Pivalic acid

Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pivalic acid?

Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pivalic acid

MeSH term MeSH ID Detail
Arrhythmias, Cardiac D001145 42 associated lipids
Body Weight D001835 333 associated lipids
Dermatitis D003872 30 associated lipids
Hemolysis D006461 131 associated lipids
Hyperinsulinism D006946 27 associated lipids
Otitis Media D010033 12 associated lipids
Psoriasis D011565 47 associated lipids
Purine-Pyrimidine Metabolism, Inborn Errors D011686 5 associated lipids
Seizures D012640 87 associated lipids
Toxocariasis D014120 3 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Pivalic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pivalic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Pivalic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pivalic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pivalic acid

Download all related citations
Per page 10 20 50 100 | Total 272
Authors Title Published Journal PubMed Link
Goswami S et al. Recognition of carboxylate anions and carboxylic acids by selenium-based new chromogenic fluorescent sensor: a remarkable fluorescence enhancement of hindered carboxylates. 2009 Org. Lett. pmid:19728733
Shishilov ON et al. Palladium(II) carboxylates and palladium(I) carbonyl carboxylate complexes as catalysts for olefin cyclopropanation with ethyl diazoacetate. 2009 Dalton Trans pmid:19672507
Ito T Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism. 2009 J Toxicol Sci pmid:19571472
Todesco L et al. Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2. 2009 Chem. Biol. Interact. pmid:19539806
Ako AM et al. Tridecanuclear [Mn(III)5Ln(III)8] complexes derived from N-(t)butyl-diethanolamine: synthesis, structures, and magnetic properties. 2009 Inorg Chem pmid:19530694
Quintas C et al. The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. 2009 Neurochem. Int. pmid:19447154
Bianchi PB and Davis AT Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats. 1991 J. Nutr. pmid:1941267
Huang JK et al. Effect of MK-886 on Ca2+ level and viability in PC3 human prostate cancer cells. 2009 Basic Clin. Pharmacol. Toxicol. pmid:19371256
Akhtar MN et al. Family of heterometallic semicircular Mn(III)2Ln(III)3 strands. 2009 Inorg Chem pmid:19317423
Goossen LJ et al. C(aryl)-O activation of aryl carboxylates in nickel-catalyzed biaryl syntheses. 2009 Angew. Chem. Int. Ed. Engl. pmid:19280618
Mandal D et al. Tetra-, tri-, and mononuclear manganese(II/III) complexes of a phenol-based N2O2 capping ligand: use of carboxylates as ancillary ligands in tuning the nuclearity of the complexes. 2009 Inorg Chem pmid:19235946
Goikhman R et al. C-H bonds as ubiquitous functionality: a general approach to complex arylated pyrazoles via sequential regioselective C-arylation and N-alkylation enabled by SEM-group transposition. 2009 J. Am. Chem. Soc. pmid:19206533
Liégault B et al. Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds. 2009 J. Org. Chem. pmid:19206211
Gaskell RM and Povey RC Experimental induction of feline viral rhinotracheitis virus re-excretion in FVR-recovered cats. 1977 Vet. Rec. pmid:191978
Zhao D et al. Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst. 2009 Chemistry pmid:19115287
Li BJ et al. Cross-coupling of aryl/alkenyl pivalates with organozinc reagents through nickel-catalyzed C-O bond activation under mild reaction conditions. 2008 Angew. Chem. Int. Ed. Engl. pmid:19016280
Berkovitch G et al. Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation. 2008 J. Med. Chem. pmid:19007111
Ruff LJ and Brass EP Metabolic effects of pivalate in isolated rat hepatocytes. 1991 Toxicol. Appl. Pharmacol. pmid:1891775
Quasdorf KW et al. Cross-coupling reactions of aryl pivalates with boronic acids. 2008 J. Am. Chem. Soc. pmid:18839946
Tomić S et al. Partial purification of esterases from rabbit serum and their use in regioselective deacylations of sugars. 1991 Carbohydr. Res. pmid:1878876
Hong AW et al. An expedient route to Montanine-type Amaryllidaceae alkaloids: total syntheses of (-)-brunsvigine and (-)-manthine. 2008 J. Org. Chem. pmid:18781802
Ohnishi S et al. Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment. 2008 Drug Metab. Pharmacokinet. pmid:18762717
Grillo MP and Hua F Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes. 2008 Chem. Res. Toxicol. pmid:18680316
Jacobson KA et al. Development of selective agonists and antagonists of P2Y receptors. 2009 Purinergic Signal. pmid:18600475
Ikeda M et al. Scanning tunneling microscopy study of black dye and deoxycholic acid adsorbed on a rutile TiO2(110). 2008 Langmuir pmid:18590297
Liégault B et al. Intramolecular Pd(II)-catalyzed oxidative biaryl synthesis under air: reaction development and scope. 2008 J. Org. Chem. pmid:18543991
Leone G et al. Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias. 2008 Curr. Med. Chem. pmid:18537607
Li G et al. Au-catalyzed synthesis of (1Z,3E)-2-pivaloxy-1,3-dienes from propargylic pivalates. 2008 J. Am. Chem. Soc. pmid:18311985
Wiemer AJ et al. Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. 2008 Bioorg. Med. Chem. pmid:18308574
Dilks JR and Flaumenhaft R Fluoxetine (Prozac) augments platelet activation mediated through protease-activated receptors. 2008 J. Thromb. Haemost. pmid:18194419
Berg ER et al. Ion-pair interaction in pyridinium carboxylate solutions. 2008 J Phys Chem A pmid:18189374
Greaves TL et al. Protic ionic liquids: physicochemical properties and behavior as amphiphile self-assembly solvents. 2008 J Phys Chem B pmid:18166036
Zizzo MG et al. Inhibitory purinergic transmission in mouse caecum: role for P2Y1 receptors as prejunctional modulators of ATP release. 2007 Neuroscience pmid:17997228
Mascolo G et al. Effectiveness of UV-based advanced oxidation processes for the remediation of hydrocarbon pollution in the groundwater: a laboratory investigation. 2008 J. Hazard. Mater. pmid:17890002
Milios CJ et al. Toward a magnetostructural correlation for a family of Mn6 SMMs. 2007 J. Am. Chem. Soc. pmid:17887755
Chisholm MH Mixed valence complexes involving MM quadruple bonds (M=Mo or W). 2008 Philos Trans A Math Phys Eng Sci pmid:17846014
Makino Y et al. Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid. 2007 Pediatrics pmid:17724113
Kvach MV et al. 5(6)-carboxyfluorescein revisited: new protecting group, separation of isomers, and their spectral properties on oligonucleotides. 2007 Sep-Oct Bioconjug. Chem. pmid:17696491
Cornwell PD and Ulrich RG Investigating the mechanistic basis for hepatic toxicity induced by an experimental chemokine receptor 5 (CCR5) antagonist using a compendium of gene expression profiles. 2007 Toxicol Pathol pmid:17654398
Kalavala M et al. Tixocortol pivalate: what is the right concentration? 2007 Contact Derm. pmid:17577357
Kaitner B and Stilinović V Conformational enantiomeric disorder in tripivaloylmethane. 2007 Acta Crystallogr C pmid:17551202
Doberenz J et al. Pivalate lowers litter sizes and weights in female rats independent of its effect on carnitine status. 2007 Reprod. Toxicol. pmid:17482425
Murakami K et al. Chromium-catalyzed arylmagnesiation of alkynes. 2007 Org. Lett. pmid:17352489
Zizzo MG et al. Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon. 2007 Br. J. Pharmacol. pmid:17351663
Lafrance M and Fagnou K Palladium-catalyzed benzene arylation: incorporation of catalytic pivalic acid as a proton shuttle and a key element in catalyst design. 2006 J. Am. Chem. Soc. pmid:17177387
Sibi MP and Zimmerman J Pyrones to pyrans: enantioselective radical additions to acyloxy pyrones. 2006 J. Am. Chem. Soc. pmid:17031933
Shanmugam M et al. Studies of a molecular hourglass: synthesis and magnetic characterisation of a cyclic dodecanuclear {Cr10Cu2} complex. 2006 Chemistry pmid:17009364
Sugiura T et al. 1D helical polymeric chain with a pseudo-5(3) screw axis formed by cuprophilicity. synthesis and crystal structure of copper(I) pivalate. 2006 Inorg Chem pmid:16961347
Mansell PD et al. Induction of parturition in dairy cattle and its effects on health and subsequent lactation and reproductive performance. 2006 Aust. Vet. J. pmid:16958626
Chakraborti AK and Shivani S Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst. 2006 J. Org. Chem. pmid:16839166