Pivalic acid

Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pivalic acid?

Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pivalic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Otitis Media D010033 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Body Weight D001835 333 associated lipids
Psoriasis D011565 47 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Seizures D012640 87 associated lipids
Dermatitis D003872 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hyperinsulinism D006946 27 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Pivalic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pivalic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pivalic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pivalic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pivalic acid

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Authors Title Published Journal PubMed Link
pmid:
Ohashi R et al. Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. 1999 J. Pharmacol. Exp. Ther. pmid:10525100
Blanton MP et al. Examining the noncompetitive antagonist-binding site in the ion channel of the nicotinic acetylcholine receptor in the resting state. 2000 J. Biol. Chem. pmid:10652341
Wagner CA et al. Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2. 2000 Am. J. Physiol. Renal Physiol. pmid:10966938
Yuan LC et al. Effect of carbonate salts on the kinetics of acid-catalyzed dimerization of adefovir dipivoxil. 2000 Pharm. Res. pmid:11087042
Celenligil-Cetin R et al. Synthesis, characterization, and reactivity of ferrous and ferric oxo/peroxo pivalate complexes in relation to Gif-type oxygenation of substrates. 2000 Inorg Chem pmid:11151387
Song R et al. Electrophilic substitution of (diamine)tetrahydroxoplatinum(IV) with carboxylic anhydrides. Synthesis and characterization of (diamine)platinum(IV) complexes of mixed carboxylates. 2000 Aug, 7 Inorg Chem pmid:11196816
Arrigoni-Martelli E and Caso V Carnitine protects mitochondria and removes toxic acyls from xenobiotics. 2001 Drugs Exp Clin Res pmid:11276827
Darbeau RW et al. Boundary conditions on the partitioning of deaminatively generated benzyl cations. 2001 J. Org. Chem. pmid:11304187
Okudaira N et al. Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid. 2001 Pharm. Res. pmid:11451029
Cossy J et al. Synthesis of stereotriads by oxymercuration of substituted cyclopropylcarbinols. 2001 Org. Lett. pmid:11483062
Ricciolini R et al. The effect of pivalate treatment of pregnant rats on body mass and insulin levels in the adult offspring. 2001 Life Sci. pmid:11665835
Fulkerson WJ and McDowell GH Artificial induction of lactation in cattle by use of dexamethasone trimethylacetate. 1975 Aust. J. Biol. Sci. pmid:1167131
Arulsamy N and Bohle DS Multiplicity control in the polygeminal diazeniumdiolation of active hydrogen bearing carbons: chemistry of a new type of trianionic molecular propeller. 2001 J. Am. Chem. Soc. pmid:11686687
Broderick TL et al. Short-term carnitine deficiency does not alter aerobic rat heart function but depresses reperfusion recovery after ischemia. 2001 Can. J. Physiol. Pharmacol. pmid:11697749
Cutts SM et al. Molecular basis for the synergistic interaction of adriamycin with the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate (AN-9). 2001 Cancer Res. pmid:11719450
Kornilov AV et al. Preparative route to glucuronyl donors bearing temporary protecting group at O-3 via 6,3-lactonisation by Bz(2)O or Piv(2)O. 2001 Carbohydr. Res. pmid:11728399
Mitani MM et al. Kinetics and products of reactions of MTBE with ozone and ozone/hydrogen peroxide in water. 2002 J. Hazard. Mater. pmid:11744205
Bursten BE et al. Oxalate-bridged complexes of dimolybdenum and ditungsten supported by pivalate ligands: ((t)BuCO(2))(3)M(2)(mu-O(2)CCO(2))M(2)(O(2)C(t)Bu)(3). Correlation of the solid-state, molecular, and electronic structures with Raman, resonance Raman, and electronic spectral data. 2002 J. Am. Chem. Soc. pmid:11902897
Nishimura S et al. Application of a surface plasmon resonance sensor to analyses of amine compounds with the use of a polymer film and an acid-base reaction. 2002 Anal Sci pmid:11918182
Niezen JH et al. The effect of feeding sulla (Hedysarum coronarium) or lucerne (Medicago sativa) on lamb parasite burdens and development of immunity to gastrointestinal nematodes. 2002 Vet. Parasitol. pmid:11934463
Barroca N and Jacquinet JC An access to various sulfation patterns in dermatan sulfate: chemical syntheses of sulfoforms of trisaccharide methyl glycosides. 2002 Carbohydr. Res. pmid:11950464
Ebbing MH et al. Resorcinarenes with 2-benzimidazolone bridges: self-aggregation, self-assembled dimeric capsules, and guest encapsulation. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11959947
Czerkawski JW and Breckenridge G New inhibitors of methane production by rumen micro-organisms. Development and testing of inhibitors in vitro. 1975 Br. J. Nutr. pmid:1201267
Overgaard J et al. Host-guest chemistry of the chromium-wheel complex [Cr8F8(tBuCO2)16]: prediction of inclusion capabilities by using an electrostatic potential distribution determined by modeling synchrotron X-ray structure factors at 16 K. 2002 Chemistry pmid:12391657
Brass EP Pivalate-generating prodrugs and carnitine homeostasis in man. 2002 Pharmacol. Rev. pmid:12429869
Li C et al. Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes. 2002 Chem. Res. Toxicol. pmid:12437340
Fulkerson WJ et al. Artificial induction of lactation in ewes: the role of prolactin. 1975 Aust. J. Biol. Sci. pmid:1243818
Sloan CA Proceedings: Comparison of dexamethasone trimethylacetate and prostaglandin F-2alpha as abortifacients in the cow. 1976 J. Reprod. Fertil. pmid:1255625
Färber K et al. Selective desensitization of jasmonate- and pH-dependent signaling in the induction of benzophenanthridine biosynthesis in cells of Eschscholzia californica. 2003 Phytochemistry pmid:12620362
Probian C et al. Anaerobic mineralization of quaternary carbon atoms: isolation of denitrifying bacteria on pivalic acid (2,2-dimethylpropionic acid). 2003 Appl. Environ. Microbiol. pmid:12620885
Li C et al. In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. 2003 Toxicol. Appl. Pharmacol. pmid:12649042
Li C et al. In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat. 2003 J. Pharmacol. Exp. Ther. pmid:12649376
Wang SS et al. Cleavage and deprotection of peptides on MBHA-resin with hydrogen bromide. 1992 Sep-Oct Int. J. Pept. Protein Res. pmid:1335998
Konishi M and Hashimoto H Determination of pivaloylcarnitine in human plasma and urine by high-performance liquid chromatography with fluorescence detection. 1992 J Pharm Sci pmid:1432617
Spino C et al. A stereodivergent approach to chiral nonracemic N-protected alpha,alpha-dialkylated amino acids. 2003 J. Am. Chem. Soc. pmid:14518992
Aromí G et al. Synthetic and structural studies of cobalt-pivalate complexes. 2003 Chemistry pmid:14562332
Goossen LJ and Rodríguez N A mild and efficient protocol for the conversion of carboxylic acids to olefins by a catalytic decarbonylative elimination reaction. 2004 Chem. Commun. (Camb.) pmid:15010800
Totsuka K et al. Metabolism of S-1108, a new oral cephem antibiotic, and metabolic profiles of its metabolites in humans. 1992 Antimicrob. Agents Chemother. pmid:1503437
Nakashima M et al. Phase I clinical studies of S-1108: safety and pharmacokinetics in a multiple-administration study with special emphasis on the influence on carnitine body stores. 1992 Antimicrob. Agents Chemother. pmid:1503438
Rispoli V et al. Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert. 2004 Neurosci. Lett. pmid:15036629
Holme E et al. Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children. 1992 Scand. J. Clin. Lab. Invest. pmid:1514015
Christian P et al. Structural, magnetic and DFT studies of a hydroxide-bridged [Cr8] wheel. 2004 Dalton Trans pmid:15252595
Solano-Serena F et al. Degradation of isooctane by Mycobacterium austroafricanum IFP 2173: growth and catabolic pathway. 2004 J. Appl. Microbiol. pmid:15281945
Qian H et al. Platinum-catalyzed intramolecular hydroalkoxylation of gamma- and delta-hydroxy olefins to form cyclic ethers. 2004 J. Am. Chem. Soc. pmid:15291546
Rispoli V et al. Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats. 2004 Pharmacol. Biochem. Behav. pmid:15301920
Christian P et al. Synthesis and studies of a trinuclear Mn(II) carboxylate complex. 2004 Dalton Trans pmid:15303171
Carlsson H et al. Structural and functional models of the active site of zinc phosphotriesterase. 2004 Inorg Chem pmid:15332820
Mazauric FX and Alligier B [Trial of tixocortol pivalate (Pivalone) in otorhinolaryngology]. 1978 J Fr Otorhinolaryngol Audiophonol Chir Maxillofac pmid:154555
Chaboussant G et al. Nickel pivalate complexes: structural variations and magnetic susceptibility and inelastic neutron scattering studies. 2004 Dalton Trans pmid:15514763
Stanley CA Carnitine deficiency disorders in children. 2004 Ann. N. Y. Acad. Sci. pmid:15591002
Rodemann T et al. Isoelectric buffers for capillary electrophoresis. 2. Bismorpholine derivative of a carboxylic acid as a low molecular weight isoelectric buffer. 2005 Anal. Chem. pmid:15623286
Davis AT and Monroe TJ Carnitine deficiency and supplementation do not affect the gene expression of carnitine biosynthetic enzymes in rats. 2005 J. Nutr. pmid:15795431
Wang X et al. Direct C-arylation of free (NH)-indoles and pyrroles catalyzed by Ar-Rh(III) complexes assembled in situ. 2005 J. Am. Chem. Soc. pmid:15810815
Rajaraman G et al. Theoretical studies on di- and tetra-nuclear Ni pivalate complexes. 2005 Chem. Commun. (Camb.) pmid:15959582
Kumar P et al. [131I]Iodoazomycin arabinoside for low-dose-rate isotope radiotherapy: radiolabeling, stability, long-term whole-body clearance and radiation dosimetry estimates in mice. 2005 Nucl. Med. Biol. pmid:16026712
Zhou JH et al. Syntheses, structures, and magnetic properties of unusual nonlinear polynuclear copper(II) complexes containing derivatives of 1,2,4-triazole and pivalate ligands. 2005 Inorg Chem pmid:16241151
Lee J et al. 2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands. 2006 Bioorg. Med. Chem. pmid:16297629
Milios CJ et al. 1,1,1-Tris(hydroxymethyl)propane in manganese carboxylate chemistry: synthesis, structure and magnetic properties of a mixed-valence [MnIII4MnII4] cluster featuring the novel [MnIII4MnII4(mu3-OR)6(mu2-OR)8]6+ core. 2006 Dalton Trans pmid:16365649
Yamaguchi T et al. Possible mechanism for species difference on the toxicity of pivalic acid between dogs and rats. 2006 Toxicol. Appl. Pharmacol. pmid:16430936
Wu M et al. Synthesis of 9-[1-(substituted)-3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents. 2005 Nucleosides Nucleotides Nucleic Acids pmid:16438034
Sasahara A et al. STM observation of a ruthenium dye adsorbed on a TiO2(110) surface. 2006 J Phys Chem B pmid:16526711
Wittick LM et al. New mixed-valence MnII2MnIII2 clusters exhibiting an unprecedented MnII/III oxidation state distribution in their magnetically coupled cores. 2006 Dalton Trans pmid:16538272
Suga K et al. Photocatalytic oxygenation of pivalic acid with molecular oxygen via photoinduced electron transfer using 10-methylacridinium ions. 2006 J Phys Chem A pmid:16539406
Zídek Z et al. Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir. 2005 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub pmid:16601779
Romani G et al. H extrusion and potassium uptake associated with potential hyperpolarization in maize and wheat root segments treated with permeant weak acids. 1985 Plant Physiol. pmid:16664483
Basso B and Ullrich-Eberius CI Membrane Potential and Proton Cotransport of Alanine and Phosphate as Affected by Permeant Weak Acids in Lemna gibba. 1987 Plant Physiol. pmid:16665758
Weis R et al. Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols. 2006 Eur J Pharm Sci pmid:16713699
Biswas P et al. Synthesis, reactivities, and magnetostructural properties of FeIII, FeIII-O-FeIII, and ZnIIFeIII-O-FeIIIZnII complexes of a tetraiminodiphenolate macrocycle. 2006 Inorg Chem pmid:16749848
Broderick TL Hypocarnitinaemia induced by sodium pivalate in the rat is associated with left ventricular dysfunction and impaired energy metabolism. 2006 Drugs R D pmid:16752941
Ovcharenko V et al. Synthesis, structure, and magnetic properties of (6-9)-nuclear Ni(II) trimethylacetates and their heterospin complexes with nitroxides. 2006 Inorg Chem pmid:16813397
Okamura N et al. Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid. 2006 Pharm. Res. pmid:16826461
Chakraborti AK and Shivani S Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst. 2006 J. Org. Chem. pmid:16839166
Mansell PD et al. Induction of parturition in dairy cattle and its effects on health and subsequent lactation and reproductive performance. 2006 Aust. Vet. J. pmid:16958626
Sugiura T et al. 1D helical polymeric chain with a pseudo-5(3) screw axis formed by cuprophilicity. synthesis and crystal structure of copper(I) pivalate. 2006 Inorg Chem pmid:16961347
Shanmugam M et al. Studies of a molecular hourglass: synthesis and magnetic characterisation of a cyclic dodecanuclear {Cr10Cu2} complex. 2006 Chemistry pmid:17009364
Sibi MP and Zimmerman J Pyrones to pyrans: enantioselective radical additions to acyloxy pyrones. 2006 J. Am. Chem. Soc. pmid:17031933
Lafrance M and Fagnou K Palladium-catalyzed benzene arylation: incorporation of catalytic pivalic acid as a proton shuttle and a key element in catalyst design. 2006 J. Am. Chem. Soc. pmid:17177387
Zizzo MG et al. Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon. 2007 Br. J. Pharmacol. pmid:17351663
Murakami K et al. Chromium-catalyzed arylmagnesiation of alkynes. 2007 Org. Lett. pmid:17352489
Doberenz J et al. Pivalate lowers litter sizes and weights in female rats independent of its effect on carnitine status. 2007 Reprod. Toxicol. pmid:17482425
Kaitner B and Stilinović V Conformational enantiomeric disorder in tripivaloylmethane. 2007 Acta Crystallogr C pmid:17551202
Kalavala M et al. Tixocortol pivalate: what is the right concentration? 2007 Contact Derm. pmid:17577357
Cornwell PD and Ulrich RG Investigating the mechanistic basis for hepatic toxicity induced by an experimental chemokine receptor 5 (CCR5) antagonist using a compendium of gene expression profiles. 2007 Toxicol Pathol pmid:17654398
Kvach MV et al. 5(6)-carboxyfluorescein revisited: new protecting group, separation of isomers, and their spectral properties on oligonucleotides. 2007 Sep-Oct Bioconjug. Chem. pmid:17696491
Makino Y et al. Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid. 2007 Pediatrics pmid:17724113
Chisholm MH Mixed valence complexes involving MM quadruple bonds (M=Mo or W). 2008 Philos Trans A Math Phys Eng Sci pmid:17846014
Milios CJ et al. Toward a magnetostructural correlation for a family of Mn6 SMMs. 2007 J. Am. Chem. Soc. pmid:17887755
Mascolo G et al. Effectiveness of UV-based advanced oxidation processes for the remediation of hydrocarbon pollution in the groundwater: a laboratory investigation. 2008 J. Hazard. Mater. pmid:17890002
Zizzo MG et al. Inhibitory purinergic transmission in mouse caecum: role for P2Y1 receptors as prejunctional modulators of ATP release. 2007 Neuroscience pmid:17997228
Greaves TL et al. Protic ionic liquids: physicochemical properties and behavior as amphiphile self-assembly solvents. 2008 J Phys Chem B pmid:18166036
Berg ER et al. Ion-pair interaction in pyridinium carboxylate solutions. 2008 J Phys Chem A pmid:18189374
Dilks JR and Flaumenhaft R Fluoxetine (Prozac) augments platelet activation mediated through protease-activated receptors. 2008 J. Thromb. Haemost. pmid:18194419
Wiemer AJ et al. Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. 2008 Bioorg. Med. Chem. pmid:18308574
Li G et al. Au-catalyzed synthesis of (1Z,3E)-2-pivaloxy-1,3-dienes from propargylic pivalates. 2008 J. Am. Chem. Soc. pmid:18311985
Leone G et al. Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias. 2008 Curr. Med. Chem. pmid:18537607
Liégault B et al. Intramolecular Pd(II)-catalyzed oxidative biaryl synthesis under air: reaction development and scope. 2008 J. Org. Chem. pmid:18543991
Ikeda M et al. Scanning tunneling microscopy study of black dye and deoxycholic acid adsorbed on a rutile TiO2(110). 2008 Langmuir pmid:18590297
Jacobson KA et al. Development of selective agonists and antagonists of P2Y receptors. 2009 Purinergic Signal. pmid:18600475
Grillo MP and Hua F Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes. 2008 Chem. Res. Toxicol. pmid:18680316