| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Urinary Tract Infections | D014552 | 11 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Dermatitis | D003872 | 30 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
Pivalic acid
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Pivalic acid?
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Pivalic acid
PubChem Associated disorders and diseases
What pathways are associated with Pivalic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Pivalic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Pivalic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Pivalic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Pivalic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with Pivalic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Pivalic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Slusarski T et al. | Electronic structure and magnetic properties of a molecular octanuclear chromium-based ring. | 2011 | J Nanosci Nanotechnol | pmid:22400306 |
| Xu W et al. | Identification and characterization of three impurities in clocortolone pivalate. | 2012 | J Pharm Biomed Anal | pmid:22264563 |
| Wu DR et al. | Additive free preparative chiral SFC separations of 2,2-dimethyl-3-aryl-propanoic acids. | 2016 | J Pharm Biomed Anal | pmid:27522108 |
| Hussain MA et al. | Improvement of the oral bioavailability of naltrexone in dogs: a prodrug approach. | 1987 | J Pharm Sci | pmid:3656096 |
| Konishi M and Hashimoto H | Determination of pivaloylcarnitine in human plasma and urine by high-performance liquid chromatography with fluorescence detection. | 1992 | J Pharm Sci | pmid:1432617 |
| Giordano F et al. | Crystal forms of piroxicam pivalate: preparation and characterization of two polymorphs. | 1998 | J Pharm Sci | pmid:9523987 |
| Suga K et al. | Photocatalytic oxygenation of pivalic acid with molecular oxygen via photoinduced electron transfer using 10-methylacridinium ions. | 2006 | J Phys Chem A | pmid:16539406 |
| Berg ER et al. | Ion-pair interaction in pyridinium carboxylate solutions. | 2008 | J Phys Chem A | pmid:18189374 |
| Greaves TL et al. | Protic ionic liquids: physicochemical properties and behavior as amphiphile self-assembly solvents. | 2008 | J Phys Chem B | pmid:18166036 |
| Sasahara A et al. | STM observation of a ruthenium dye adsorbed on a TiO2(110) surface. | 2006 | J Phys Chem B | pmid:16526711 |
| Ito T | Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism. | 2009 | J Toxicol Sci | pmid:19571472 |
| Goikhman R et al. | C-H bonds as ubiquitous functionality: a general approach to complex arylated pyrazoles via sequential regioselective C-arylation and N-alkylation enabled by SEM-group transposition. | 2009 | J. Am. Chem. Soc. | pmid:19206533 |
| Douglas KT et al. | Mechanistic studies of carboxypeptidase Y. Kinetic detection of an acyl-enzyme intermediate in trimethylacetate esterase action. | 1976 | J. Am. Chem. Soc. | pmid:993522 |
| Ferrer Flegeau E et al. | Autocatalysis for C-H bond activation by ruthenium(II) complexes in catalytic arylation of functional arenes. | 2011 | J. Am. Chem. Soc. | pmid:21604765 |
| Spino C et al. | A stereodivergent approach to chiral nonracemic N-protected alpha,alpha-dialkylated amino acids. | 2003 | J. Am. Chem. Soc. | pmid:14518992 |
| Rousseaux S et al. | Investigation of the mechanism of C(sp3)-H bond cleavage in Pd(0)-catalyzed intramolecular alkane arylation adjacent to amides and sulfonamides. | 2010 | J. Am. Chem. Soc. | pmid:20681702 |
| Li G et al. | Au-catalyzed synthesis of (1Z,3E)-2-pivaloxy-1,3-dienes from propargylic pivalates. | 2008 | J. Am. Chem. Soc. | pmid:18311985 |
| Sibi MP and Zimmerman J | Pyrones to pyrans: enantioselective radical additions to acyloxy pyrones. | 2006 | J. Am. Chem. Soc. | pmid:17031933 |
| Quasdorf KW et al. | Cross-coupling reactions of aryl pivalates with boronic acids. | 2008 | J. Am. Chem. Soc. | pmid:18839946 |
| Lafrance M and Fagnou K | Palladium-catalyzed benzene arylation: incorporation of catalytic pivalic acid as a proton shuttle and a key element in catalyst design. | 2006 | J. Am. Chem. Soc. | pmid:17177387 |
| Arulsamy N and Bohle DS | Multiplicity control in the polygeminal diazeniumdiolation of active hydrogen bearing carbons: chemistry of a new type of trianionic molecular propeller. | 2001 | J. Am. Chem. Soc. | pmid:11686687 |
| Milios CJ et al. | Toward a magnetostructural correlation for a family of Mn6 SMMs. | 2007 | J. Am. Chem. Soc. | pmid:17887755 |
| Muto K et al. | Isolation, structure, and reactivity of an arylnickel(II) pivalate complex in catalytic C-H/C-O biaryl coupling. | 2013 | J. Am. Chem. Soc. | pmid:24152083 |
| Zhou Q et al. | Nickel-catalyzed cross-couplings of benzylic pivalates with arylboroxines: stereospecific formation of diarylalkanes and triarylmethanes. | 2013 | J. Am. Chem. Soc. | pmid:23425080 |
| Wang X et al. | Direct C-arylation of free (NH)-indoles and pyrroles catalyzed by Ar-Rh(III) complexes assembled in situ. | 2005 | J. Am. Chem. Soc. | pmid:15810815 |
| Qian H et al. | Platinum-catalyzed intramolecular hydroalkoxylation of gamma- and delta-hydroxy olefins to form cyclic ethers. | 2004 | J. Am. Chem. Soc. | pmid:15291546 |
| Bursten BE et al. | Oxalate-bridged complexes of dimolybdenum and ditungsten supported by pivalate ligands: ((t)BuCO(2))(3)M(2)(mu-O(2)CCO(2))M(2)(O(2)C(t)Bu)(3). Correlation of the solid-state, molecular, and electronic structures with Raman, resonance Raman, and electronic spectral data. | 2002 | J. Am. Chem. Soc. | pmid:11902897 |
| Lu Q et al. | Mechanistic study of chemoselectivity in Ni-catalyzed coupling reactions between azoles and aryl carboxylates. | 2014 | J. Am. Chem. Soc. | pmid:24823646 |
| Solano-Serena F et al. | Degradation of isooctane by Mycobacterium austroafricanum IFP 2173: growth and catabolic pathway. | 2004 | J. Appl. Microbiol. | pmid:15281945 |
| Schmidt J et al. | Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. | 2011 | J. Biol. Chem. | pmid:21220428 |
| Cracan V and Banerjee R | Novel coenzyme B12-dependent interconversion of isovaleryl-CoA and pivalyl-CoA. | 2012 | J. Biol. Chem. | pmid:22167181 |
| Blanton MP et al. | Examining the noncompetitive antagonist-binding site in the ion channel of the nicotinic acetylcholine receptor in the resting state. | 2000 | J. Biol. Chem. | pmid:10652341 |
| Mascolo G et al. | Effectiveness of UV-based advanced oxidation processes for the remediation of hydrocarbon pollution in the groundwater: a laboratory investigation. | 2008 | J. Hazard. Mater. | pmid:17890002 |
| Mitani MM et al. | Kinetics and products of reactions of MTBE with ozone and ozone/hydrogen peroxide in water. | 2002 | J. Hazard. Mater. | pmid:11744205 |
| Rasmussen J et al. | Primary carnitine deficiency and pivalic acid exposure causing encephalopathy and fatal cardiac events. | 2013 | J. Inherit. Metab. Dis. | pmid:22566287 |
| Will KW et al. | Quantification and evidence for mechanically metered release of pygidial secretions in formic acid-producing carabid beetles. | 2010 | J. Insect Sci. | pmid:20575743 |
| Shoman ME et al. | Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties. | 2011 | J. Med. Chem. | pmid:21247168 |
| Berkovitch G et al. | Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation. | 2008 | J. Med. Chem. | pmid:19007111 |
| Haradahira T et al. | Potential tumor- or organ-imaging agents. 29. Radioiodinated esters and amides of 20-hydroxy- and 20-aminopregn-5-en-3 beta-ols. | 1989 | J. Med. Chem. | pmid:2918507 |
| Wurm A et al. | Endogenous purinergic signaling is required for osmotic volume regulation of retinal glial cells. | 2010 | J. Neurochem. | pmid:20002522 |
| Deutsch C et al. | Synaptosomes from rat brain: morphology, compartmentation, and transmembrane pH and electrical gradients. | 1981 | J. Neurochem. | pmid:7241148 |
| Witney TH et al. | Preclinical evaluation of 3-18F-fluoro-2,2-dimethylpropionic acid as an imaging agent for tumor detection. | 2014 | J. Nucl. Med. | pmid:25012458 |
| Bianchi PB and Davis AT | Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats. | 1991 | J. Nutr. | pmid:1941267 |
| Nakajima H et al. | Pivalate affects carnitine status but causes no severe metabolic changes in rat liver. | 1996 | J. Nutr. | pmid:8648443 |
| Bianchi PB and Davis AT | beta-Hydroxybutyrate oxidation is reduced and hepatic balance of ketone bodies and free fatty acids is unaltered in carnitine-depleted, pivalate-treated rats. | 1996 | J. Nutr. | pmid:8914959 |
| Bianchi PB et al. | Carnitine supplementation ameliorates the steatosis and ketosis induced by pivalate in rats. | 1996 | J. Nutr. | pmid:8914960 |
| Davis AT and Monroe TJ | Carnitine deficiency and supplementation do not affect the gene expression of carnitine biosynthetic enzymes in rats. | 2005 | J. Nutr. | pmid:15795431 |
| Nakamura T et al. | Effect of d,l-alpha-tocopheryl esters on vitamin E-deficient rats. | 1978 | J. Nutr. Sci. Vitaminol. | pmid:731332 |
| Hong AW et al. | An expedient route to Montanine-type Amaryllidaceae alkaloids: total syntheses of (-)-brunsvigine and (-)-manthine. | 2008 | J. Org. Chem. | pmid:18781802 |
| Chakraborti AK and Shivani S | Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst. | 2006 | J. Org. Chem. | pmid:16839166 |