| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Urinary Tract Infections | D014552 | 11 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Dermatitis | D003872 | 30 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
Pivalic acid
Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Pivalic acid?
Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Pivalic acid
PubChem Associated disorders and diseases
What pathways are associated with Pivalic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Pivalic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Pivalic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Pivalic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Pivalic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with Pivalic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Pivalic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Diep QN et al. | Formation of pivaloylcarnitine in heart and brown adipose tissue in the rat. | 1995 | Biochim. Biophys. Acta | pmid:7827109 |
| Abrahamsson K et al. | Impaired ketogenesis in carnitine depletion caused by short-term administration of pivalic acid prodrug. | 1994 | Biochem. Med. Metab. Biol. | pmid:7917463 |
| Reckers VR and Wendt H | [Multicentre-clinical trial of the novel corticosteroid diflucortolone valerate in the forms of cream, ointment and fatty ointment. Part I: Comparative study of diflucortolone valerate with fluocortolone, -capronate, -pivalate in a double-blind contralateral design with topical application (author's transl)]. | 1976 | Arzneimittelforschung | pmid:795433 |
| Fujii R et al. | [Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients]. | 1993 | Jpn J Antibiot | pmid:8254895 |
| Melegh B et al. | Preferential elimination of pivalate with supplemental carnitine via formation of pivaloylcarnitine in man. | 1993 | Xenobiotica | pmid:8310709 |
| Shimizu K et al. | Carnitine status and safety after administration of S-1108, a new oral cephem, to patients. | 1993 | Antimicrob. Agents Chemother. | pmid:8517691 |
| Davis AT | Carnitine depletion in rat pups of lactating mothers given sodium pivalate. | 1995 | Biol. Neonate | pmid:8534786 |
| Abrahamsson K et al. | Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid. | 1995 | Br Heart J | pmid:8541173 |
| Broderick TL et al. | L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts. | 1995 | Cardiovasc. Res. | pmid:8595631 |
| Nakajima H et al. | Pivalate affects carnitine status but causes no severe metabolic changes in rat liver. | 1996 | J. Nutr. | pmid:8648443 |
| Sauber K et al. | A new esterase for the cleavage of pivalic acid-containing prodrug esters of cephalosporins. | 1996 | Enzyme Microb. Technol. | pmid:8672280 |
| Zanelli U et al. | Selective depletion of mitochondrial glutathione content by pivalic acid and valproic acid in rat liver: possibility of a common mechanism. | 1996 | Adv. Exp. Med. Biol. | pmid:8794200 |
| Metges CC et al. | Gas chromatography/combustion/isotope ratio mass spectrometric comparison of N-acetyl- and N-pivaloyl amino acid esters to measure 15N isotopic abundances in physiological samples: a pilot study on amino acid synthesis in the upper gastro-intestinal tract of minipigs. | 1996 | J Mass Spectrom | pmid:8799283 |
| Zanelli U et al. | Induction of peroxisomal beta-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney. | 1996 | Arch. Toxicol. | pmid:8825670 |
| Bianchi PB and Davis AT | beta-Hydroxybutyrate oxidation is reduced and hepatic balance of ketone bodies and free fatty acids is unaltered in carnitine-depleted, pivalate-treated rats. | 1996 | J. Nutr. | pmid:8914959 |
| Bianchi PB et al. | Carnitine supplementation ameliorates the steatosis and ketosis induced by pivalate in rats. | 1996 | J. Nutr. | pmid:8914960 |
| Abrahamsson K et al. | Pivalic acid-induced carnitine deficiency and physical exercise in humans. | 1996 | Metab. Clin. Exp. | pmid:8969283 |
| Cooper TG et al. | Successful lowering of epididymal carnitine by administration of pivalate to rats. | 1997 | Int. J. Androl. | pmid:9354188 |
| Lewin LM et al. | Effects of pivalic acid and sodium pivalate on L-carnitine concentrations in the cauda epididymidis and on male fertility in the hamster. | 1997 | Reprod. Fertil. Dev. | pmid:9402252 |
| Giordano F et al. | Crystal forms of piroxicam pivalate: preparation and characterization of two polymorphs. | 1998 | J Pharm Sci | pmid:9523987 |
| Czerkawski JW | The use of pivalic acid as a reference substance in measurements of production of volatile fatty acids by rumen micro-organisms in vitro. | 1976 | Br. J. Nutr. | pmid:952843 |
| Douglas KT et al. | Mechanistic studies of carboxypeptidase Y. Kinetic detection of an acyl-enzyme intermediate in trimethylacetate esterase action. | 1976 | J. Am. Chem. Soc. | pmid:993522 |