Pivalic acid

Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pivalic acid?

Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pivalic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Otitis Media D010033 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Body Weight D001835 333 associated lipids
Psoriasis D011565 47 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Seizures D012640 87 associated lipids
Dermatitis D003872 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hyperinsulinism D006946 27 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Pivalic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pivalic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pivalic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pivalic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pivalic acid

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Authors Title Published Journal PubMed Link
Zanelli U et al. Induction of peroxisomal beta-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney. 1996 Arch. Toxicol. pmid:8825670
Sauber K et al. A new esterase for the cleavage of pivalic acid-containing prodrug esters of cephalosporins. 1996 Enzyme Microb. Technol. pmid:8672280
Broderick TL et al. L-propionylcarnitine effects on cardiac carnitine content and function in secondary carnitine deficiency. 1995 Can. J. Physiol. Pharmacol. pmid:7671193
Broderick TL et al. Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency. 1995 Metab. Clin. Exp. pmid:7723673
Broderick TL et al. L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts. 1995 Cardiovasc. Res. pmid:8595631
Davis AT Carnitine depletion in rat pups of lactating mothers given sodium pivalate. 1995 Biol. Neonate pmid:8534786
Abrahamsson K et al. Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid. 1995 Br Heart J pmid:8541173
Morris GS et al. Sodium pivalate reduces cardiac carnitine content and increases glucose oxidation without affecting cardiac functional capacity. 1995 Life Sci. pmid:7475977
Mizojiri K et al. Disposition of S-1108, a new oral cephem antibiotic, and metabolic fate of pivalic acid liberated from [pivaloyl-14C]S-1108 in rats and dogs. 1995 Antimicrob. Agents Chemother. pmid:7492083
Diep QN et al. Formation of pivaloylcarnitine in isolated rat heart cells. 1995 Biochim. Biophys. Acta pmid:7488636
Abrahamsson K et al. Effect of short-term treatment with pivalic acid containing antibiotics on serum carnitine concentration--a risk irrespective of age. 1995 Biochem. Mol. Med. pmid:7551831
Diep QN et al. Formation of pivaloylcarnitine in heart and brown adipose tissue in the rat. 1995 Biochim. Biophys. Acta pmid:7827109
Diep QN and Bøhmer T Increased pivaloylcarnitine in the liver of the sodium pivalate treated rat exposed to clofibrate. 1995 Biochim. Biophys. Acta pmid:7766704
Abrahamsson K et al. Impaired ketogenesis in carnitine depletion caused by short-term administration of pivalic acid prodrug. 1994 Biochem. Med. Metab. Biol. pmid:7917463
Fujii R et al. [Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients]. 1993 Jpn J Antibiot pmid:8254895
Shimizu K et al. Carnitine status and safety after administration of S-1108, a new oral cephem, to patients. 1993 Antimicrob. Agents Chemother. pmid:8517691
Melegh B et al. Preferential elimination of pivalate with supplemental carnitine via formation of pivaloylcarnitine in man. 1993 Xenobiotica pmid:8310709
Wang SS et al. Cleavage and deprotection of peptides on MBHA-resin with hydrogen bromide. 1992 Sep-Oct Int. J. Pept. Protein Res. pmid:1335998
Holme E et al. Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children. 1992 Scand. J. Clin. Lab. Invest. pmid:1514015
Konishi M and Hashimoto H Determination of pivaloylcarnitine in human plasma and urine by high-performance liquid chromatography with fluorescence detection. 1992 J Pharm Sci pmid:1432617
Totsuka K et al. Metabolism of S-1108, a new oral cephem antibiotic, and metabolic profiles of its metabolites in humans. 1992 Antimicrob. Agents Chemother. pmid:1503437
Nakashima M et al. Phase I clinical studies of S-1108: safety and pharmacokinetics in a multiple-administration study with special emphasis on the influence on carnitine body stores. 1992 Antimicrob. Agents Chemother. pmid:1503438
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Ruff LJ and Brass EP Metabolic effects of pivalate in isolated rat hepatocytes. 1991 Toxicol. Appl. Pharmacol. pmid:1891775
Bianchi PB and Davis AT Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats. 1991 J. Nutr. pmid:1941267
Holme E et al. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. 1989 Lancet pmid:2570185
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Foussereau J and Jelen G [An unrecognized cause of allergic eczema of the face: a corticoid, tixocortol pivalate]. 1987 Presse Med pmid:2954110
Chattopadhyay SP et al. Betamethasone dipropionate (0.05%) plus salicylic acid (3%) ointment versus dexamethasone trimethyl acetate (1%) and salicylic acid 4% ointments in chronic dermatoses. 1987 Indian J Dermatol pmid:3453353
Melegh B et al. Pivampicillin-promoted excretion of pivaloylcarnitine in humans. 1987 Biochem. Pharmacol. pmid:3675603
Sciotti V and Gallant S Resistance to mineralocorticoid-induced hypertensive vascular disease. 1987 Hypertension pmid:3610293
Hussain MA et al. Improvement of the oral bioavailability of naltrexone in dogs: a prodrug approach. 1987 J Pharm Sci pmid:3656096
Lelièvre V et al. Correlation between binding activity, inhibition of lymphoblastic transformation and metabolism of tixocortol 21 pivalate in mouse thymocytes. 1987 Agents Actions pmid:3500591
Basso B and Ullrich-Eberius CI Membrane Potential and Proton Cotransport of Alanine and Phosphate as Affected by Permeant Weak Acids in Lemna gibba. 1987 Plant Physiol. pmid:16665758
Johnston NE and Stewart JA The effect of glucocorticoids and prematurity on absorption of colostral immunoglobulin in the calf. 1986 Aust. Vet. J. pmid:3767799
Vickers S et al. Carnitine and glucuronic acid conjugates of pivalic acid. 1985 Xenobiotica pmid:4036169
Dzielak DJ and Norman RA Renal nerves are not necessary for onset or maintenance of DOC-salt hypertension in rats. 1985 Am. J. Physiol. pmid:4061671
Romani G et al. H extrusion and potassium uptake associated with potential hyperpolarization in maize and wheat root segments treated with permeant weak acids. 1985 Plant Physiol. pmid:16664483
Vickers S et al. Metabolism of methyldopa in man after oral administration of the pivaloyloxyethyl ester. 1984 Mar-Apr Drug Metab. Dispos. pmid:6144491
Van Dort M et al. Potential tumor or organ-imaging agents, 24. Radioiodinated pregnenolone esters. 1984 Steroids pmid:6537047
Ercolani L and Schulte WE Metabolic and morphologic effects of colchicine on human T-lymphocyte expression of Fc mu and Fc gamma receptors. 1983 Cell. Immunol. pmid:6303602
Tamaru RD et al. Comparison of ocular disposition of free pivalic acid and pivalic acid esterified in dipivefrin. 1983 Arch. Ophthalmol. pmid:6347153
Andersson L et al. Glucose concentrations in plasma and urine after glucocorticoid injection in healthy cows. 1982 Apr-May Nord Vet Med pmid:6184673
Mattocks AR and Cabral JR Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues. 1982 Cancer Lett. pmid:6817913
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Fairclough RJ et al. Dexamethasone concentrations in plasma and milk of cows following the injection of long- and short-acting dexamethasone esters. 1981 Aust. J. Biol. Sci. pmid:7295211
Lloyd S et al. The effect of corticosteroid therapy on infection with Toxocara canis in dogs. 1981 Z Parasitenkd pmid:7324542
Staatz WD et al. Cytotoxicity of pivalylphenylephrine and pivalic acid to corneal endothelium. 1980 Arch. Ophthalmol. pmid:7396784
Goldberg I et al. Dipivefrin: current concepts. 1980 Aust J Ophthalmol pmid:7004425
Crofton JT et al. The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat. 1979 Jan-Feb Hypertension pmid:544512
MacDiarmid SC Betamethasone alcohol suspensions for the induction of parturition in dairy cows: a comparison with dexamethasone trimethyl acetate. 1979 N Z Vet J pmid:292913
Wexler BC Corticotropin stimulation of hypertensive rats with and without arteriosclerosis. 1978 Arch. Pathol. Lab. Med. pmid:214053
Mazauric FX and Alligier B [Trial of tixocortol pivalate (Pivalone) in otorhinolaryngology]. 1978 J Fr Otorhinolaryngol Audiophonol Chir Maxillofac pmid:154555
Peel CJ et al. The importance of prolactin and the milking stimulus in the artificial induction of lactation in cows. 1978 Aust. J. Biol. Sci. pmid:678223
Nakamura T et al. Effect of d,l-alpha-tocopheryl esters on vitamin E-deficient rats. 1978 J. Nutr. Sci. Vitaminol. pmid:731332
Gaskell RM and Povey RC Experimental induction of feline viral rhinotracheitis virus re-excretion in FVR-recovered cats. 1977 Vet. Rec. pmid:191978
Czerkawski JW The use of pivalic acid as a reference substance in measurements of production of volatile fatty acids by rumen micro-organisms in vitro. 1976 Br. J. Nutr. pmid:952843
Douglas KT et al. Mechanistic studies of carboxypeptidase Y. Kinetic detection of an acyl-enzyme intermediate in trimethylacetate esterase action. 1976 J. Am. Chem. Soc. pmid:993522
Sloan CA Proceedings: Comparison of dexamethasone trimethylacetate and prostaglandin F-2alpha as abortifacients in the cow. 1976 J. Reprod. Fertil. pmid:1255625
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Fulkerson WJ and McDowell GH Artificial induction of lactation in cattle by use of dexamethasone trimethylacetate. 1975 Aust. J. Biol. Sci. pmid:1167131
Czerkawski JW and Breckenridge G New inhibitors of methane production by rumen micro-organisms. Development and testing of inhibitors in vitro. 1975 Br. J. Nutr. pmid:1201267
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