| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Urinary Tract Infections | D014552 | 11 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Dermatitis | D003872 | 30 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
Pivalic acid
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Pivalic acid?
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Pivalic acid
PubChem Associated disorders and diseases
What pathways are associated with Pivalic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Pivalic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Pivalic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Pivalic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Pivalic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with Pivalic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Pivalic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| ZÃdek Z et al. | Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir. | 2005 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:16601779 |
| Lee J et al. | 2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands. | 2006 | Bioorg. Med. Chem. | pmid:16297629 |
| Wiemer AJ et al. | Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. | 2008 | Bioorg. Med. Chem. | pmid:18308574 |
| Tong L et al. | Development of a prodrug of hydantoin based TACE inhibitor. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28711352 |
| Rumschinski P et al. | Set-base dynamical parameter estimation and model invalidation for biochemical reaction networks. | 2010 | BMC Syst Biol | pmid:20500862 |
| Abrahamsson K et al. | Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid. | 1995 | Br Heart J | pmid:8541173 |
| Czerkawski JW | The use of pivalic acid as a reference substance in measurements of production of volatile fatty acids by rumen micro-organisms in vitro. | 1976 | Br. J. Nutr. | pmid:952843 |
| Czerkawski JW and Breckenridge G | New inhibitors of methane production by rumen micro-organisms. Development and testing of inhibitors in vitro. | 1975 | Br. J. Nutr. | pmid:1201267 |
| Govindan S et al. | Ca(2+) signalling by P2Y receptors in cultured rat aortic smooth muscle cells. | 2010 | Br. J. Pharmacol. | pmid:20649593 |
| Andó RD et al. | A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain. | 2010 | Br. J. Pharmacol. | pmid:20136836 |
| Zizzo MG et al. | Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon. | 2007 | Br. J. Pharmacol. | pmid:17351663 |
| Broderick TL et al. | L-propionylcarnitine effects on cardiac carnitine content and function in secondary carnitine deficiency. | 1995 | Can. J. Physiol. Pharmacol. | pmid:7671193 |
| Broderick TL et al. | Short-term carnitine deficiency does not alter aerobic rat heart function but depresses reperfusion recovery after ischemia. | 2001 | Can. J. Physiol. Pharmacol. | pmid:11697749 |
| Mattocks AR and Cabral JR | Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues. | 1982 | Cancer Lett. | pmid:6817913 |
| Cutts SM et al. | Molecular basis for the synergistic interaction of adriamycin with the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate (AN-9). | 2001 | Cancer Res. | pmid:11719450 |
| Barroca N and Jacquinet JC | An access to various sulfation patterns in dermatan sulfate: chemical syntheses of sulfoforms of trisaccharide methyl glycosides. | 2002 | Carbohydr. Res. | pmid:11950464 |
| Tomić S et al. | Partial purification of esterases from rabbit serum and their use in regioselective deacylations of sugars. | 1991 | Carbohydr. Res. | pmid:1878876 |
| Kornilov AV et al. | Preparative route to glucuronyl donors bearing temporary protecting group at O-3 via 6,3-lactonisation by Bz(2)O or Piv(2)O. | 2001 | Carbohydr. Res. | pmid:11728399 |
| Broderick TL et al. | L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts. | 1995 | Cardiovasc. Res. | pmid:8595631 |
| Kuka J et al. | A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function. | 2012 | Cardiovasc. Toxicol. | pmid:22539084 |