al. | Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment. | 2008 | Drug Metab. Pharmacokinet. | pmid:18762717 |
Berg ER et al. | Ion-pair interaction in pyridinium carboxylate solutions. | 2008 | J Phys Chem A | pmid:18189374 |
Mascolo G et al. | Effectiveness of UV-based advanced oxidation processes for the remediation of hydrocarbon pollution in the groundwater: a laboratory investigation. | 2008 | J. Hazard. Mater. | pmid:17890002 |
Liégault B et al. | Intramolecular Pd(II)-catalyzed oxidative biaryl synthesis under air: reaction development and scope. | 2008 | J. Org. Chem. | pmid:18543991 |
Goikhman R et al. | C-H bonds as ubiquitous functionality: a general approach to complex arylated pyrazoles via sequential regioselective C-arylation and N-alkylation enabled by SEM-group transposition. | 2009 | J. Am. Chem. Soc. | pmid:19206533 |
Chen XD et al. | Aqua-(1,10-phenanthroline-κN,N')bis-(trimethyl-acetato)-κO,O';κO-cobalt(II). | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21583436 |
Thoss M et al. | (R)-Di-tert-butyl 1,1'-binaphthyl-2,2'-dicarboxyl-ate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581860 |
Sun Y et al. | μ(3)-Oxido-hexa-μ(2)-pivalato-tris[(methanol-κO)cobalt(III)] chloride. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578144 |
Jacobson KA et al. | Development of selective agonists and antagonists of P2Y receptors. | 2009 | Purinergic Signal. | pmid:18600475 |
Shishilov ON et al. | Palladium(II) carboxylates and palladium(I) carbonyl carboxylate complexes as catalysts for olefin cyclopropanation with ethyl diazoacetate. | 2009 | Dalton Trans | pmid:19672507 |
Huang JK et al. | Effect of MK-886 on Ca2+ level and viability in PC3 human prostate cancer cells. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19371256 |
Goossen LJ et al. | C(aryl)-O activation of aryl carboxylates in nickel-catalyzed biaryl syntheses. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19280618 |
Zhao D et al. | Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst. | 2009 | Chemistry | pmid:19115287 |
Ito T | Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism. | 2009 | J Toxicol Sci | pmid:19571472 |
Todesco L et al. | Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2. | 2009 | Chem. Biol. Interact. | pmid:19539806 |
Rao ChB et al. | An efficient protocol for alcohol protection under solvent- and catalyst-free conditions. | 2009 | J. Org. Chem. | pmid:19839567 |
Alborés P and Rentschler E | A Co36 cluster assembled from the reaction of cobalt pivalate with 2,3-dicarboxypyrazine. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19890926 |
Boeer AB et al. | Linkage isomerism and spin frustration in heterometallic rings: synthesis, structural characterization, and magnetic and EPR spectroscopic studies of Cr(7)Ni, Cr(6)Ni(2), and Cr(7)Ni(2) rings templated about imidazolium cations. | 2009 | Chemistry | pmid:19859922 |
Goswami S et al. | Recognition of carboxylate anions and carboxylic acids by selenium-based new chromogenic fluorescent sensor: a remarkable fluorescence enhancement of hindered carboxylates. | 2009 | Org. Lett. | pmid:19728733 |
Ako AM et al. | Tridecanuclear [Mn(III)5Ln(III)8] complexes derived from N-(t)butyl-diethanolamine: synthesis, structures, and magnetic properties. | 2009 | Inorg Chem | pmid:19530694 |
Quintas C et al. | The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. | 2009 | Neurochem. Int. | pmid:19447154 |
Akhtar MN et al. | Family of heterometallic semicircular Mn(III)2Ln(III)3 strands. | 2009 | Inorg Chem | pmid:19317423 |
Liégault B et al. | Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds. | 2009 | J. Org. Chem. | pmid:19206211 |
Mandal D et al. | Tetra-, tri-, and mononuclear manganese(II/III) complexes of a phenol-based N2O2 capping ligand: use of carboxylates as ancillary ligands in tuning the nuclearity of the complexes. | 2009 | Inorg Chem | pmid:19235946 |
Villa G et al. | Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus. | 2010 | Mol Pain | pmid:21143950 |
Kotal A et al. | Ultrasound-induced in situ formation of coordination organogels from isobutyric acids and zinc oxide nanoparticles. | 2010 | Langmuir | pmid:20020763 |
Zhao XQ et al. | Synthesis, structures and magnetic properties of a series of 3d-4f tetranuclear Co(II)â‚‚Ln(III)â‚‚ cubanes. | 2010 | Dalton Trans | pmid:20401413 |
Liu TF et al. | An alcoholysis route to a Cu16 cluster, and the influence of the alcohol. | 2010 | Dalton Trans | pmid:20354607 |
Cox AD et al. | Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: chemical strategies to prepare glycoconjugates with good carbohydrate loading. | 2010 | Glycoconj. J. | pmid:20340043 |