MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Dermatitis | D003872 | 30 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Arrhythmias, Cardiac | D001145 | 42 associated lipids |
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Pivalic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Dermatitis | D003872 | 30 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Arrhythmias, Cardiac | D001145 | 42 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Stanton BA | Characterization of apical and basolateral membrane conductances of rat inner medullary collecting duct. | 1989 | Am. J. Physiol. | pmid:2719119 |
Wagner CA et al. | Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2. | 2000 | Am. J. Physiol. Renal Physiol. | pmid:10966938 |
Nishimura S et al. | Application of a surface plasmon resonance sensor to analyses of amine compounds with the use of a polymer film and an acid-base reaction. | 2002 | Anal Sci | pmid:11918182 |
Rodemann T et al. | Isoelectric buffers for capillary electrophoresis. 2. Bismorpholine derivative of a carboxylic acid as a low molecular weight isoelectric buffer. | 2005 | Anal. Chem. | pmid:15623286 |
Goossen LJ et al. | C(aryl)-O activation of aryl carboxylates in nickel-catalyzed biaryl syntheses. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19280618 |
Li BJ et al. | Cross-coupling of aryl/alkenyl pivalates with organozinc reagents through nickel-catalyzed C-O bond activation under mild reaction conditions. | 2008 | Angew. Chem. Int. Ed. Engl. | pmid:19016280 |
Shimasaki T et al. | Nickel-catalyzed amination of aryl pivalates by the cleavage of aryl C-O bonds. | 2010 | Angew. Chem. Int. Ed. Engl. | pmid:20229558 |
Alborés P and Rentschler E | A Co36 cluster assembled from the reaction of cobalt pivalate with 2,3-dicarboxypyrazine. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19890926 |
Trost BM et al. | Palladium-catalyzed asymmetric allylic alkylation of 3-aryloxindoles with allylidene dipivalate: a useful enol pivalate product. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23335176 |
Stanley CA | Carnitine deficiency disorders in children. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15591002 |
Totsuka K et al. | Metabolism of S-1108, a new oral cephem antibiotic, and metabolic profiles of its metabolites in humans. | 1992 | Antimicrob. Agents Chemother. | pmid:1503437 |
Nakashima M et al. | Phase I clinical studies of S-1108: safety and pharmacokinetics in a multiple-administration study with special emphasis on the influence on carnitine body stores. | 1992 | Antimicrob. Agents Chemother. | pmid:1503438 |
Shimizu K et al. | Carnitine status and safety after administration of S-1108, a new oral cephem, to patients. | 1993 | Antimicrob. Agents Chemother. | pmid:8517691 |
Mizojiri K et al. | Disposition of S-1108, a new oral cephem antibiotic, and metabolic fate of pivalic acid liberated from [pivaloyl-14C]S-1108 in rats and dogs. | 1995 | Antimicrob. Agents Chemother. | pmid:7492083 |
Probian C et al. | Anaerobic mineralization of quaternary carbon atoms: isolation of denitrifying bacteria on pivalic acid (2,2-dimethylpropionic acid). | 2003 | Appl. Environ. Microbiol. | pmid:12620885 |
Rezanka T et al. | Biosynthesis and metabolic pathways of pivalic acid. | 2012 | Appl. Microbiol. Biotechnol. | pmid:22790609 |
Tamaru RD et al. | Comparison of ocular disposition of free pivalic acid and pivalic acid esterified in dipivefrin. | 1983 | Arch. Ophthalmol. | pmid:6347153 |
Staatz WD et al. | Cytotoxicity of pivalylphenylephrine and pivalic acid to corneal endothelium. | 1980 | Arch. Ophthalmol. | pmid:7396784 |
Wexler BC | Corticotropin stimulation of hypertensive rats with and without arteriosclerosis. | 1978 | Arch. Pathol. Lab. Med. | pmid:214053 |
Maurer H and Kessler C | Identification and quantification of ethylene glycol and diethylene glycol in plasma using gas chromatography-mass spectrometry. | 1988 | Arch. Toxicol. | pmid:3190459 |