MeSH term | MeSH ID | Detail |
---|---|---|
Psoriasis | D011565 | 47 associated lipids |
Seizures | D012640 | 87 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Pivalic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Psoriasis | D011565 | 47 associated lipids |
Seizures | D012640 | 87 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Douglas KT et al. | Mechanistic studies of carboxypeptidase Y. Kinetic detection of an acyl-enzyme intermediate in trimethylacetate esterase action. | 1976 | J. Am. Chem. Soc. | pmid:993522 |
Czerkawski JW | The use of pivalic acid as a reference substance in measurements of production of volatile fatty acids by rumen micro-organisms in vitro. | 1976 | Br. J. Nutr. | pmid:952843 |
Giordano F et al. | Crystal forms of piroxicam pivalate: preparation and characterization of two polymorphs. | 1998 | J Pharm Sci | pmid:9523987 |
Lewin LM et al. | Effects of pivalic acid and sodium pivalate on L-carnitine concentrations in the cauda epididymidis and on male fertility in the hamster. | 1997 | Reprod. Fertil. Dev. | pmid:9402252 |
Cooper TG et al. | Successful lowering of epididymal carnitine by administration of pivalate to rats. | 1997 | Int. J. Androl. | pmid:9354188 |
Abrahamsson K et al. | Pivalic acid-induced carnitine deficiency and physical exercise in humans. | 1996 | Metab. Clin. Exp. | pmid:8969283 |
Bianchi PB et al. | Carnitine supplementation ameliorates the steatosis and ketosis induced by pivalate in rats. | 1996 | J. Nutr. | pmid:8914960 |
Bianchi PB and Davis AT | beta-Hydroxybutyrate oxidation is reduced and hepatic balance of ketone bodies and free fatty acids is unaltered in carnitine-depleted, pivalate-treated rats. | 1996 | J. Nutr. | pmid:8914959 |
Zanelli U et al. | Induction of peroxisomal beta-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney. | 1996 | Arch. Toxicol. | pmid:8825670 |
Metges CC et al. | Gas chromatography/combustion/isotope ratio mass spectrometric comparison of N-acetyl- and N-pivaloyl amino acid esters to measure 15N isotopic abundances in physiological samples: a pilot study on amino acid synthesis in the upper gastro-intestinal tract of minipigs. | 1996 | J Mass Spectrom | pmid:8799283 |
Zanelli U et al. | Selective depletion of mitochondrial glutathione content by pivalic acid and valproic acid in rat liver: possibility of a common mechanism. | 1996 | Adv. Exp. Med. Biol. | pmid:8794200 |
Sauber K et al. | A new esterase for the cleavage of pivalic acid-containing prodrug esters of cephalosporins. | 1996 | Enzyme Microb. Technol. | pmid:8672280 |
Nakajima H et al. | Pivalate affects carnitine status but causes no severe metabolic changes in rat liver. | 1996 | J. Nutr. | pmid:8648443 |
Broderick TL et al. | L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts. | 1995 | Cardiovasc. Res. | pmid:8595631 |
Abrahamsson K et al. | Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid. | 1995 | Br Heart J | pmid:8541173 |
Davis AT | Carnitine depletion in rat pups of lactating mothers given sodium pivalate. | 1995 | Biol. Neonate | pmid:8534786 |
Shimizu K et al. | Carnitine status and safety after administration of S-1108, a new oral cephem, to patients. | 1993 | Antimicrob. Agents Chemother. | pmid:8517691 |
Melegh B et al. | Preferential elimination of pivalate with supplemental carnitine via formation of pivaloylcarnitine in man. | 1993 | Xenobiotica | pmid:8310709 |
Fujii R et al. | [Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients]. | 1993 | Jpn J Antibiot | pmid:8254895 |
Reckers VR and Wendt H | [Multicentre-clinical trial of the novel corticosteroid diflucortolone valerate in the forms of cream, ointment and fatty ointment. Part I: Comparative study of diflucortolone valerate with fluocortolone, -capronate, -pivalate in a double-blind contralateral design with topical application (author's transl)]. | 1976 | Arzneimittelforschung | pmid:795433 |