MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Dermatitis | D003872 | 30 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Arrhythmias, Cardiac | D001145 | 42 associated lipids |
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Pivalic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Dermatitis | D003872 | 30 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Arrhythmias, Cardiac | D001145 | 42 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Färber K et al. | Selective desensitization of jasmonate- and pH-dependent signaling in the induction of benzophenanthridine biosynthesis in cells of Eschscholzia californica. | 2003 | Phytochemistry | pmid:12620362 |
Romani G et al. | H extrusion and potassium uptake associated with potential hyperpolarization in maize and wheat root segments treated with permeant weak acids. | 1985 | Plant Physiol. | pmid:16664483 |
Basso B and Ullrich-Eberius CI | Membrane Potential and Proton Cotransport of Alanine and Phosphate as Affected by Permeant Weak Acids in Lemna gibba. | 1987 | Plant Physiol. | pmid:16665758 |
Lam KK et al. | Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis. | 2012 | PLoS Pathog. | pmid:22589723 |
Foussereau J and Jelen G | [An unrecognized cause of allergic eczema of the face: a corticoid, tixocortol pivalate]. | 1987 | Presse Med | pmid:2954110 |
Ebbing MH et al. | Resorcinarenes with 2-benzimidazolone bridges: self-aggregation, self-assembled dimeric capsules, and guest encapsulation. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11959947 |
Jacobson KA et al. | Development of selective agonists and antagonists of P2Y receptors. | 2009 | Purinergic Signal. | pmid:18600475 |
Lewin LM et al. | Effects of pivalic acid and sodium pivalate on L-carnitine concentrations in the cauda epididymidis and on male fertility in the hamster. | 1997 | Reprod. Fertil. Dev. | pmid:9402252 |
Doberenz J et al. | Pivalate lowers litter sizes and weights in female rats independent of its effect on carnitine status. | 2007 | Reprod. Toxicol. | pmid:17482425 |
Hughes CS et al. | Effects of certain stress factors on the re-excretion of infectious laryngotracheitis virus from latently infected carrier birds. | 1989 | Res. Vet. Sci. | pmid:2539638 |
Holme E et al. | Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children. | 1992 | Scand. J. Clin. Lab. Invest. | pmid:1514015 |
Van Dort M et al. | Potential tumor or organ-imaging agents, 24. Radioiodinated pregnenolone esters. | 1984 | Steroids | pmid:6537047 |
Nakajima Y et al. | Detection of pivaloylcarnitine in pediatric patients with hypocarnitinemia after long-term administration of pivalate-containing antibiotics. | 2010 | Tohoku J. Exp. Med. | pmid:20651467 |
Cornwell PD and Ulrich RG | Investigating the mechanistic basis for hepatic toxicity induced by an experimental chemokine receptor 5 (CCR5) antagonist using a compendium of gene expression profiles. | 2007 | Toxicol Pathol | pmid:17654398 |
Ruff LJ and Brass EP | Metabolic effects of pivalate in isolated rat hepatocytes. | 1991 | Toxicol. Appl. Pharmacol. | pmid:1891775 |
Yamaguchi T et al. | Possible mechanism for species difference on the toxicity of pivalic acid between dogs and rats. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16430936 |
Li C et al. | In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12649042 |
Niezen JH et al. | The effect of feeding sulla (Hedysarum coronarium) or lucerne (Medicago sativa) on lamb parasite burdens and development of immunity to gastrointestinal nematodes. | 2002 | Vet. Parasitol. | pmid:11934463 |
Gaskell RM and Povey RC | Experimental induction of feline viral rhinotracheitis virus re-excretion in FVR-recovered cats. | 1977 | Vet. Rec. | pmid:191978 |
Vickers S et al. | Carnitine and glucuronic acid conjugates of pivalic acid. | 1985 | Xenobiotica | pmid:4036169 |
Melegh B et al. | Preferential elimination of pivalate with supplemental carnitine via formation of pivaloylcarnitine in man. | 1993 | Xenobiotica | pmid:8310709 |
Lloyd S et al. | The effect of corticosteroid therapy on infection with Toxocara canis in dogs. | 1981 | Z Parasitenkd | pmid:7324542 |