| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Urinary Tract Infections | D014552 | 11 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Dermatitis | D003872 | 30 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
Pivalic acid
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Pivalic acid?
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Pivalic acid
PubChem Associated disorders and diseases
What pathways are associated with Pivalic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Pivalic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Pivalic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Pivalic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Pivalic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with Pivalic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Pivalic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Douglas KT et al. | Mechanistic studies of carboxypeptidase Y. Kinetic detection of an acyl-enzyme intermediate in trimethylacetate esterase action. | 1976 | J. Am. Chem. Soc. | pmid:993522 |
| Czerkawski JW | The use of pivalic acid as a reference substance in measurements of production of volatile fatty acids by rumen micro-organisms in vitro. | 1976 | Br. J. Nutr. | pmid:952843 |
| Giordano F et al. | Crystal forms of piroxicam pivalate: preparation and characterization of two polymorphs. | 1998 | J Pharm Sci | pmid:9523987 |
| Lewin LM et al. | Effects of pivalic acid and sodium pivalate on L-carnitine concentrations in the cauda epididymidis and on male fertility in the hamster. | 1997 | Reprod. Fertil. Dev. | pmid:9402252 |
| Cooper TG et al. | Successful lowering of epididymal carnitine by administration of pivalate to rats. | 1997 | Int. J. Androl. | pmid:9354188 |
| Abrahamsson K et al. | Pivalic acid-induced carnitine deficiency and physical exercise in humans. | 1996 | Metab. Clin. Exp. | pmid:8969283 |
| Bianchi PB et al. | Carnitine supplementation ameliorates the steatosis and ketosis induced by pivalate in rats. | 1996 | J. Nutr. | pmid:8914960 |
| Bianchi PB and Davis AT | beta-Hydroxybutyrate oxidation is reduced and hepatic balance of ketone bodies and free fatty acids is unaltered in carnitine-depleted, pivalate-treated rats. | 1996 | J. Nutr. | pmid:8914959 |
| Zanelli U et al. | Induction of peroxisomal beta-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney. | 1996 | Arch. Toxicol. | pmid:8825670 |
| Metges CC et al. | Gas chromatography/combustion/isotope ratio mass spectrometric comparison of N-acetyl- and N-pivaloyl amino acid esters to measure 15N isotopic abundances in physiological samples: a pilot study on amino acid synthesis in the upper gastro-intestinal tract of minipigs. | 1996 | J Mass Spectrom | pmid:8799283 |
| Zanelli U et al. | Selective depletion of mitochondrial glutathione content by pivalic acid and valproic acid in rat liver: possibility of a common mechanism. | 1996 | Adv. Exp. Med. Biol. | pmid:8794200 |
| Sauber K et al. | A new esterase for the cleavage of pivalic acid-containing prodrug esters of cephalosporins. | 1996 | Enzyme Microb. Technol. | pmid:8672280 |
| Nakajima H et al. | Pivalate affects carnitine status but causes no severe metabolic changes in rat liver. | 1996 | J. Nutr. | pmid:8648443 |
| Broderick TL et al. | L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts. | 1995 | Cardiovasc. Res. | pmid:8595631 |
| Abrahamsson K et al. | Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid. | 1995 | Br Heart J | pmid:8541173 |
| Davis AT | Carnitine depletion in rat pups of lactating mothers given sodium pivalate. | 1995 | Biol. Neonate | pmid:8534786 |
| Shimizu K et al. | Carnitine status and safety after administration of S-1108, a new oral cephem, to patients. | 1993 | Antimicrob. Agents Chemother. | pmid:8517691 |
| Melegh B et al. | Preferential elimination of pivalate with supplemental carnitine via formation of pivaloylcarnitine in man. | 1993 | Xenobiotica | pmid:8310709 |
| Fujii R et al. | [Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients]. | 1993 | Jpn J Antibiot | pmid:8254895 |
| Reckers VR and Wendt H | [Multicentre-clinical trial of the novel corticosteroid diflucortolone valerate in the forms of cream, ointment and fatty ointment. Part I: Comparative study of diflucortolone valerate with fluocortolone, -capronate, -pivalate in a double-blind contralateral design with topical application (author's transl)]. | 1976 | Arzneimittelforschung | pmid:795433 |
| Abrahamsson K et al. | Impaired ketogenesis in carnitine depletion caused by short-term administration of pivalic acid prodrug. | 1994 | Biochem. Med. Metab. Biol. | pmid:7917463 |
| Diep QN et al. | Formation of pivaloylcarnitine in heart and brown adipose tissue in the rat. | 1995 | Biochim. Biophys. Acta | pmid:7827109 |
| Diep QN and Bøhmer T | Increased pivaloylcarnitine in the liver of the sodium pivalate treated rat exposed to clofibrate. | 1995 | Biochim. Biophys. Acta | pmid:7766704 |
| Broderick TL et al. | Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency. | 1995 | Metab. Clin. Exp. | pmid:7723673 |
| Broderick TL et al. | L-propionylcarnitine effects on cardiac carnitine content and function in secondary carnitine deficiency. | 1995 | Can. J. Physiol. Pharmacol. | pmid:7671193 |
| Abrahamsson K et al. | Effect of short-term treatment with pivalic acid containing antibiotics on serum carnitine concentration--a risk irrespective of age. | 1995 | Biochem. Mol. Med. | pmid:7551831 |
| Mizojiri K et al. | Disposition of S-1108, a new oral cephem antibiotic, and metabolic fate of pivalic acid liberated from [pivaloyl-14C]S-1108 in rats and dogs. | 1995 | Antimicrob. Agents Chemother. | pmid:7492083 |
| Diep QN et al. | Formation of pivaloylcarnitine in isolated rat heart cells. | 1995 | Biochim. Biophys. Acta | pmid:7488636 |
| Morris GS et al. | Sodium pivalate reduces cardiac carnitine content and increases glucose oxidation without affecting cardiac functional capacity. | 1995 | Life Sci. | pmid:7475977 |
| Staatz WD et al. | Cytotoxicity of pivalylphenylephrine and pivalic acid to corneal endothelium. | 1980 | Arch. Ophthalmol. | pmid:7396784 |
| Lloyd S et al. | The effect of corticosteroid therapy on infection with Toxocara canis in dogs. | 1981 | Z Parasitenkd | pmid:7324542 |
| Nakamura T et al. | Effect of d,l-alpha-tocopheryl esters on vitamin E-deficient rats. | 1978 | J. Nutr. Sci. Vitaminol. | pmid:731332 |
| Fairclough RJ et al. | Dexamethasone concentrations in plasma and milk of cows following the injection of long- and short-acting dexamethasone esters. | 1981 | Aust. J. Biol. Sci. | pmid:7295211 |
| Deutsch C et al. | Synaptosomes from rat brain: morphology, compartmentation, and transmembrane pH and electrical gradients. | 1981 | J. Neurochem. | pmid:7241148 |
| Goldberg I et al. | Dipivefrin: current concepts. | 1980 | Aust J Ophthalmol | pmid:7004425 |
| Mattocks AR and Cabral JR | Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues. | 1982 | Cancer Lett. | pmid:6817913 |
| Peel CJ et al. | The importance of prolactin and the milking stimulus in the artificial induction of lactation in cows. | 1978 | Aust. J. Biol. Sci. | pmid:678223 |
| Van Dort M et al. | Potential tumor or organ-imaging agents, 24. Radioiodinated pregnenolone esters. | 1984 | Steroids | pmid:6537047 |
| Tamaru RD et al. | Comparison of ocular disposition of free pivalic acid and pivalic acid esterified in dipivefrin. | 1983 | Arch. Ophthalmol. | pmid:6347153 |
| Ercolani L and Schulte WE | Metabolic and morphologic effects of colchicine on human T-lymphocyte expression of Fc mu and Fc gamma receptors. | 1983 | Cell. Immunol. | pmid:6303602 |
| Andersson L et al. | Glucose concentrations in plasma and urine after glucocorticoid injection in healthy cows. | 1982 Apr-May | Nord Vet Med | pmid:6184673 |
| Vickers S et al. | Metabolism of methyldopa in man after oral administration of the pivaloyloxyethyl ester. | 1984 Mar-Apr | Drug Metab. Dispos. | pmid:6144491 |
| Crofton JT et al. | The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat. | 1979 Jan-Feb | Hypertension | pmid:544512 |
| Bailey LF et al. | The use of dexamethasone trimethylacetate to advance parturition in dairy cows. | 1973 | Aust. Vet. J. | pmid:4777214 |
| Dzielak DJ and Norman RA | Renal nerves are not necessary for onset or maintenance of DOC-salt hypertension in rats. | 1985 | Am. J. Physiol. | pmid:4061671 |
| Vickers S et al. | Carnitine and glucuronic acid conjugates of pivalic acid. | 1985 | Xenobiotica | pmid:4036169 |
| Johnston NE and Stewart JA | The effect of glucocorticoids and prematurity on absorption of colostral immunoglobulin in the calf. | 1986 | Aust. Vet. J. | pmid:3767799 |
| Melegh B et al. | Pivampicillin-promoted excretion of pivaloylcarnitine in humans. | 1987 | Biochem. Pharmacol. | pmid:3675603 |
| Hussain MA et al. | Improvement of the oral bioavailability of naltrexone in dogs: a prodrug approach. | 1987 | J Pharm Sci | pmid:3656096 |
| Sciotti V and Gallant S | Resistance to mineralocorticoid-induced hypertensive vascular disease. | 1987 | Hypertension | pmid:3610293 |
| Lelièvre V et al. | Correlation between binding activity, inhibition of lymphoblastic transformation and metabolism of tixocortol 21 pivalate in mouse thymocytes. | 1987 | Agents Actions | pmid:3500591 |
| Chattopadhyay SP et al. | Betamethasone dipropionate (0.05%) plus salicylic acid (3%) ointment versus dexamethasone trimethyl acetate (1%) and salicylic acid 4% ointments in chronic dermatoses. | 1987 | Indian J Dermatol | pmid:3453353 |
| Bruner CA et al. | Area postrema ablation and vascular reactivity in deoxycorticosterone-salt-treated rats. | 1988 | Hypertension | pmid:3391678 |
| Ueno Y et al. | Characteristics of hormonal and neurogenic mechanisms of deoxycorticosterone-induced hypertension. | 1988 | Hypertension | pmid:3346052 |
| Maurer H and Kessler C | Identification and quantification of ethylene glycol and diethylene glycol in plasma using gas chromatography-mass spectrometry. | 1988 | Arch. Toxicol. | pmid:3190459 |
| Foussereau J and Jelen G | [An unrecognized cause of allergic eczema of the face: a corticoid, tixocortol pivalate]. | 1987 | Presse Med | pmid:2954110 |
| MacDiarmid SC | Betamethasone alcohol suspensions for the induction of parturition in dairy cows: a comparison with dexamethasone trimethyl acetate. | 1979 | N Z Vet J | pmid:292913 |
| Haradahira T et al. | Potential tumor- or organ-imaging agents. 29. Radioiodinated esters and amides of 20-hydroxy- and 20-aminopregn-5-en-3 beta-ols. | 1989 | J. Med. Chem. | pmid:2918507 |
| Tong L et al. | Development of a prodrug of hydantoin based TACE inhibitor. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28711352 |
| Freed JJ et al. | Evidence for acyloxymethyl esters of pyrimidine 5'-deoxyribonucleotides as extracellular sources of active 5'-deoxyribonucleotides in cultured cells. | 1989 | Biochem. Pharmacol. | pmid:2818620 |
| Takahashi Y et al. | A case of sudden unexpected infant death involving a homozygotic twin with the thermolabile CPT2 variant, accompanied by rotavirus infection and treatment with an antibiotic containing pivalic acid. | 2016 | Leg Med (Tokyo) | pmid:27591533 |
| Wu DR et al. | Additive free preparative chiral SFC separations of 2,2-dimethyl-3-aryl-propanoic acids. | 2016 | J Pharm Biomed Anal | pmid:27522108 |
| Stanton BA | Characterization of apical and basolateral membrane conductances of rat inner medullary collecting duct. | 1989 | Am. J. Physiol. | pmid:2719119 |
| Lin Y et al. | Cooperative catalysis of N-heterocyclic carbene and Brønsted acid for a highly enantioselective route to unprotected spiro-indoline-pyrans. | 2015 | Chem. Commun. (Camb.) | pmid:25882587 |
| Melegh B | Carnitine supplementation in pivampicillin treatment. | 1989 | Lancet | pmid:2572813 |
| Holme E et al. | Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. | 1989 | Lancet | pmid:2570185 |
| Hughes CS et al. | Effects of certain stress factors on the re-excretion of infectious laryngotracheitis virus from latently infected carrier birds. | 1989 | Res. Vet. Sci. | pmid:2539638 |
| Nasu T et al. | Newborn hypocarnitinemia due to long-term transplacental pivalic acid passage. | 2014 | Pediatr Int | pmid:25335995 |
| Manolikakes SM et al. | Air-stable solid aryl and heteroaryl organozinc pivalates: syntheses and applications in organic synthesis. | 2014 | Chemistry | pmid:25116852 |
| Witney TH et al. | Preclinical evaluation of 3-18F-fluoro-2,2-dimethylpropionic acid as an imaging agent for tumor detection. | 2014 | J. Nucl. Med. | pmid:25012458 |
| Srinivas HD et al. | Enantiospecific, nickel-catalyzed cross-couplings of allylic pivalates and arylboroxines. | 2014 | Org. Lett. | pmid:24927013 |
| Yahyaoui R et al. | [C5-carnitine false positive results in newborn screening: what is the cause?]. | 2015 | Med Clin (Barc) | pmid:24889749 |
| Lu Q et al. | Mechanistic study of chemoselectivity in Ni-catalyzed coupling reactions between azoles and aryl carboxylates. | 2014 | J. Am. Chem. Soc. | pmid:24823646 |
| Zhou Q et al. | In situ generation of palladium nanoparticles: ligand-free palladium catalyzed pivalic acid assisted carbonylative Suzuki reactions at ambient conditions. | 2014 | J. Org. Chem. | pmid:24397578 |
| Boemer F et al. | Surprising causes of C5-carnitine false positive results in newborn screening. | 2014 | Mol. Genet. Metab. | pmid:24291264 |
| Muto K et al. | Isolation, structure, and reactivity of an arylnickel(II) pivalate complex in catalytic C-H/C-O biaryl coupling. | 2013 | J. Am. Chem. Soc. | pmid:24152083 |
| Zhou Q et al. | Nickel-catalyzed cross-couplings of benzylic pivalates with arylboroxines: stereospecific formation of diarylalkanes and triarylmethanes. | 2013 | J. Am. Chem. Soc. | pmid:23425080 |
| Trost BM et al. | Palladium-catalyzed asymmetric allylic alkylation of 3-aryloxindoles with allylidene dipivalate: a useful enol pivalate product. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23335176 |
| Demory E et al. | Fast Pd- and Pd/Cu-catalyzed direct C-H arylation of cyclic nitrones. Application to the synthesis of enantiopure quaternary α-amino esters. | 2012 | J. Org. Chem. | pmid:22946756 |
| Aljaar N et al. | Cu-catalyzed reaction of 1,2-dihalobenzenes with 1,3-cyclohexanediones for the synthesis of 3,4-dihydrodibenzo[b,d]furan-1(2H)-ones. | 2012 | J. Org. Chem. | pmid:22917488 |
| Del Rosso JQ and Kircik L | A Comprehensive Review of Clocortolone Pivalate 0.1% Cream: Structural Development, Formulation Characteristics, and Studies Supporting Treatment of Corticosteroid-responsive Dermatoses. | 2012 | J Clin Aesthet Dermatol | pmid:22798972 |
| Singh S and Mann BK | Clinical utility of clocortolone pivalate for the treatment of corticosteroid-responsive skin disorders: a systematic review. | 2012 | Clin Cosmet Investig Dermatol | pmid:22791998 |
| Rezanka T et al. | Biosynthesis and metabolic pathways of pivalic acid. | 2012 | Appl. Microbiol. Biotechnol. | pmid:22790609 |
| Barberán J et al. | Update on the clinical utility and optimal use of cefditoren. | 2012 | Int J Gen Med | pmid:22675264 |
| Tomkowicz Z et al. | Magnetooptical and structural investigations of five dimeric cobalt(II) complexes mimicking metalloenzyme active sites. | 2012 | Inorg Chem | pmid:22621284 |
| Cao G et al. | Bis[(1H-1,2,3-benzotriazol-1-yl)methyl 2,2-dimethyl-propano-ato-κN(3)]dichlorido-copper(II). | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22590111 |
| Xu S and Shen Y | (1H-1,2,3-Benzotriazol-1-yl)methyl 2,2-dimethyl-propano-ate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22589933 |
| Lam KK et al. | Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis. | 2012 | PLoS Pathog. | pmid:22589723 |
| Rasmussen J et al. | Primary carnitine deficiency and pivalic acid exposure causing encephalopathy and fatal cardiac events. | 2013 | J. Inherit. Metab. Dis. | pmid:22566287 |
| Shan Y et al. | Rapid acyl migration between pyrogallyl 1,2- and 1,3-dipivaloates. | 2012 | Nat Prod Commun | pmid:22545406 |
| Kuka J et al. | A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function. | 2012 | Cardiovasc. Toxicol. | pmid:22539084 |
| Dorofeeva VN et al. | 2D porous honeycomb polymers versus discrete nanocubes from trigonal trinuclear complexes and ligands with variable topology. | 2012 | Chemistry | pmid:22407897 |
| Slusarski T et al. | Electronic structure and magnetic properties of a molecular octanuclear chromium-based ring. | 2011 | J Nanosci Nanotechnol | pmid:22400306 |
| Xu W et al. | Identification and characterization of three impurities in clocortolone pivalate. | 2012 | J Pharm Biomed Anal | pmid:22264563 |
| Yang G et al. | (E)-2-(4-tert-But-ylphen-yl)-2-cyano-1-(3-methyl-1-vinyl-1H-pyrazol-5-yl)vinyl 2,2-dimethyl-propano-ate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22259565 |
| Meng Q et al. | Di-μ-pivalato-κO,O':O';κO:O,O'-bis-[(methanol-κO)bis-(2,2,6,6-tetra-methylhepta-ne-3,5-dionato)praseo-dymium(III)]. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:22219764 |
| Gensch T et al. | Snapshot of the palladium(II)-catalyzed oxidative biaryl bond formation by X-ray analysis of the intermediate diaryl palladium(II) complex. | 2012 | Chemistry | pmid:22170766 |
| Cracan V and Banerjee R | Novel coenzyme B12-dependent interconversion of isovaleryl-CoA and pivalyl-CoA. | 2012 | J. Biol. Chem. | pmid:22167181 |
| Mereacre V et al. | Contribution of spin and anisotropy to single molecule magnet behavior in a family of bell-shaped Mn11Ln2 coordination clusters. | 2011 | Inorg Chem | pmid:22047593 |
| Kim D and Hong S | Palladium(II)-catalyzed direct intermolecular alkenylation of chromones. | 2011 | Org. Lett. | pmid:21797199 |