Pivalic acid

Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pivalic acid?

Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pivalic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Otitis Media D010033 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Body Weight D001835 333 associated lipids
Psoriasis D011565 47 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Seizures D012640 87 associated lipids
Dermatitis D003872 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hyperinsulinism D006946 27 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Pivalic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pivalic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pivalic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pivalic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pivalic acid

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Per page 10 20 50 100 | Total 272
Authors Title Published Journal PubMed Link
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Nasu T et al. Newborn hypocarnitinemia due to long-term transplacental pivalic acid passage. 2014 Pediatr Int pmid:25335995
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Hussain MA et al. Improvement of the oral bioavailability of naltrexone in dogs: a prodrug approach. 1987 J Pharm Sci pmid:3656096
Melegh B et al. Pivampicillin-promoted excretion of pivaloylcarnitine in humans. 1987 Biochem. Pharmacol. pmid:3675603
Johnston NE and Stewart JA The effect of glucocorticoids and prematurity on absorption of colostral immunoglobulin in the calf. 1986 Aust. Vet. J. pmid:3767799
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Tamaru RD et al. Comparison of ocular disposition of free pivalic acid and pivalic acid esterified in dipivefrin. 1983 Arch. Ophthalmol. pmid:6347153
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Staatz WD et al. Cytotoxicity of pivalylphenylephrine and pivalic acid to corneal endothelium. 1980 Arch. Ophthalmol. pmid:7396784
Morris GS et al. Sodium pivalate reduces cardiac carnitine content and increases glucose oxidation without affecting cardiac functional capacity. 1995 Life Sci. pmid:7475977
Diep QN et al. Formation of pivaloylcarnitine in isolated rat heart cells. 1995 Biochim. Biophys. Acta pmid:7488636
Mizojiri K et al. Disposition of S-1108, a new oral cephem antibiotic, and metabolic fate of pivalic acid liberated from [pivaloyl-14C]S-1108 in rats and dogs. 1995 Antimicrob. Agents Chemother. pmid:7492083
Abrahamsson K et al. Effect of short-term treatment with pivalic acid containing antibiotics on serum carnitine concentration--a risk irrespective of age. 1995 Biochem. Mol. Med. pmid:7551831
Broderick TL et al. L-propionylcarnitine effects on cardiac carnitine content and function in secondary carnitine deficiency. 1995 Can. J. Physiol. Pharmacol. pmid:7671193
Broderick TL et al. Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency. 1995 Metab. Clin. Exp. pmid:7723673
Diep QN and Bøhmer T Increased pivaloylcarnitine in the liver of the sodium pivalate treated rat exposed to clofibrate. 1995 Biochim. Biophys. Acta pmid:7766704