Pivalic acid

Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pivalic acid?

Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pivalic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Otitis Media D010033 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Body Weight D001835 333 associated lipids
Psoriasis D011565 47 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Seizures D012640 87 associated lipids
Dermatitis D003872 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hyperinsulinism D006946 27 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Pivalic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pivalic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pivalic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pivalic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pivalic acid

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Per page 10 20 50 100 | Total 272
Authors Title Published Journal PubMed Link
pmid:
Bailey LF et al. The use of dexamethasone trimethylacetate to advance parturition in dairy cows. 1973 Aust. Vet. J. pmid:4777214
Fulkerson WJ and McDowell GH Artificial induction of lactation in cattle by use of dexamethasone trimethylacetate. 1975 Aust. J. Biol. Sci. pmid:1167131
Czerkawski JW and Breckenridge G New inhibitors of methane production by rumen micro-organisms. Development and testing of inhibitors in vitro. 1975 Br. J. Nutr. pmid:1201267
Fulkerson WJ et al. Artificial induction of lactation in ewes: the role of prolactin. 1975 Aust. J. Biol. Sci. pmid:1243818
Czerkawski JW The use of pivalic acid as a reference substance in measurements of production of volatile fatty acids by rumen micro-organisms in vitro. 1976 Br. J. Nutr. pmid:952843
Douglas KT et al. Mechanistic studies of carboxypeptidase Y. Kinetic detection of an acyl-enzyme intermediate in trimethylacetate esterase action. 1976 J. Am. Chem. Soc. pmid:993522
Sloan CA Proceedings: Comparison of dexamethasone trimethylacetate and prostaglandin F-2alpha as abortifacients in the cow. 1976 J. Reprod. Fertil. pmid:1255625
Reckers VR and Wendt H [Multicentre-clinical trial of the novel corticosteroid diflucortolone valerate in the forms of cream, ointment and fatty ointment. Part I: Comparative study of diflucortolone valerate with fluocortolone, -capronate, -pivalate in a double-blind contralateral design with topical application (author's transl)]. 1976 Arzneimittelforschung pmid:795433
Gaskell RM and Povey RC Experimental induction of feline viral rhinotracheitis virus re-excretion in FVR-recovered cats. 1977 Vet. Rec. pmid:191978
Wexler BC Corticotropin stimulation of hypertensive rats with and without arteriosclerosis. 1978 Arch. Pathol. Lab. Med. pmid:214053
Mazauric FX and Alligier B [Trial of tixocortol pivalate (Pivalone) in otorhinolaryngology]. 1978 J Fr Otorhinolaryngol Audiophonol Chir Maxillofac pmid:154555
Peel CJ et al. The importance of prolactin and the milking stimulus in the artificial induction of lactation in cows. 1978 Aust. J. Biol. Sci. pmid:678223
Nakamura T et al. Effect of d,l-alpha-tocopheryl esters on vitamin E-deficient rats. 1978 J. Nutr. Sci. Vitaminol. pmid:731332
MacDiarmid SC Betamethasone alcohol suspensions for the induction of parturition in dairy cows: a comparison with dexamethasone trimethyl acetate. 1979 N Z Vet J pmid:292913
Crofton JT et al. The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat. 1979 Jan-Feb Hypertension pmid:544512
Staatz WD et al. Cytotoxicity of pivalylphenylephrine and pivalic acid to corneal endothelium. 1980 Arch. Ophthalmol. pmid:7396784
Goldberg I et al. Dipivefrin: current concepts. 1980 Aust J Ophthalmol pmid:7004425
Deutsch C et al. Synaptosomes from rat brain: morphology, compartmentation, and transmembrane pH and electrical gradients. 1981 J. Neurochem. pmid:7241148
Fairclough RJ et al. Dexamethasone concentrations in plasma and milk of cows following the injection of long- and short-acting dexamethasone esters. 1981 Aust. J. Biol. Sci. pmid:7295211
Lloyd S et al. The effect of corticosteroid therapy on infection with Toxocara canis in dogs. 1981 Z Parasitenkd pmid:7324542
Mattocks AR and Cabral JR Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues. 1982 Cancer Lett. pmid:6817913
Andersson L et al. Glucose concentrations in plasma and urine after glucocorticoid injection in healthy cows. 1982 Apr-May Nord Vet Med pmid:6184673
Ercolani L and Schulte WE Metabolic and morphologic effects of colchicine on human T-lymphocyte expression of Fc mu and Fc gamma receptors. 1983 Cell. Immunol. pmid:6303602
Tamaru RD et al. Comparison of ocular disposition of free pivalic acid and pivalic acid esterified in dipivefrin. 1983 Arch. Ophthalmol. pmid:6347153
Van Dort M et al. Potential tumor or organ-imaging agents, 24. Radioiodinated pregnenolone esters. 1984 Steroids pmid:6537047
Vickers S et al. Metabolism of methyldopa in man after oral administration of the pivaloyloxyethyl ester. 1984 Mar-Apr Drug Metab. Dispos. pmid:6144491
Vickers S et al. Carnitine and glucuronic acid conjugates of pivalic acid. 1985 Xenobiotica pmid:4036169
Dzielak DJ and Norman RA Renal nerves are not necessary for onset or maintenance of DOC-salt hypertension in rats. 1985 Am. J. Physiol. pmid:4061671
Romani G et al. H extrusion and potassium uptake associated with potential hyperpolarization in maize and wheat root segments treated with permeant weak acids. 1985 Plant Physiol. pmid:16664483
Johnston NE and Stewart JA The effect of glucocorticoids and prematurity on absorption of colostral immunoglobulin in the calf. 1986 Aust. Vet. J. pmid:3767799
Foussereau J and Jelen G [An unrecognized cause of allergic eczema of the face: a corticoid, tixocortol pivalate]. 1987 Presse Med pmid:2954110
Chattopadhyay SP et al. Betamethasone dipropionate (0.05%) plus salicylic acid (3%) ointment versus dexamethasone trimethyl acetate (1%) and salicylic acid 4% ointments in chronic dermatoses. 1987 Indian J Dermatol pmid:3453353
Melegh B et al. Pivampicillin-promoted excretion of pivaloylcarnitine in humans. 1987 Biochem. Pharmacol. pmid:3675603
Sciotti V and Gallant S Resistance to mineralocorticoid-induced hypertensive vascular disease. 1987 Hypertension pmid:3610293
Hussain MA et al. Improvement of the oral bioavailability of naltrexone in dogs: a prodrug approach. 1987 J Pharm Sci pmid:3656096
Lelièvre V et al. Correlation between binding activity, inhibition of lymphoblastic transformation and metabolism of tixocortol 21 pivalate in mouse thymocytes. 1987 Agents Actions pmid:3500591
Basso B and Ullrich-Eberius CI Membrane Potential and Proton Cotransport of Alanine and Phosphate as Affected by Permeant Weak Acids in Lemna gibba. 1987 Plant Physiol. pmid:16665758
Bruner CA et al. Area postrema ablation and vascular reactivity in deoxycorticosterone-salt-treated rats. 1988 Hypertension pmid:3391678
Ueno Y et al. Characteristics of hormonal and neurogenic mechanisms of deoxycorticosterone-induced hypertension. 1988 Hypertension pmid:3346052
Maurer H and Kessler C Identification and quantification of ethylene glycol and diethylene glycol in plasma using gas chromatography-mass spectrometry. 1988 Arch. Toxicol. pmid:3190459
Holme E et al. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. 1989 Lancet pmid:2570185
Melegh B Carnitine supplementation in pivampicillin treatment. 1989 Lancet pmid:2572813
Hughes CS et al. Effects of certain stress factors on the re-excretion of infectious laryngotracheitis virus from latently infected carrier birds. 1989 Res. Vet. Sci. pmid:2539638
Stanton BA Characterization of apical and basolateral membrane conductances of rat inner medullary collecting duct. 1989 Am. J. Physiol. pmid:2719119
Haradahira T et al. Potential tumor- or organ-imaging agents. 29. Radioiodinated esters and amides of 20-hydroxy- and 20-aminopregn-5-en-3 beta-ols. 1989 J. Med. Chem. pmid:2918507
Freed JJ et al. Evidence for acyloxymethyl esters of pyrimidine 5'-deoxyribonucleotides as extracellular sources of active 5'-deoxyribonucleotides in cultured cells. 1989 Biochem. Pharmacol. pmid:2818620
Tomić S et al. Partial purification of esterases from rabbit serum and their use in regioselective deacylations of sugars. 1991 Carbohydr. Res. pmid:1878876
Ruff LJ and Brass EP Metabolic effects of pivalate in isolated rat hepatocytes. 1991 Toxicol. Appl. Pharmacol. pmid:1891775
Bianchi PB and Davis AT Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats. 1991 J. Nutr. pmid:1941267