Pivalic acid

Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pivalic acid?

Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pivalic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Otitis Media D010033 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Body Weight D001835 333 associated lipids
Psoriasis D011565 47 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Seizures D012640 87 associated lipids
Dermatitis D003872 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hyperinsulinism D006946 27 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Pivalic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pivalic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pivalic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pivalic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pivalic acid

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Authors Title Published Journal PubMed Link
pmid:
Bailey LF et al. The use of dexamethasone trimethylacetate to advance parturition in dairy cows. 1973 Aust. Vet. J. pmid:4777214
Fulkerson WJ and McDowell GH Artificial induction of lactation in cattle by use of dexamethasone trimethylacetate. 1975 Aust. J. Biol. Sci. pmid:1167131
Czerkawski JW and Breckenridge G New inhibitors of methane production by rumen micro-organisms. Development and testing of inhibitors in vitro. 1975 Br. J. Nutr. pmid:1201267
Fulkerson WJ et al. Artificial induction of lactation in ewes: the role of prolactin. 1975 Aust. J. Biol. Sci. pmid:1243818
Czerkawski JW The use of pivalic acid as a reference substance in measurements of production of volatile fatty acids by rumen micro-organisms in vitro. 1976 Br. J. Nutr. pmid:952843
Douglas KT et al. Mechanistic studies of carboxypeptidase Y. Kinetic detection of an acyl-enzyme intermediate in trimethylacetate esterase action. 1976 J. Am. Chem. Soc. pmid:993522
Sloan CA Proceedings: Comparison of dexamethasone trimethylacetate and prostaglandin F-2alpha as abortifacients in the cow. 1976 J. Reprod. Fertil. pmid:1255625
Reckers VR and Wendt H [Multicentre-clinical trial of the novel corticosteroid diflucortolone valerate in the forms of cream, ointment and fatty ointment. Part I: Comparative study of diflucortolone valerate with fluocortolone, -capronate, -pivalate in a double-blind contralateral design with topical application (author's transl)]. 1976 Arzneimittelforschung pmid:795433
Gaskell RM and Povey RC Experimental induction of feline viral rhinotracheitis virus re-excretion in FVR-recovered cats. 1977 Vet. Rec. pmid:191978
Wexler BC Corticotropin stimulation of hypertensive rats with and without arteriosclerosis. 1978 Arch. Pathol. Lab. Med. pmid:214053
Mazauric FX and Alligier B [Trial of tixocortol pivalate (Pivalone) in otorhinolaryngology]. 1978 J Fr Otorhinolaryngol Audiophonol Chir Maxillofac pmid:154555
Peel CJ et al. The importance of prolactin and the milking stimulus in the artificial induction of lactation in cows. 1978 Aust. J. Biol. Sci. pmid:678223
Nakamura T et al. Effect of d,l-alpha-tocopheryl esters on vitamin E-deficient rats. 1978 J. Nutr. Sci. Vitaminol. pmid:731332
MacDiarmid SC Betamethasone alcohol suspensions for the induction of parturition in dairy cows: a comparison with dexamethasone trimethyl acetate. 1979 N Z Vet J pmid:292913
Crofton JT et al. The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat. 1979 Jan-Feb Hypertension pmid:544512
Staatz WD et al. Cytotoxicity of pivalylphenylephrine and pivalic acid to corneal endothelium. 1980 Arch. Ophthalmol. pmid:7396784
Goldberg I et al. Dipivefrin: current concepts. 1980 Aust J Ophthalmol pmid:7004425
Deutsch C et al. Synaptosomes from rat brain: morphology, compartmentation, and transmembrane pH and electrical gradients. 1981 J. Neurochem. pmid:7241148
Fairclough RJ et al. Dexamethasone concentrations in plasma and milk of cows following the injection of long- and short-acting dexamethasone esters. 1981 Aust. J. Biol. Sci. pmid:7295211
Lloyd S et al. The effect of corticosteroid therapy on infection with Toxocara canis in dogs. 1981 Z Parasitenkd pmid:7324542
Mattocks AR and Cabral JR Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues. 1982 Cancer Lett. pmid:6817913
Andersson L et al. Glucose concentrations in plasma and urine after glucocorticoid injection in healthy cows. 1982 Apr-May Nord Vet Med pmid:6184673
Ercolani L and Schulte WE Metabolic and morphologic effects of colchicine on human T-lymphocyte expression of Fc mu and Fc gamma receptors. 1983 Cell. Immunol. pmid:6303602
Tamaru RD et al. Comparison of ocular disposition of free pivalic acid and pivalic acid esterified in dipivefrin. 1983 Arch. Ophthalmol. pmid:6347153
Van Dort M et al. Potential tumor or organ-imaging agents, 24. Radioiodinated pregnenolone esters. 1984 Steroids pmid:6537047
Vickers S et al. Metabolism of methyldopa in man after oral administration of the pivaloyloxyethyl ester. 1984 Mar-Apr Drug Metab. Dispos. pmid:6144491
Vickers S et al. Carnitine and glucuronic acid conjugates of pivalic acid. 1985 Xenobiotica pmid:4036169
Dzielak DJ and Norman RA Renal nerves are not necessary for onset or maintenance of DOC-salt hypertension in rats. 1985 Am. J. Physiol. pmid:4061671
Romani G et al. H extrusion and potassium uptake associated with potential hyperpolarization in maize and wheat root segments treated with permeant weak acids. 1985 Plant Physiol. pmid:16664483
Johnston NE and Stewart JA The effect of glucocorticoids and prematurity on absorption of colostral immunoglobulin in the calf. 1986 Aust. Vet. J. pmid:3767799
Foussereau J and Jelen G [An unrecognized cause of allergic eczema of the face: a corticoid, tixocortol pivalate]. 1987 Presse Med pmid:2954110
Chattopadhyay SP et al. Betamethasone dipropionate (0.05%) plus salicylic acid (3%) ointment versus dexamethasone trimethyl acetate (1%) and salicylic acid 4% ointments in chronic dermatoses. 1987 Indian J Dermatol pmid:3453353
Melegh B et al. Pivampicillin-promoted excretion of pivaloylcarnitine in humans. 1987 Biochem. Pharmacol. pmid:3675603
Sciotti V and Gallant S Resistance to mineralocorticoid-induced hypertensive vascular disease. 1987 Hypertension pmid:3610293
Hussain MA et al. Improvement of the oral bioavailability of naltrexone in dogs: a prodrug approach. 1987 J Pharm Sci pmid:3656096
Lelièvre V et al. Correlation between binding activity, inhibition of lymphoblastic transformation and metabolism of tixocortol 21 pivalate in mouse thymocytes. 1987 Agents Actions pmid:3500591
Basso B and Ullrich-Eberius CI Membrane Potential and Proton Cotransport of Alanine and Phosphate as Affected by Permeant Weak Acids in Lemna gibba. 1987 Plant Physiol. pmid:16665758
Bruner CA et al. Area postrema ablation and vascular reactivity in deoxycorticosterone-salt-treated rats. 1988 Hypertension pmid:3391678
Ueno Y et al. Characteristics of hormonal and neurogenic mechanisms of deoxycorticosterone-induced hypertension. 1988 Hypertension pmid:3346052
Maurer H and Kessler C Identification and quantification of ethylene glycol and diethylene glycol in plasma using gas chromatography-mass spectrometry. 1988 Arch. Toxicol. pmid:3190459
Holme E et al. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. 1989 Lancet pmid:2570185
Melegh B Carnitine supplementation in pivampicillin treatment. 1989 Lancet pmid:2572813
Hughes CS et al. Effects of certain stress factors on the re-excretion of infectious laryngotracheitis virus from latently infected carrier birds. 1989 Res. Vet. Sci. pmid:2539638
Stanton BA Characterization of apical and basolateral membrane conductances of rat inner medullary collecting duct. 1989 Am. J. Physiol. pmid:2719119
Haradahira T et al. Potential tumor- or organ-imaging agents. 29. Radioiodinated esters and amides of 20-hydroxy- and 20-aminopregn-5-en-3 beta-ols. 1989 J. Med. Chem. pmid:2918507
Freed JJ et al. Evidence for acyloxymethyl esters of pyrimidine 5'-deoxyribonucleotides as extracellular sources of active 5'-deoxyribonucleotides in cultured cells. 1989 Biochem. Pharmacol. pmid:2818620
Tomić S et al. Partial purification of esterases from rabbit serum and their use in regioselective deacylations of sugars. 1991 Carbohydr. Res. pmid:1878876
Ruff LJ and Brass EP Metabolic effects of pivalate in isolated rat hepatocytes. 1991 Toxicol. Appl. Pharmacol. pmid:1891775
Bianchi PB and Davis AT Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats. 1991 J. Nutr. pmid:1941267
Holme E et al. Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children. 1992 Scand. J. Clin. Lab. Invest. pmid:1514015
Konishi M and Hashimoto H Determination of pivaloylcarnitine in human plasma and urine by high-performance liquid chromatography with fluorescence detection. 1992 J Pharm Sci pmid:1432617
Totsuka K et al. Metabolism of S-1108, a new oral cephem antibiotic, and metabolic profiles of its metabolites in humans. 1992 Antimicrob. Agents Chemother. pmid:1503437
Nakashima M et al. Phase I clinical studies of S-1108: safety and pharmacokinetics in a multiple-administration study with special emphasis on the influence on carnitine body stores. 1992 Antimicrob. Agents Chemother. pmid:1503438
Wang SS et al. Cleavage and deprotection of peptides on MBHA-resin with hydrogen bromide. 1992 Sep-Oct Int. J. Pept. Protein Res. pmid:1335998
Fujii R et al. [Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients]. 1993 Jpn J Antibiot pmid:8254895
Shimizu K et al. Carnitine status and safety after administration of S-1108, a new oral cephem, to patients. 1993 Antimicrob. Agents Chemother. pmid:8517691
Melegh B et al. Preferential elimination of pivalate with supplemental carnitine via formation of pivaloylcarnitine in man. 1993 Xenobiotica pmid:8310709
Abrahamsson K et al. Impaired ketogenesis in carnitine depletion caused by short-term administration of pivalic acid prodrug. 1994 Biochem. Med. Metab. Biol. pmid:7917463
Broderick TL et al. L-propionylcarnitine effects on cardiac carnitine content and function in secondary carnitine deficiency. 1995 Can. J. Physiol. Pharmacol. pmid:7671193
Broderick TL et al. Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency. 1995 Metab. Clin. Exp. pmid:7723673
Broderick TL et al. L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts. 1995 Cardiovasc. Res. pmid:8595631
Davis AT Carnitine depletion in rat pups of lactating mothers given sodium pivalate. 1995 Biol. Neonate pmid:8534786
Abrahamsson K et al. Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid. 1995 Br Heart J pmid:8541173
Morris GS et al. Sodium pivalate reduces cardiac carnitine content and increases glucose oxidation without affecting cardiac functional capacity. 1995 Life Sci. pmid:7475977
Mizojiri K et al. Disposition of S-1108, a new oral cephem antibiotic, and metabolic fate of pivalic acid liberated from [pivaloyl-14C]S-1108 in rats and dogs. 1995 Antimicrob. Agents Chemother. pmid:7492083
Diep QN et al. Formation of pivaloylcarnitine in isolated rat heart cells. 1995 Biochim. Biophys. Acta pmid:7488636
Abrahamsson K et al. Effect of short-term treatment with pivalic acid containing antibiotics on serum carnitine concentration--a risk irrespective of age. 1995 Biochem. Mol. Med. pmid:7551831
Diep QN et al. Formation of pivaloylcarnitine in heart and brown adipose tissue in the rat. 1995 Biochim. Biophys. Acta pmid:7827109
Diep QN and Bøhmer T Increased pivaloylcarnitine in the liver of the sodium pivalate treated rat exposed to clofibrate. 1995 Biochim. Biophys. Acta pmid:7766704
Nakajima H et al. Pivalate affects carnitine status but causes no severe metabolic changes in rat liver. 1996 J. Nutr. pmid:8648443
Zanelli U et al. Selective depletion of mitochondrial glutathione content by pivalic acid and valproic acid in rat liver: possibility of a common mechanism. 1996 Adv. Exp. Med. Biol. pmid:8794200
Metges CC et al. Gas chromatography/combustion/isotope ratio mass spectrometric comparison of N-acetyl- and N-pivaloyl amino acid esters to measure 15N isotopic abundances in physiological samples: a pilot study on amino acid synthesis in the upper gastro-intestinal tract of minipigs. 1996 J Mass Spectrom pmid:8799283
Zanelli U et al. Induction of peroxisomal beta-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney. 1996 Arch. Toxicol. pmid:8825670
Sauber K et al. A new esterase for the cleavage of pivalic acid-containing prodrug esters of cephalosporins. 1996 Enzyme Microb. Technol. pmid:8672280
Abrahamsson K et al. Pivalic acid-induced carnitine deficiency and physical exercise in humans. 1996 Metab. Clin. Exp. pmid:8969283
Bianchi PB and Davis AT beta-Hydroxybutyrate oxidation is reduced and hepatic balance of ketone bodies and free fatty acids is unaltered in carnitine-depleted, pivalate-treated rats. 1996 J. Nutr. pmid:8914959
Bianchi PB et al. Carnitine supplementation ameliorates the steatosis and ketosis induced by pivalate in rats. 1996 J. Nutr. pmid:8914960
Lewin LM et al. Effects of pivalic acid and sodium pivalate on L-carnitine concentrations in the cauda epididymidis and on male fertility in the hamster. 1997 Reprod. Fertil. Dev. pmid:9402252
Cooper TG et al. Successful lowering of epididymal carnitine by administration of pivalate to rats. 1997 Int. J. Androl. pmid:9354188
Giordano F et al. Crystal forms of piroxicam pivalate: preparation and characterization of two polymorphs. 1998 J Pharm Sci pmid:9523987
Ohashi R et al. Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. 1999 J. Pharmacol. Exp. Ther. pmid:10525100
Celenligil-Cetin R et al. Synthesis, characterization, and reactivity of ferrous and ferric oxo/peroxo pivalate complexes in relation to Gif-type oxygenation of substrates. 2000 Inorg Chem pmid:11151387
Blanton MP et al. Examining the noncompetitive antagonist-binding site in the ion channel of the nicotinic acetylcholine receptor in the resting state. 2000 J. Biol. Chem. pmid:10652341
Yuan LC et al. Effect of carbonate salts on the kinetics of acid-catalyzed dimerization of adefovir dipivoxil. 2000 Pharm. Res. pmid:11087042
Wagner CA et al. Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2. 2000 Am. J. Physiol. Renal Physiol. pmid:10966938
Song R et al. Electrophilic substitution of (diamine)tetrahydroxoplatinum(IV) with carboxylic anhydrides. Synthesis and characterization of (diamine)platinum(IV) complexes of mixed carboxylates. 2000 Aug, 7 Inorg Chem pmid:11196816
Cutts SM et al. Molecular basis for the synergistic interaction of adriamycin with the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate (AN-9). 2001 Cancer Res. pmid:11719450
Kornilov AV et al. Preparative route to glucuronyl donors bearing temporary protecting group at O-3 via 6,3-lactonisation by Bz(2)O or Piv(2)O. 2001 Carbohydr. Res. pmid:11728399
Ricciolini R et al. The effect of pivalate treatment of pregnant rats on body mass and insulin levels in the adult offspring. 2001 Life Sci. pmid:11665835
Arrigoni-Martelli E and Caso V Carnitine protects mitochondria and removes toxic acyls from xenobiotics. 2001 Drugs Exp Clin Res pmid:11276827
Okudaira N et al. Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid. 2001 Pharm. Res. pmid:11451029
Arulsamy N and Bohle DS Multiplicity control in the polygeminal diazeniumdiolation of active hydrogen bearing carbons: chemistry of a new type of trianionic molecular propeller. 2001 J. Am. Chem. Soc. pmid:11686687
Darbeau RW et al. Boundary conditions on the partitioning of deaminatively generated benzyl cations. 2001 J. Org. Chem. pmid:11304187
Broderick TL et al. Short-term carnitine deficiency does not alter aerobic rat heart function but depresses reperfusion recovery after ischemia. 2001 Can. J. Physiol. Pharmacol. pmid:11697749
Cossy J et al. Synthesis of stereotriads by oxymercuration of substituted cyclopropylcarbinols. 2001 Org. Lett. pmid:11483062
Nishimura S et al. Application of a surface plasmon resonance sensor to analyses of amine compounds with the use of a polymer film and an acid-base reaction. 2002 Anal Sci pmid:11918182
Ebbing MH et al. Resorcinarenes with 2-benzimidazolone bridges: self-aggregation, self-assembled dimeric capsules, and guest encapsulation. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11959947
Li C et al. Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes. 2002 Chem. Res. Toxicol. pmid:12437340
Overgaard J et al. Host-guest chemistry of the chromium-wheel complex [Cr8F8(tBuCO2)16]: prediction of inclusion capabilities by using an electrostatic potential distribution determined by modeling synchrotron X-ray structure factors at 16 K. 2002 Chemistry pmid:12391657