MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Dermatitis | D003872 | 30 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Arrhythmias, Cardiac | D001145 | 42 associated lipids |
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Pivalic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Dermatitis | D003872 | 30 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Arrhythmias, Cardiac | D001145 | 42 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Abrahamsson K et al. | Impaired ketogenesis in carnitine depletion caused by short-term administration of pivalic acid prodrug. | 1994 | Biochem. Med. Metab. Biol. | pmid:7917463 |
Huang JK et al. | Effect of MK-886 on Ca2+ level and viability in PC3 human prostate cancer cells. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19371256 |
Johnston NE and Stewart JA | The effect of glucocorticoids and prematurity on absorption of colostral immunoglobulin in the calf. | 1986 | Aust. Vet. J. | pmid:3767799 |
Bailey LF et al. | The use of dexamethasone trimethylacetate to advance parturition in dairy cows. | 1973 | Aust. Vet. J. | pmid:4777214 |
Mansell PD et al. | Induction of parturition in dairy cattle and its effects on health and subsequent lactation and reproductive performance. | 2006 | Aust. Vet. J. | pmid:16958626 |
Peel CJ et al. | The importance of prolactin and the milking stimulus in the artificial induction of lactation in cows. | 1978 | Aust. J. Biol. Sci. | pmid:678223 |
Fulkerson WJ and McDowell GH | Artificial induction of lactation in cattle by use of dexamethasone trimethylacetate. | 1975 | Aust. J. Biol. Sci. | pmid:1167131 |
Fulkerson WJ et al. | Artificial induction of lactation in ewes: the role of prolactin. | 1975 | Aust. J. Biol. Sci. | pmid:1243818 |
Fairclough RJ et al. | Dexamethasone concentrations in plasma and milk of cows following the injection of long- and short-acting dexamethasone esters. | 1981 | Aust. J. Biol. Sci. | pmid:7295211 |
Goldberg I et al. | Dipivefrin: current concepts. | 1980 | Aust J Ophthalmol | pmid:7004425 |
Reckers VR and Wendt H | [Multicentre-clinical trial of the novel corticosteroid diflucortolone valerate in the forms of cream, ointment and fatty ointment. Part I: Comparative study of diflucortolone valerate with fluocortolone, -capronate, -pivalate in a double-blind contralateral design with topical application (author's transl)]. | 1976 | Arzneimittelforschung | pmid:795433 |
Maurer H and Kessler C | Identification and quantification of ethylene glycol and diethylene glycol in plasma using gas chromatography-mass spectrometry. | 1988 | Arch. Toxicol. | pmid:3190459 |
Zanelli U et al. | Induction of peroxisomal beta-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney. | 1996 | Arch. Toxicol. | pmid:8825670 |
Wexler BC | Corticotropin stimulation of hypertensive rats with and without arteriosclerosis. | 1978 | Arch. Pathol. Lab. Med. | pmid:214053 |
Tamaru RD et al. | Comparison of ocular disposition of free pivalic acid and pivalic acid esterified in dipivefrin. | 1983 | Arch. Ophthalmol. | pmid:6347153 |
Staatz WD et al. | Cytotoxicity of pivalylphenylephrine and pivalic acid to corneal endothelium. | 1980 | Arch. Ophthalmol. | pmid:7396784 |
Rezanka T et al. | Biosynthesis and metabolic pathways of pivalic acid. | 2012 | Appl. Microbiol. Biotechnol. | pmid:22790609 |
Probian C et al. | Anaerobic mineralization of quaternary carbon atoms: isolation of denitrifying bacteria on pivalic acid (2,2-dimethylpropionic acid). | 2003 | Appl. Environ. Microbiol. | pmid:12620885 |
Totsuka K et al. | Metabolism of S-1108, a new oral cephem antibiotic, and metabolic profiles of its metabolites in humans. | 1992 | Antimicrob. Agents Chemother. | pmid:1503437 |
Shimizu K et al. | Carnitine status and safety after administration of S-1108, a new oral cephem, to patients. | 1993 | Antimicrob. Agents Chemother. | pmid:8517691 |