Pivalic acid

Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pivalic acid?

Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pivalic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Otitis Media D010033 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Body Weight D001835 333 associated lipids
Psoriasis D011565 47 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Seizures D012640 87 associated lipids
Dermatitis D003872 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hyperinsulinism D006946 27 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Pivalic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pivalic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Pivalic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pivalic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pivalic acid

Download all related citations
Per page 10 20 50 100 | Total 272
Authors Title Published Journal PubMed Link
Hong AW et al. An expedient route to Montanine-type Amaryllidaceae alkaloids: total syntheses of (-)-brunsvigine and (-)-manthine. 2008 J. Org. Chem. pmid:18781802
Rao ChB et al. An efficient protocol for alcohol protection under solvent- and catalyst-free conditions. 2009 J. Org. Chem. pmid:19839567
Chakraborti AK and Shivani S Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst. 2006 J. Org. Chem. pmid:16839166
Liégault B et al. Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds. 2009 J. Org. Chem. pmid:19206211
Darbeau RW et al. Boundary conditions on the partitioning of deaminatively generated benzyl cations. 2001 J. Org. Chem. pmid:11304187
Zhou Q et al. In situ generation of palladium nanoparticles: ligand-free palladium catalyzed pivalic acid assisted carbonylative Suzuki reactions at ambient conditions. 2014 J. Org. Chem. pmid:24397578
Liégault B et al. Intramolecular Pd(II)-catalyzed oxidative biaryl synthesis under air: reaction development and scope. 2008 J. Org. Chem. pmid:18543991
Li C et al. In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat. 2003 J. Pharmacol. Exp. Ther. pmid:12649376
Ohashi R et al. Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. 1999 J. Pharmacol. Exp. Ther. pmid:10525100
Sloan CA Proceedings: Comparison of dexamethasone trimethylacetate and prostaglandin F-2alpha as abortifacients in the cow. 1976 J. Reprod. Fertil. pmid:1255625
Dilks JR and Flaumenhaft R Fluoxetine (Prozac) augments platelet activation mediated through protease-activated receptors. 2008 J. Thromb. Haemost. pmid:18194419
Fujii R et al. [Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients]. 1993 Jpn J Antibiot pmid:8254895
Holme E et al. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. 1989 Lancet pmid:2570185
Melegh B Carnitine supplementation in pivampicillin treatment. 1989 Lancet pmid:2572813
Kotal A et al. Ultrasound-induced in situ formation of coordination organogels from isobutyric acids and zinc oxide nanoparticles. 2010 Langmuir pmid:20020763
Ikeda M et al. Scanning tunneling microscopy study of black dye and deoxycholic acid adsorbed on a rutile TiO2(110). 2008 Langmuir pmid:18590297
Takahashi Y et al. A case of sudden unexpected infant death involving a homozygotic twin with the thermolabile CPT2 variant, accompanied by rotavirus infection and treatment with an antibiotic containing pivalic acid. 2016 Leg Med (Tokyo) pmid:27591533
Morris GS et al. Sodium pivalate reduces cardiac carnitine content and increases glucose oxidation without affecting cardiac functional capacity. 1995 Life Sci. pmid:7475977
Ricciolini R et al. The effect of pivalate treatment of pregnant rats on body mass and insulin levels in the adult offspring. 2001 Life Sci. pmid:11665835
Fagerholm AE et al. Calyculins and related marine natural products as serine-threonine protein phosphatase PP1 and PP2A inhibitors and total syntheses of calyculin A, B, and C. 2010 Mar Drugs pmid:20161975
Yahyaoui R et al. [C5-carnitine false positive results in newborn screening: what is the cause?]. 2015 Med Clin (Barc) pmid:24889749
Broderick TL et al. Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency. 1995 Metab. Clin. Exp. pmid:7723673
Abrahamsson K et al. Pivalic acid-induced carnitine deficiency and physical exercise in humans. 1996 Metab. Clin. Exp. pmid:8969283
Rohwerder T and Müller RH Biosynthesis of 2-hydroxyisobutyric acid (2-HIBA) from renewable carbon. 2010 Microb. Cell Fact. pmid:20184738
Villa G et al. Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus. 2010 Mol Pain pmid:21143950
Boemer F et al. Surprising causes of C5-carnitine false positive results in newborn screening. 2014 Mol. Genet. Metab. pmid:24291264
Xu S et al. Transport of L-carnitine in human corneal and conjunctival epithelial cells. 2010 Mol. Vis. pmid:21045919
MacDiarmid SC Betamethasone alcohol suspensions for the induction of parturition in dairy cows: a comparison with dexamethasone trimethyl acetate. 1979 N Z Vet J pmid:292913
Shan Y et al. Rapid acyl migration between pyrogallyl 1,2- and 1,3-dipivaloates. 2012 Nat Prod Commun pmid:22545406
Quintas C et al. The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. 2009 Neurochem. Int. pmid:19447154
Rispoli V et al. Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert. 2004 Neurosci. Lett. pmid:15036629
Zizzo MG et al. Inhibitory purinergic transmission in mouse caecum: role for P2Y1 receptors as prejunctional modulators of ATP release. 2007 Neuroscience pmid:17997228
Andersson L et al. Glucose concentrations in plasma and urine after glucocorticoid injection in healthy cows. 1982 Apr-May Nord Vet Med pmid:6184673
Kumar P et al. [131I]Iodoazomycin arabinoside for low-dose-rate isotope radiotherapy: radiolabeling, stability, long-term whole-body clearance and radiation dosimetry estimates in mice. 2005 Nucl. Med. Biol. pmid:16026712
Sobkowski M et al. Stereochemistry of internucleotide bond formation by the H-phosphonate method. 5. The role of Brønsted and H-bonding base catalysis in ribonucleoside H-phosphonate condensation-chemical and stereochemical consequences. 2010 Nucleosides Nucleotides Nucleic Acids pmid:20661816
Wu M et al. Synthesis of 9-[1-(substituted)-3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents. 2005 Nucleosides Nucleotides Nucleic Acids pmid:16438034
Kim D and Hong S Palladium(II)-catalyzed direct intermolecular alkenylation of chromones. 2011 Org. Lett. pmid:21797199
Goswami S et al. Recognition of carboxylate anions and carboxylic acids by selenium-based new chromogenic fluorescent sensor: a remarkable fluorescence enhancement of hindered carboxylates. 2009 Org. Lett. pmid:19728733
Murakami K et al. Chromium-catalyzed arylmagnesiation of alkynes. 2007 Org. Lett. pmid:17352489
Srinivas HD et al. Enantiospecific, nickel-catalyzed cross-couplings of allylic pivalates and arylboroxines. 2014 Org. Lett. pmid:24927013
Cossy J et al. Synthesis of stereotriads by oxymercuration of substituted cyclopropylcarbinols. 2001 Org. Lett. pmid:11483062
Nasu T et al. Newborn hypocarnitinemia due to long-term transplacental pivalic acid passage. 2014 Pediatr Int pmid:25335995
Makino Y et al. Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid. 2007 Pediatrics pmid:17724113
Okudaira N et al. Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid. 2001 Pharm. Res. pmid:11451029
Yuan LC et al. Effect of carbonate salts on the kinetics of acid-catalyzed dimerization of adefovir dipivoxil. 2000 Pharm. Res. pmid:11087042
Okamura N et al. Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid. 2006 Pharm. Res. pmid:16826461
Rispoli V et al. Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats. 2004 Pharmacol. Biochem. Behav. pmid:15301920
Brass EP Pivalate-generating prodrugs and carnitine homeostasis in man. 2002 Pharmacol. Rev. pmid:12429869
Chisholm MH Mixed valence complexes involving MM quadruple bonds (M=Mo or W). 2008 Philos Trans A Math Phys Eng Sci pmid:17846014
Lyubinetsky I et al. Adsorption states and mobility of trimethylacetic acid molecules on reduced TiO(2)(110) surface. 2010 Phys Chem Chem Phys pmid:20490397
Färber K et al. Selective desensitization of jasmonate- and pH-dependent signaling in the induction of benzophenanthridine biosynthesis in cells of Eschscholzia californica. 2003 Phytochemistry pmid:12620362
Romani G et al. H extrusion and potassium uptake associated with potential hyperpolarization in maize and wheat root segments treated with permeant weak acids. 1985 Plant Physiol. pmid:16664483
Basso B and Ullrich-Eberius CI Membrane Potential and Proton Cotransport of Alanine and Phosphate as Affected by Permeant Weak Acids in Lemna gibba. 1987 Plant Physiol. pmid:16665758
Lam KK et al. Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis. 2012 PLoS Pathog. pmid:22589723
Foussereau J and Jelen G [An unrecognized cause of allergic eczema of the face: a corticoid, tixocortol pivalate]. 1987 Presse Med pmid:2954110
Ebbing MH et al. Resorcinarenes with 2-benzimidazolone bridges: self-aggregation, self-assembled dimeric capsules, and guest encapsulation. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11959947
Jacobson KA et al. Development of selective agonists and antagonists of P2Y receptors. 2009 Purinergic Signal. pmid:18600475
Lewin LM et al. Effects of pivalic acid and sodium pivalate on L-carnitine concentrations in the cauda epididymidis and on male fertility in the hamster. 1997 Reprod. Fertil. Dev. pmid:9402252
Doberenz J et al. Pivalate lowers litter sizes and weights in female rats independent of its effect on carnitine status. 2007 Reprod. Toxicol. pmid:17482425
Hughes CS et al. Effects of certain stress factors on the re-excretion of infectious laryngotracheitis virus from latently infected carrier birds. 1989 Res. Vet. Sci. pmid:2539638
Holme E et al. Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children. 1992 Scand. J. Clin. Lab. Invest. pmid:1514015
Van Dort M et al. Potential tumor or organ-imaging agents, 24. Radioiodinated pregnenolone esters. 1984 Steroids pmid:6537047
Nakajima Y et al. Detection of pivaloylcarnitine in pediatric patients with hypocarnitinemia after long-term administration of pivalate-containing antibiotics. 2010 Tohoku J. Exp. Med. pmid:20651467
Cornwell PD and Ulrich RG Investigating the mechanistic basis for hepatic toxicity induced by an experimental chemokine receptor 5 (CCR5) antagonist using a compendium of gene expression profiles. 2007 Toxicol Pathol pmid:17654398
Ruff LJ and Brass EP Metabolic effects of pivalate in isolated rat hepatocytes. 1991 Toxicol. Appl. Pharmacol. pmid:1891775
Yamaguchi T et al. Possible mechanism for species difference on the toxicity of pivalic acid between dogs and rats. 2006 Toxicol. Appl. Pharmacol. pmid:16430936
Li C et al. In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. 2003 Toxicol. Appl. Pharmacol. pmid:12649042
Niezen JH et al. The effect of feeding sulla (Hedysarum coronarium) or lucerne (Medicago sativa) on lamb parasite burdens and development of immunity to gastrointestinal nematodes. 2002 Vet. Parasitol. pmid:11934463
Gaskell RM and Povey RC Experimental induction of feline viral rhinotracheitis virus re-excretion in FVR-recovered cats. 1977 Vet. Rec. pmid:191978
Vickers S et al. Carnitine and glucuronic acid conjugates of pivalic acid. 1985 Xenobiotica pmid:4036169
Melegh B et al. Preferential elimination of pivalate with supplemental carnitine via formation of pivaloylcarnitine in man. 1993 Xenobiotica pmid:8310709
Lloyd S et al. The effect of corticosteroid therapy on infection with Toxocara canis in dogs. 1981 Z Parasitenkd pmid:7324542