Pivalic acid

Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pivalic acid?

Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pivalic acid

MeSH term MeSH ID Detail
Dihydropyrimidine Dehydrogenase Deficiency D054067 1 associated lipids
Toxocariasis D014120 3 associated lipids
Vitamin B Deficiency D014804 4 associated lipids
Purine-Pyrimidine Metabolism, Inborn Errors D011686 5 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Otitis Media D010033 12 associated lipids
Hyperinsulinism D006946 27 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Dermatitis D003872 30 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Pivalic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pivalic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pivalic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pivalic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pivalic acid

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Authors Title Published Journal PubMed Link
Berkovitch G et al. Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation. 2008 J. Med. Chem. pmid:19007111
Gupta SK et al. Recent advances in pharmacotherapy of glaucoma. 2008 Indian J Pharmacol pmid:20040958
Leone G et al. Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias. 2008 Curr. Med. Chem. pmid:18537607
Grillo MP and Hua F Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes. 2008 Chem. Res. Toxicol. pmid:18680316
Hong AW et al. An expedient route to Montanine-type Amaryllidaceae alkaloids: total syntheses of (-)-brunsvigine and (-)-manthine. 2008 J. Org. Chem. pmid:18781802
Li BJ et al. Cross-coupling of aryl/alkenyl pivalates with organozinc reagents through nickel-catalyzed C-O bond activation under mild reaction conditions. 2008 Angew. Chem. Int. Ed. Engl. pmid:19016280
Greaves TL et al. Protic ionic liquids: physicochemical properties and behavior as amphiphile self-assembly solvents. 2008 J Phys Chem B pmid:18166036
Li G et al. Au-catalyzed synthesis of (1Z,3E)-2-pivaloxy-1,3-dienes from propargylic pivalates. 2008 J. Am. Chem. Soc. pmid:18311985
Quasdorf KW et al. Cross-coupling reactions of aryl pivalates with boronic acids. 2008 J. Am. Chem. Soc. pmid:18839946
Ikeda M et al. Scanning tunneling microscopy study of black dye and deoxycholic acid adsorbed on a rutile TiO2(110). 2008 Langmuir pmid:18590297
Wiemer AJ et al. Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. 2008 Bioorg. Med. Chem. pmid:18308574
Ohnishi S et al. Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment. 2008 Drug Metab. Pharmacokinet. pmid:18762717
Berg ER et al. Ion-pair interaction in pyridinium carboxylate solutions. 2008 J Phys Chem A pmid:18189374
Mascolo G et al. Effectiveness of UV-based advanced oxidation processes for the remediation of hydrocarbon pollution in the groundwater: a laboratory investigation. 2008 J. Hazard. Mater. pmid:17890002
Liégault B et al. Intramolecular Pd(II)-catalyzed oxidative biaryl synthesis under air: reaction development and scope. 2008 J. Org. Chem. pmid:18543991
Shishilov ON et al. Palladium(II) carboxylates and palladium(I) carbonyl carboxylate complexes as catalysts for olefin cyclopropanation with ethyl diazoacetate. 2009 Dalton Trans pmid:19672507
Alborés P and Rentschler E A Co36 cluster assembled from the reaction of cobalt pivalate with 2,3-dicarboxypyrazine. 2009 Angew. Chem. Int. Ed. Engl. pmid:19890926
Boeer AB et al. Linkage isomerism and spin frustration in heterometallic rings: synthesis, structural characterization, and magnetic and EPR spectroscopic studies of Cr(7)Ni, Cr(6)Ni(2), and Cr(7)Ni(2) rings templated about imidazolium cations. 2009 Chemistry pmid:19859922
Goswami S et al. Recognition of carboxylate anions and carboxylic acids by selenium-based new chromogenic fluorescent sensor: a remarkable fluorescence enhancement of hindered carboxylates. 2009 Org. Lett. pmid:19728733
Ako AM et al. Tridecanuclear [Mn(III)5Ln(III)8] complexes derived from N-(t)butyl-diethanolamine: synthesis, structures, and magnetic properties. 2009 Inorg Chem pmid:19530694