MeSH term | MeSH ID | Detail |
---|---|---|
Psoriasis | D011565 | 47 associated lipids |
Seizures | D012640 | 87 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Pivalic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Psoriasis | D011565 | 47 associated lipids |
Seizures | D012640 | 87 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Schmidt J et al. | Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. | 2011 | J. Biol. Chem. | pmid:21220428 |
Rohwerder T and Müller RH | Biosynthesis of 2-hydroxyisobutyric acid (2-HIBA) from renewable carbon. | 2010 | Microb. Cell Fact. | pmid:20184738 |
Villa G et al. | Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus. | 2010 | Mol Pain | pmid:21143950 |
Xu S et al. | Transport of L-carnitine in human corneal and conjunctival epithelial cells. | 2010 | Mol. Vis. | pmid:21045919 |
Nakajima Y et al. | Detection of pivaloylcarnitine in pediatric patients with hypocarnitinemia after long-term administration of pivalate-containing antibiotics. | 2010 | Tohoku J. Exp. Med. | pmid:20651467 |
Govindan S et al. | Ca(2+) signalling by P2Y receptors in cultured rat aortic smooth muscle cells. | 2010 | Br. J. Pharmacol. | pmid:20649593 |
Will KW et al. | Quantification and evidence for mechanically metered release of pygidial secretions in formic acid-producing carabid beetles. | 2010 | J. Insect Sci. | pmid:20575743 |
Rumschinski P et al. | Set-base dynamical parameter estimation and model invalidation for biochemical reaction networks. | 2010 | BMC Syst Biol | pmid:20500862 |
Fagerholm AE et al. | Calyculins and related marine natural products as serine-threonine protein phosphatase PP1 and PP2A inhibitors and total syntheses of calyculin A, B, and C. | 2010 | Mar Drugs | pmid:20161975 |
Andó RD et al. | A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain. | 2010 | Br. J. Pharmacol. | pmid:20136836 |
Xu M et al. | (E)-2-(4-tert-Butyl-phen-yl)-1-(4-chloro-1-ethyl-3-methyl-1H-pyrazol-5-yl)-2-cyano-ethenyl 2,2-dimethyl-propano-ate. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21589554 |
Gu XB et al. | tert-Butyl 6-amino-3,4-dihydro-2H-1,4-benzoxazine-4-carboxyl-ate. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21589552 |
Lohier JF et al. | tert-Butyl 6-bromo-1,4-dimethyl-9H-carbazole-9-carboxyl-ate. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21588291 |
Gu XB | tert-Butyl 6-acetamido-3,4-dihydro-2H-1,4-benzoxazine-4-carboxyl-ate. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21587577 |
Ozair LN et al. | Tetra-kis(μ(2)-2,2-dimethyl-propanoato-κO,O')bis-[(pyridine-κN)copper(II)]: a monoclinic polymorph. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21579064 |
Walling HW and Swick BL | Update on the management of chronic eczema: new approaches and emerging treatment options. | 2010 | Clin Cosmet Investig Dermatol | pmid:21437065 |
Wurm A et al. | Endogenous purinergic signaling is required for osmotic volume regulation of retinal glial cells. | 2010 | J. Neurochem. | pmid:20002522 |
Kotal A et al. | Ultrasound-induced in situ formation of coordination organogels from isobutyric acids and zinc oxide nanoparticles. | 2010 | Langmuir | pmid:20020763 |
Shimasaki T et al. | Nickel-catalyzed amination of aryl pivalates by the cleavage of aryl C-O bonds. | 2010 | Angew. Chem. Int. Ed. Engl. | pmid:20229558 |
Abbas G et al. | Series of isostructural planar lanthanide complexes [Ln(III)4(mu3-OH)2(mdeaH)2(piv)8] with single molecule magnet behavior for the Dy4 analogue. | 2010 | Inorg Chem | pmid:20704320 |
Rousseaux S et al. | Investigation of the mechanism of C(sp3)-H bond cleavage in Pd(0)-catalyzed intramolecular alkane arylation adjacent to amides and sulfonamides. | 2010 | J. Am. Chem. Soc. | pmid:20681702 |
Sobkowski M et al. | Stereochemistry of internucleotide bond formation by the H-phosphonate method. 5. The role of Brønsted and H-bonding base catalysis in ribonucleoside H-phosphonate condensation-chemical and stereochemical consequences. | 2010 | Nucleosides Nucleotides Nucleic Acids | pmid:20661816 |
Lyubinetsky I et al. | Adsorption states and mobility of trimethylacetic acid molecules on reduced TiO(2)(110) surface. | 2010 | Phys Chem Chem Phys | pmid:20490397 |
Zhao XQ et al. | Synthesis, structures and magnetic properties of a series of 3d-4f tetranuclear Co(II)â‚‚Ln(III)â‚‚ cubanes. | 2010 | Dalton Trans | pmid:20401413 |
Liu TF et al. | An alcoholysis route to a Cu16 cluster, and the influence of the alcohol. | 2010 | Dalton Trans | pmid:20354607 |
Cox AD et al. | Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: chemical strategies to prepare glycoconjugates with good carbohydrate loading. | 2010 | Glycoconj. J. | pmid:20340043 |
Jarenmark M et al. | Unsymmetrical dizinc complexes as models for the active sites of phosphohydrolases. | 2010 | Dalton Trans | pmid:20683537 |
Goikhman R et al. | C-H bonds as ubiquitous functionality: a general approach to complex arylated pyrazoles via sequential regioselective C-arylation and N-alkylation enabled by SEM-group transposition. | 2009 | J. Am. Chem. Soc. | pmid:19206533 |
Chen XD et al. | Aqua-(1,10-phenanthroline-κN,N')bis-(trimethyl-acetato)-κO,O';κO-cobalt(II). | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21583436 |
Thoss M et al. | (R)-Di-tert-butyl 1,1'-binaphthyl-2,2'-dicarboxyl-ate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581860 |
Sun Y et al. | μ(3)-Oxido-hexa-μ(2)-pivalato-tris[(methanol-κO)cobalt(III)] chloride. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578144 |
Jacobson KA et al. | Development of selective agonists and antagonists of P2Y receptors. | 2009 | Purinergic Signal. | pmid:18600475 |
Shishilov ON et al. | Palladium(II) carboxylates and palladium(I) carbonyl carboxylate complexes as catalysts for olefin cyclopropanation with ethyl diazoacetate. | 2009 | Dalton Trans | pmid:19672507 |
Huang JK et al. | Effect of MK-886 on Ca2+ level and viability in PC3 human prostate cancer cells. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19371256 |
Goossen LJ et al. | C(aryl)-O activation of aryl carboxylates in nickel-catalyzed biaryl syntheses. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19280618 |
Zhao D et al. | Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst. | 2009 | Chemistry | pmid:19115287 |
Ito T | Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism. | 2009 | J Toxicol Sci | pmid:19571472 |
Todesco L et al. | Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2. | 2009 | Chem. Biol. Interact. | pmid:19539806 |
Rao ChB et al. | An efficient protocol for alcohol protection under solvent- and catalyst-free conditions. | 2009 | J. Org. Chem. | pmid:19839567 |
Alborés P and Rentschler E | A Co36 cluster assembled from the reaction of cobalt pivalate with 2,3-dicarboxypyrazine. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19890926 |
Boeer AB et al. | Linkage isomerism and spin frustration in heterometallic rings: synthesis, structural characterization, and magnetic and EPR spectroscopic studies of Cr(7)Ni, Cr(6)Ni(2), and Cr(7)Ni(2) rings templated about imidazolium cations. | 2009 | Chemistry | pmid:19859922 |
Goswami S et al. | Recognition of carboxylate anions and carboxylic acids by selenium-based new chromogenic fluorescent sensor: a remarkable fluorescence enhancement of hindered carboxylates. | 2009 | Org. Lett. | pmid:19728733 |
Ako AM et al. | Tridecanuclear [Mn(III)5Ln(III)8] complexes derived from N-(t)butyl-diethanolamine: synthesis, structures, and magnetic properties. | 2009 | Inorg Chem | pmid:19530694 |
Quintas C et al. | The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. | 2009 | Neurochem. Int. | pmid:19447154 |
Akhtar MN et al. | Family of heterometallic semicircular Mn(III)2Ln(III)3 strands. | 2009 | Inorg Chem | pmid:19317423 |
Liégault B et al. | Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds. | 2009 | J. Org. Chem. | pmid:19206211 |
Mandal D et al. | Tetra-, tri-, and mononuclear manganese(II/III) complexes of a phenol-based N2O2 capping ligand: use of carboxylates as ancillary ligands in tuning the nuclearity of the complexes. | 2009 | Inorg Chem | pmid:19235946 |
Berkovitch G et al. | Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation. | 2008 | J. Med. Chem. | pmid:19007111 |
Quasdorf KW et al. | Cross-coupling reactions of aryl pivalates with boronic acids. | 2008 | J. Am. Chem. Soc. | pmid:18839946 |
Ohnishi S et al. | Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment. | 2008 | Drug Metab. Pharmacokinet. | pmid:18762717 |